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Extract from the Register of European Patents

EP About this file: EP2552914

EP2552914 - BENZONAPHTHYRIDINAMINES AS AUTOTAXIN INHIBITORS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  16.09.2016
Database last updated on 03.10.2024
Most recent event   Tooltip08.02.2019Change - lapse in a contracting statepublished on 13.03.2019  [2019/11]
Applicant(s)For all designated states
Merck Patent GmbH
Frankfurter Strasse 250
64293 Darmstadt / DE
[2013/06]
Inventor(s)01 / STAEHLE, Wolfgang
Neuweg 14C
55218 Ingelheim / DE
02 / SCHULTZ, Melanie
Heinrich-Fuhr-Strasse 17
64287 Darmstadt / DE
03 / SCHIEMANN, Kai
Am Roedergraben 8
64342 Seeheim-Jugenheim / DE
 [2013/06]
Application number, filing date11706181.228.02.2011
[2015/46]
WO2011EP00964
Priority number, dateEP2010000328226.03.2010         Original published format: EP 10003282
[2013/06]
Filing languageDE
Procedural languageDE
PublicationType: A1 Application with search report
No.:WO2011116867
Date:29.09.2011
Language:DE
[2011/39]
Type: A1 Application with search report 
No.:EP2552914
Date:06.02.2013
Language:DE
The application published by WIPO in one of the EPO official languages on 29.09.2011 takes the place of the publication of the European patent application.
[2013/06]
Type: B1 Patent specification 
No.:EP2552914
Date:11.11.2015
Language:DE
[2015/46]
Search report(s)International search report - published on:EP29.09.2011
ClassificationIPC:C07D471/04, A61K31/4375, A61P35/00
[2013/06]
CPC:
C07D471/04 (EP,US); A61P1/00 (EP); A61P1/04 (EP);
A61P11/00 (EP); A61P11/02 (EP); A61P11/06 (EP);
A61P17/02 (EP); A61P17/06 (EP); A61P19/02 (EP);
A61P19/06 (EP); A61P19/10 (EP); A61P21/00 (EP);
A61P25/00 (EP); A61P25/28 (EP); A61P27/02 (EP);
A61P29/00 (EP); A61P3/10 (EP); A61P35/00 (EP);
A61P35/02 (EP); A61P35/04 (EP); A61P37/00 (EP);
A61P37/06 (EP); A61P37/08 (EP); A61P43/00 (EP);
A61P5/14 (EP); A61P9/00 (EP); A61P9/10 (EP) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2013/06]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:BENZONAPHTHYRIDINAMINE ALS AUTOTAXIN-INHIBITOREN[2013/06]
English:BENZONAPHTHYRIDINAMINES AS AUTOTAXIN INHIBITORS[2013/06]
French:BENZONAPHTHYRIDINAMINES EN TANT QU'INHIBITEURS D'AUTOTAXINE[2013/06]
Entry into regional phase24.07.2012National basic fee paid 
24.07.2012Designation fee(s) paid 
24.07.2012Examination fee paid 
Examination procedure24.07.2012Examination requested  [2013/06]
08.02.2013Amendment by applicant (claims and/or description)
17.04.2014Despatch of a communication from the examining division (Time limit: M04)
30.06.2014Reply to a communication from the examining division
26.05.2015Communication of intention to grant the patent
17.09.2015Fee for grant paid
17.09.2015Fee for publishing/printing paid
17.09.2015Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  17.04.2014
Opposition(s)12.08.2016No opposition filed within time limit [2016/42]
Fees paidRenewal fee
12.02.2013Renewal fee patent year 03
12.02.2014Renewal fee patent year 04
11.02.2015Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU28.02.2011
AL11.11.2015
BG11.11.2015
CY11.11.2015
