EP2563932 - DETECTION OF IMMUNE CELLS, IN PARTICULAR T CELLS THROUGH DNA-METHYLATION ANALYSIS OF THE GENES CCR6 [Right-click to bookmark this link] | |||
Former [2013/10] | DETECTION OF IMMUNE CELLS, IN PARTICULAR T CELLS THROUGH DNA-METHYLATION ANALYSIS OF THE GENES CCR6 AND BLR1 | ||
[2017/48] | Status | No opposition filed within time limit Status updated on 05.10.2018 Database last updated on 30.07.2024 | |
Former | The patent has been granted Status updated on 27.10.2017 | ||
Former | Grant of patent is intended Status updated on 27.06.2017 | ||
Former | Examination is in progress Status updated on 20.01.2017 | Most recent event Tooltip | 10.07.2020 | Lapse of the patent in a contracting state New state(s): AL, IS | published on 12.08.2020 [2020/33] | Applicant(s) | For all designated states Epiontis GmbH Rudower Chaussee 29 12489 Berlin / DE | [2013/10] | Inventor(s) | 01 /
OLEK, Sven Boothstrasse 16 12207 Berlin / DE | [2013/10] | Representative(s) | Krauss, Jan Boehmert & Boehmert Anwaltspartnerschaft mbB Pettenkoferstrasse 22 80336 München / DE | [2017/48] |
Former [2013/10] | Krauss, Jan Boehmert & Boehmert Pettenkoferstrasse 20-22 80336 München / DE | Application number, filing date | 11716573.8 | 29.04.2011 | [2017/48] | WO2011EP56871 | Priority number, date | US20100329229P | 29.04.2010 Original published format: US 329229 P | [2013/10] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2011135088 | Date: | 03.11.2011 | Language: | EN | [2011/44] | Type: | A1 Application with search report | No.: | EP2563932 | Date: | 06.03.2013 | Language: | EN | The application published by WIPO in one of the EPO official languages on 03.11.2011 takes the place of the publication of the European patent application. | [2013/10] | Type: | B1 Patent specification | No.: | EP2563932 | Date: | 29.11.2017 | Language: | EN | [2017/48] | Search report(s) | International search report - published on: | EP | 03.11.2011 | Classification | IPC: | C12Q1/68 | [2013/10] | CPC: |
C12Q1/6883 (EP,US);
C12Q1/686 (US);
C12Q1/6876 (US);
C12Q1/6869 (US);
C12Q2523/125 (US);
C12Q2600/154 (EP,US)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2013/10] | Extension states | BA | Not yet paid | ME | Not yet paid | Title | German: | NACHWEIS VON IMMUNZELLEN MITTELS DNA-METHYLIERUNGSANALYSE DES GENS CCR6 | [2017/48] | English: | DETECTION OF IMMUNE CELLS, IN PARTICULAR T CELLS THROUGH DNA-METHYLATION ANALYSIS OF THE GENES CCR6 | [2017/48] | French: | DÉTECTION DES CELLULES IMMUNITAIRES, EN PARTICULIER VIA L'ANALYSE DE MÉTHYLATION DE L'ADN DU GÈNES CCR6 | [2017/48] |
Former [2013/10] | NACHWEIS VON IMMUNZELLEN, IM BESONDEREN T-ZELLEN, DURCH DNA-METHYLIERUNGSANALYSE DER GENE CCR6 UND BLR1 | ||
Former [2013/10] | DETECTION OF IMMUNE CELLS, IN PARTICULAR T CELLS THROUGH DNA-METHYLATION ANALYSIS OF THE GENES CCR6 AND BLR1 | ||
