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EP2452686
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| EP2452686 - Methods and compositions for prevention and treatment of diabetic and aged skin [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 21.03.2014 Database last updated on 03.09.2024 | Most recent event Tooltip | 21.03.2014 | Application deemed to be withdrawn | published on 23.04.2014 [2014/17] | Applicant(s) | For all designated states HealOr Ltd. Ruhrberg Science Building Graham Bell Entrance, Floor 5 3 Pekeris Street 76702 Rehovot / IL | [2012/20] | Inventor(s) | 01 /
Tennenbaum, Tamar 12 Herzl Boulevard IL-96105 Jerusalem / IL | 02 /
Braiman-Wiksman, Liora 24 Stephan Weiss Street IL-75400 Rishon Lezion / IL | 03 /
Solomonik, Inessa 3 HaMizpa Street IL-55900 Ganei Tikva / IL | 04 /
Meir, Michael 19 Yehuda Karni Street IL-69025 Tel Aviv / IL | [2012/20] | Representative(s) | Helbig, Christian Wagner + Helbig Patentanwälte Pfarrstrasse 14 80538 München / DE | [2012/20] | Application number, filing date | 11189741.9 | 29.08.2006 | [2012/20] | Priority number, date | US20050711666P | 29.08.2005 Original published format: US 711666 P | [2012/20] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | EP2452686 | Date: | 16.05.2012 | Language: | EN | [2012/20] | Type: | A3 Search report | No.: | EP2452686 | Date: | 05.09.2012 | Language: | EN | [2012/36] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 02.08.2012 | Classification | IPC: | A61K35/12, A61K38/00 | [2012/20] | CPC: |
A61K38/28 (EP,US);
A61K31/427 (EP,US);
A61K31/445 (EP,US);
A61K38/02 (EP,US);
A61K38/085 (EP,US);
A61K38/1709 (EP,US);
A61K38/191 (EP,US);
A61K38/2006 (EP,US);
A61K38/2026 (EP,US);
A61K38/204 (EP,US);
A61K38/2053 (EP,US);
A61K38/2264 (EP,US);
A61K38/2271 (EP,US);
A61K38/45 (EP,US);
A61K38/4886 (EP,US);
A61K38/57 (EP,US);
A61P17/00 (EP);
A61P17/16 (EP);
| Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR [2012/20] | Extension states | AL | 18.11.2011 | BA | 18.11.2011 | HR | 18.11.2011 | MK | 18.11.2011 | RS | 18.11.2011 | Title | German: | Verfahren und Zusammensetzungen zur Vorbeugung und Behandlung von diabetischer und alternder Haut | [2012/20] | English: | Methods and compositions for prevention and treatment of diabetic and aged skin | [2012/20] | French: | Procédés et compositions pour la prévention et le traitement du diabète et du vieillissement de la peau | [2012/20] | Examination procedure | 18.11.2011 | Examination requested [2012/20] | 01.03.2013 | Amendment by applicant (claims and/or description) | 07.05.2013 | Despatch of a communication from the examining division (Time limit: M06) | 19.11.2013 | Application deemed to be withdrawn, date of legal effect [2014/17] | 12.12.2013 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2014/17] | Parent application(s) Tooltip | EP06780442.7 / EP1940440 | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20060780442) is 19.11.2009 | Fees paid | Renewal fee | 18.11.2011 | Renewal fee patent year 03 | 18.11.2011 | Renewal fee patent year 04 | 18.11.2011 | Renewal fee patent year 05 | 18.11.2011 | Renewal fee patent year 06 | 27.08.2012 | Renewal fee patent year 07 | 27.08.2013 | Renewal fee patent year 08 |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [Y]WO0209639 (UNIV BAR