EP2502897 - METHOD FOR PRODUCING OPTICALLY ACTIVE BICYCLO [3.1.0]HEXANE DERIVATIVE USING ENZYME [Right-click to bookmark this link] | |||
Former [2012/39] | METHOD FOR PRODUCING OPTICALLY ACTIVE BICYCLO [3.1.0]HEXANE DERIVATIVE USING OXYGEN | ||
[2014/10] | Status | No opposition filed within time limit Status updated on 15.05.2015 Database last updated on 09.09.2024 | Most recent event Tooltip | 12.10.2018 | Lapse of the patent in a contracting state New state(s): AL | published on 14.11.2018 [2018/46] | Applicant(s) | For all designated states Taisho Pharmaceutical Co., Ltd. 24-1, Takada 3-chome Toshima-ku Tokyo 170-8633 / JP | [2012/39] | Inventor(s) | 01 /
SASAKI, Joji c/o TAISHO PHARMACEUTICAL CO. LTD. 24-1, Takada 3-chome Toshima-ku Tokyo 170-8633 / JP | [2012/39] | Representative(s) | Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastraße 30 81925 München / DE | [N/P] |
Former [2012/39] | HOFFMANN EITLE Patent- und Rechtsanwälte Arabellastrasse 4 81925 München / DE | Application number, filing date | 10831333.9 | 18.11.2010 | WO2010JP06756 | Priority number, date | JP20090262827 | 18.11.2009 Original published format: JP 2009262827 | [2012/39] | Filing language | JA | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2011061934 | Date: | 26.05.2011 | Language: | JA | [2011/21] | Type: | A1 Application with search report | No.: | EP2502897 | Date: | 26.09.2012 | Language: | EN | [2012/39] | Type: | B1 Patent specification | No.: | EP2502897 | Date: | 09.07.2014 | Language: | EN | [2014/28] | Search report(s) | International search report - published on: | JP | 26.05.2011 | (Supplementary) European search report - dispatched on: | EP | 14.03.2013 | Classification | IPC: | C07C67/303, C07C69/753, C12P7/62, C07B53/00, C07B57/00, C07B61/00 | [2012/39] | CPC: |
C07C69/757 (EP,US);
C07B53/00 (EP,US);
C07B57/00 (EP,US);
C07C67/303 (EP,US);
C07C67/313 (EP,US);
C07C67/327 (EP,US);
| C-Set: |
C07C67/303, C07C69/757 (US,EP);
C07C67/313, C07C69/757 (EP,US);
C07C67/327, C07C69/757 (US,EP)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2012/39] | Extension states | BA | 11.06.2012 | ME | 11.06.2012 | Title | German: | VERFAHREN ZUR HERSTELLUNG EINES OPTISCH AKTIVEN BICYCLO-[3.1.0-]HEXANDERIVATS MITHILFE EINES ENZYMS | [2014/10] | English: | METHOD FOR PRODUCING OPTICALLY ACTIVE BICYCLO [3.1.0]HEXANE DERIVATIVE USING ENZYME | [2014/10] | French: | PROCÉDÉ DE PRODUCTION D'UN DÉRIVÉ DE BICYCLO[3.1.0]HEXANE OPTIQUEMENT ACTIF À L'AIDE D'UNE ENZYME | [2014/10] |