Former [2013/10] | DÉTECTION DE CELLULES IMMUNITAIRES, EN PARTICULIER DE LYMPHOCYTES T, PAR L'ANALYSE DE LA MÉTHYLATION DE L'ADN DES GÈNES CCR6 ET BLR1 | Entry into regional phase | 29.11.2012 | National basic fee paid | 29.11.2012 | Designation fee(s) paid | 29.11.2012 | Examination fee paid | Examination procedure | 29.11.2012 | Examination requested [2013/10] | 18.07.2013 | Amendment by applicant (claims and/or description) | 19.09.2016 | Despatch of a communication from the examining division (Time limit: M04) | 17.01.2017 | Reply to a communication from the examining division | 28.06.2017 | Communication of intention to grant the patent | 20.10.2017 | Fee for grant paid | 20.10.2017 | Fee for publishing/printing paid | 20.10.2017 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 19.09.2016 | Opposition(s) | 30.08.2018 | No opposition filed within time limit [2018/45] | Fees paid | Renewal fee | 12.04.2013 | Renewal fee patent year 03 | 26.02.2014 | Renewal fee patent year 04 | 10.04.2015 | Renewal fee patent year 05 | 29.03.2016 | Renewal fee patent year 06 | 10.04.2017 | Renewal fee patent year 07 |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 29.04.2011 | AL | 29.11.2017 | CY | 29.11.2017 | EE | 29.11.2017 | FI | 29.11.2017 | HR | 29.11.2017 | LT | 29.11.2017 | LV | 29.11.2017 | MC | 29.11.2017 | MK | 29.11.2017 | PT | 29.11.2017 | RO | 29.11.2017 | RS | 29.11.2017 | SI | 29.11.2017 | SK | 29.11.2017 | SM | 29.11.2017 | TR | 29.11.2017 | BG | 28.02.2018 | NO | 28.02.2018 | GR | 01.03.2018 | IS | 29.03.2018 | MT | 29.04.2018 | [2020/33] |
Former [2020/31] | HU | 29.04.2011 | |
CY | 29.11.2017 | ||
EE | 29.11.2017 | ||
FI | 29.11.2017 | ||
HR | 29.11.2017 | ||
LT | 29.11.2017 | ||
LV | 29.11.2017 | ||
MC | 29.11.2017 | ||
MK | 29.11.2017 | ||
PT | 29.11.2017 | ||
RO | 29.11.2017 | ||
RS | 29.11.2017 | ||
SI | 29.11.2017 | ||
SK | 29.11.2017 | ||
SM | 29.11.2017 | ||
TR | 29.11.2017 | ||
BG | 28.02.2018 | ||
NO | 28.02.2018 | ||
GR | 01.03.2018 | ||
MT | 29.04.2018 | ||
Former [2020/27] | HU | 29.04.2011 | |
CY | 29.11.2017 | ||
EE | 29.11.2017 | ||
FI | 29.11.2017 | ||
HR | 29.11.2017 | ||
LT | 29.11.2017 | ||
LV | 29.11.2017 | ||
MC | 29.11.2017 | ||
PT | 29.11.2017 | ||
RO | 29.11.2017 | ||
RS | 29.11.2017 | ||
SI | 29.11.2017 | ||
SK | 29.11.2017 | ||
SM | 29.11.2017 | ||
TR | 29.11.2017 | ||
BG | 28.02.2018 | ||
NO | 28.02.2018 | ||
GR | 01.03.2018 | ||
MT | 29.04.2018 | ||
Former [2020/16] | CY | 29.11.2017 | |
EE | 29.11.2017 | ||
FI | 29.11.2017 | ||
HR | 29.11.2017 | ||
LT | 29.11.2017 | ||
LV | 29.11.2017 | ||
MC | 29.11.2017 | ||
RO | 29.11.2017 | ||
RS | 29.11.2017 | ||
SI | 29.11.2017 | ||
SK | 29.11.2017 | ||
SM | 29.11.2017 | ||
TR | 29.11.2017 | ||
BG | 28.02.2018 | ||
NO | 28.02.2018 | ||
GR | 01.03.2018 | ||
MT | 29.04.2018 | ||