ILAN [IL], et al) [Y] 1,2,5-15 * claims 1,3 *; | [XY]WO2005007072 (UNIV BAR ILAN [IL], et al) [X] 1,2,7-15 * examples 22-25 * * page 9, paragraph 3; example 25 * [Y] 5,6; | [XY]WO2005009437 (BETHESDA PHARMACEUTICALS INC [US], et al) [X] 1,2,7-15 * paragraphs [0009] , [0 14] , [0 76] * [Y] 5,6; | [XY]WO2005013885 (HEALOR LTD [IL], et al) [X] 1,2,7-15 * page 1, paragraph 23; claims 17-18, 67-70 * * page 30, line 30 - line 32 * [Y] 5,6; | [XY] - C N Ellis ET AL, "Troglitazone improves psoriasis and normalizes models of proliferative skin disease: ligands for peroxisome proliferator-activated receptor-gamma inhibit keratinocyte proliferation.", Arch Dermatol. 136(5), (20000501), pages 609 - 616, URL: http://archderm.ama-assn.org/cgi/reprint/136/5/609.pdf, (20120402), XP055023556 [X] 1,2,7-15 * the whole document * * page 613, column l * [Y] 5,6 DOI: http://dx.doi.org/10.1001/archderm.136.5.609 | [Y] - FERRINGER T ET AL, "CUTANEOUS MANIFESTATIONS OF DIABETES MELLITUS", DERMATOLOGIC CLINICS, W.B. SAUNDERS CO., LONDON, GB, (20020101), vol. 20, no. 3, doi:10.1016/S0733-8635(02)00018-9, ISSN 0733-8635, pages 483 - 492, XP008011468 [Y] 1,2,5-15 * the whole document * DOI: http://dx.doi.org/10.1016/S0733-8635(02)00018-9 | [T] - MICHALIK ET AL, "Peroxisome proliferator-activated receptors (PPARs) in skin health, repair and disease", BIOCHIMICA AND BIOPHYSICA ACTA. MOLECULAR AND CELL BIOLOGY OF LIPIDS, ELSEVIER, AMSTERDAM, NL, (20070807), vol. 1771, no. 8, doi:10.1016/J.BBALIP.2007.02.004, ISSN 1388-1981, pages 991 - 998, XP022189884 [T] * the whole document * * page 996, column l * DOI: http://dx.doi.org/10.1016/j.bbalip.2007.02.004 | by applicant | WO0209639 | WO2005007072 | WO2005013885 | - Remington's Pharmaceutical Sciences, MACK PUBLISHING CO. | - Remington: The Science and Practice of Pharmacy, 19th Ed., MACK PUBLISHING CO., (1995), pages 1399 - 1404 | - ALT, A. OHBA; M. LI; L. GARTSBEIN; M. BELANGER; A. DENNING; M.F. KUROKI; T. YUSPA; S.H. TENNENBAUM, T., "Protein kinase Cdelta-mediated phosphorylation of alpha6beta4 is associated with reduced integrin localization to the hemidesmosome and decreased keratinocyte attachment", CANCER RES., (2001), vol. 61, pages 4591 - 4598 | - BENES, C.H. WU; N. ELIA; A.E.H. DHARIA; T. CANTLEY; L.C.SOLTOFF, S.P., "The C2 domain of PKC6 is a phosphotyrosine binding domain", CELL, (2005), vol. 121, pages 271 - 280 | - CHANG, L. CHIANG; S.H. SALTIEL, A.R., "Insulin signaling and the regulation of glucose transport", MOL MED., (2004), vol. 10, pages 65 - 71, XP002490816 | - CONNERY, L.E.; COURSIN, D.B., "Assessment and therapy of selected endocrine disorders", ANESTHESIOL. CLIN. NORTH AMERICA, (2004), vol. 22, pages 93 - 123 | - ELIAS, P.M.; GHADIALLY, R., "The aged epidermal permeability barrier: basis for functional abnormalities", CLIN GERIATRMED., (2002), vol. 18, doi:doi:10.1016/S0749-0690(03)00037-5, pages 103 - 120, XP009114232 DOI: http://dx.doi.org/10.1016/S0749-0690(03)00037-5 | - FARESE, R.V.; SAJAN, M.P.; STANDAERT, M.L., "Insulin-sensitive protein kinases (atypical protein kinase C and protein kinase B/Akt): actions and defects in obesity and type II diabetes", EXP BIOI MED, (2005), vol. 230, pages 593 - 605 | - FLIERS, E.; KREIER, F.; VOSHOL, P.J.; HAVEKES, L.M.; SAUERWEIN, H.P.; KALSBEEK, A.; BUIJS, R.M.; ROMIJN, J.A.; WHITE