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Extract from the Register of European Patents

EP About this file: EP2423327

EP2423327 - Genetic polymorphism associated with liver fibrosis methods of detection and uses thereof [Right-click to bookmark this link]
Former [2012/09]Genetic polymorphisms associated with liver fibrosis methods of detection and uses thereof
[2013/30]
StatusNo opposition filed within time limit
Status updated on  14.11.2014
Database last updated on 24.04.2024
Most recent event   Tooltip15.07.2016Lapse of the patent in a contracting state
New state(s): TR		published on 17.08.2016  [2016/33]
Applicant(s)For all designated states
Celera Corporation
1401 Harbor Bay Parkway
Alameda, CA 94502 / US
[2012/09]
Inventor(s)01 / Cargill, Michele
60 Tarry Lane
Orinda, CA 94563 / US
02 / Huang, Hongjin
5855 Carmel Way
Union City, CA 94587 / US
 [2012/09]
Representative(s)Weber, Martin
Jones Day
Prinzregentenstraße 11
80538 München / DE
[2012/09]
Application number, filing date11165274.909.05.2005
[2012/09]
Priority number, dateUS20040568846P07.05.2004         Original published format: US 568846 P
US20040599554P09.08.2004         Original published format: US 599554 P
US20040582609P25.06.2004         Original published format: US 582609 P
[2012/09]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP2423327
Date:29.02.2012
Language:EN
[2012/09]
Type: A3 Search report 
No.:EP2423327
Date:23.05.2012
Language:EN
[2012/21]
Type: B1 Patent specification 
No.:EP2423327
Date:08.01.2014
Language:EN
[2014/02]
Search report(s)(Supplementary) European search report - dispatched on:EP19.04.2012
ClassificationIPC:C12Q1/68
[2012/09]
CPC:
C12Q1/6883 (EP,US); C12Q2600/118 (US); C12Q2600/156 (EP,US);
C12Q2600/158 (EP,US); C12Q2600/172 (EP,US)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2012/09]
TitleGerman:Genetischer Polymorphismus und Leberfibrose, Verfahren zur Erkennung und Verwendung davon[2013/30]
English:Genetic polymorphism associated with liver fibrosis methods of detection and uses thereof[2013/30]
French:Polymorphisme génétique associée à des techniques de detection de cirrhose du foie et utilisation de ces polymorphismes[2013/30]
Former [2012/09]Genetische Polymorphismen und Leberfibrose, Verfahren zur Erkennung und Verwendung davon
Former [2012/09]Genetic polymorphisms associated with liver fibrosis methods of detection and uses thereof
Former [2012/09]Polymorphismes génétiques associés à des techniques de detection de cirrhose du foie et utilisation de ces polymorphismes
Examination procedure14.11.2012Amendment by applicant (claims and/or description)
14.11.2012Examination requested  [2012/52]
29.01.2013Despatch of a communication from the examining division (Time limit: M04)
07.06.2013Reply to a communication from the examining division
30.07.2013Communication of intention to grant the patent
29.11.2013Fee for grant paid
29.11.2013Fee for publishing/printing paid
Parent application(s)   TooltipEP05746576.7  / EP1745154
Opposition(s)09.10.2014No opposition filed within time limit [2014/51]
Fees paidRenewal fee
09.05.2011Renewal fee patent year 03
09.05.2011Renewal fee patent year 04
09.05.2011Renewal fee patent year 05
09.05.2011Renewal fee patent year 06
09.05.2011Renewal fee patent year 07
25.05.2012Renewal fee patent year 08
28.05.2013Renewal fee patent year 09
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU09.05.2005
AT08.01.2014
BE08.01.2014
BG08.01.2014
CY08.01.2014
CZ08.01.2014
DK08.01.2014
EE08.01.2014
ES08.01.2014
FI08.01.2014
IT08.01.2014
LT08.01.2014
MC08.01.2014