Former [2020/08] | CY | 29.11.2017 | |
EE | 29.11.2017 | ||
FI | 29.11.2017 | ||
HR | 29.11.2017 | ||
LT | 29.11.2017 | ||
LV | 29.11.2017 | ||
MC | 29.11.2017 | ||
RO | 29.11.2017 | ||
RS | 29.11.2017 | ||
SI | 29.11.2017 | ||
SK | 29.11.2017 | ||
SM | 29.11.2017 | ||
BG | 28.02.2018 | ||
NO | 28.02.2018 | ||
GR | 01.03.2018 | ||
MT | 29.04.2018 | ||
Former [2018/52] | CY | 29.11.2017 | |
EE | 29.11.2017 | ||
FI | 29.11.2017 | ||
HR | 29.11.2017 | ||
LT | 29.11.2017 | ||
LV | 29.11.2017 | ||
MC | 29.11.2017 | ||
RO | 29.11.2017 | ||
RS | 29.11.2017 | ||
SI | 29.11.2017 | ||
SK | 29.11.2017 | ||
SM | 29.11.2017 | ||
BG | 28.02.2018 | ||
NO | 28.02.2018 | ||
GR | 01.03.2018 | ||
Former [2018/40] | CY | 29.11.2017 | |
EE | 29.11.2017 | ||
FI | 29.11.2017 | ||
HR | 29.11.2017 | ||
LT | 29.11.2017 | ||
LV | 29.11.2017 | ||
RO | 29.11.2017 | ||
RS | 29.11.2017 | ||
SK | 29.11.2017 | ||
SM | 29.11.2017 | ||
BG | 28.02.2018 | ||
NO | 28.02.2018 | ||
GR | 01.03.2018 | ||
Former [2018/37] | CY | 29.11.2017 | |
EE | 29.11.2017 | ||
FI | 29.11.2017 | ||
HR | 29.11.2017 | ||
LT | 29.11.2017 | ||
LV | 29.11.2017 | ||
RS | 29.11.2017 | ||
SK | 29.11.2017 | ||
SM | 29.11.2017 | ||
BG | 28.02.2018 | ||
NO | 28.02.2018 | ||
GR | 01.03.2018 | ||
Former [2018/25] | FI | 29.11.2017 | |
HR | 29.11.2017 | ||
LT | 29.11.2017 | ||
LV | 29.11.2017 | ||
RS | 29.11.2017 | ||
BG | 28.02.2018 | ||
NO | 28.02.2018 | ||
GR | 01.03.2018 | ||
Former [2018/22] | FI | 29.11.2017 | |
LT | 29.11.2017 | ||
NO | 28.02.2018 | Cited in | International search | [XYI] - BARON UDO ET AL, "DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3(+) conventional T cells.", EUROPEAN JOURNAL OF IMMUNOLOGY, (200709), vol. 37, no. 9, ISSN 0014-2980, pages 2378 - 2389, XP002639439 [X] 1-7,12-17 * the whole document * [Y] 18 [I] 8-11,19-22 | [XI] - Baron U. et. al., "Suporting information: DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3+ conventional T cells", European Journal of Immunology, URL: http://www.wiley-vch.de/contents/jc_2040/2007/37594_s.pdf, (200709), XP002644060 [X] 1-7,12-17 * the whole document * [I] 8-11,19-22 | [IAY] - KOENEN HANS J P M ET AL, "Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells.", BLOOD, (20080915), vol. 112, no. 6, ISSN 1528-0020, pages 2340 - 2352, XP002639440 [I] 18 * the whole document * [A] 1-17,19-23 [Y] 18 DOI: http://dx.doi.org/101.1182/BLOOD-2008-01-133967 | [IA] - MIZUKAMI TAKUO ET AL, "Five azacytidine, a DNA methyltransferase inhibitor, specifically inhibits testicular cord formation and Sertoli cell differentiation in vitro.", MOLECULAR REPRODUCTION AND DEVELOPMENT, (200806), vol. 75, no. 6, ISSN 1098-2795, pages 1002 - 1010, XP002639441 [I] 19,20 * the whole document * [A] 1-18,21-23 DOI: http://dx.doi.org/10.1002/MRD.20850 | [A] - KLEINEWIETFELD MARKUS