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Extract from the Register of European Patents

EP About this file: EP2702073

EP2702073 - POLYMUTANT TAU PROTEIN VARIANTS AND THEIR USE FOR RECAPITULATING HUMAN TAUOPATHIES [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  15.12.2017
Database last updated on 17.07.2024
FormerThe patent has been granted
Status updated on  06.01.2017
FormerGrant of patent is intended
Status updated on  03.01.2017
Most recent event   Tooltip17.07.2020Lapse of the patent in a contracting state
New state(s): AL, IS		published on 19.08.2020  [2020/34]
Applicant(s)For all designated states
Universität Leipzig
Ritterstrasse 26
04109 Leipzig / DE
[2014/10]
Inventor(s)01 / ROBITZKI, Andrea
Brunhildstr. 8
68519 Viernheim / DE
02 / JAHNKE, Heinz-Georg
Lange Reihe 46
04299 Leipzig / DE
03 / KRINKE, Dana
Gletschersteinstr. 35
04299 Leipzig / DE
04 / STRIGGOW, Frank
Putergarten 7
39175 Gerwisch / DE
05 / MACK, Till
Leibnizstr. 10
39104 Magdeburg / DE
 [2014/10]
Representative(s)Kalhammer, Georg, et al
Lederer & Keller
Patentanwälte Partnerschaft mbB
Unsöldstrasse 2
80538 München / DE
[2017/06]
Former [2014/10]Kalhammer, Georg, et al
Lederer & Keller Patentanwälte Unsöldstrasse 2
80538 München / DE
Application number, filing date11716418.628.04.2011
[2017/06]
WO2011EP56741
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2012146285
Date:01.11.2012
Language:EN
[2012/44]
Type: A1 Application with search report 
No.:EP2702073
Date:05.03.2014
Language:EN
The application published by WIPO in one of the EPO official languages on 01.11.2012 takes the place of the publication of the European patent application.
[2014/10]
Type: B1 Patent specification 
No.:EP2702073
Date:08.02.2017
Language:EN
[2017/06]
Search report(s)International search report - published on:EP01.11.2012
ClassificationIPC:C07K14/47
[2014/10]
CPC:
C07K14/4711 (EP,US); C07K14/47 (KR,US); C12N15/11 (KR);
C12N5/10 (KR)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/10]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:POLYMUTANTE TAU-PROTEINVARIANTEN UND IHRE VERWENDUNG ZUR REKAPITULIERUNG VON MENSCHLICHEN TAUOPATHIEN[2014/10]
English:POLYMUTANT TAU PROTEIN VARIANTS AND THEIR USE FOR RECAPITULATING HUMAN TAUOPATHIES[2014/10]
French:VARIANTS POLYMUTANTS DE LA PROTÉINE TAU ET LEUR UTILISATION DANS LA RÉCAPITULATION DES TAUOPATHIES HUMAINES[2014/10]
Entry into regional phase29.10.2013National basic fee paid 
29.10.2013Designation fee(s) paid 
29.10.2013Examination fee paid 
Examination procedure29.10.2013Examination requested  [2014/10]
16.06.2014Amendment by applicant (claims and/or description)
26.11.2014Despatch of a communication from the examining division (Time limit: M06)
15.05.2015Reply to a communication from the examining division