NL08.01.2014
PL08.01.2014
RO08.01.2014
SE08.01.2014
SI08.01.2014
SK08.01.2014
TR08.01.2014
GR09.04.2014
IS08.05.2014
PT08.05.2014
IE09.05.2014
LU09.05.2014
CH31.05.2014
LI31.05.2014
[2016/33]
Former [2016/32]HU09.05.2005
AT08.01.2014
BE08.01.2014
BG08.01.2014
CY08.01.2014
CZ08.01.2014
DK08.01.2014
EE08.01.2014
ES08.01.2014
FI08.01.2014
IT08.01.2014
LT08.01.2014
MC08.01.2014
NL08.01.2014
PL08.01.2014
RO08.01.2014
SE08.01.2014
SI08.01.2014
SK08.01.2014
GR09.04.2014
IS08.05.2014
PT08.05.2014
IE09.05.2014
LU09.05.2014
CH31.05.2014
LI31.05.2014
Former [2016/29]AT08.01.2014
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BG08.01.2014
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EE08.01.2014
ES08.01.2014
FI08.01.2014
IT08.01.2014
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MC08.01.2014
NL08.01.2014
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SK08.01.2014
GR09.04.2014
IS08.05.2014
PT08.05.2014
IE09.05.2014
LU09.05.2014
CH31.05.2014
LI31.05.2014
Former [2016/28]AT08.01.2014
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MC08.01.2014
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PL08.01.2014
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GR09.04.2014
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PT08.05.2014
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CH31.05.2014
LI31.05.2014
Former [2016/25]AT08.01.2014
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BG08.01.2014
CY08.01.2014
CZ08.01.2014
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EE08.01.2014
ES08.01.2014
FI08.01.2014
LT08.01.2014
MC08.01.2014
NL08.01.2014
PL08.01.2014
RO08.01.2014
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IS08.05.2014
PT08.05.2014
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LU09.05.2014
CH31.05.2014
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Former [2015/24]AT08.01.2014
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NL08.01.2014
PL08.01.2014
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PT08.05.2014
IE09.05.2014
LU09.05.2014
CH31.05.2014
LI31.05.2014
Former [2015/21]AT08.01.2014
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PT08.05.2014
IE09.05.2014
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CH31.05.2014
LI31.05.2014
Former [2015/09]AT08.01.2014
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PL08.01.2014
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IS08.05.2014
PT08.05.2014
LU09.05.2014
CH31.05.2014
LI31.05.2014
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PT08.05.2014
LU09.05.2014
CH31.05.2014
LI31.05.2014
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EE08.01.2014
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PL08.01.2014
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LU09.05.2014
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EE08.01.2014
ES08.01.2014
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LT08.01.2014
NL08.01.2014
PL08.01.2014
RO08.01.2014
SE08.01.2014
SK08.01.2014
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PT08.05.2014
Former [2014/49]AT08.01.2014
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EE08.01.2014
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LT08.01.2014
NL08.01.2014
RO08.01.2014
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PT08.05.2014
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EE08.01.2014
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LT08.01.2014
NL08.01.2014
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PT08.05.2014
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LT08.01.2014