ET AL, "CCR6 expression defines regulatory effector/memory-like cells within the CD25(+)CD4+ T-cell subset.", BLOOD, (20050401), vol. 105, no. 7, ISSN 0006-4971, pages 2877 - 2886, XP002639442 [A] 1-23 * the whole document * DOI: http://dx.doi.org/10.1182/BLOOD-2004-07-2505 | [A] - HENNEKEN MAREN ET AL, "Differential expression of chemokine receptors on peripheral blood B cells from patients with rheumatoid arthritis and systemic lupus erythematosus.", ARTHRITIS RESEARCH & THERAPY, (2005), vol. 7, no. 5, ISSN 1478-6362, pages R1001 - R1013, XP002639443 [A] 1-23 * the whole document * DOI: http://dx.doi.org/10.1186/AR1776 | [A] - WIECZOREK GEORG ET AL, "Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue.", CANCER RESEARCH, (20090115), vol. 69, no. 2, ISSN 1538-7445, pages 599 - 608, XP002639444 [A] 1-23 * the whole document * | [A] - HOFFMANN PETRA ET AL, "Loss of FOXP3 expression in natural human CD4+CD25+ regulatory T cells upon repetitive in vitro stimulation.", EUROPEAN JOURNAL OF IMMUNOLOGY, (200904), vol. 39, no. 4, ISSN 1521-4141, pages 1088 - 1097, XP002639445 [A] 1-23 * the whole document * | [A] - POLANSKY JULIA K ET AL, "DNA methylation controls Foxp3 gene expression.", EUROPEAN JOURNAL OF IMMUNOLOGY, (200806), vol. 38, no. 6, ISSN 0014-2980, pages 1654 - 1663, XP002639446 [A] 1-23 * the whole document * DOI: http://dx.doi.org/10.1002/EJI.200838105 | by applicant | WO9928468 | US6110695 | WO03014153 | - KAISER E, FORSTER R, WOLF I, EBENSPERGER C, KUEHL WM, LIPP M., "The G protein-coupled receptor BLR1 is involved in murine B cell differentiation and is also expressed in neuronal tissues", EUR J IMMUNOL., (199310), vol. 23, no. 10, doi:doi:10.1002/eji.1830231023, pages 2532 - 9, XP002097372 DOI: http://dx.doi.org/10.1002/eji.1830231023 | - FORSTER R, WOLF I, KAISER E, LIPP M., "Selective expression of the murine homologue of the G-protein-coupled receptor BLR1 in B cell differentiation, B cell neoplasia and defined areas of the cerebellum", CELL MOL BIOL, (199405), vol. 40, no. 3, pages 381 - 7, XP008137125 | - BERAHOVICH RD, LAI NL, WEI Z, LANIER LL, SCHALL TJ., "Evidence for NK cell subsets based on chemokine receptor expression", J IMMUNOL., (2006), vol. 177, pages 7833 - 7840 | - DIEU MC, VANBERVLIET B, VICARI A ET AL., "Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites", J EXP MED., (1998), vol. 188, pages 373 - 386 | - HIROTA K, YOSHITOMI H, HASHIMOTO M ET AL., "Preferential recruitment of CCR6- expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model", J EXP MED., (2007), vol. 204, pages 2803 - 2812 | - HIROTA K, YOSHITOMI H, HASHIMOTO M ET AL., "Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model", J EXP MED., (2007), vol. 204, pages 2803 - 2812 | - RUTH JH, SHAHRARA S, PARK CC ET AL., "Role of macrophage inflammatory protein-3alpha