09.12.2015Despatch of a communication from the examining division (Time limit: M04)
19.04.2016Reply to a communication from the examining division
10.08.2016Communication of intention to grant the patent
20.12.2016Fee for grant paid
20.12.2016Fee for publishing/printing paid
20.12.2016Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  26.11.2014
Opposition(s)09.11.2017No opposition filed within time limit [2018/03]
Fees paidRenewal fee
29.10.2013Renewal fee patent year 03
29.04.2014Renewal fee patent year 04
25.03.2015Renewal fee patent year 05
14.04.2016Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU28.04.2011
AL08.02.2017
AT08.02.2017
CY08.02.2017
CZ08.02.2017
DK08.02.2017
EE08.02.2017
ES08.02.2017
FI08.02.2017
HR08.02.2017
IT08.02.2017
LT08.02.2017
LV08.02.2017
MC08.02.2017
MK08.02.2017
NL08.02.2017
PL08.02.2017
RO08.02.2017
RS08.02.2017
SI08.02.2017
SK08.02.2017
SM08.02.2017
TR08.02.2017
IE28.04.2017
LU28.04.2017
MT28.04.2017
BE30.04.2017
BG08.05.2017
NO08.05.2017
GR09.05.2017
IS08.06.2017
PT08.06.2017
[2020/33]
Former [2020/15]HU28.04.2011
AT08.02.2017
CY08.02.2017
CZ08.02.2017
DK08.02.2017
EE08.02.2017
ES08.02.2017
FI08.02.2017
HR08.02.2017
IT08.02.2017
LT08.02.2017
LV08.02.2017
MC08.02.2017
MK08.02.2017
NL08.02.2017
PL08.02.2017
RO08.02.2017
RS08.02.2017
SI08.02.2017
SK08.02.2017
SM08.02.2017
TR08.02.2017
IE28.04.2017
LU28.04.2017
MT28.04.2017
BE30.04.2017
BG08.05.2017
NO08.05.2017
GR09.05.2017
PT08.06.2017
Former [2019/51]HU28.04.2011
AT08.02.2017
CY08.02.2017
CZ08.02.2017
DK08.02.2017
EE08.02.2017
ES08.02.2017
FI08.02.2017
HR08.02.2017
IT08.02.2017
LT08.02.2017
LV08.02.2017
MC08.02.2017
MK08.02.2017
NL08.02.2017
PL08.02.2017
RO08.02.2017
RS08.02.2017
SI08.02.2017
SK08.02.2017
SM08.02.2017
IE28.04.2017
LU28.04.2017
MT28.04.2017
BE30.04.2017
BG08.05.2017
NO08.05.2017
GR09.05.2017
PT08.06.2017
Former [2019/46]HU28.04.2011
AT08.02.2017
CY08.02.2017
CZ08.02.2017
DK08.02.2017
EE08.02.2017
ES08.02.2017
FI08.02.2017
HR08.02.2017
IT08.02.2017
LT08.02.2017
LV08.02.2017
MC08.02.2017
NL08.02.2017
PL08.02.2017
RO08.02.2017
RS08.02.2017
SI08.02.2017
SK08.02.2017
SM08.02.2017
IE28.04.2017
LU28.04.2017
MT28.04.2017
BE30.04.2017
BG08.05.2017
NO08.05.2017
GR09.05.2017
PT08.06.2017
Former [2019/31]HU28.04.2011
AT08.02.2017
CZ08.02.2017
DK08.02.2017
EE08.02.2017
ES08.02.2017
FI08.02.2017
HR08.02.2017
IT08.02.2017
LT08.02.2017
LV08.02.2017
MC08.02.2017
NL08.02.2017
PL08.02.2017
RO08.02.2017
RS08.02.2017
SI08.02.2017
SK08.02.2017
SM08.02.2017
IE28.04.2017
LU28.04.2017
MT28.04.2017
BE30.04.2017
BG08.05.2017
NO08.05.2017
GR09.05.2017
PT08.06.2017
Former [2018/43]AT08.02.2017
CZ08.02.2017
DK08.02.2017
EE08.02.2017
ES08.02.2017
FI08.02.2017
HR08.02.2017
IT08.02.2017
LT08.02.2017
LV08.02.2017