NL08.01.2014
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PT08.05.2014
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ES08.01.2014
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LT08.01.2014
NL08.01.2014
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PT08.05.2014
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Documents cited:Search[I]US2003119010  (POWELL ELIZABETH ELLEN [AU], et al) [I] 1-6,10,12,14 * see whole doc. esp. claims *;
 [I]WO03093506  (RENOVO LTD [GB], et al) [I] 1-6,10,12,14 * the whole document *;
 [X]  - BATALLER R. ET AL.,, "genetic polymorphisms and the progression of liver fibrosis: a cirtical appraisal", HEPATOLOGY, (200303), vol. 37, no. 3, pages 493 - 503, XP002357306 [X] 1-6,10,12,14 * see whole doc. esp. Tables 1 and 2, *

DOI:   http://dx.doi.org/10.1053/jhep.2003.50127
 [X]  - BAHR M.J. ET AL.,, "cytokine gene polymorphisms and the susceptibility to liver cirrhosisi in patients with chronic hepatitis C", LIVER INTRENATIONAL, (200312), vol. 23, pages 420 - 425, XP002357307 [X] 1-6,10,12,14 * see whole doc. esp. Tables *

DOI:   http://dx.doi.org/10.1111/j.1478-3231.2003.00873.x
 [A]  - NAMIKAWA CHIKAKO ET AL, "Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis", JOURNAL OF HEPATOLOGY, (20040501), vol. 40, no. 5, ISSN 0168-8278, pages 781 - 786, XP002660676 [A] 1-6,10,12,14 * the whole document *

DOI:   http://dx.doi.org/10.1016/J.JHEP.2004.01.028
by applicantWO9740462
 US4683195
 US4683202
 US5270184
 US5422252
 US5399491
 US6027923
 US5539082
 US5527675
 US5623049
 US5714331
 US4835263
 US5801115
 EP0235726
 WO8911548
 US4988617
 US4458066
 WO9322456
 US5210015
 US5538848
 US5118801
 US5312728
 US5866336
 US6117635
 US5837832
 WO9511995
 US5807522
 US6124478
 US6107024
 US5994073
 US5981768
 US5871938
 US5843681
 US5800999
 US5773628
 US2002110828
 WO9525116
 US5589136
 US6153073
 US6156181
 US4988167
 US6027889
 US6268148
 US5494810
 US5830711
 US6054564
 WO9731256
 WO0056927
 WO9416101
 US5498531
 US4107288
 US5145684
 US6119096
 US5283317
 WO9410300
 US4816567
 US4816397
 US5693762
 US5585089
 US5565332
 US4946778
 US5637677
 US4736866
 US4870009
 US4873191
 WO9707668
 WO9707669
    - LAUER ET AL., N ENG J MED, (2001), vol. 345, pages 41 - 52
    - POYNARD, LANCET, (1997), vol. 349, pages 825 - 832
    - POYNARD ET AL., LANCET, (1997), vol. 349, pages 825 - 832
    - WRIGHT ET AL., GUT, (2003), vol. 52, no. 4, pages 574 - 9
    - POWELL ET AL., HEPATOLOGY, (2000), vol. 31, no. 4, pages 828 - 33
    - TANAKA ET AL., J. INFEC. DIS., (2003), vol. 187, pages 1822 - 5
    - YAMAUCHI ET AL., J. HEPATOLOGY, (1995), vol. 23, no. 5, pages 519 - 23
    - BERNARD ET AL., DIABETOLOGIA, (2000), vol. 43, no. 8, pages 995 - 9
    - BATALLER ET AL., HEPATOLOGY, (2003), vol. 37, no. 3, pages 493 - 503
    - SMITH ET AL., HEPATOLOGY, (1998), vol. 27, no. 6, pages 1695 - 9
    - THORBURN, GUT, (2002), vol. 50, no. 2, pages 248 - 52
    - GUSELLA, ANN. REV. BIOCHEM., (1986), vol. 55, pages 831 - 854
    - WEBER ET AL., "Human diallelic insertion/deletion polymorphisms", AM J HUM GENET, (200210), vol. 71, no. 4, pages 854 - 62
    - STEPHENS ET AL., SCIENCE, (20010720), vol. 293, pages 489 - 493
    - LINDER ET AL., CLINICAL CHEMISTRY, (1997), vol. 43, page 254
    - MARSHALL, NATURE BIOTECHNOLOGY, (1997), vol. 15, page 1249
    - SCHAFER ET AL., NATURE BIOTECHNOLOGY, (1998), vol. 16:3
    - WU, WALLACE, GENOMICS, (1989), vol. 4, page 560
    - LANDEGREN ET AL., SCIENCE, (1988), vol. 241, page 1077
    - GUATELLI ET AL., PROC. NATL. ACAD. SCI. USA, (1990), vol. 87, page 1874
