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Extract from the Register of European Patents

EP About this file: EP2516682

EP2516682 - A METHOD FOR CONTROLLING CULTURE PARAMETERS IN A BIOREACTOR [Right-click to bookmark this link]
StatusPatent revoked
Status updated on  03.12.2025
Database last updated on 11.04.2026
FormerThe patent has been granted
Status updated on  24.01.2020
FormerGrant of patent is intended
Status updated on  24.09.2019
FormerExamination is in progress
Status updated on  26.10.2018
Most recent event   Tooltip05.12.2025Revocation of patentpublished on 07.01.2026  [2026/02]
Applicant(s)For all designated states
Cytiva Sweden AB
Björkgatan 30
751 84 Uppsala / SE
[2020/33]
Former [2020/09]For all designated states
GE Healthcare Bio-Sciences AB
Björkgatan 30
75184 Uppsala / SE
Former [2012/44]For all designated states
GE Healthcare Bio-Sciences AB
Patent Department Björkgatan 30
75184 Uppsala / SE
Inventor(s)01 / GEBAUER, Klaus
GE Healthcare
Björkgatan 30
S-751 84 Uppsala / SE
02 / LINDSKOG, Eva
GE Healthcare
Björkgatan 30
S-751 84 Uppsala / SE
03 / MAGNUSSON, Lars
GE Healthcare
Björkgatan 30
S-751 84 Uppsala / SE
 [2012/44]
Representative(s)Fennell, Gareth Charles
Kilburn & Strode LLP
Lacon London
84 Theobalds Road
London WC1X 8NL / GB
[N/P]
Former [2020/09]Cavill, Ross David, et al
GE Healthcare UK Limited
Pollards Wood
Nightingales Lane
Chalfont St Giles, Buckinghamshire HP8 4SP / GB
Former [2012/44]Stavbom, Ellen Elisabet
GE Healthcare Bio-Sciences AB Patent Department Björkgatan 30
751 84 Uppsala / SE
Application number, filing date10839894.220.12.2010
[2020/09]
WO2010SE51425
Priority number, dateSE2009005100622.12.2009         Original published format: SE 0951006
[2012/44]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2011078773
Date:30.06.2011
Language:EN
[2011/26]
Type: A1 Application with search report 
No.:EP2516682
Date:31.10.2012
Language:EN
The application published by WIPO in one of the EPO official languages on 30.06.2011 takes the place of the publication of the European patent application.
[2012/44]
Type: B1 Patent specification 
No.:EP2516682
Date:26.02.2020
Language:EN
[2020/09]
Search report(s)International search report - published on:SE30.06.2011
(Supplementary) European search report - dispatched on:EP10.06.2016
ClassificationIPC:C12Q3/00, C12M1/00, C12M1/02, C12M1/34, C12M1/36, C12M3/06, G05B13/00
[2019/41]
CPC:
C12M23/14 (EP,US); C12M27/16 (EP,US); C12M41/12 (EP,US);
C12M41/18 (EP,US); C12M41/26 (EP,US); C12M41/34 (EP,US);
C12M41/36 (EP,US); C12M41/48 (EP,US) (-)
Former IPC [2012/44]C12Q3/00, C12M1/36, G05B13/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2012/44]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:VERFAHREN ZUR STEUERUNG VON KULTURPARAMETERN IN EINEM BIOREAKTOR[2012/44]
English:A METHOD FOR CONTROLLING CULTURE PARAMETERS IN A BIOREACTOR[2012/44]
French:PROCÉDÉ POUR CONTRÔLER LES PARAMÈTRES DE CULTURE DANS UN BIORÉACTEUR[2012/44]
Entry into regional phase18.06.2012National basic fee paid 