Former [2012/39] | VERFAHREN ZUR HERSTELLUNG EINES OPTISCH AKTIVEN BICYCLO-[3.1.0-]HEXANDERIVATS MITHILFE VON SAUERSTOFF | ||
Former [2012/39] | METHOD FOR PRODUCING OPTICALLY ACTIVE BICYCLO [3.1.0]HEXANE DERIVATIVE USING OXYGEN | ||
Former [2012/39] | PROCÉDÉ DE PRODUCTION D'UN DÉRIVÉ DE BICYCLO[3.1.0]HEXANE OPTIQUEMENT ACTIF À L'AIDE D'OXYGÈNE | Entry into regional phase | 11.06.2012 | Translation filed | 11.06.2012 | National basic fee paid | 11.06.2012 | Search fee paid | 11.06.2012 | Designation fee(s) paid | 11.06.2012 | Examination fee paid | Examination procedure | 11.06.2012 | Examination requested [2012/39] | 25.09.2013 | Amendment by applicant (claims and/or description) | 12.02.2014 | Communication of intention to grant the patent | 16.05.2014 | Fee for grant paid | 16.05.2014 | Fee for publishing/printing paid | 16.05.2014 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 12.02.2014 | Opposition(s) | 10.04.2015 | No opposition filed within time limit [2015/25] | Fees paid | Renewal fee | 14.11.2012 | Renewal fee patent year 03 | 16.11.2013 | Renewal fee patent year 04 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 18.11.2010 | AL | 09.07.2014 | AT | 09.07.2014 | BE | 09.07.2014 | CY | 09.07.2014 | CZ | 09.07.2014 | DK | 09.07.2014 | EE | 09.07.2014 | ES | 09.07.2014 | FI | 09.07.2014 | HR | 09.07.2014 | IT | 09.07.2014 | LT | 09.07.2014 | LV | 09.07.2014 | MC | 09.07.2014 | MK | 09.07.2014 | MT | 09.07.2014 | NL | 09.07.2014 | PL | 09.07.2014 | RO | 09.07.2014 | RS | 09.07.2014 | SE | 09.07.2014 | SI | 09.07.2014 | SK | 09.07.2014 | SM | 09.07.2014 | TR | 09.07.2014 | BG | 09.10.2014 | NO | 09.10.2014 | GR | 10.10.2014 | IS | 09.11.2014 | PT | 10.11.2014 | IE | 18.11.2014 | LU | 18.11.2014 | CH | 30.11.2014 | LI | 30.11.2014 | [2018/46] |
Former [2018/30] | HU | 18.11.2010 | |
AT | 09.07.2014 | ||
BE | 09.07.2014 | ||
CY | 09.07.2014 | ||
CZ | 09.07.2014 | ||
DK | 09.07.2014 | ||
EE | 09.07.2014 | ||
ES | 09.07.2014 | ||
FI | 09.07.2014 | ||
HR | 09.07.2014 | ||
IT | 09.07.2014 | ||
LT | 09.07.2014 | ||
LV | 09.07.2014 | ||
MC | 09.07.2014 | ||
MK | 09.07.2014 | ||
MT | 09.07.2014 | ||
NL | 09.07.2014 | ||
PL | 09.07.2014 | ||
RO | 09.07.2014 | ||
RS | 09.07.2014 | ||
SE | 09.07.2014 | ||
SI | 09.07.2014 | ||
SK | 09.07.2014 | ||
SM | 09.07.2014 | ||
TR | 09.07.2014 | ||
BG | 09.10.2014 | ||
NO | 09.10.2014 | ||
GR | 10.10.2014 | ||
IS | 09.11.2014 | ||
PT | 10.11.2014 | ||
IE | 18.11.2014 | ||
LU | 18.11.2014 | ||
CH | 30.11.2014 | ||
