blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability

2022.02.11

More...
blank News flashes

Italy joins the Federated Register

Click here for more information on the Federated Register.

2025-06-12

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register User Manual
European Patent Register – pocket guide
FAQ - European Patent Register
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP2368551

EP2368551 - Methods of use for cyclopamine analogs [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  25.07.2014
Database last updated on 10.03.2026
Most recent event   Tooltip04.09.2015Lapse of the patent in a contracting state
New state(s): MT		published on 07.10.2015  [2015/41]
Applicant(s)For all designated states
Infinity Discovery, Inc.
780 Memorial Drive
Cambridge, MA 02139 / US
For all designated states
The Johns Hopkins University
3400 North Charles Street
Baltimore, MD 21218 / US
[2012/07]
Former [2011/39]For all designated states
Infinity Discovery, Inc.
780 Memorial Drive
Cambridge, MA 02139 / US
For all designated states
THE JOHNS-HOPKINS UNIVERSITY
3400 North Charles Street
Baltimore, MD 21218 / US
Inventor(s)01 / Matsui, William
105 Bellemore Road
Baltimore, MD 21210 / US
02 / Tremblay, Martin R.
47 Heywood Avenue
Melrose, MA 02176 / US
03 / Castro, Alfredo C.
43 Wildwood Street
Winchester, MA 01890 / US
04 / Grogan, Michael J.
27 Dunster Road
Winchester, MA 01890 / US
05 / McGovern, Karen J.
71 Lovers Lane
Groton, MA 01450 / US
 [2011/39]
Representative(s)Jansen, Cornelis Marinus, et al
V.O.
Johan de Wittlaan 7
2517 JR Den Haag / NL
[2013/38]
Former [2011/43]Jansen, Cornelis Marinus, et al
VEREENIGDE Johan de Wittlaan 7
2517 JR Den Haag / NL
Former [2011/39]Jansen, Cornelis Marinus
VEREENIGDE Johan de Wittlaan 7
2517 JR Den Haag / NL
Application number, filing date11165825.827.12.2007
[2011/39]
Priority number, dateUS20060878018P28.12.2006         Original published format: US 878018 P
US20070941596P01.06.2007         Original published format: US 941596 P
[2011/39]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP2368551
Date:28.09.2011
Language:EN
[2011/39]
Type: A8 Corrected patent application 
No.:EP2368551
Date:30.11.2011
[2011/48]
Type: A3 Search report 
No.:EP2368551
Date:21.12.2011
Language:EN
[2011/51]
Type: B1 Patent specification 
No.:EP2368551
Date:18.09.2013
Language:EN
[2013/38]
Search report(s)(Supplementary) European search report - dispatched on:EP22.11.2011
ClassificationIPC:A61K31/4355, A61K31/58, A61P35/00, A61P35/02, C07D491/04, C07D491/10, C07J69/00
[2011/51]
CPC:
A61K31/4355 (EP,US); C07D491/10 (EP,NO,US); A61K31/4747 (KR);
A61K31/17 (EP,US); A61K31/196 (EP,US); A61K31/198 (EP,US);
A61K31/454 (EP,US); A61K31/4741 (KR); A61K31/4745 (EP,US);
A61K31/519 (EP,US); A61K31/56 (EP,US); A61K31/573 (EP,US);
A61K31/58 (EP,NO,US); A61K31/664 (EP,US); A61K31/69 (EP,US);
A61K31/704 (EP,US); A61K31/7068 (EP,US); A61K31/7076 (EP,US);
A61K38/21 (EP,US); A61K45/06 (US); A61K9/0014 (US);
A61N5/10 (US); A61P35/00 (EP); A61P35/02 (EP);
A61P35/04 (EP); A61P43/00 (EP); C07D307/94 (EP,US);
C07D471/04 (EP,US); C07D471/10 (EP,US); C07D491/04 (EP,US);
C07D491/048 (EP,US); C07D491/107 (EP,US); C07J69/00 (EP,US) (-)
Former IPC [2011/39]A61K31/4355, A61K31/58, A61P35/00, A61P35/02
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2011/39]
Extension statesAL12.05.2011
BA12.05.2011
HR12.05.2011
MK12.05.2011
RS12.05.2011
TitleGerman:Verfahren zur Verwendung von Cyclopamin-Analoga[2011/39]
English:Methods of use for cyclopamine analogs[2011/39]
French:Procédés pour l'utilisation d'analogues de la cyclopamine[2011/39]
Examination procedure12.05.2011Examination requested  [2011/39]