MC08.02.2017
NL08.02.2017
PL08.02.2017
RO08.02.2017
RS08.02.2017
SI08.02.2017
SK08.02.2017
SM08.02.2017
IE28.04.2017
LU28.04.2017
MT28.04.2017
BE30.04.2017
BG08.05.2017
NO08.05.2017
GR09.05.2017
PT08.06.2017
Former [2018/23]AT08.02.2017
CZ08.02.2017
DK08.02.2017
EE08.02.2017
ES08.02.2017
FI08.02.2017
HR08.02.2017
IT08.02.2017
LT08.02.2017
LV08.02.2017
MC08.02.2017
NL08.02.2017
PL08.02.2017
RO08.02.2017
RS08.02.2017
SI08.02.2017
SK08.02.2017
SM08.02.2017
IE28.04.2017
LU28.04.2017
BE30.04.2017
BG08.05.2017
NO08.05.2017
GR09.05.2017
PT08.06.2017
Former [2018/14]AT08.02.2017
CZ08.02.2017
DK08.02.2017
EE08.02.2017
ES08.02.2017
FI08.02.2017
HR08.02.2017
IT08.02.2017
LT08.02.2017
LV08.02.2017
MC08.02.2017
NL08.02.2017
PL08.02.2017
RO08.02.2017
RS08.02.2017
SI08.02.2017
SK08.02.2017
SM08.02.2017
LU28.04.2017
BG08.05.2017
NO08.05.2017
GR09.05.2017
PT08.06.2017
Former [2018/06]AT08.02.2017
CZ08.02.2017
DK08.02.2017
EE08.02.2017
ES08.02.2017
FI08.02.2017
HR08.02.2017
IT08.02.2017
LT08.02.2017
LV08.02.2017
MC08.02.2017
NL08.02.2017
PL08.02.2017
RO08.02.2017
RS08.02.2017
SK08.02.2017
SM08.02.2017
BG08.05.2017
NO08.05.2017
GR09.05.2017
PT08.06.2017
Former [2017/51]AT08.02.2017
CZ08.02.2017
DK08.02.2017
EE08.02.2017
ES08.02.2017
FI08.02.2017
HR08.02.2017
IT08.02.2017
LT08.02.2017
LV08.02.2017
NL08.02.2017
PL08.02.2017
RO08.02.2017
RS08.02.2017
SK08.02.2017
SM08.02.2017
BG08.05.2017
NO08.05.2017
GR09.05.2017
PT08.06.2017
Former [2017/50]AT08.02.2017
CZ08.02.2017
DK08.02.2017
EE08.02.2017
ES08.02.2017
FI08.02.2017
HR08.02.2017
IT08.02.2017
LT08.02.2017
LV08.02.2017
NL08.02.2017
PL08.02.2017
RO08.02.2017
RS08.02.2017
SK08.02.2017
BG08.05.2017
NO08.05.2017
GR09.05.2017
PT08.06.2017
Former [2017/49]AT08.02.2017
CZ08.02.2017
EE08.02.2017
ES08.02.2017
FI08.02.2017
HR08.02.2017
IT08.02.2017
LT08.02.2017
LV08.02.2017
NL08.02.2017
RO08.02.2017
RS08.02.2017
SK08.02.2017
BG08.05.2017
NO08.05.2017
GR09.05.2017
PT08.06.2017
Former [2017/48]AT08.02.2017
CZ08.02.2017
ES08.02.2017
FI08.02.2017
HR08.02.2017
LT08.02.2017
LV08.02.2017
NL08.02.2017
RS08.02.2017
BG08.05.2017
NO08.05.2017
GR09.05.2017
PT08.06.2017
Former [2017/41]AT08.02.2017
ES08.02.2017
FI08.02.2017
HR08.02.2017
LT08.02.2017
LV08.02.2017
NL08.02.2017
RS08.02.2017
BG08.05.2017
NO08.05.2017
GR09.05.2017
PT08.06.2017
Cited inInternational search[XI]  - LIM ET AL, "FTDP-17 Mutations in tau Transgenic Mice Provoke Lysosomal Abnormalities and Tau Filaments in Forebrain", MOLECULAR AND CELLULAR NEUROSCIENCE, (20011201), vol. 18, no. 6, doi:10.1006/mcne.2001.1051, ISSN 1044-7431, pages 702 - 714, XP055001856 [X] 1,4,6,8,9,22-24 * abstract * * page 703, column l, paragraph 3 - paragraph 4 * * page 706, column r, paragraph 2 - page 707, column l, paragraph 1 * * figure 3 * [I] 2,3,5,7,10-21