LI | 30.11.2014 | ||
Former [2016/33] | HU | 18.11.2010 | |
AT | 09.07.2014 | ||
BE | 09.07.2014 | ||
CY | 09.07.2014 | ||
CZ | 09.07.2014 | ||
DK | 09.07.2014 | ||
EE | 09.07.2014 | ||
ES | 09.07.2014 | ||
FI | 09.07.2014 | ||
HR | 09.07.2014 | ||
IT | 09.07.2014 | ||
LT | 09.07.2014 | ||
LV | 09.07.2014 | ||
MC | 09.07.2014 | ||
MT | 09.07.2014 | ||
NL | 09.07.2014 | ||
PL | 09.07.2014 | ||
RO | 09.07.2014 | ||
RS | 09.07.2014 | ||
SE | 09.07.2014 | ||
SI | 09.07.2014 | ||
SK | 09.07.2014 | ||
SM | 09.07.2014 | ||
TR | 09.07.2014 | ||
BG | 09.10.2014 | ||
NO | 09.10.2014 | ||
GR | 10.10.2014 | ||
IS | 09.11.2014 | ||
PT | 10.11.2014 | ||
IE | 18.11.2014 | ||
LU | 18.11.2014 | ||
CH | 30.11.2014 | ||
LI | 30.11.2014 | ||
Former [2016/32] | HU | 18.11.2010 | |
AT | 09.07.2014 | ||
BE | 09.07.2014 | ||
CY | 09.07.2014 | ||
CZ | 09.07.2014 | ||
DK | 09.07.2014 | ||
EE | 09.07.2014 | ||
ES | 09.07.2014 | ||
FI | 09.07.2014 | ||
HR | 09.07.2014 | ||
IT | 09.07.2014 | ||
LT | 09.07.2014 | ||
LV | 09.07.2014 | ||
MC | 09.07.2014 | ||
NL | 09.07.2014 | ||
PL | 09.07.2014 | ||
RO | 09.07.2014 | ||
RS | 09.07.2014 | ||
SE | 09.07.2014 | ||
SI | 09.07.2014 | ||
SK | 09.07.2014 | ||
SM | 09.07.2014 | ||
TR | 09.07.2014 | ||
BG | 09.10.2014 | ||
NO | 09.10.2014 | ||
GR | 10.10.2014 | ||
IS | 09.11.2014 | ||
PT | 10.11.2014 | ||
IE | 18.11.2014 | ||
LU | 18.11.2014 | ||
CH | 30.11.2014 | ||
LI | 30.11.2014 | ||
Former [2016/22] | AT | 09.07.2014 | |
CY | 09.07.2014 | ||
CZ | 09.07.2014 | ||
DK | 09.07.2014 | ||
EE | 09.07.2014 | ||
ES | 09.07.2014 | ||
FI | 09.07.2014 | ||
HR | 09.07.2014 | ||
IT | 09.07.2014 | ||
LT | 09.07.2014 | ||
LV | 09.07.2014 | ||
MC | 09.07.2014 | ||
NL | 09.07.2014 | ||
PL | 09.07.2014 | ||
RO | 09.07.2014 | ||
RS | 09.07.2014 | ||
SE | 09.07.2014 | ||
SI | 09.07.2014 | ||
SK | 09.07.2014 | ||
SM | 09.07.2014 | ||
BG | 09.10.2014 | ||
NO | 09.10.2014 | ||
GR | 10.10.2014 | ||
IS | 09.11.2014 | ||
PT | 10.11.2014 | ||
IE | 18.11.2014 | ||
LU | 18.11.2014 | ||
BE | 30.11.2014 | ||
CH | 30.11.2014 | ||
LI | 30.11.2014 | ||
Former [2015/50] | AT | 09.07.2014 | |
CY | 09.07.2014 | ||
CZ | 09.07.2014 | ||
DK | 09.07.2014 | ||
EE | 09.07.2014 | ||
ES | 09.07.2014 | ||
FI | 09.07.2014 | ||
HR | 09.07.2014 | ||
IT | 09.07.2014 | ||
LT | 09.07.2014 | ||
LV | 09.07.2014 | ||
MC | 09.07.2014 | ||
NL | 09.07.2014 | ||
PL | 09.07.2014 | ||
RO | 09.07.2014 | ||
RS | 09.07.2014 | ||
SE | 09.07.2014 | ||
SI | 09.07.2014 | ||
SK | 09.07.2014 | ||
BG | 09.10.2014 | ||