14.06.2012Amendment by applicant (claims and/or description)
28.08.2012Despatch of a communication from the examining division (Time limit: M06)
06.03.2013Reply to a communication from the examining division
05.04.2013Communication of intention to grant the patent
06.08.2013Fee for grant paid
06.08.2013Fee for publishing/printing paid
Parent application(s)   TooltipEP07870006.9  / EP2101580
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20070870006) is  21.11.2011
Opposition(s)19.06.2014No opposition filed within time limit [2014/35]
Fees paidRenewal fee
12.05.2011Renewal fee patent year 03
12.05.2011Renewal fee patent year 04
27.12.2011Renewal fee patent year 05
26.12.2012Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAT18.09.2013
BE18.09.2013
BG18.09.2013
CY18.09.2013
CZ18.09.2013
DK18.09.2013
EE18.09.2013
ES18.09.2013
FI18.09.2013
LT18.09.2013
LV18.09.2013
MC18.09.2013
MT18.09.2013
PL18.09.2013
RO18.09.2013
SI18.09.2013
SK18.09.2013
TR18.09.2013
GR19.12.2013
LU27.12.2013
IS18.01.2014
PT20.01.2014
[2015/41]
Former [2015/35]AT18.09.2013
BE18.09.2013
BG18.09.2013
CY18.09.2013
CZ18.09.2013
DK18.09.2013
EE18.09.2013
ES18.09.2013
FI18.09.2013
LT18.09.2013
LV18.09.2013
MC18.09.2013
PL18.09.2013
RO18.09.2013
SI18.09.2013
SK18.09.2013
TR18.09.2013
GR19.12.2013
LU27.12.2013
IS18.01.2014
PT20.01.2014
Former [2015/32]AT18.09.2013
BE18.09.2013
CY18.09.2013
CZ18.09.2013
DK18.09.2013
EE18.09.2013
ES18.09.2013
FI18.09.2013
LT18.09.2013
LV18.09.2013
MC18.09.2013
PL18.09.2013
RO18.09.2013
SI18.09.2013
SK18.09.2013
TR18.09.2013
GR19.12.2013
LU27.12.2013
IS18.01.2014
PT20.01.2014
Former [2015/23]AT18.09.2013
BE18.09.2013
CY18.09.2013
CZ18.09.2013
DK18.09.2013
EE18.09.2013
ES18.09.2013
FI18.09.2013
LT18.09.2013
LV18.09.2013
MC18.09.2013
PL18.09.2013
RO18.09.2013
SI18.09.2013
SK18.09.2013
GR19.12.2013
LU27.12.2013
IS18.01.2014
PT20.01.2014
Former [2015/21]AT18.09.2013
BE18.09.2013
CY18.09.2013
CZ18.09.2013
DK18.09.2013
EE18.09.2013
ES18.09.2013
FI18.09.2013
LT18.09.2013
LV18.09.2013
MC18.09.2013
PL18.09.2013
SI18.09.2013
SK18.09.2013
GR19.12.2013
LU27.12.2013
IS18.01.2014
PT20.01.2014
Former [2014/41]AT18.09.2013
BE18.09.2013
CY18.09.2013
CZ18.09.2013
DK18.09.2013
EE18.09.2013
ES18.09.2013
FI18.09.2013
LT18.09.2013
LV18.09.2013
PL18.09.2013
SI18.09.2013
SK18.09.2013
GR19.12.2013
LU27.12.2013
IS18.01.2014
PT20.01.2014
Former [2014/38]AT18.09.2013
BE18.09.2013
CY18.09.2013
CZ18.09.2013
EE18.09.2013
ES18.09.2013
FI18.09.2013
LT18.09.2013
LV18.09.2013
PL18.09.2013
SI18.09.2013
SK18.09.2013
GR19.12.2013
LU27.12.2013
IS18.01.2014
PT20.01.2014
Former [2014/28]AT18.09.2013
BE18.09.2013
CY18.09.2013
CZ18.09.2013
EE18.09.2013
ES18.09.2013
FI18.09.2013
LT18.09.2013
LV18.09.2013
PL18.09.2013
SI18.09.2013
SK18.09.2013
GR19.12.2013
IS18.01.2014
PT20.01.2014
Former [2014/24]AT18.09.2013
BE18.09.2013
CY18.09.2013
CZ18.09.2013
EE18.09.2013
ES18.09.2013
FI18.09.2013
LT18.09.2013
LV18.09.2013
PL18.09.2013
SI18.09.2013
SK18.09.2013
GR19.12.2013
IS18.01.2014
Former [2014/23]BE18.09.2013
CY18.09.2013
CZ18.09.2013
EE18.09.2013
FI18.09.2013
LT18.09.2013
LV18.09.2013
SI18.09.2013
SK18.09.2013
GR19.12.2013
IS18.01.2014
Former [2014/18]BE18.09.2013
CY18.09.2013
FI18.09.2013
LT18.09.2013
LV18.09.2013
SI18.09.2013
GR19.12.2013
Former [2014/12]CY19.06.2013
FI18.09.2013
LT18.09.2013
LV18.09.2013
SI18.09.2013
GR19.12.2013
Former [2014/10]CY19.06.2013
LT18.09.2013
Former [2014/08]LT18.09.2013
Documents cited:Search[A]   RUBIN LEE L ET AL: "Targeting the Hedgehog pathway in cancer", NATURE REVIEWS. DRUG DISCOVERY, NATURE PUBLISHING GROUP, GB, vol. 5, no. 12, 1 December 2006 (2006-12-01), pages 1026 - 1033, XP002520119, ISSN: 1474-1776, DOI: 10.1038/NRD2086