and its ligand CCR6 in rheumatoid arthritis", LAB INVEST., (2003), vol. 83, doi:doi:10.1097/01.LAB.0000062854.30195.52, pages 579 - 588, XP055178014 DOI: http://dx.doi.org/10.1097/01.LAB.0000062854.30195.52 | - HOMEY B, DIEU-NOSJEAN MC, WIESENBORN A ET AL., "Up-regulation of macrophage inflammatory protein-3 alpha/CCL20 and CC chemokine receptor 6 in psoriasis", J IMMUNOL., (2000), vol. 164, pages 6621 - 6632, XP002241101 | - HEDRICK MN, LONSDORF AS, SHIRAKAWA AK ET AL., "CCR6 is required for IL-23-induced psoriasis-like inflammation in mice", J CLIN INVEST., (2009), vol. 119, doi:doi:10.1172/JCI37378, pages 2317 - 2329, XP055034265 DOI: http://dx.doi.org/10.1172/JCI37378 | - KASER A, LUDWICZEK 0, HOLZMANN S ET AL., "Increased expression of CCL20 in human inflammatory bowel disease", J CLIN IMMUNOL., (2004), vol. 24, pages 74 - 85 | - REBOLDI A, COISNE C, BAUMJOHANN D ET AL., "C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE", NAT IMMUNOL., (2009), vol. 10, pages 514 - 523 | - VARONA R, CADENAS V, FLORES J, MARTINEZ AC, MARQUEZ G., "CCR6 has a non-redundant role in the development of inflammatory bowel disease", EUR J IMMUNOL., (2003), vol. 33, doi:doi:10.1002/eji.200324347, pages 2937 - 2946, XP008048156 DOI: http://dx.doi.org/10.1002/eji.200324347 | - MATSUI T, AKAHOSHI T, NAMAI R ET AL., "Selective recruitment of CCR6-expressing cells by increased production of MIP-3 alpha in rheumatoid arthritis", CLIN EXP IMMUNOL., (2001), vol. 125, doi:doi:10.1046/j.1365-2249.2001.01542.x, pages 155 - 161, XP002965711 DOI: http://dx.doi.org/10.1046/j.1365-2249.2001.01542.x | - BUTCHER EC, PICKER LJ., "Lymphocyte homing and homeostasis", SCIENCE, (1996), vol. 272, pages 60 - 66 | - ACOSTA-RODRIGUEZ EV, RIVINO L, GEGINAT J ET AL., "Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells", NAT IMMUNOL., (2007), vol. 8, doi:doi:10.1038/ni1467, pages 639 - 646, XP002496162 DOI: http://dx.doi.org/10.1038/ni1467 | - ANSEL KM, LEE DU, RAO A, "An epigenetic view of helper T cell differentiation", NAT IMMUNOL., (2003), vol. 4, doi:doi:10.1038/ni0703-616, pages 616 - 623, XP055004912 DOI: http://dx.doi.org/10.1038/ni0703-616 | - ZHU J, PAUL WE., "CD4 T cells: fates, functions, and faults", BLOOD, (2008), vol. 112, pages 1557 - 1569 | - WILSON CB, ROWELL E, SEKIMATA M, "Epigenetic control of T-helper-cell differentiation", NAT REV IMMUNOL., (2009), vol. 9, doi:doi:10.1038/nri2487, pages 91 - 105, XP055004880 DOI: http://dx.doi.org/10.1038/nri2487 | - FLOESS S, FREYER J, SIEWERT C ET AL., "Epigenetic control of the foxp3 locus in regulatory T cells", PLOS BIOL., (2007), vol. 5, page E38 | - HUEHN J, POLANSKY JK, HAMANN A., "Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?", NAT REV IMMUNOL., (2009), vol. 9, doi:doi:10.1038/nri2474, pages 83 - 89, XP055325587 | - BARON U, FLOESS S, WIECZOREK