18.06.2012Search fee paid 
18.06.2012Designation fee(s) paid 
18.06.2012Examination fee paid 
Examination procedure18.06.2012Examination requested  [2012/44]
06.01.2017Amendment by applicant (claims and/or description)
29.10.2018Despatch of a communication from the examining division (Time limit: M06)
07.05.2019Reply to a communication from the examining division
25.09.2019Communication of intention to grant the patent
16.01.2020Fee for grant paid
16.01.2020Fee for publishing/printing paid
16.01.2020Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  29.10.2018
Opposition(s)Opponent(s)01  23.11.2020   
Sartorius Stedim Biotech GmbH
August-Spindler-Strasse 11
37079 Göttingen / DE
Opponent's representative
Müller-Boré & Partner Patentanwälte PartG mbB
Friedenheimer Brücke 21
80639 München / DE
 [2021/01]
15.12.2020Invitation to proprietor to file observations on the notice of opposition
20.04.2021Reply of patent proprietor to notice(s) of opposition
07.12.2022Date of oral proceedings
22.12.2022Despatch of interlocutory decision in opposition
22.12.2022Despatch of minutes of oral proceedings
12.02.2025Legal effect of revocation of patent [2026/02]
28.11.2025Despatch of communication that the patent will be revoked
Appeal following opposition01.03.2023Appeal received No.  T0455/23
01.03.2023Payment of appeal fee
28.04.2023Statement of grounds filed
12.02.2025Result of appeal procedure: revocation of the patent
28.11.2025Despatch of the decision of the Board of Appeal
12.02.2025Date of oral proceedings
Fees paidRenewal fee
26.12.2012Renewal fee patent year 03
27.12.2013Renewal fee patent year 04
29.12.2014Renewal fee patent year 05
28.12.2015Renewal fee patent year 06
27.12.2016Renewal fee patent year 07
27.12.2017Renewal fee patent year 08
02.01.2019Renewal fee patent year 09
19.12.2019Renewal fee patent year 10
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU20.12.2010
AL26.02.2020
AT26.02.2020
CY26.02.2020
CZ26.02.2020
DK26.02.2020
EE26.02.2020
ES26.02.2020
FI26.02.2020
HR26.02.2020
IT26.02.2020
LT26.02.2020
LV26.02.2020
MC26.02.2020
MK26.02.2020
MT26.02.2020
NL26.02.2020
PL26.02.2020
RO26.02.2020
RS26.02.2020
SE26.02.2020
SI26.02.2020
SK26.02.2020
SM26.02.2020
TR26.02.2020
BG26.05.2020
NO26.05.2020
GR27.05.2020
IS26.06.2020
PT19.07.2020
IE20.12.2020
LU20.12.2020
BE31.12.2020
CH31.12.2020
LI31.12.2020
[2022/33]
Former [2022/31]HU20.12.2010
AL26.02.2020
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CZ26.02.2020
DK26.02.2020
EE26.02.2020
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PL26.02.2020
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SE26.02.2020
SI26.02.2020
SK26.02.2020
SM26.02.2020
TR26.02.2020
BG26.05.2020
NO26.05.2020
GR27.05.2020
IS26.06.2020
PT19.07.2020
IE20.12.2020
LU20.12.2020
CH31.12.2020
LI31.12.2020
Former [2022/30]HU20.12.2010
AL26.02.2020
AT26.02.2020
CY26.02.2020
CZ26.02.2020
DK26.02.2020
EE26.02.2020
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FI26.02.2020
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IT26.02.2020