NO | 09.10.2014 | ||
GR | 10.10.2014 | ||
IS | 09.11.2014 | ||
PT | 10.11.2014 | ||
IE | 18.11.2014 | ||
LU | 18.11.2014 | ||
BE | 30.11.2014 | ||
CH | 30.11.2014 | ||
LI | 30.11.2014 | ||
Former [2015/46] | AT | 09.07.2014 | |
CY | 09.07.2014 | ||
CZ | 09.07.2014 | ||
DK | 09.07.2014 | ||
EE | 09.07.2014 | ||
ES | 09.07.2014 | ||
FI | 09.07.2014 | ||
HR | 09.07.2014 | ||
IT | 09.07.2014 | ||
LT | 09.07.2014 | ||
LV | 09.07.2014 | ||
MC | 09.07.2014 | ||
NL | 09.07.2014 | ||
PL | 09.07.2014 | ||
RO | 09.07.2014 | ||
RS | 09.07.2014 | ||
SE | 09.07.2014 | ||
SK | 09.07.2014 | ||
BG | 09.10.2014 | ||
NO | 09.10.2014 | ||
GR | 10.10.2014 | ||
IS | 09.11.2014 | ||
PT | 10.11.2014 | ||
IE | 18.11.2014 | ||
LU | 18.11.2014 | ||
BE | 30.11.2014 | ||
CH | 30.11.2014 | ||
LI | 30.11.2014 | ||
Former [2015/33] | AT | 09.07.2014 | |
CY | 09.07.2014 | ||
CZ | 09.07.2014 | ||
DK | 09.07.2014 | ||
EE | 09.07.2014 | ||
ES | 09.07.2014 | ||
FI | 09.07.2014 | ||
HR | 09.07.2014 | ||
IT | 09.07.2014 | ||
LT | 09.07.2014 | ||
LV | 09.07.2014 | ||
MC | 09.07.2014 | ||
NL | 09.07.2014 | ||
PL | 09.07.2014 | ||
RO | 09.07.2014 | ||
RS | 09.07.2014 | ||
SE | 09.07.2014 | ||
SK | 09.07.2014 | ||
BG | 09.10.2014 | ||
NO | 09.10.2014 | ||
GR | 10.10.2014 | ||
IS | 09.11.2014 | ||
PT | 10.11.2014 | ||
LU | 18.11.2014 | ||
BE | 30.11.2014 | ||
CH | 30.11.2014 | ||
LI | 30.11.2014 | ||
Former [2015/32] | AT | 09.07.2014 | |
CY | 09.07.2014 | ||
CZ | 09.07.2014 | ||
DK | 09.07.2014 | ||
EE | 09.07.2014 | ||
ES | 09.07.2014 | ||
FI | 09.07.2014 | ||
HR | 09.07.2014 | ||
IT | 09.07.2014 | ||
LT | 09.07.2014 | ||
LV | 09.07.2014 | ||
MC | 09.07.2014 | ||
NL | 09.07.2014 | ||
PL | 09.07.2014 | ||
RO | 09.07.2014 | ||
RS | 09.07.2014 | ||
SE | 09.07.2014 | ||
SK | 09.07.2014 | ||
BG | 09.10.2014 | ||
NO | 09.10.2014 | ||
GR | 10.10.2014 | ||
IS | 09.11.2014 | ||
PT | 10.11.2014 | ||
LU | 18.11.2014 | ||
BE | 30.11.2014 | ||
Former [2015/30] | AT | 09.07.2014 | |
CY | 09.07.2014 | ||
CZ | 09.07.2014 | ||
DK | 09.07.2014 | ||
EE | 09.07.2014 | ||
ES | 09.07.2014 | ||
FI | 09.07.2014 | ||
HR | 09.07.2014 | ||
IT | 09.07.2014 | ||
LT | 09.07.2014 | ||
LV | 09.07.2014 | ||
NL | 09.07.2014 | ||
PL | 09.07.2014 | ||
RO | 09.07.2014 | ||
RS | 09.07.2014 | ||
SE | 09.07.2014 | ||
SK | 09.07.2014 | ||
BG | 09.10.2014 | ||
NO | 09.10.2014 | ||
GR | 10.10.2014 | ||
IS | 09.11.2014 | ||
PT | 10.11.2014 | ||
LU | 18.11.2014 | ||
BE | 30.11.2014 | ||
Former [2015/23] | AT | 09.07.2014 | |
CY | 09.07.2014 | ||