DOI:   http://dx.doi.org/10.1006/mcne.2001.1051
 [A]  - VOGELSBERG-RAGAGLIA V ET AL, "Distinct FTDP-17 missense mutations in tau produce tau aggregates and other pathological phenotypes in transfected CHO cells", MOLECULAR BIOLOGY OF THE CELL, AMERICAN SOCIETY FOR CELL BIOLOGY, US, (20001201), vol. 11, no. 12, ISSN 1059-1524, pages 4093 - 4104, XP002224857 [A] 1-24 * abstract * * page 4094, column l, paragraph l * * page 4098, column l, paragraph l - page 4099, column l, paragraph 1 * * page 4099, column l, paragraph l - page 4100, column l, paragraph 1 * * page 4101, column r, paragraph l - page 4102 * * figures 6, 8-10 *
 [A]  - NORBERT ZILKA ET AL, "Misfolded tau protein and disease modifying pathways in transgenic rodent models of human tauopathies", ACTA NEUROPATHOLOGICA, SPRINGER, BERLIN, DE, (20090224), vol. 118, no. 1, ISSN 1432-0533, pages 71 - 86, XP019713381 [A] 1-24 * page 73, column r, paragraph l * * page 77 * * table 1 *
 [A]  - HERNÁNDEZ F ET AL, "Tauopathies", CMLS CELLULAR AND MOLECULAR LIFE SCIENCES, BIRKHÄUSER-VERLAG, BA, (20070702), vol. 64, no. 17, doi:DOI:10.1007/S00018-007-7220-X, ISSN 1420-9071, pages 2219 - 2233, XP019536892 [A] 1-24 * page 2225, column l, paragraph 3 *

