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Extract from the Register of European Patents

EP About this file: EP2515946

EP2515946 - NANOCONJUGATES AND NANOCONJUGATE FORMULATIONS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  27.03.2020
Database last updated on 14.06.2024
FormerThe patent has been granted
Status updated on  19.04.2019
FormerGrant of patent is intended
Status updated on  29.11.2018
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
The Board of Trustees of the University of Illinois
352 Henry Administration Building
506 South Wright Street
Urbana, IL 61801 / US
[2014/01]
Former [2012/44]For all designated states
BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
352 Henry Administration Building 506 South Wright Street
Urbana, IL 61801 / US
Inventor(s)01 / CHENG, Jianjun
2304 Lynwood Drive
Champaign IL 61821 / US
02 / TONG, Rong
100 Memorial Drive
Apt 8-20B
Cambridge, MA 02142 / US
 [2012/44]
Representative(s)Avidity IP
Broers Building
Hauser Forum
21 JJ Thomson Avenue
Cambridge CB3 0FA / GB
[2019/21]
Former [2013/03]Blance, Stephen John, et al
Avidity IP
Merlin House
Falconry Court
Baker's Lane
Epping, Essex CM16 5DQ / GB
Former [2012/44]Mannion, Sally Kim, et al
Avidity IP Ltd
Merlin House
Falconry Court
Baker's Lane
Epping, Essex CM16 5DQ / GB
Application number, filing date10840174.623.12.2010
[2019/21]
WO2010US62030
Priority number, dateUS20090289893P23.12.2009         Original published format: US 289893 P
[2012/44]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2011079279
Date:30.06.2011
Language:EN
[2011/26]
Type: A2 Application without search report 
No.:EP2515946
Date:31.10.2012
Language:EN
The application published by WIPO in one of the EPO official languages on 30.06.2011 takes the place of the publication of the European patent application.
[2012/44]
Type: B1 Patent specification 
No.:EP2515946
Date:22.05.2019
Language:EN
[2019/21]
Search report(s)International search report - published on:KR01.12.2011
(Supplementary) European search report - dispatched on:EP03.09.2015
ClassificationIPC:A61K47/60, A61K47/59, A61K47/69, A61K31/337, A61K9/00, A61K9/51, A61P35/00, A61K9/16
[2018/51]
CPC:
A61K9/0019 (EP,US); A61K9/1658 (US); A61K31/337 (EP,US);
A61K47/593 (EP,US); A61K47/60 (EP,US); A61K47/6935 (EP,US);
A61K9/5169 (EP,US); A61P35/00 (EP) (-)
Former IPC [2018/50]A61K47/50, A61K47/60, A61K47/42, A61K47/30, A61K9/24, A61K9/20, A61K31/7028
Former IPC [2012/44]A61K47/48, A61K47/30, A61K47/42, A61K9/24, A61K9/20, A61K31/7028
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2012/44]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:NANOKONJUGATE UND NANOKONJUGATFORMULIERUNGEN[2012/44]
English:NANOCONJUGATES AND NANOCONJUGATE FORMULATIONS[2012/44]
French:NANOCONJUGUÉS ET COMPOSITIONS DE NANOCONJUGUÉS[2012/44]
Entry into regional phase17.07.2012National basic fee paid 
17.07.2012Search fee paid 
17.07.2012Designation fee(s) paid 
17.07.2012Examination fee paid 
Examination procedure17.07.2012Examination requested  [2012/44]
01.04.2016Amendment by applicant (claims and/or description)
30.11.2018Communication of intention to grant the patent
09.04.2019Fee for grant paid
09.04.2019Fee for publishing/printing paid
09.04.2019Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  30.11.2018
Opposition(s)25.02.2020No opposition filed within time limit [2020/18]
Fees paidRenewal fee
14.12.2012Renewal fee patent year 03
18.10.2013Renewal fee patent year 04
29.12.2014Renewal fee patent year 05
31.12.2015Renewal fee patent year 06
03.01.2017Renewal fee patent year 07
27.12.2017Renewal fee patent year 08
31.12.2018Renewal fee patent year 09
Penalty fee
Additional fee for renewal fee
31.12.201607   M06   Fee paid on   03.01.2017
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU23.12.2010
AL22.05.2019
AT22.05.2019
CY22.05.2019
CZ22.05.2019
DK22.05.2019
EE22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
IT22.05.2019
LT22.05.2019
LV22.05.2019
MC22.05.2019
MK22.05.2019
MT22.05.2019
NL22.05.2019
PL22.05.2019
RO22.05.2019
RS22.05.2019
SE22.05.2019
SI22.05.2019
SK22.05.2019
SM22.05.2019
TR22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
IS22.09.2019
PT22.09.2019
LU23.12.2019
BE31.12.2019
CH31.12.2019
LI31.12.2019
[2022/31]
Former [2021/34]HU23.12.2010
AL22.05.2019
AT22.05.2019
CY22.05.2019
CZ22.05.2019
DK22.05.2019
EE22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
IT22.05.2019
LT22.05.2019
LV22.05.2019
MC22.05.2019
MT22.05.2019
NL22.05.2019
PL22.05.2019
RO22.05.2019
RS22.05.2019
SE22.05.2019
SI22.05.2019
SK22.05.2019
SM22.05.2019
TR22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
IS22.09.2019
PT22.09.2019
LU23.12.2019
BE31.12.2019
CH31.12.2019
LI31.12.2019
Former [2021/32]HU23.12.2010
AL22.05.2019
AT22.05.2019
CY22.05.2019
CZ22.05.2019
DK22.05.2019
EE22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
IT22.05.2019
LT22.05.2019
LV22.05.2019
MC22.05.2019
NL22.05.2019
PL22.05.2019
RO22.05.2019
RS22.05.2019
SE22.05.2019
SI22.05.2019
SK22.05.2019
SM22.05.2019
TR22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