CZ11.11.2015
DK11.11.2015
EE11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
MC11.11.2015
MK11.11.2015
MT11.11.2015
NL11.11.2015
PL11.11.2015
RO11.11.2015
RS11.11.2015
SE11.11.2015
SI11.11.2015
SK11.11.2015
SM11.11.2015
TR11.11.2015
NO11.02.2016
GR12.02.2016
AT28.02.2016
IE28.02.2016
LU28.02.2016
BE29.02.2016
IS11.03.2016
PT11.03.2016
[2019/11]
Former [2018/46]HU28.02.2011
AL11.11.2015
BG11.11.2015
CY11.11.2015
CZ11.11.2015
DK11.11.2015
EE11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
MC11.11.2015
MK11.11.2015
MT11.11.2015
NL11.11.2015
PL11.11.2015
RO11.11.2015
RS11.11.2015
SE11.11.2015
SI11.11.2015
SK11.11.2015
SM11.11.2015
TR11.11.2015
NO11.02.2016
GR12.02.2016
AT28.02.2016
IE28.02.2016
LU28.02.2016
BE29.02.2016
IS11.03.2016
PT11.03.2016
Former [2018/38]HU28.02.2011
BG11.11.2015
CY11.11.2015
CZ11.11.2015
DK11.11.2015
EE11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
MC11.11.2015
MK11.11.2015
MT11.11.2015
NL11.11.2015
PL11.11.2015
RO11.11.2015
RS11.11.2015
SE11.11.2015
SI11.11.2015
SK11.11.2015
SM11.11.2015
TR11.11.2015
NO11.02.2016
GR12.02.2016
AT28.02.2016
IE28.02.2016
LU28.02.2016
BE29.02.2016
IS11.03.2016
PT11.03.2016
Former [2018/29]HU28.02.2011
CY11.11.2015
CZ11.11.2015
DK11.11.2015
EE11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
MC11.11.2015
MK11.11.2015
MT11.11.2015
NL11.11.2015
PL11.11.2015
RO11.11.2015
RS11.11.2015
SE11.11.2015
SI11.11.2015
SK11.11.2015
SM11.11.2015
TR11.11.2015
NO11.02.2016
GR12.02.2016
AT28.02.2016
IE28.02.2016
LU28.02.2016
BE29.02.2016
IS11.03.2016
PT11.03.2016
Former [2018/28]HU28.02.2011
CY11.11.2015
CZ11.11.2015
DK11.11.2015
EE11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
MC11.11.2015
MK11.11.2015
MT11.11.2015
NL11.11.2015
PL11.11.2015
RO11.11.2015
RS11.11.2015
SE11.11.2015
SI11.11.2015
SK11.11.2015
SM11.11.2015
NO11.02.2016
GR12.02.2016
AT28.02.2016
IE28.02.2016
LU28.02.2016
BE29.02.2016
IS11.03.2016
PT11.03.2016
Former [2017/40]CZ11.11.2015
DK11.11.2015
EE11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
MC11.11.2015
MT11.11.2015
NL11.11.2015
PL11.11.2015
RO11.11.2015
RS11.11.2015
SE11.11.2015
SI11.11.2015
SK11.11.2015
SM11.11.2015
NO11.02.2016
GR12.02.2016
AT28.02.2016
IE28.02.2016
LU28.02.2016
BE29.02.2016
IS11.03.2016
PT11.03.2016
Former [2017/36]CZ11.11.2015
DK11.11.2015
EE11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
MC11.11.2015
NL11.11.2015
PL11.11.2015
RO11.11.2015
RS11.11.2015
SE11.11.2015
SI11.11.2015
SK11.11.2015
SM11.11.2015
NO11.02.2016
GR12.02.2016
AT28.02.2016
IE28.02.2016
IT28.02.2016
LU28.02.2016
BE29.02.2016
IS11.03.2016
PT11.03.2016
Former [2017/07]CZ11.11.2015
DK11.11.2015
EE11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
MC11.11.2015
NL11.11.2015
PL11.11.2015
RO11.11.2015
RS11.11.2015
SE11.11.2015
SI11.11.2015
SK11.11.2015
SM11.11.2015
NO11.02.2016
GR12.02.2016
IE28.02.2016
LU28.02.2016
BE29.02.2016
IS11.03.2016
PT11.03.2016
Former [2016/49]CZ11.11.2015
DK11.11.2015
EE11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
MC11.11.2015
NL11.11.2015
PL11.11.2015
RO11.11.2015
RS11.11.2015
SE11.11.2015
SI11.11.2015
SK11.11.2015
SM11.11.2015
NO11.02.2016
GR12.02.2016