CZ | 09.07.2014 | ||
DK | 09.07.2014 | ||
EE | 09.07.2014 | ||
ES | 09.07.2014 | ||
FI | 09.07.2014 | ||
HR | 09.07.2014 | ||
IT | 09.07.2014 | ||
LT | 09.07.2014 | ||
LV | 09.07.2014 | ||
NL | 09.07.2014 | ||
PL | 09.07.2014 | ||
RO | 09.07.2014 | ||
RS | 09.07.2014 | ||
SE | 09.07.2014 | ||
SK | 09.07.2014 | ||
BG | 09.10.2014 | ||
NO | 09.10.2014 | ||
GR | 10.10.2014 | ||
IS | 09.11.2014 | ||
PT | 10.11.2014 | ||
Former [2015/22] | AT | 09.07.2014 | |
CY | 09.07.2014 | ||
DK | 09.07.2014 | ||
ES | 09.07.2014 | ||
FI | 09.07.2014 | ||
HR | 09.07.2014 | ||
IT | 09.07.2014 | ||
LT | 09.07.2014 | ||
LV | 09.07.2014 | ||
NL | 09.07.2014 | ||
PL | 09.07.2014 | ||
RO | 09.07.2014 | ||
RS | 09.07.2014 | ||
SE | 09.07.2014 | ||
BG | 09.10.2014 | ||
NO | 09.10.2014 | ||
GR | 10.10.2014 | ||
IS | 09.11.2014 | ||
PT | 10.11.2014 | ||
Former [2015/12] | AT | 09.07.2014 | |
CY | 09.07.2014 | ||
ES | 09.07.2014 | ||
FI | 09.07.2014 | ||
HR | 09.07.2014 | ||
LT | 09.07.2014 | ||
LV | 09.07.2014 | ||
NL | 09.07.2014 | ||
PL | 09.07.2014 | ||
RS | 09.07.2014 | ||
SE | 09.07.2014 | ||
BG | 09.10.2014 | ||
NO | 09.10.2014 | ||
GR | 10.10.2014 | ||
IS | 09.11.2014 | ||
PT | 10.11.2014 | ||
Former [2015/11] | CY | 09.07.2014 | |
ES | 09.07.2014 | ||
FI | 09.07.2014 | ||
LT | 09.07.2014 | ||
PL | 09.07.2014 | ||
SE | 09.07.2014 | ||
BG | 09.10.2014 | ||
NO | 09.10.2014 | ||
GR | 10.10.2014 | ||
PT | 10.11.2014 | ||
Former [2015/10] | ES | 09.07.2014 | |
FI | 09.07.2014 | ||
LT | 09.07.2014 | ||
SE | 09.07.2014 | ||
BG | 09.10.2014 | ||
NO | 09.10.2014 | ||
Former [2015/09] | FI | 09.07.2014 | |
LT | 09.07.2014 | ||
SE | 09.07.2014 | ||
Former [2015/08] | LT | 09.07.2014 | Documents cited: | Search | [A]WO2005047215 (MERCK & CO INC [US], et al) [A] 1,2,11,12 * examples 14,15 * * page 22, scheme 2: compound 18 *; | [E]EP2298755 (TAISHO PHARMACEUTICAL CO LTD [JP]) [E] 2,11 * paragraph [0163]; compounds 2,3' * * paragraph [0168]; table 2 * * paragraph [0176]; table 6 * * [0188]: compound 3-1' after chiral HPLC * * [0198]: compound 3-6' after chiral HPLC *; | [A] - THEIL, FRITZ ET AL, "Enzymes in organic synthesis. Part 1. Synthesis of (1S,4R)-(-)-4-hydroxy-2-cyclopentenyl acetate by a high enantioselective enzyme catalyzed transesterification in organic solvents", SYNTHESIS, (7), 540 -1 CODEN: SYNTBF; ISSN: 0039-7881, (1988), XP002693017 [A] 1,2,11,12 * the whole document * DOI: http://dx.doi.org/10.1055/s-1988-27630 | International search | [XP]WO2009142184 (TAISHO PHARMACEUTICAL CO LTD [JP], et