IS22.09.2019
PT22.09.2019
LU23.12.2019
BE31.12.2019
CH31.12.2019
LI31.12.2019
Former [2021/31]AL22.05.2019
AT22.05.2019
CY22.05.2019
CZ22.05.2019
DK22.05.2019
EE22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
IT22.05.2019
LT22.05.2019
LV22.05.2019
MC22.05.2019
NL22.05.2019
PL22.05.2019
RO22.05.2019
RS22.05.2019
SE22.05.2019
SI22.05.2019
SK22.05.2019
SM22.05.2019
TR22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
IS22.09.2019
PT22.09.2019
LU23.12.2019
BE31.12.2019
CH31.12.2019
LI31.12.2019
Former [2021/26]AL22.05.2019
AT22.05.2019
CY22.05.2019
CZ22.05.2019
DK22.05.2019
EE22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
IT22.05.2019
LT22.05.2019
LV22.05.2019
MC22.05.2019
NL22.05.2019
PL22.05.2019
RO22.05.2019
RS22.05.2019
SE22.05.2019
SI22.05.2019
SK22.05.2019
SM22.05.2019
TR22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
PT22.09.2019
LU23.12.2019
BE31.12.2019
CH31.12.2019
LI31.12.2019
Former [2020/51]AL22.05.2019
AT22.05.2019
CZ22.05.2019
DK22.05.2019
EE22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
IT22.05.2019
LT22.05.2019
LV22.05.2019
MC22.05.2019
NL22.05.2019
PL22.05.2019
RO22.05.2019
RS22.05.2019
SE22.05.2019
SI22.05.2019
SK22.05.2019
SM22.05.2019
TR22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
PT22.09.2019
LU23.12.2019
BE31.12.2019
CH31.12.2019
LI31.12.2019
Former [2020/46]AL22.05.2019
AT22.05.2019
CZ22.05.2019
DK22.05.2019
EE22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
IT22.05.2019
LT22.05.2019
LV22.05.2019
MC22.05.2019
NL22.05.2019
PL22.05.2019
RO22.05.2019
RS22.05.2019
SE22.05.2019
SI22.05.2019
SK22.05.2019
SM22.05.2019
TR22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
PT22.09.2019
LU23.12.2019
Former [2020/39]AL22.05.2019
AT22.05.2019
CZ22.05.2019
DK22.05.2019
EE22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
IT22.05.2019
LT22.05.2019
LV22.05.2019
MC22.05.2019
NL22.05.2019
PL22.05.2019
RO22.05.2019
RS22.05.2019
SE22.05.2019
SI22.05.2019
SK22.05.2019
SM22.05.2019
TR22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
PT22.09.2019
Former [2020/25]AL22.05.2019
AT22.05.2019
CZ22.05.2019
DK22.05.2019
EE22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
IT22.05.2019
LT22.05.2019
LV22.05.2019
NL22.05.2019
PL22.05.2019
RO22.05.2019
RS22.05.2019
SE22.05.2019
SI22.05.2019
SK22.05.2019
SM22.05.2019
TR22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
PT22.09.2019
Former [2020/17]AL22.05.2019
AT22.05.2019
CZ22.05.2019
DK22.05.2019
EE22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
IT22.05.2019
LT22.05.2019
LV22.05.2019
NL22.05.2019
RO22.05.2019
RS22.05.2019
SE22.05.2019
SK22.05.2019
SM22.05.2019
TR22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
PT22.09.2019
Former [2020/14]AL22.05.2019
AT22.05.2019
CZ22.05.2019
DK22.05.2019
EE22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
IT22.05.2019
LT22.05.2019
LV22.05.2019
NL22.05.2019
RO22.05.2019
RS22.05.2019
SE22.05.2019
SK22.05.2019
SM22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
PT22.09.2019
Former [2020/12]AL22.05.2019
AT22.05.2019
CZ22.05.2019
DK22.05.2019
EE22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
IT22.05.2019
LT22.05.2019
LV22.05.2019
NL22.05.2019
RO22.05.2019
RS22.05.2019
SE22.05.2019
SK22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
PT22.09.2019
Former [2020/11]AL22.05.2019
AT22.05.2019
CZ22.05.2019
DK22.05.2019
EE22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
LT22.05.2019
LV22.05.2019
NL22.05.2019
RO22.05.2019
RS22.05.2019
SE22.05.2019
SK22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
PT22.09.2019
Former [2020/10]AL22.05.2019
AT22.05.2019
CZ22.05.2019
DK22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
LT22.05.2019
LV22.05.2019
NL22.05.2019
RO22.05.2019
RS22.05.2019
SE22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
PT22.09.2019
Former [2020/09]AL22.05.2019
CZ22.05.2019
DK22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
LT22.05.2019
LV22.05.2019
NL22.05.2019
RS22.05.2019
SE22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
PT22.09.2019
Former [2019/51]AL22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
LT22.05.2019
LV22.05.2019
NL22.05.2019
RS22.05.2019
SE22.05.2019
BG22.08.2019
NO22.08.2019
GR23.08.2019
PT22.09.2019
Former [2019/50]AL22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
LT22.05.2019
LV22.05.2019
NL22.05.2019
RS22.05.2019
SE22.05.2019
NO22.08.2019
GR23.08.2019
PT22.09.2019
Former [2019/49]AL22.05.2019
ES22.05.2019
FI22.05.2019
HR22.05.2019
LT22.05.2019
NL22.05.2019
SE22.05.2019
NO22.08.2019
PT22.09.2019
Former [2019/48]ES22.05.2019
FI22.05.2019
LT22.05.2019
SE22.05.2019
NO22.08.2019
PT22.09.2019
Former [2019/47]ES22.05.2019
FI22.05.2019
LT22.05.2019
NO22.08.2019
Documents cited:Search[Y]  - ALLARD E ET AL, "Convection-enhanced delivery of nanocarriers for the treatment of brain tumors", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 30, no. 12, doi:10.1016/J.BIOMATERIALS.2009.01.003, ISSN 0142-9612, (20090401), pages 2302 - 2318, (20090124), XP025990555 [Y] 1-15 * page 2309, paragraphs 3.2,1 *