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MC26.02.2020
MT26.02.2020
NL26.02.2020
PL26.02.2020
RO26.02.2020
RS26.02.2020
SE26.02.2020
SI26.02.2020
SK26.02.2020
SM26.02.2020
TR26.02.2020
BG26.05.2020
NO26.05.2020
GR27.05.2020
IS26.06.2020
PT19.07.2020
IE20.12.2020
LU20.12.2020
CH31.12.2020
LI31.12.2020
Former [2022/27]HU20.12.2010
AT26.02.2020
CY26.02.2020
CZ26.02.2020
DK26.02.2020
EE26.02.2020
ES26.02.2020
FI26.02.2020
HR26.02.2020
IT26.02.2020
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LV26.02.2020
MC26.02.2020
MT26.02.2020
NL26.02.2020
PL26.02.2020
RO26.02.2020
RS26.02.2020
SE26.02.2020
SI26.02.2020
SK26.02.2020
SM26.02.2020
TR26.02.2020
BG26.05.2020
NO26.05.2020
GR27.05.2020
IS26.06.2020
PT19.07.2020
IE20.12.2020
LU20.12.2020
CH31.12.2020
LI31.12.2020
Former [2022/26]AT26.02.2020
CZ26.02.2020
DK26.02.2020
EE26.02.2020
ES26.02.2020
FI26.02.2020
HR26.02.2020
IT26.02.2020
LT26.02.2020
LV26.02.2020
MC26.02.2020
NL26.02.2020
PL26.02.2020
RO26.02.2020
RS26.02.2020
SE26.02.2020
SI26.02.2020
SK26.02.2020
SM26.02.2020
TR26.02.2020
BG26.05.2020
NO26.05.2020
GR27.05.2020
IS26.06.2020
PT19.07.2020
IE20.12.2020
LU20.12.2020
CH31.12.2020
LI31.12.2020
Former [2021/52]AT26.02.2020
CZ26.02.2020
DK26.02.2020
EE26.02.2020
ES26.02.2020
FI26.02.2020
HR26.02.2020
IT26.02.2020
LT26.02.2020
LV26.02.2020
MC26.02.2020
NL26.02.2020
PL26.02.2020
RO26.02.2020
RS26.02.2020
SE26.02.2020
SI26.02.2020
SK26.02.2020
SM26.02.2020
BG26.05.2020
NO26.05.2020
GR27.05.2020
IS26.06.2020
PT19.07.2020
IE20.12.2020
LU20.12.2020
CH31.12.2020
LI31.12.2020
Former [2021/47]AT26.02.2020
CZ26.02.2020
DK26.02.2020
EE26.02.2020
ES26.02.2020
FI26.02.2020
HR26.02.2020
IT26.02.2020
LT26.02.2020
LV26.02.2020
MC26.02.2020
NL26.02.2020
PL26.02.2020
RO26.02.2020
RS26.02.2020
SE26.02.2020
SI26.02.2020
SK26.02.2020
SM26.02.2020
BG26.05.2020
NO26.05.2020
GR27.05.2020
IS26.06.2020
PT19.07.2020
IE20.12.2020
LU20.12.2020
Former [2021/46]AT26.02.2020
CZ26.02.2020
DK26.02.2020
EE26.02.2020
ES26.02.2020
FI26.02.2020
HR26.02.2020
IT26.02.2020
LT26.02.2020
LV26.02.2020
MC26.02.2020
NL26.02.2020
PL26.02.2020
RO26.02.2020
RS26.02.2020
SE26.02.2020
SI26.02.2020
SK26.02.2020
SM26.02.2020
BG26.05.2020
NO26.05.2020
GR27.05.2020
IS26.06.2020
PT19.07.2020
IE20.12.2020
Former [2021/40]AT26.02.2020
CZ26.02.2020
DK26.02.2020
EE26.02.2020
ES26.02.2020
FI26.02.2020
HR26.02.2020
IT26.02.2020
LT26.02.2020
LV26.02.2020
MC26.02.2020
NL26.02.2020
PL26.02.2020
RO26.02.2020
RS26.02.2020
SE26.02.2020
SI26.02.2020
SK26.02.2020
SM26.02.2020
BG26.05.2020
NO26.05.2020
GR27.05.2020
IS26.06.2020
PT19.07.2020
Former [2021/10]AT26.02.2020
CZ26.02.2020
DK26.02.2020
EE26.02.2020
ES26.02.2020
FI26.02.2020
HR26.02.2020
IT26.02.2020
LT26.02.2020
LV26.02.2020
NL26.02.2020
PL26.02.2020
RO26.02.2020
RS26.02.2020
SE26.02.2020
SI26.02.2020
SK26.02.2020
SM26.02.2020
BG26.05.2020
NO26.05.2020
GR27.05.2020
IS26.06.2020
PT19.07.2020
Former [2020/50]CZ26.02.2020
DK26.02.2020
EE26.02.2020
ES26.02.2020
FI26.02.2020
HR26.02.2020