LU28.02.2016
BE29.02.2016
IS11.03.2016
PT11.03.2016
Former [2016/43]CZ11.11.2015
DK11.11.2015
EE11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
MC11.11.2015
NL11.11.2015
PL11.11.2015
RO11.11.2015
RS11.11.2015
SE11.11.2015
SK11.11.2015
SM11.11.2015
NO11.02.2016
GR12.02.2016
LU28.02.2016
BE29.02.2016
IS11.03.2016
PT11.03.2016
Former [2016/42]CZ11.11.2015
DK11.11.2015
EE11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
MC11.11.2015
NL11.11.2015
PL11.11.2015
RO11.11.2015
RS11.11.2015
SE11.11.2015
SK11.11.2015
SM11.11.2015
NO11.02.2016
GR12.02.2016
BE29.02.2016
IS11.03.2016
PT11.03.2016
Former [2016/39]CZ11.11.2015
DK11.11.2015
EE11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
NL11.11.2015
PL11.11.2015
RO11.11.2015
RS11.11.2015
SE11.11.2015
SK11.11.2015
SM11.11.2015
NO11.02.2016
GR12.02.2016
BE29.02.2016
IS11.03.2016
PT11.03.2016
Former [2016/38]CZ11.11.2015
EE11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
NL11.11.2015
PL11.11.2015
RO11.11.2015
RS11.11.2015
SE11.11.2015
SK11.11.2015
SM11.11.2015
NO11.02.2016
GR12.02.2016
BE29.02.2016
IS11.03.2016
PT11.03.2016
Former [2016/36]CZ11.11.2015
EE11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
NL11.11.2015
PL11.11.2015
RO11.11.2015
RS11.11.2015
SE11.11.2015
SK11.11.2015
NO11.02.2016
GR12.02.2016
BE29.02.2016
IS11.03.2016
PT11.03.2016
Former [2016/34]CZ11.11.2015
FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
NL11.11.2015
PL11.11.2015
RS11.11.2015
SE11.11.2015
NO11.02.2016
GR12.02.2016
BE29.02.2016
IS11.03.2016
PT11.03.2016
Former [2016/25]FI11.11.2015
HR11.11.2015
LT11.11.2015
LV11.11.2015
NL11.11.2015
PL11.11.2015
RS11.11.2015
SE11.11.2015
NO11.02.2016
GR12.02.2016
BE29.02.2016
IS11.03.2016
PT11.03.2016
Former [2016/24]FI11.11.2015
HR11.11.2015
LT11.11.2015
NL11.11.2015
PL11.11.2015
RS11.11.2015
SE11.11.2015
NO11.02.2016
GR12.02.2016
BE29.02.2016
IS11.03.2016
PT11.03.2016
Former [2016/23]HR11.11.2015
LT11.11.2015
NL11.11.2015
RS11.11.2015
SE11.11.2015
NO11.02.2016
IS11.03.2016
Former [2016/22]LT11.11.2015
NL11.11.2015
NO11.02.2016
IS11.03.2016
Former [2016/21]LT11.11.2015
NO11.02.2016
Former [2016/20]LT11.11.2015
Cited inInternational search[X]GB1186061  (AMERICAN HOME PROD [US]) [X] 14 * column 1; compound I * * table 1 * * example 9 *;
 [X]EP0997462  (NIPPON KAYAKU KK [JP]) [X] 14 * examples 10,11,15,19 *;
 [X]  - FRANCO GATTA ET AL, "Synthesis of 10-Amino-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridines and Related Derivatives", JOURNAL OF HETEROCYCLIC CHEMISTRY, WILEY-BLACKWELL PUBLISHING, INC, US, (19960101), vol. 33, doi:DOI:10.1002/JHET.5570330642, ISSN 0022-152X, pages 1807 - 1814, XP009132640 [X] 14 * scheme 1, Verbindungen 11, 18; scheme 1, Verbindungen 6-10, 13-17 mit R1=H *

DOI:   http://dx.doi.org/10.1002/jhet.5570330642
 [A]  - HOEGLUND ADRIENNE B ET AL, "Characterization of non-lipid autotaxin inhibitors.", BIOORGANIC & MEDICINAL CHEMISTRY 15 JAN 2010 LNKD- PUBMED:20005724, (20100115), vol. 18, no. 2, ISSN 1464-3391, pages 769 - 776, XP002637116 [A] 1-14 * figures 1,2 *

DOI:   http://dx.doi.org/10.1016/J.BMC.2009.11.056
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.