DOI:   http://dx.doi.org/10.1016/j.biomaterials.2009.01.003
 [Y]  - VERRECCHIA T ET AL, "Non-stealth (poly(lactic acid/albumin)) and stealth (poly(lactic acid-polyethylene glycol)) nanoparticles as injectable drug carriers", JOURNAL OF CONTROLLED RELEASE, ELSEVIER, AMSTERDAM, NL, (19950901), vol. 36, no. 1, doi:10.1016/0168-3659(95)00053-B, ISSN 0168-3659, pages 49 - 61, XP004037468 [Y] 1-15 * abstract *

DOI:   http://dx.doi.org/10.1016/0168-3659(95)00053-B
International search[X]US6346274  (KOLL HANS [DE], et al);
 [A]US7399486  (LEE HEE YONG [KR], et al);
 [Y]  - ZHANG,X. ET AL., "Synthesis and characterization of the paclitaxel/MPEG-PLA block copolymer conjugate.", BIOMATERIALS, (2005), vol. 26, pages 2121 - 2128, XP027768165
 [Y]  - STOLNIK,S. ET AL., "Surface modification of poly(lactide-co-glycolide) nanospheres by biodegradable poly(lactide)-poly(ethylene glycol) copolymers.", PHARMACEUTICAL RESEARCH., (1994), vol. 11, no. 12, pages 1800 - 1808, XP055095353
 [A]  - LEE,H. ET AL., "Hyaluronic acid-paclitaxel conjugate micelles; synthesis, characterization, and antitumor activity.", BIOCONJUGATE CHEM., (2008), vol. 19, pages 1319 - 1325, XP055095354

DOI:   http://dx.doi.org/10.1021/bc8000485
 [A]  - CHANG,A. ET AL., "Stabilization of tetanus toxoid in poly(DL-lactic- co-glycolic acid) microspheres for the controlled release of antigen.", JOURNAL OF PHARMACEUTICAL SCIENCES., (1996), vol. 85, no. 2, pages 129 - 132, XP000554765

DOI:   http://dx.doi.org/10.1021/js950365v
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.