DOI:   http://dx.doi.org/10.1038/NRD2086
 [A]   SALDANHA G: "THE HEDGEHOG SIGNALLING PATHWAY AND CANCER", JOURNAL OF PATHOLOGY, JOHN WILEY & SONS LTD, GB, vol. 193, no. 4, 1 April 2001 (2001-04-01), pages 427 - 432, XP008015850, ISSN: 0022-3417, DOI: 10.1002/1096-9896(2000)9999:9999<::AID-PATH815>3.0.CO;2-N

DOI:   http://dx.doi.org/10.1002/1096-9896(2000)9999:9999<::AID-PATH815>3.0.CO;2-N
 [A]   DI MAGLIANO MARINA PASCA ET AL: "Hedgehog signalling in cancer formation and maintenance", NATURE REVIEWS. CANCER, NATUR PUBLISHING GROUP, LONDON, GB, vol. 3, no. 12, 1 December 2003 (2003-12-01), pages 903 - 911, XP002591182, ISSN: 1474-175X, DOI: 10.1038/NRC1229

DOI:   http://dx.doi.org/10.1038/NRC1229
 [A]   MASAMUNE T ET AL: "Syntheses and NMR sprectra of 22,27-imino-17,23-oxidojervane derivatives", TETRAHEDRON,, vol. 23, 1 January 1967 (1967-01-01), pages 1591 - 1612, XP002609210
Examination  TREMBLAY MARTIN R ET AL: "Semisynthetic Cyclopamine Analogues as Potent and Orally Bioavailable Hedgehog Pathway Antagonists", JOURNAL OF MEDICINAL CHEMISTRY, vol. 51, no. 21, November 2008 (2008-11-01), pages 6646 - 6649, ISSN: 0022-2623
   MARTIN R. TREMBLAY ET AL: "Discovery of a Potent and Orally Active Hedgehog Pathway Antagonist (IPI-926)", JOURNAL OF MEDICINAL CHEMISTRY, vol. 52, no. 14, 23 July 2009 (2009-07-23), pages 4400 - 4418, XP055036024, ISSN: 0022-2623, DOI: 10.1021/jm900305z

DOI:   http://dx.doi.org/10.1021/jm900305z
by applicantWO2006026430
 WO2005013800
   GREENE, T. W., WUTS, P.G.M.: "Protective Groups in Organic Synthesis", 1991, WILEY
   BERGE ET AL.: "Pharmaceutical Salts", J. PHARM. SCI., vol. 66, 1977, pages 1 - 19, XP002675560, DOI: doi:10.1002/jps.2600660104

DOI:   http://dx.doi.org/10.1002/jps.2600660104
   GREEN, T. W., WUTS, P. G.: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS, INC.
   MASALOV ET AL., ORGANIC LETTERS, vol. 6, 2004, pages 2365 - 2368
   HANSEN ET AL., CHEM. COMM., 2006, pages 4838 - 4840
   XIE ET AL., NATURE, vol. 391, 1998, pages 90 - 92
   REIFENBERGER ET AL., CANCER RES, vol. 58, 1998, pages 1798 - 1803
   BERMAN ET AL., NATURE, vol. 425, 2003, pages 846 - 851
   THAYER ET AL., NATURE, vol. 425, 2003, pages 851 - 856
   WATKINS ET AL., NATURE, vol. 422, 2003, pages 313 - 317
   KARHADKAR ET AL., NATURE, vol. 431, 2004, pages 707 - 712
   SHENG ET AL., MOLECULAR CANCER, vol. 3, 2004, pages 29 - 42
   FAN ET AL., ENDOCRINOLOGY, vol. 145, 2004, pages 3961 - 3970
   KUBO ET AL., CANCER RESEARCH, vol. 64, 2004, pages 6071 - 6074
   LEWIS ET AL., JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA, vol. 2, 2004, pages 165 - 181
   SICKLICK ET AL., ASCO CONFERENCE, 2005
   MOHINI ET AL., AACR CONFERENCE, 2005
   WILLIAMS ET AL., PNAS, vol. 100, 2003, pages 4616 - 4621
   BERMAN ET AL., SCIENCE, vol. 297, 2002, pages 1559 - 1561
   PATIL ET AL., 96 TH ANNUAL AACR CONFERENCE, 2005
   SICKLICK ET AL., ASCO ANNUAL MEETING, 2005
   BALE, YU, HUMAN MOLEC. GENET., vol. 10, 2001, pages 757 - 762
   PIETSCH ET AL., CANCER RES., vol. 57, 1997, pages 2085 - 2088
   MA ET AL., CARCINOGENESIS, 19 May 2005 (2005-05-19)
   TAS ET AL., DERMATOLOGY, vol. 209, 2004, pages 126 - 131
   NAKAMURA ET AL., BBRC, vol. 237, 1997, pages 465
   VAN DER HORST ET AL., BONE, vol. 33, 2003, pages 899
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.