G ET AL., "DNA demethylation in the human FOXP3 locus discriminates regulatory T cells from activated FOXP3+ conventional T cells", EUR J IMMUNOL., (2007), vol. 37, pages 2378 - 2389 | - SCOTET E, SCHROEDER S, LANZAVECCHIA A., "Molecular regulation of CC-chemokine receptor 3 expression in human T helper 2 cells", BLOOD, (2001), vol. 98, pages 2568 - 2570 | - SYRBE U, JENNRICH S, SCHOTTELIUS A, RICHTER A, RADBRUCH A, HAMANN A., "Differential regulation of P-selectin ligand expression in naive versus memory T cells: evidence for epigenetic regulation of involved glycosyltransferase genes", BLOOD, (2004), vol. 104, pages 3243 - 3248 | - SATO N, MATSUBAYASHI H, FUKUSHIMA N, GOGGINS M., "The chemokine receptor CXCR4 is regulated by DNA methylation in pancreatic cancer", CANCER BIOL THER., (2005), vol. 4, pages 70 - 76 | - MORI T, KIM J, YAMANO T ET AL., "Epigenetic up-regulation of C-C chemokine receptor 7 and C-X-C chemokine receptor 4 expression in melanoma cells", CANCER RES., (2005), vol. 65, pages 1800 - 1807 | - BABA, M., IMAI, T., NISHIMURA, M., KAKIZAKI, M., TAKAGI, S., HIESHIMA, K., NOMIYAMA, H., YOSHIE, O., "Identification of CCR6, the specific receptor for a novel lymphocyte-directed CC chemokine LARC", J. BIOL. CHEM., (1997), vol. 272, no. 23, doi:doi:10.1074/jbc.272.23.14893, pages 14893 - 14898, XP002055488 DOI: http://dx.doi.org/10.1074/jbc.272.23.14893 | - RUBIE, C., OLIVEIRA, V., KEMPF, K., WAGNER, M., TILTON, B., RAU, B., KRUSE, B., KONIG, J., SCHILLING, M., INVOLVEMENT OF CHEMOKINE RECEPTOR CCR6 IN COLORECTAL CANCER METASTASIS TUMOUR BIOL., (2006), vol. 27, no. 3, pages 166 - 174 | - ANTEQUERA, BIRD, PROC NATL ACAD SCI U S A., (1993), vol. 90, pages 11995 - 9 | - JONES, LAIRD, NATURE GENETICS, (1999), vol. 21, pages 163 - 167 | - ESTELLER, ONCOGENE, (2002), vol. 21, pages 5427 - 5440 | - LAIRD, NATURE REVIEWS/CANCER, (2003), vol. 3, pages 253 - 266 | - J CELLULAR CHEM, (2003), vol. 88, pages 899 - 910 | - BIRD, GENES AND DEV, (2002), vol. 16, pages 6 - 21 | - LI, NATURE REVIEWS/GENETICS, (2002), vol. 3, pages 662 - 673 | - ERLICH, J CELLULAR CHEM, (2003), vol. 88, pages 899 - 910 | - ANSEL ET AL., NATURE IMMUNOL, (2003), vol. 4, pages 616 - 623 | - ATTWOOD ET AL., CMLS, (2002), vol. 59, pages 241 - 257 | - LEE ET AL., IMMUNITY, (2002), vol. 16, pages 649 - 660 | - BRUNIQUEL, SCHWARTZ, NAT IMMUNOL., (2003), vol. 4, pages 235 - 40 | - KUCHARZIK T, HUDSON JT, 3RD, WAIKEL RL, MARTIN WD, WILLIAMS IR., "CCR6 expression distinguishes mouse myeloid and lymphoid dendritic cell subsets: demonstration using a CCR6 EGFP knock-in mouse", EUR J IMMUNOL., (2002), vol. 32, pages 104 - 112 | - MANEL N, UNUTMAZ D, LITTMAN DR., "The differentiation of human T(H)-17 cells requires transforming growth factor- beta and induction of the nuclear receptor ROR-gamma-t", NAT