    - COREY, "Peptide nucleic acids: expanding the scope of nucleic acid recognition", TRENDS BIOTECHNOL., (199706), vol. 15, no. 6, pages 224 - 9
    - HYRUP ET AL., "Peptide nucleic acids (PNA): synthesis, properties and potential applications", BIOORG MED CHEM., (199601), vol. 4, no. 1, pages 5 - 23
    - NEEDLEMAN, WUNSCH, J. MOL. BIOL., (1970), pages 444 - 453
    - DEVEREUX, J. ET AL., NUCLEIC ACIDS RES., (1984), vol. 12, no. 1, page 387
    - E. MYERS, W. MILLER, CABIOS, (1989), vol. 4, pages 11 - 17
    - ALTSCHUL ET AL., J. MOL. BIOL., (1990), vol. 215, pages 403 - 10
    - ALTSCHUL ET AL., NUCLEIC ACIDS RES., (1997), vol. 25, no. 17, pages 3389 - 3402
    - PEARSON, METHODS MOL. BIOL., (1994), vol. 25, pages 365 - 389
    - DUFRESNE ET AL., NAT BIOTECHNOL, (200212), vol. 20, no. 12, pages 1269 - 71
    - SAIKI ET AL., NATURE, (1986), vol. 324, pages 163 - 166
    - NARANG ET AL., METHODS IN ENZYMOLOGY, (1979), vol. 68, page 90
    - BROWN ET AL., METHODS IN ENZYMOLOGY, (1979), vol. 68, page 109
    - BEAUCAGE ET AL., TETRAHEDRON LETTERS, (1981), vol. 22, page 1859
    - GIBBS, NUCLEIC ACID RES., (1989), vol. 17, pages 2427 - 2448
    - LIVAK ET AL., PCR METHOD APPL., (1995), vol. 4, pages 357 - 362
    - TYAGI ET AL., NATURE BIOTECHNOLOGY, (1996), vol. 14, pages 303 - 308
    - NAZARENKO ET AL., NUCL. ACIDS RES., (1997), vol. 25, pages 2516 - 2521
    - LOCKHART, D. J. ET AL., NAT. BIOTECH., (1996), vol. 14, pages 1675 - 1680
    - SCHENA, M. ET AL., PROC. NATL. ACAD. SCI., (1996), vol. 93, pages 10614 - 10619
    - ZAMMATTEO ET AL., "New chips for molecular biology and diagnostics", BIOTECHNOL ANNU REV., (2002), vol. 8, pages 85 - 101
    - SOSNOWSKI ET AL., "Active microelectronic array system for DNA hybridization, genotyping and pharmacogenomic applications", PSYCHIATR GENET., (200212), vol. 12, no. 4, pages 181 - 92
    - HELLER, "DNA microarray technology: devices, systems, and applications", ANNU REV BIOMED ENG., (2002), vol. 4, pages 129 - 53
    - KOLCHINSKY ET AL., "Analysis of SNPs and other genomic variations using gel-based chips", HUM MUTAT., (200204), vol. 19, no. 4, pages 343 - 60
    - MCGALL ET AL., "High-density genechip oligonucleotide probe arrays", ADV BIOCHEM ENG BIOTECHNOL., (2002), vol. 77, pages 21 - 42
    - Current Protocols in Molecular Biology, JOHN WILEY & SONS, (1989), pages 6.3.1 - 6.3.6
    - WEIGL ET AL., "Lab-on-a-chip for drug development", ADV DRUG DELIV REV, (20030224), vol. 55, no. 3, pages 349 - 77
    - CHEN ET AL., "Single nucleotide polymorphism genotyping: biochemistry, protocol, cost and throughput", PHARMACOGENOMICS,J., (2003), vol. 3, no. 2, pages 77 - 96
    - KWOK ET AL., "Detection of single nucleotide polymorphisms", CURR ISSUES MOL BIOL., (200304), vol. 5, no. 2, pages 43 - 60
    - SHI, "Technologies for individual genotyping: detection of genetic polymorphisms in drug targets and disease genes", AM J PHARMACOGENOMICS., (2002), vol. 2, no. 3, pages 197 - 205
    - KWOK, "Methods for genotyping single nucleotide polymorphisms", ANNU REV GENOMICS HUM GENET, (2001), vol. 2, pages 235 - 58
    - MARNELLOS, "High-throughput SNP analysis for genetic association studies", CURR OPIN DRUG DISCOV DEVEL., (200305), vol. 6, no. 3, pages 317 - 21
    - MYERS ET AL., SCIENCE, (1985), vol. 230, page 1242
    - COTTON ET AL., PNAS, (1988), vol. 85, page 4397
    - SALEEBA ET AL., METH. ENZYMOL., (1992), vol. 217, pages 286 - 295
    - ORITA ET AL., PNAS, (1989), vol. 86, page 2766
    - COTTON ET AL., MUTAT. RES., (1993), vol. 285, pages 125 - 144
