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Extract from the Register of European Patents

EP About this file: EP2480557

EP2480557 - PROCESS FOR THE PREPARATION OF RAPAMYCIN DERIVATIVES [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  20.03.2015
Database last updated on 26.07.2024
Most recent event   Tooltip17.03.2017Change - prioritypublished on 19.04.2017  [2017/16]
Applicant(s)For all designated states
Cadila Healthcare Limited
Zydus Tower Satellite Cross Roads
Ahmedabad 380 015, Gujarat / IN
[2012/31]
Inventor(s)01 / DAVE, Mayank, Ghanshyambhai
Cadila Healthcare Limited
Zydus Tower
Satellite Cross Roads
Ahmedabad 380015
Gujarat / IN
02 / PANDEY, Bipin
Cadila Healthcare Limited
Zydus Tower
Satellite Cross Roads
Ahmedabad 380015
Gujarat / IN
 [2012/31]
Representative(s)Harris, Jennifer Lucy, et al
Kilburn & Strode LLP
Lacon London
84 Theobalds Road
London WC1X 8NL / GB
[N/P]
Former [2013/22]Harris, Jennifer Lucy, et al
Kilburn & Strode LLP 20 Red Lion Street
London WC1R 4PJ / GB
Former [2012/31]Jennings, Nigel Robin, et al
Kilburn & Strode LLP 20 Red Lion Street
London WC1R 4PJ / GB
Application number, filing date10810987.724.09.2010
WO2010IN00646
Priority number, dateIN2009MUM223425.09.2009         Original published format: IN 2234MU2009
[2017/16]
Former [2012/31]IN2009MUM223425.09.2009
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2011051960
Date:05.05.2011
Language:EN
[2011/18]
Type: A2 Application without search report 
No.:EP2480557
Date:01.08.2012
Language:EN
The application published by WIPO in one of the EPO official languages on 05.05.2011 takes the place of the publication of the European patent application.
[2012/31]
Search report(s)International search report - published on:EP23.06.2011
ClassificationIPC:C07D498/18, A61K31/435, A61P37/06, C07D319/06, C07D319/08
[2012/31]
CPC:
C07D498/18 (EP,US); A61P37/06 (EP); C07D319/06 (EP,US);
C07D319/08 (EP,US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   SM,   TR [2012/31]
TitleGerman:VERFAHREN ZUR HERSTELLUNG VON RAPAMYCINDERIVATEN[2012/31]
English:PROCESS FOR THE PREPARATION OF RAPAMYCIN DERIVATIVES[2012/31]
French:PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS DE RAPAMYCINE[2012/31]
Entry into regional phase19.04.2012National basic fee paid 
19.04.2012Designation fee(s) paid 
19.04.2012Examination fee paid 
Examination procedure07.04.2011Request for preliminary examination filed
International Preliminary Examining Authority: EP
19.04.2012Amendment by applicant (claims and/or description)
19.04.2012Examination requested  [2012/31]
04.04.2013Despatch of a communication from the examining division (Time limit: M04)
28.04.2013Observations by third parties
13.08.2013Reply to a communication from the examining division
26.09.2013Despatch of a communication from the examining division (Time limit: M04)
24.01.2014Reply to a communication from the examining division
17.02.2014Despatch of a communication from the examining division (Time limit: M04)
17.06.2014Reply to a communication from the examining division
03.07.2014Despatch of a communication from the examining division (Time limit: M04)
14.11.2014Application deemed to be withdrawn, date of legal effect  [2015/17]
15.12.2014Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2015/17]
Divisional application(s)EP14182880.6   Application refused  : 02.02.2015
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  04.04.2013
Fees paidRenewal fee
11.07.2012Renewal fee patent year 03
12.07.2013Renewal fee patent year 04
25.07.2014Renewal fee patent year 05
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Cited inInternational search[XDYI]US5362718  (SKOTNICKI JERAULD S [US], et al) [XD] 8,10,12 * examples 13,14; claims 1,17 * [Y] 1-7 [I] 9,11,13;
 [Y]WO2005016935  (WYETH CORP [US], et al) [Y] 14-22,24-27 * page 11 *;
 [A]WO2005035528  (REDDYS LAB LTD DR [IN], et al) [A] 9* page 40; compound B *;
 [Y]WO2006095185  (BIOTICA TECH LTD [GB], et al) [Y] 1-7 * pages 34,35 *;
 [XYI]  - SORBERA L A ET AL, "CCI-779: Oncolytic mTOR inhibitor", DRUGS OF THE FUTURE 2002 ES LNKD- DOI:10.1358/DOF.2002.027.01.654066, (2002), vol. 27, no. 1, ISSN 0377-8282, pages 7 - 13, XP002631962 [X] 8,10,12 * Scheme 1, 2 * [Y] 1-7,14 [I] 9,11,13

DOI:   http://dx.doi.org/10.1358/DOF.2002.027.01.654066
 [XI]  - GU JIANXIN ET AL, "lipase-catalyzed regioselective esterification of rapamycin: synthesis of temsirolimus (CCI-779).", ORGANIC LETTERS 1 SEP 2005 LNKD- PUBMED:16119938, (20050901), vol. 7, no. 18, ISSN 1523-7060, pages 3945 - 3948, XP002631963 [X] 8 * compounds 8,9 * [I] 9,12

DOI:   http://dx.doi.org/10.1021/OL0514395
 [XY]  - CHEN YANQIU ET AL, "Conformational changes of rapamycin and analogs upon complexing with FKBP associated with activity: An application of second derivative CD spectroscopy", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (1994), vol. 116, no. 6, ISSN 0002-7863, pages 2683 - 2684, XP002631964 [X] 23 * compounds 4-6 * [Y] 14-22,24-27
by applicantUS5362718
 US6277983
 WO2005016935
 US2005234086
 US2007129395
    - T. W. GREENE; PETER G. M WUTS, Protective Groups in Organic Synthesis, JOHN WILEY AND SONS
otherUS5362718
 WO03099787
 WO2006095185
    - BRUICE T.C. ET AL, "A search for carboxyl-group catalysis in ketal hydrolysis", JOURNAL OF THE AMERICAL CHEMICAL SOCIETY, (19670705), vol. 89, no. 14, pages 3568 - 3576, XP003031122

DOI:   http://dx.doi.org/10.1021/ja00990a039
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.