ADIPOSE TISSU, J NEUROENDOCRINOL., (2003), vol. 15, pages 1005 - 1010 | - FORMISANO, P.; ORIENTY, F.; FIORY, F.; CARUSO, M.; MIELE, C.; MAITAN, M.A.; ANDREOZZI, F.; VIGLIOTTA, G.; CONDORELLI, G.; BEGUINOT, "Insulin-activated protein kinase Cbeta bypasses Ras and stimulates mitogen-activated protein kinase activity and cell proliferation in muscle cells", MOL CELL BIOL., (2000), vol. 20, pages 6323 - 6333 | - GARTSBEIN, M.; ALT, A.; HASHIMOTO, K.; NAKAJIMA, K.; KUROKI, T.; TENNENBAUM, T., "The role of protein kinase C delta activation and STAT3 Ser727 phosphorylation in insulin-induced keratinocyte proliferation", J CELL SCI., (2006), vol. 119, pages 470 - 481 | - GREGOIRE, F.M., "Adipocyte differentiation: from fibroblast to endocrine cell", EXP BIOL MED, (2001), vol. 226, pages 997 - 1002 | - HOFMANN, J., "The potential for isoenzyme-selective modulation of protein kinase C", THE FASEB J, (1997), vol. 11, pages 649 - 669 | - ISHIKI, M.; KLIP, A., "Minireview: recent developments in the regulation of glucose transporter-4 traffic: new signals, locations, and partners", ENDOCRINOLOGY, (2005), vol. 146, pages 5071 - 5078 | - JACKSON, S.M.; WILLIAMS, M.L.; FEINGOLD K.R.; ELIAS, P.M., "Pathobiology of the stratum corneum", WEST JMED., (1993), vol. 158, pages 279 - 285 | - LAVIOLA, L.; PERRINI, S.; CIGNARELLI, A.; GIORGINO, F., "Insulin signalling in human adipose tissue", ARCH PHYSIOL BIOCHEM., (2006), vol. 112, pages 82 - 88 | - MAIANU, L.; KELLER, S.R.; GARVEY, W.T., "Adipocytes exhibit abnormal subcellular distribution and translocation of vesicles containing glucose transporter 4 and insulin-regulated aminopeptidase in type 2 diabetes mellitus: implications regarding defects in vesicle trafficking", J CLIN ENDOCRINOL METAB., (2001), vol. 86, pages 5450 - 5456 | - MONTAGNA, W.; CARLISLE, K., "Structural changes in aging human skin", J INVEST DERMATOL., (1979), vol. 73, pages 47 - 53 | - MULLER, L.M.; GORTER, K.J.; HAK, E.; GOUDZWAARD, W.L.; SCHELLEVIS, F.G.; HOEPELMAN, A.I.; RUTTEN, G.E., "Increased risk of common infections in patients with type 1 and type 2 diabetes mellitus", CLIN INFECT DIS., (2005), vol. 41, pages 281 - 288 | - NG, T.; PARSONS, M.; HUGHES, W.E.; MONYPENNY, J.; ZICHA, D.; GAUTREAU, A.; ARPIN, M.; GSCHMEISSNER, S.; VERVEER, P.J.; BASTIAENS,, "Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility", EMBO J., (2001), vol. 20, pages 2723 - 2741 | - PANTANETTI, P.; GARRAPA, G.G.; MANTERO, F.; BOSCARO, M.; FALOIA, E.; VENARUCCI, D., "Adipose tissue as an endocrine organ? A review of recent data related to cardiovascular complications of endocrine dysfunctions", CLIN EXP HYPERTENS., (2004), vol. 26, pages 387 - 398 | - PATEL, N.; HUANG, C.; KLIP, A., "Cellular location of insulin-triggered signals and implications for glucose uptake", PFLUGERS ARCH., (2006), vol. 451, doi:doi:10.1007/s00424-005-1475-6, pages 499 - 510, XP019344109 DOI: http://dx.doi.org/10.1007/s00424-005-1475-6 | - "Structure and dynamics of the skin barrier", SCHAEFER, H.; REDELMEIER, T.E., Skin barrier: principles of percutaneous absorption, (1996), pages 1 - 42 | - SHEN, S.; ALT, A.; WERTHEIMER, E.; GARTSBEIN, M.; KUROKI, T.; OHBA, M.; BRAIMAN, L.; SAMPSON, S.R.; TENNENBAUM, T., "PKCdelta activation: a divergence point in the signaling