al); | [A] - NAKAZATO ATSURO ET AL., "Synthesis, in Vitro Pharmacology, Structure-Activity Relationships, and Pharmacokinetics of 3-Alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Derivatives as Potent and Selective Group II Metabotropic Glutamate Receptor Antagonists", JOURNAL OF MEDICINAL CHEMISTRY, (20040826), vol. 47, no. 18, pages 4570 - 4587, XP008157980 DOI: http://dx.doi.org/10.1021/jm0400294 | [A] - YASUHARA AKITO ET AL., "Synthesis, in vitro pharmacology, and structure-activity relationships of 2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as mGluR2 antagonists", BIOORGANIC & MEDICINAL CHEMISTRY, (20060515), vol. 14, no. 10, pages 3405 - 3420, XP008157938 DOI: http://dx.doi.org/10.1016/j.bmc.2005.12.061 | [A] - YASUHARA AKITO ET AL., "Prodrugs of 3-(3,4-dichlorobenzyloxy)-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (MGS0039): A potent and orally active group II mGluR antagonist with antidepressant-like potential", BIOORGANIC & MEDICINAL CHEMISTRY, (20060615), vol. 14, no. 12, pages 4193 - 4207, XP008157987 DOI: http://dx.doi.org/10.1016/j.bmc.2006.01.060 | [A] - ZHANG FEI ET AL., "Enantioselective Preparation of Ring-Fused 1-Fluorocyclopropane-1-carboxylate Derivatives: En Route to mGluR 2 Receptor Agonist MGS0028", ORGANIC LETTERS, (20041014), vol. 6, no. 21, pages 3775 - 3777, XP008157968 DOI: http://dx.doi.org/10.1021/ol0484512 | [A] - WONG AUDREY ET AL., "Reactive resin facilitated preparation of an enantiopure fluorobicycloketone", ORGANIC & BIOMOLECULAR CHEMISTRY, (2004), no. 2, pages 168 - 174, XP008157985 DOI: http://dx.doi.org/10.1039/B312180C | by applicant | JPH0952887 | WO0200595 | WO03061698 | WO2005000790 | WO2005000791 | - SCIENCE, (1992), vol. 258, pages 597 - 603 | - TRENDS PHARMACOL. SCI., (1990), vol. 11, pages 508 - 515 | - TRENDS PHARMACOL. SCI., (1993), vol. 14, pages 13 - 20 | - J. MED. CHEM., (2004), vol. 47, pages 4570 - 4587 | - BIOORG. MED. CHEM., (2006), vol. 14, pages 3405 - 3420 | - BIOORG. MED. CHEM., (2006), vol. 14, pages 4193 - 4207 | - ORG. LETT., (2004), vol. 6, pages 3775 - 3777 | - J. MED. CHEM., (2000), vol. 43, pages 4893 - 4909 | - TETRAHEDRON, (2001), vol. 57, pages 7487 - 7493 | - ORG. BIOMOL. CHEM., (2004), vol. 2, pages 168 - 174 | - J. AM. CHEM. SOC., (1960), vol. 82, page 4328 | - ORG. SYNTH., (1962), vol. 42, page 50 | - ORG. LETT., (2005), vol. 7, page 4573 | - SYNLETT, (1995), vol. 827 | - TETRAHEDRON LETTERS, (1996), vol. 37, page 7131 | - ORG. LETT., (2000), vol. 2, page 4189 |