DOI:   http://dx.doi.org/10.1007/s00018-007-7220-x
 [A]  - BRANDT R ET AL, "Tau alteration and neuronal degeneration in tauopathies: mechanisms and models", BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE, AMSTERDAM, NL, vol. 1739, no. 2-3, doi:DOI:10.1016/J.BBADIS.2004.06.018, ISSN 0925-4439, (20050103), pages 331 - 354, (20050103), XP025329114 [A] 1-24 * figure 2 * * tables 1, 4 *

DOI:   http://dx.doi.org/10.1016/j.bbadis.2004.06.018
 [A]  - WANG J Z ET AL, "Microtubule-associated protein tau in development, degeneration and protection of neurons", PROGRESS IN NEUROBIOLOGY, PERGAMON PRESS, GB, vol. 85, no. 2, doi:DOI:10.1016/J.PNEUROBIO.2008.03.002, ISSN 0301-0082, (20080601), pages 148 - 175, (20080322), XP022667043 [A] 1-24 * figure 2 * * table 2 *

DOI:   http://dx.doi.org/10.1016/j.pneurobio.2008.03.002
by applicantWO9311231
 WO2007088400
 WO0153340
 EP2103933
    - TATUSOVA ET AL., FEMS MICROBIOL. LETT., (1999), vol. 174, pages 247 - 250
    - FOSTER NL, WILHELMSEN K, SIMA AA, JONES MZ, D'AMATO CJ, GILMAN S, "Frontotemporal dementia and parkinsonism linked to chromosome 17: a consensus conference, Conference Participants", ANN NEUROL, (1997), vol. 41, pages 706 - 715
    - GOSSEN, BUJARD, PROC NATL ACAD SCI USA, (19911215), vol. 89, no. 12, pages 5547 - 51
    - GOSSEN ET AL., SCIENCE, (19950623), vol. 268, no. 5218, pages 1766 - 9
    - KISTNER ET AL., PROC NATL ACAD SCI USA, (1996), vol. 93, pages 10933 - 10938
    - HOPPE ET AL., MOL THER, (2000), vol. 1, pages 159 - 164
    - NO ET AL., PROC NATL ACAD SCI USA, (1996), vol. 93, pages 3346 - 3351
    - ORNITZ ET AL., PROC NATL ACAD SCI USA, (19910201), vol. 88, no. 3, pages 698 - 702
    - HO ET AL., NATURE, (19960829), vol. 382, no. 6594, pages 822 - 6
    - POLLOCK ET AL., PROC NATL ACAD SCI USA, (20001121), vol. 97, no. 24, pages 13221 - 6
    - BOORSMA ET AL., NAT BIOTECHNOL, (2000), vol. 18, no. 4, pages 429 - 32
    - OTTO ET AL., JOURNAL OF NEUROSCIENCE METHODS, (2003), vol. 128, pages 173 - 181
    - PANKRATZ ET AL., STEM CELLS, (2007), vol. 25, no. 6, pages 1511 - 1520
    - HU ET AL., PNAS, (2010), vol. 107, no. 9, pages 4335 - 4340
    - VIERBUCHEN ET AL., NATURE, (2010), vol. 463, pages 1035 - 1041
    - AGHOLME ET AL., JOURNAL OF ALZHEIMER'S DISEASE, (2010), vol. 20, pages 1069 - 1082
    - TREMBLEY ET AL., JOURNAL OF NEUROSCIENCE METHODS, (2010), vol. 186, pages 60 - 67
    - ZHONG ET AL., JOURNAL OF NEUROCHEMISTRY, vol. 68, no. 6, pages 2291 - 2299
    - SCHIMMELPFENIG ET AL., JOURNAL OF NEUROSCIENCE METHODS, (2004), vol. 139, pages 299 - 306
    - JICHA, G.A., BOWSER, R., KAZAM, I.G., DAVIES, P., J. NEUROSCI. RES., (1997), vol. 48, no. 2, pages 128 - 132
    - DAVIS ET AL., JOURNAL OF NEUROSCIENCE RESEARCH, (1994), vol. 39, no. 5, pages 589 - 594
    - JAHNKE ET AL., LAB CHIP, (2009), vol. 9, pages 1422 - 1428
    - BRAAK, H., BRAAK, E., NEUROBIOL AGING, (1995), vol. 16, pages 271 - 8
    - FRIEDHOFF ET AL., BIOCHEMISTRY, (1998), vol. 37, pages 10223 - 30
    - JOHNSON, G. V., HARTIGAN, J. A., J ALZHEIMERS DIS, (1999), vol. 1, pages 329 - 51
    - MACK ET AL., NAT NEUROSCI, (2001), vol. 4, pages 1199 - 206
    - RUTTEN ET AL., AM J PATHOL, (2005), vol. 167, pages 161 - 73
    - BANDYOPADHYAY, B., G. LI, H. YIN, J. KURET, "Tau aggregation and toxicity in a cell culture model of tauopathy", J 8IOL CHEM., (2007), vol. 282, pages 16454 - 64
    - ITTNER, L.M., Y.D. KE, F. DELERUE, M. BI, A. GLADBACH, J. VAN EERSEL, H. WOLFING, B.C. CHIENG, M.J. CHRISTIE, I.A. NAPIER, "Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models", CELL, (2010), vol. 142, doi:doi:10.1016/j.cell.2010.06.036, pages 387 - 97, XP028931189

DOI:   http://dx.doi.org/10.1016/j.cell.2010.06.036
    - JAHNKE, H.G., ROTHERMEL, A., STERNBERGER, I., MACK, T.G., KURZ, R.G., PANKE, 0., STRIGGOW, F., ROBITZKI, A.A., "An impedimetric microelectrode-based array sensor for label-free detection of tau hyperphosphorylation in human cells", LABCHIP., (2009), vol. 21, no. 10, page 9
    - JEGANATHAN, S., A. HASCHER, S. CHINNATHAMBI, J. BIERNAT, E.M. MANDELKOW, E. MANDELKOW, "Proline-directed pseudo-phosphorylation at AT8 and PHF1 epitopes induces a compaction of the paperclip folding of Tau and generates a pathological (MC-1) conformation", J BIOL CHEM., (2008), vol. 283, pages 32066 - 76
    - KANG, J., LEMAIRE, H. G., UNTERBECK, A., SALBAUM, J. M., MASTERS, C. L., GRZESCHIK, K. H., MULTHAUP, G., BEYREUTHER, K., MULLER-HI, "The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor", NATURE, (1987), vol. 325, pages 733 - 6
    - KNAUER, M. F., SOREGHAN, B., BURDICK, D, KOSMOSKI, J., GLABE, C. G., "Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein", PROC NATL ACAD SCI U S A, (1992), vol. 89, pages 7437 - 41
    - KO, L.W., T. RUSH, N. SAHARA, J.S. KERSH, C. EASSON, M. DETURE, W.L. LIN, Y.D. CONNOR, S.H. YEN., "Assembly of filamentous tau aggregates in human neuronal cells", J ALZHEIMERS DIS, (2004), vol. 6, pages 605 - 22
    - LIM, F., F. HERNANDEZ, J.J. LUCAS, P. GOMEZ-RAMOS, M.A. MORAN, J. AVILA., "FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain", MOL CELL NEUROSCI, (2001), vol. 18, doi:doi:10.1006/mcne.2001.1051, pages 702 - 14, XP055001856