of insulin and IGF-1-induced proliferation of skin keratinocytes", DIABETES, (2001), vol. 50, doi:doi:10.2337/diabetes.50.2.255, pages 255 - 264, XP002223026 DOI: http://dx.doi.org/10.2337/diabetes.50.2.255 | - SPRAVCHIKOV, N.; SIZYAKOV, G.; GARTSBEIN, M.; ACCILI, D.; TENNENBAUM, T.; WERTHEIMER, E., "Glucose effects on skin keratinocytes: implications for diabetes skin complications", DIABETES, (2000), vol. 50, doi:doi:10.2337/diabetes.50.7.1627, pages 1627 - 1635, XP002223027 DOI: http://dx.doi.org/10.2337/diabetes.50.7.1627 | - TAHA, C.; KLIP, A., "The insulin signaling pathway", J MEMBRANE BIOL., (1999), vol. 169, pages 1 - 12 | - TENNENBAUM, T.; YUSPA, S.H.; KNOX, B.; SOBEL, M.E.; CASTRONOVO, V.; YAMADA, Y.; DE LUCA, L.M., "Alterations in attachment to laminin and localization of laminin binding proteins during differentiation of primary mouse keratinocytes in vitro (Abstract", J INVEST. DERMATOL., (1991), page 96 | - TINGO, X.T.; DIMG, S.Y.; HANSEN, B.C., "Paradoxical increase in dermal microvascular flow in pre-diabetes associated with elevated levels of CRP", CLIN HEMORHEOL MICROCIRC., (2006), vol. 34, pages 273 - 282 | - VARANI, J.; DAME, M.K.; RITTIE, L.; FLIGIEL, S.E.; KANG, S.; FISHER, G.J.; VOORHEES, J.J., "Decreased collagen production in chronologically aged skin: roles of age- dependent alteration in fibroblast function and defective mechanical stimulation", AM J PATHOL., (2006), vol. 168, pages 1861 - 1868 | - WANG, Y.R.; MARGOLIS, D., "The prevalence of diagnosed cutaneous manifestations during ambulatory diabetes visits in the United States", DERMATOLOGY, (1998), vol. 212, pages 229 - 234 | - WERTHEIMER, E.; SPRAVCHIKOV, N.; TREBICZ, M.; GARTSBEIN, M.; ACCILI, D.; AVINOAH, I.; NOFEH-MOSES, S.; SIZYAKOV, G.; TENNENBAUM, T, "The regulation of skin proliferation and differentiation in the IR null mouse: implications for skin complications of diabetes", ENDOCRINOLOGY, (2001), vol. 142, doi:doi:10.1210/en.142.3.1234, pages 1234 - 1241, XP002223028 DOI: http://dx.doi.org/10.1210/en.142.3.1234 | - WERTHEIMER, E., "Diabetic skin complications: a need for reorganizing the categories of diabetes-associated complications", ISR. MED ASSOC. J, (2004), vol. 6, pages 287 - 289 | - WEST, M.D., "The cellular and molecular biology of skin aging", ARCH DERMATOL., (1994), vol. 130, pages 87 - 95 | - WHITE, M.F., "The insulin signalling system and the IRS proteins", DIABETOLOGIA, (1997), vol. 40, no. 2, pages 2 - 17 | - WYSOCKI, A.B., "Skin, anatomy, physiology, and pathophysiology", NURS. CLIN. NORTH AM., (1999), vol. 34, pages 777 - 797 | - YANG, S.; LITCHFIELD, J.E.; BAYNES, J.W., "AGE-breakers cleave model compounds, but do not break Maillard crosslinks in skin and tail collagen from diabetic rats", ARCH BIOCHEM BIOPHYS., (2003), vol. 412, pages 42 - 46 | - YOON, H.S.; BAIK, S.H.; OH, C.H., "Quantitative measurement of desquamation and skin elasticity in diabetic patients", SKIN RES TECHNOL., (2002), vol. 8, pages 250 - 254 | - YUSPA, S.H.; KILKENNY, A.E.; STEINERT, P.M.; ROOP, D.R., "Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro", J CELL BIOL., (1989), vol. 109, doi:doi:10.1083/jcb.109.3.1207, pages 1207 - 1217, XP002520093 DOI: http://dx.doi.org/10.1083/jcb.109.3.1207 | US20000629970 | US20020169801 | US20060332774 | US20060348527 |