    - HAYASHI ET AL., GENET. ANAL. TECH. APPL., (1992), vol. 9, pages 73 - 79
    - MYERS ET AL., NATURE, (1985), vol. 313, page 495
    - WISE ET AL., "A standard protocol for single nucleotide primer extension in the human genome using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry", RAPID COMMUN MASS SPECTROM., (2003), vol. 17, no. 11, pages 1195 - 202
    - BOCKER, "SNP and mutation discovery using base-specific cleavage and MALDI-TOF mass spectrometry", BIOINFORMATICS, (200307), vol. 19, no. 1, pages 144 - 153
    - STORM ET AL., "MALDI-TOF mass spectrometry-based SNP genotyping", METHODS MOL BIOL., (2003), vol. 212, pages 241 - 62
    - JURINKE ET AL., "The use of Mass ARRAY technology for high throughput genotyping", ADV BIOCHEM ENG BIOTECHNOL., (2002), vol. 77, pages 57 - 74
    - JURINKE ET AL., "Automated genotyping using the DNA MassArray technology", METHODS MOL BIOL., (2002), vol. 187, pages 179 - 92
    - BIOTECLINIQUES, (1995), vol. 19, page 448
    - COHEN ET AL., ADV. CHROMATOGR., (1996), vol. 36, pages 127 - 162
    - GRIFFIN ET AL., APPL. BIOCHEM. BIOTECHNOL., (1993), vol. 38, pages 147 - 159
    - ORITA ET AL., PROC. NAT. ACAD
    - Modem Epidemiology, LIPPINCOTT WILLIAMS & WILKINS, (1998), pages 609 - 622
    - DALY ET AL., NATURE GENETICS, (2001), vol. 29, pages 232 - 235
    - SCHAID ET AL., AM. J. HUM. GENET., (2002), vol. 70, pages 425 - 434
    - BENJAMINI, HOCHBERG, JOURNAL OF THE ROYAL STATISTICAL SOCIETY, SERIES B, (1995), vol. 57, pages 1289 - 1300
    - Modern Epidemiology, LIPPINCOTT WILLIAMS & WILKINS, (1998), pages 643 - 673
    - EWENS, SPIELMAN, AM. J. HUM. GENET., (1995), vol. 62, pages 450 - 458
    - PRITCHARD ET AL., AM. J. HUM. GEN., (1999), vol. 65, pages 220 - 228
    - DEVLIN ET AL., BIOMETRICS, (1999), vol. 55, pages 997 - 1004
    - DEVLIN ET AL., GENET. EPIDEM., vol. 20001, no. 21, pages 273 - 284
    - BACANU ET AL., AM. J. HUM. GENET., (2000), vol. 66, pages 1933 - 1944
    - KEHOE ET AL., HUM. MOL. GENET., (1999), vol. 8, pages 237 - 245
    - WALL ET AL., "Haplotype blocks and linkage disequilibrium in the human genome", NAT REV GENET., (200308), vol. 4, no. 8, pages 587 - 97
    - GARNER ET AL., "On selecting markers for association studies: patterns of linkage disequilibrium between two and three diallelic loci", GENET EPIDEMIOL., (200301), vol. 24, no. 1, pages 57 - 67
    - ARDLIE ET AL., "Patterns of linkage disequilibrium in the human .genome", NAT REV GENET., (200204), vol. 3, no. 4, pages 299 - 309
    - NAT REV GENET, (200207), vol. 3, no. 7, page 566
    - REMM ET AL., "High-density genotyping and linkage disequilibrium in the human genome using chromosome 22 as a model", CURR OPIN CHEM BIOL., (200202), vol. 6, no. 1, pages 24 - 30
    - ROSES, NATURE, (2000), vol. 405, pages 857 - 865
    - GOULD ROTHBERG, NATURE BIOTECHNOLOGY, (2001), vol. 19, pages 209 - 211
    - EICHELBAUM, CLIN. EXP. PHARMACOL. PHYSIOL., (1996), vol. 23, no. 10-11, pages 983 - 985
    - LINDER, CLIN. CHEM., (1997), vol. 43, no. 2, pages 254 - 266
    - ROSE ET AL., "Pharmacogenetic analysis of clinically relevant genetic polymorphisms", METHODS MOL MED., (2003), vol. 85, pages 225 - 37
    - CACABELOS, "Pharmacogenomics for the treatment of dementia", ANN MED., (2002), vol. 34, no. 5, pages 357 - 79
    - MAIMONE ET AL., "Pharmacogenomics of neurodegenerative diseases", EUR J PHARMACOL., (20010209), vol. 413, no. 1, pages 11 - 29
    - POIRIER, "Apolipoprotein E: a pharmacogenetic target for the treatment of Alzheimer's disease", MOL DIAGN., (199912), vol. 4, no. 4, pages 335 - 41