DOI:   http://dx.doi.org/10.1006/mcne.2001.1051
    - LECORRE, S., KLAFKI, H.W., PLESNILA, N., HüBINGER, G., OBERMEIER, A., SAHAGU, H., MONSE, B., SENECI, P., LEWIS, J., ERIKSEN, J., "An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice", PNAS., (2006), vol. 103, no. 25, pages 9673 - 78
    - NIE, C.L., Y. WEI, X. CHEN, Y.Y. LIU, W. DUI, Y. LIU, M.C. DAVIES, S.J. TENDLER, R.G. HE, "Formaldehyde at low concentration induces protein tau into globular amyloid-like aggregates in vitro and in vivo", PLOS ONE., (2007), vol. 2, page E629
    - ROSENMANN, H., N. GRIGORIADIS, H. ELDAR-LEVY, A. AVITAL, L. ROZENSTEIN, O. TOULOUMI, L. BEHAR, T. BEN-HUR, Y. AVRAHAM, E. BERRY, "A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics", EXP NEUROL, (2008), vol. 212, doi:doi:10.1016/j.expneurol.2008.03.007, pages 71 - 84, XP022714963

DOI:   http://dx.doi.org/10.1016/j.expneurol.2008.03.007
    - SANTACRUZ, K., J. LEWIS, T. SPIRES, J. PAULSON, L. KOTILINEK, M. INGELSSON, A. GUIMARAES, M. DETURE, M. RAMSDEN, E. MCGOWAN, "Tau suppression in a neurodegenerative mouse model improves memory function", SCIENCE, (2005), vol. 309, doi:doi:10.1126/science.1113694, pages 476 - 81, XP055007424

DOI:   http://dx.doi.org/10.1126/science.1113694
    - SELENICA, M.L., JENSEN, H.S., LARSEN, A.K., PEDERSEN, M.L., HELBOE L, LEIST, M., LOTHARIUS, J., "Efficacy of small-molecule glycogen synthase kinase-3 inhibitors in the postnatal rat model of tau hyperphosphorylation", BR J PHARMACOL., (2007), vol. 152, no. 6, pages 969 - 79
    - SCHINDOWSKI, K., A. BRETTEVILLE, K. LEROY, S. BEGARD, J.P. BRION, M. HAMDANE, L. BUEE, "Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits", AM J PATHOL, (2006), vol. 169, pages 599 - 616
    - TSUKANE, M., C. YOSHIZAKI, T. YAMAUCHI., "Development and specific induction of apoptosis of cultured cell models overexpressing human tau during neural differentiation: Implication in Alzheimer's disease", ANAL BIOCHEM., (2007), vol. 360, doi:doi:10.1016/j.ab.2006.10.003, pages 114 - 22, XP005725310

DOI:   http://dx.doi.org/10.1016/j.ab.2006.10.003
    - VAN SWIETEN, J., M.G. SPILLANTINI., "Hereditary frontotemporal dementia caused by Tau gene mutations", BRAIN PATHOL., (2007), vol. 17, pages 63 - 73
    - ZEMPEL, H., E. THIES, E. MANDELKOW, E.M. MANDELKOW, "Abeta oligomers cause localized Ca(2+) elevation, missorting of endogenous Tau into dendrites, Tau phosphorylation, and destruction of microtubules and spines", J NEUROSCI., (2010), vol. 30, pages 11938 - 50
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