LT26.02.2020
LV26.02.2020
NL26.02.2020
RO26.02.2020
RS26.02.2020
SE26.02.2020
SK26.02.2020
SM26.02.2020
BG26.05.2020
NO26.05.2020
GR27.05.2020
IS26.06.2020
PT19.07.2020
Former [2020/49]CZ26.02.2020
DK26.02.2020
ES26.02.2020
FI26.02.2020
HR26.02.2020
LT26.02.2020
LV26.02.2020
NL26.02.2020
RO26.02.2020
RS26.02.2020
SE26.02.2020
SK26.02.2020
SM26.02.2020
BG26.05.2020
NO26.05.2020
GR27.05.2020
IS26.06.2020
PT19.07.2020
Former [2020/48]DK26.02.2020
ES26.02.2020
FI26.02.2020
HR26.02.2020
LT26.02.2020
LV26.02.2020
NL26.02.2020
RO26.02.2020
RS26.02.2020
SE26.02.2020
SM26.02.2020
BG26.05.2020
NO26.05.2020
GR27.05.2020
IS26.06.2020
PT19.07.2020
Former [2020/47]DK26.02.2020
ES26.02.2020
FI26.02.2020
HR26.02.2020
LT26.02.2020
LV26.02.2020
NL26.02.2020
RS26.02.2020
SE26.02.2020
BG26.05.2020
NO26.05.2020
GR27.05.2020
IS26.06.2020
Former [2020/45]FI26.02.2020
HR26.02.2020
LV26.02.2020
NL26.02.2020
RS26.02.2020
SE26.02.2020
BG26.05.2020
NO26.05.2020
GR27.05.2020
IS26.06.2020
Former [2020/40]FI26.02.2020
HR26.02.2020
LV26.02.2020
RS26.02.2020
SE26.02.2020
BG26.05.2020
NO26.05.2020
GR27.05.2020
IS26.06.2020
Former [2020/39]FI26.02.2020
HR26.02.2020
LV26.02.2020
RS26.02.2020
SE26.02.2020
BG26.05.2020
NO26.05.2020
GR27.05.2020
Former [2020/38]FI26.02.2020
HR26.02.2020
LV26.02.2020
RS26.02.2020
SE26.02.2020
NO26.05.2020
GR27.05.2020
Former [2020/37]FI26.02.2020
HR26.02.2020
LV26.02.2020
RS26.02.2020
SE26.02.2020
NO26.05.2020
Former [2020/35]FI26.02.2020
NO26.05.2020
Documents cited:Search[Y] US2005112542  (WEST LARRY E et al.)
 [Y] US2005272146  (HODGE GEOFFREY et al.)
 [Y] US6029101  (YOSHIDA EDWARD M et al.)
International search[X] WO2009002772  (ALGAEDYNE CORPORTION et al.) [X]
 [A] US2005112542  (WEST LARRY E et al.) [A]
 [X] US6029101  (YOSHIDA EDWARD M et al.) [X]
 [A] US2005272146  (HODGE GEOFFREY et al.) [A]
 [A] US2006019388  (HUTMACHER DIETMAR W et al.) [A]
 [A]   SVEN-OLOF ENFORS ET AL., BIOPROCESS TECHNOLOGY - FUNDAMENTALS AND APPLICATIONS, ROYAL INSTITUTE OF TECHNOLOGY, January 2000 (2000-01-01), pages 28 - 30, XP008159854 [A]
ExaminationWO2007139742
 WO2007134267
by applicantUS2005112542
 US2005272146
 US6029101
OppositionUS2005112542
 US2009042293
 US2008213874
 US2005272146
 US6029101
   ANONYMOUS: "BIOSTAT CultiBag RM 200", SARTORIUS STEDIM BIOTECH - OPERATING MANUAL, August 2008 (2008-08-01), XP055757807
   ANONYMOUS: "BIOSTAT CultiBag RM 20/50 Basic", SARTORIUS STEDIM BIOTECH - OPERATING MANUAL, March 2008 (2008-03-01), XP055757804
   ANONYMOUS: "Sartorius Stedim Biotech - DCU System for BIOSTAT CultiBag RM Optical", OPERATING MANUAL, July 2008 (2008-07-01), XP055757801
   GE HEALTHCARE: "Cell Preparation & Processing", 2008, AAAS, article "Chapter 2 Automated Cell preparation", pages: 60 - 83, XP055757795
   CAPPIA ET AL.: "Implementing Gamma-Stable RFID Tags in Single-Use Fluid Management Systems", BIOPROCESS INTERNATIONAL, vol. 7, no. Suppl 1, 1 February 2009 (2009-02-01), pages 38 - 43, XP055757792
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.