    - SIEST ET AL., "Pharmacogenomics of drugs affecting the cardiovascular system", CLIN CHEM LAB MED., (200304), vol. 41, no. 4, pages 590 - 9
    - MUKHERJEE ET AL., "Pharmacogenomics in cardiovascular diseases", PROG CARDIOVASC DIS., (200205), vol. 44, no. 6, pages 479 - 98
    - MOOSER ET AL., "Cardiovascular pharmacogenetics in the SNP era", J THROMB HAEMOST, (200307), vol. 1, no. 7, pages 1398 - 402
    - MCLEOD ET AL., "Cancer pharmacogenomics: SNPs, chips, and the individual patient", CANCER INVEST, (2003), vol. 21, no. 4, pages 630 - 40
    - WATTERS ET AL., "Cancer pharmacogenomics: current and future applications", BIOCHIM BIOPHYS ACTA, (20030317), vol. 1603, no. 2, pages 99 - 111
    - THOMPSON, DRUG DISCOVERY TODAY, (2002), vol. 7, no. 17, pages 912 - 917
    - LAVERY ET AL., "Antisense and RNAi: powerful tools in drug target discovery and validation", CURR OPIN DRUG DISCOV DEVEL., (200307), vol. 6, no. 4, pages 561 - 9
    - STEPHENS ET AL., "Antisense oligonucleotide therapy in cancer", CURR OPIN MOL THER., (200304), vol. 5, no. 2, pages 118 - 22
    - KURRECK, "Antisense technologies., Improvement through novel chemical modifications", EUR J BIOCHEM., (200304), vol. 270, no. 8
    - DIAS ET AL., "Antisense oligonucleotides: basic concepts and mechanisms", MOL. CANCER THER., (200203), vol. 1, no. 5, pages 347 - 55
    - CHEN, "Clinical development of antisense oligonucleotides as anti-cancer therapeutics", METHODS MOL MED., (2003), vol. 75, pages 621 - 36
    - WANG, "Antisense anticancer oligonucleotide therapeutics", CURR CANCER DRUG TARGETS, (200111), vol. 1, no. 3, pages 177 - 96
    - BENNETT, "Efficiency of antisense oligonucleotide drug discovery", ANTISENSE NUCLEIC ACID DRUG DEV., (200206), vol. 12, no. 3, pages 215 - 24
    - REYNOLDS, "Rational siRNA design for RNA interference", NAT BIOTECHNOL., (200403), vol. 22, no. 3, pages 326 - 30
    - CHI ET AL., "Genomewide view of gene silencing by small interfering RNAs", PNAS, (2003), vol. 100, no. 11, pages 6343 - 6346
    - VICKERS ET AL., "Efficient Reduction of Target RNAs by Small Interfering RNA and RNase H-dependent Antisense Agents", J. BIOL. CHEM., (2003), vol. 278, pages 7108 - 7118
    - AGAMI, "RNAi and related mechanisms and their potential use for therapy", CURR OPIN CHEM BIOL., (200212), vol. 6, no. 6, pages 829 - 34
    - SHI, "Mammalian RNAi for the masses", TRENDS GENET, (200301), vol. 19, no. 1, pages 9 - 12
    - SHUEY ET AL., "RNAi: gene-silencing in therapeutic intervention", DRUG DISCOVERY TODAY, (200210), vol. 7, no. 20, pages 1040 - 1046
    - MCMANUS ET AL., NAT REV GENET, (200210), vol. 3, no. 10, pages 737 - 47
    - XIA ET AL., NAT BIOTECHNOL, (200210), vol. 20, no. 10, pages 1006 - 10
    - PLASTERK ET AL., CURR OPIN GENET DEV, (200010), vol. 10, no. 5, pages 562 - 7
    - BOSHER ET AL., NATCELL BIOL, (200002), vol. 2, no. 2, pages E31 - 6
    - HUNTER, CURR BIOL, (19990617), vol. 9, no. 12, pages R440 - 2
    - KREN ET AL., PROC. NATL. ACAD. SCI. USA, (1999), vol. 96, pages 10349 - 10354
    - JAZWINSKA, A TRENDS GUIDE TO GENETIC VARIATION AND GENOMIC MEDICINE, (200203), pages S30 - S36
    - ROTHBERG, NAT BIOTECHNOL, (200103), vol. 19, no. 3, pages 209 - 11
    - GILL, "An assessment of the utility of single nucleotide polymorphisms (SNPs) for forensic purposes", INT J LEGAL MED., (2001), vol. 114, no. 4-5, pages 204 - 10
    - FRUDAKIS ET AL., "A Classifier for the SNP-Based Inference of Ancestry", JOURNAL OF FORENSIC SCIENCES, (2003), vol. 48, pages 771 - 782