IMMUNOL., (2008), vol. 9, pages 641 - 649 | - BHARAT A, FIELDS RC, MOHANAKUMAR T., REGULATORY T CELL-MEDIATED TRANSPLANTATION TOLERANCE. IMMUNOL RES. 2006, vol. 33, no. 3, pages 195 - 212 | - KHAZAIE K, VON BOEHMER H., "The impact of CD4(+)CD25(+) Treg on tumor specific CD8(+) T cell cytotoxicity and cancer", SEMIN CANCER BIOL., (20060126), vol. 16, no. 2, doi:doi:10.1016/j.semcancer.2005.11.006, pages 124 - 136, XP024908074 DOI: http://dx.doi.org/10.1016/j.semcancer.2005.11.006 | - LIAO F, RABIN RL, SMITH CS, SHARMA G, NUTMAN TB, FARBER JM., "CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3 alpha", J IMMUNOL., (1999), vol. 162, pages 186 - 194 | - SATO K, KAWASAKI H, NAGAYAMA H ET AL., "Chemokine receptor expressions and responsiveness of cord blood T cells", J IMMUNOL., (2001), vol. 166, pages 1659 - 1666 | - POLANSKY JK, KRETSCHMER K, FREYER J ET AL., "DNA methylation controls Foxp3 gene expression", EUR J IMMUNOL., (2008), vol. 38, doi:doi:10.1002/EJI.200838105, pages 1654 - 1663, XP002639446 DOI: http://dx.doi.org/10.1002/EJI.200838105 | - OLEK A, OSWALD J, WALTER J., "A modified and improved method for bisulphite based cytosine methylation analysis", NUCLEIC ACIDS RES., (1996), vol. 24, doi:doi:10.1093/nar/24.24.5064, pages 5064 - 5066, XP002106408 DOI: http://dx.doi.org/10.1093/nar/24.24.5064 | - LEWIN J, SCHMITT AO, ADORJAN P, HILDMANN T, PIEPENBROCK C., "Quantitative DNA methylation analysis based on four-dye trace data from direct sequencing of PCR amplificates", BIOINFORMATICS, (2004), vol. 20, doi:doi:10.1093/bioinformatics/bth346, pages 3005 - 3012, XP002467526 DOI: http://dx.doi.org/10.1093/bioinformatics/bth346 | - KLEINEWIETFELD M, PUENTES F, BORSELLINO G, BATTISTINI L, ROTZSCHKE 0, FALK K., "CCR6 expression defines regulatory effector/memory-like cells within the CD25+CD4+ T-cell subset", BLOOD, (2005), vol. 105, doi:doi:10.1182/BLOOD-2004-07-2505, pages 2877 - 2886, XP002639442 DOI: http://dx.doi.org/10.1182/BLOOD-2004-07-2505 | - GEGINAT J, SALLUSTO F, LANZAVECCHIA A., "Cytokine-driven proliferation and differentiation of human naive, central memory, and effector memory CD4(+) T cells", J EXP MED., (2001), vol. 194, pages 1711 - 1719 | - SALLUSTO F, KREMMER E, PALERMO B ET AL., "Switch in chemokine receptor expression upon TCR stimulation reveals novel homing potential for recently activated T cells", EUR J IMMUNOL., (1999), vol. 29, doi:doi:10.1002/(SICI)1521-4141(199906)29:06<2037::AID-IMMU2037>3.3.CO;2-M, pages 2037 - 2045, XP001008570 DOI: http://dx.doi.org/10.1002/(SICI)1521-4141(199906)29:06<2037::AID-IMMU2037>3.3.CO;2-M | - MAIER H, COLBERT J, FITZSIMMONS D, CLARK DR, HAGMAN J., "Activation of the early B-cell-specific mb-1 (Ig-alpha) gene by Pax-5 is dependent on an unmethylated Ets binding site", MOL CELL BIOL., (2003), vol. 23, pages 1946 - 1960 |