    - KRAWCZAK, "Informativity assessment for biallelic single nucleotide polymorphisms", ELECTROPHORESIS, (199906), vol. 20, no. 8, pages 1676 - 81
    - TERPE, "Overview of tag protein fusions: from molecular and biochemical fundamentals to commercial systems", APPL MICROBIOL BIOTECLZNOL., (200301), vol. 60, no. 5, pages 523 - 33
    - GRADDIS ET AL., "Designing proteins that work using recombinant technologies", CURR PHAIM BIOTECHNOL., (200212), vol. 3, no. 4, pages 285 - 97
    - NILSSON ET AL., "Affinity fusion strategies for detection, purification, and immobilization of recombinant proteins", PROTEIN EXPR PUTIF., (199710), vol. 11, no. 1, pages 1 - 16
    - BOWIE ET AL., SCIENCE, (1990), vol. 247
    - CUNNINGHAM, SCIENCE, (1989), vol. 244, pages 1081 - 1085
    - SMITH ET AL., J. MOL. BIOL., (1992), vol. 224, pages 899 - 904
    - DE VOS ET AL., SCIENCE, (1992), vol. 255, pages 306 - 312
    - WOLD, F., Posttranslational Covalent Modification of Proteins, ACADEMIC PRESS, (1983), pages 1 - 12
    - SEIFTER ET AL., METH. ENZYMOL, (1990), vol. 182, pages 626 - 646
    - RATTAN ET AL., ANN. N.Y. ACAD. SCI., (1992), vol. 663, pages 48 - 62
    - HAGE, "Immunoassays", ANAL CHEM., (19990615), vol. 71, no. 12, pages 294R - 304R
    - LAM ET AL., NATURE, (1991), vol. 354, pages 82 - 84
    - HOUGHTEN ET AL., NATURE, (1991), vol. 354, pages 84 - 86
    - SONGYANG ET AL., CELL, (1993), vol. 72, pages 767 - 778
    - HODGSON, BIO / TECHNOLOGY, (19920910), no. 9, pages 973 - 80
    - ZERVOS ET AL., CELL, (1993), vol. 72, pages 223 - 232
    - MADURA ET AL., J. BIOL. CHEM., (1993), vol. 268, pages 12046 - 12054
    - BARTEL ET AL., BIOTECHNIQUES, (1993), vol. 14, pages 920 - 924
    - IWABUCHI ET AL., ONCOGENE, (1993), vol. 8, pages 1693 - 1696
    - MORRISON ET AL., PROC. NATL. ACAD. SCI. USA, (1984), vol. 81, page 6851
    - NEUBERGER ET AL., NATURE, (1984), vol. 312, page 604
    - WARD ET AL., NATURE, (1989), vol. 334, page 544
    - SEGAL ET AL., J. IMMUNOL. METHODS, (2001), vol. 248, page 1
    - CARTER, J. IMMUNOL. METHODS, (2001), vol. 248, page 7
    - TODOROVSKA ET AL., J. IMMUNOL. METHODS, (2001), vol. 248, page 47
    - KOHLER, MILSTEIN, NATURE, (1975), vol. 256, page 495
    - HE, J. IMMUNOL., (2002), vol. 169, page 595
    - HOOGENBOOM, CHAMES, IMMUNOL. TODAY, (2000), vol. 21, page 371
    - LIU ET AL., J. MOL. BIOL., (2002), vol. 315, page 1063
    - MORGAN, "Antibody therapy for Alzheimer's disease", EXPERT REV VACCINES., (200302), vol. 2, no. 1, pages 53 - 9
    - ROSS ET AL., "Anticancer antibodies", AM J CLIN PATHOL., (200304), vol. 119, no. 4, pages 472 - 85
    - GOLDENBERG, "Advancing role of radiolabeled antibodies in the therapy of cancer", CANCER IMMUNOL IMMUNOTHER., (20030311), vol. 52, no. 5, pages 281 - 96
    - ROSS ET AL., "Antibody-based therapeutics in oncology", EXPERT REV ANTICANCER THER., (200302), vol. 3, no. 1, pages 107 - 21
    - CAO ET AL., "Bispecific antibody conjugates in therapeutics", ADV DRUG DELIV REV., (20030210), vol. 55, no. 2, pages 171 - 97
    - VON MEHREN ET AL., "Monoclonal antibody therapy for cancer", ANNU REV MED., (20011203), vol. 54, pages 343 - 69
    - HUDSON ET AL., "Engineered antibodies", NAT MED., (200301), vol. 9, no. 1, pages 129 - 34
    - BREKKE ET AL., "Tberapeutic antibodies for human diseases at the dawn of the twenty-first century", NAT REV DRUG DISCOV., (200301), vol. 2, no. 1, pages 52 - 62
    - ERRATUM, NAT REV DRUG DISCOV., (200303), vol. 2, no. 3, page 240
    - HOUDEBINE, "Antibody manufacture in transgenic animals and comparisons with other systems", CURR OPIN BIOTECHNOL., (200212), vol. 13, no. 6, pages 625 - 9
    - ANDREAKOS ET AL., "Monoclonal antibodies in immune and inflammatory diseases", CURR OPINBIOTECHNOL., (200212), vol. 13, no. 6, pages 615 - 20
    - KELLERMANN ET AL., "Antibody, discovery: the use of transgenic mice to generate human monoclonal antibodies for therapeutics", CURR OPIN BIOTECHNOL., (200212), vol. 13, no. 6, pages 593 - 7
    - PINI ET AL., "Phage display and colony filter screening for high-throughput selection of antibody libraries", COMB CHEM HIGH THROUGHPUT SCREEN., (200211), vol. 5, no. 7, pages 503 - 10
    - BATRA ET AL., "Pharmacokinetics and biodistribution of genetically engineered antibodies", CURR OPIN BIOTECHNOL., (200212), vol. 13, no. 6, pages 603 - 8
    - TANGRI ET AL., "Rationally engineered proteins or antibodies with absent or reduced immunogenicity", CURR MED CHEM., (200212), vol. 9, no. 24, pages 2191 - 9
    - LEONG ET AL., CYTOKINE, (2001), vol. 16, page 106
    - SMITH ET AL., GENE, (1988), vol. 67, pages 31 - 40
    - AMANN ET AL., GENE, (1988), vol. 69, pages 301 - 315
    - STUDIER ET AL., GENE EXPRESSION TECHNOLOGY: METHODS IN ENZYMOLOGY, (1990), vol. 185, pages 60 - 89
    - GOTTESMAN, S., Gene Expression Technology: Methods in Enzymology, ACADEMIC PRESS, (1990), vol. 185, pages 119 - 128
    - WADA ET AL., NUCLEIC ACIDS RES., (1992), vol. 20, pages 2111 - 2118
    - BALDARI ET AL., EMBO J., (1987), vol. 6, pages 229 - 234
    - KURJAN ET AL., CELL, (1982), vol. 30, pages 933 - 943
    - SCHULTZ ET AL., GENE, (1987), vol. 54, pages 113 - 123
    - SMITH ET AL., MOL. CELL BIOL, (1983), vol. 3, pages 2156 - 2165
    - LUCKLOW ET AL., VIROLOGY, (1989), vol. 170, pages 31 - 39
    - SEED, B, NATURE, (1987), vol. 329, page 840
    - KAUFMAN ET AL., EMBO J., (1987), vol. 6, pages 187 - 195
    - LAKSO ET AL., PNAS, (1992), vol. 89, pages 6232 - 6236
    - O'GORMAN ET AL., SCIENCE, (1991), vol. 251, pages 1351 - 1355
    - WILMUT, I. ET AL., NATURE, (1997), vol. 385, pages 810 - 813
    - PETTERS, "Transgenic animals as models for human disease", TRANSGENIC RES., (2000), vol. 9, no. 4-5, pages 347 - 51
    - WOLF ET AL., "Use of transgenic animals in understanding molecular mechanisms of toxicity", J PHARM PHARMACOL., (199806), vol. 50, no. 6, pages 567 - 74
    - ECHELARD, "Recombinant protein production in transgenic animals", CURR OPIN BIOTECHNOL., (199610), vol. 7, no. 5, pages 536 - 40
    - HOUDEBINE, "Transgenic animal bioreactors", TRANSGENIC. RES., (2000), vol. 9, no. 4-5, pages 305 - 20
    - PIRITY ET AL., "Embryonic stem cells, creating transgenic animals", METHODS CELL BIOL., (1998), vol. 57, pages 279 - 93
    - ROBL ET AL., "Artificial chromosome vectors and expression of complex proteins in transgenic animals", THERIOGENOLOGY, (20030101), vol. 59, no. 1, pages 107 - 13
    - ALTSCHUL ET AL., J. MOL. BIOL., (1990), vol. 215, pages 403 - 410
    - BRUTLAG ET AL., COMP. CHEM., (1993), vol. 17, pages 203 - 207
    - BATTS ET AL., AM J. SURG. PATHOL., (1995), vol. 19, pages 1409 - 1417
    - BRUNT, HEPATOLOGY, (2000), vol. 31, pages 241 - 246
    - GERMER ET AL., GENOME RESEARCH, (2000), vol. 10, pages 258 - 266
    - KNODELL ET AL., HEPATOLOGY, (1981), vol. 1, pages 431 - 435
    - GERMER S., HOLLAND M.J., HIGUCHI R., GENOME RES., (2000), vol. 10, pages 258 - 266
    - GOH ET AL., J VIROL., (2004), vol. 78, pages 5288 - 98
 US20030620332
 US20030620333
 WO2001US17329
 US20020427818
 US20030445636
 US20030445494
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