EP2558490 - METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF CANCER RESISTANT TO ANAPLASTIC LYMPHOMA KINASE (ALK) KINASE INHIBITORS [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 20.10.2017 Database last updated on 03.09.2024 | |
Former | The patent has been granted Status updated on 11.11.2016 | ||
Former | Grant of patent is intended Status updated on 02.11.2016 | Most recent event Tooltip | 10.07.2020 | Lapse of the patent in a contracting state New state(s): AL | published on 12.08.2020 [2020/33] | Applicant(s) | For all designated states St. Jude Children's Research Hospital 262 Danny Thomas Place Memphis, TN 38105-2794 / US | [2013/08] | Inventor(s) | 01 /
MORRIS, Stephan, W. 2532 Windy Oaks Drive Germantown TN 38139 / US | 02 /
JIANG, Qin 6748 Bent Tree Avenue Memphis TN 38134 / US | 03 /
CUI, Xiaoli 5304 Bears Paw Circle Memphis TN 38120 / US | 04 /
XUE, Liquan 8302 Garden Willow Lane Cordova TN 38016 / US | [2013/08] | Representative(s) | J A Kemp LLP 80 Turnmill Street London EC1M 5QU / GB | [N/P] |
Former [2013/08] | Wright, Simon Mark J A Kemp 14 South Square Gray's Inn London WC1R 5JJ / GB | Application number, filing date | 11721840.4 | 13.04.2011 | [2016/50] | WO2011US32204 | Priority number, date | US20100761050 | 15.04.2010 Original published format: US 761050 | [2013/08] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2011130340 | Date: | 20.10.2011 | Language: | EN | [2011/42] | Type: | A1 Application with search report | No.: | EP2558490 | Date: | 20.02.2013 | Language: | EN | The application published by WIPO in one of the EPO official languages on 20.10.2011 takes the place of the publication of the European patent application. | [2013/08] | Type: | B1 Patent specification | No.: | EP2558490 | Date: | 14.12.2016 | Language: | EN | [2016/50] | Search report(s) | International search report - published on: | EP | 20.10.2011 | Classification | IPC: | C07K14/71, G01N33/53, A01K67/027, C07K16/30, C12N1/15, C12N1/21, C12N5/10, C12Q1/48, C12Q1/68, G01N33/574 | [2016/22] | CPC: |
C12Q1/6886 (EP,KR,US);
C12N9/12 (KR,US);
A61P35/00 (EP);
A61P43/00 (EP);
C07K14/71 (EP,KR,US);
C12Q1/485 (EP,KR,US);
|
Former IPC [2013/08] | C07K14/71, G01N33/53, A01K67/027, C07K16/30, C12N1/15, C12N1/21, C12N5/10 | Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2013/08] | Extension states | BA | Not yet paid | ME | Not yet paid | Title | German: | VERFAHREN UND ZUSAMMENSETZUNGEN FÜR DIE DIAGNOSE UND BEHANDLUNG VON GEGENÜBER ALK-KINASEHEMMERN RESISTENTEM KREBS | [2013/08] | English: | METHODS AND COMPOSITIONS FOR THE DIAGNOSIS AND TREATMENT OF CANCER RESISTANT TO ANAPLASTIC LYMPHOMA KINASE (ALK) KINASE INHIBITORS | [2013/08] | French: | PROCÉDÉS ET COMPOSITIONS DESTINÉS AU DIAGNOSTIC ET AU TRAITEMENT D'UN CANCER RÉSISTANT AUX INHIBITEURS DE LA KINASE DU LYMPHOME ANAPLASIQUE (ALK) | [2013/08] | Entry into regional phase | 01.11.2012 | National basic fee paid | 01.11.2012 | Designation fee(s) paid | 01.11.2012 | Examination fee paid | Examination procedure | 01.11.2012 | Examination requested [2013/08] | 03.06.2013 | Amendment by applicant (claims and/or description) | 11.11.2013 | Despatch of a communication from the examining division (Time limit: M06) | 17.06.2014 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time | 27.08.2014 | Reply to a communication from the examining division | 27.11.2014 | Despatch of a communication from the examining division (Time limit: M06) | 26.05.2015 | Reply to a communication from the examining division | 10.09.2015 | Despatch of a communication from the examining division (Time limit: M04) | 20.01.2016 | Reply to a communication from the examining division | 06.06.2016 | Communication of intention to grant the patent | 17.10.2016 | Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO | 17.10.2016 | Fee for grant paid | 17.10.2016 | Fee for publishing/printing paid | 02.11.2016 | Information about intention to grant a patent | 02.11.2016 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 11.11.2013 | Opposition(s) | 15.09.2017 | No opposition filed within time limit [2017/47] | Request for further processing for: | The application is deemed to be withdrawn due to failure to reply to the examination report | 27.08.2014 | Request for further processing filed | 27.08.2014 | Full payment received (date of receipt of payment) Request granted | 08.09.2014 | Decision despatched | Fees paid | Renewal fee | 08.04.2013 | Renewal fee patent year 03 | 28.04.2014 | Renewal fee patent year 04 | 27.04.2015 | Renewal fee patent year 05 | 27.04.2016 | Renewal fee patent year 06 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 13.04.2011 | AL | 14.12.2016 | AT | 14.12.2016 | BE | 14.12.2016 | CY | 14.12.2016 | CZ | 14.12.2016 | DK | 14.12.2016 | EE | 14.12.2016 | ES | 14.12.2016 | FI | 14.12.2016 | HR | 14.12.2016 | IT | 14.12.2016 | LT | 14.12.2016 | LV | 14.12.2016 | MC | 14.12.2016 | MK | 14.12.2016 | NL | 14.12.2016 | PL | 14.12.2016 | RO | 14.12.2016 | RS | 14.12.2016 | SE | 14.12.2016 | SI | 14.12.2016 | SK | 14.12.2016 | SM | 14.12.2016 | TR | 14.12.2016 | BG | 14.03.2017 | NO | 14.03.2017 | GR | 15.03.2017 | IE | 13.04.2017 | LU | 13.04.2017 | MT | 13.04.2017 | IS | 14.04.2017 | PT | 14.04.2017 | CH | 30.04.2017 | LI | 30.04.2017 | [2020/33] |
Former [2020/15] | HU | 13.04.2011 | |
AT | 14.12.2016 | ||
BE | 14.12.2016 | ||
CY | 14.12.2016 | ||
CZ | 14.12.2016 | ||
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EE | 14.12.2016 | ||
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FI | 14.12.2016 | ||
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IT | 14.12.2016 | ||
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SM | 14.12.2016 | ||
TR | 14.12.2016 | ||
BG | 14.03.2017 | ||
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GR | 15.03.2017 | ||
IE | 13.04.2017 | ||
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MT | 13.04.2017 | ||
IS | 14.04.2017 | ||
PT | 14.04.2017 | ||
CH | 30.04.2017 | ||
LI | 30.04.2017 | ||
Former [2019/51] | HU | 13.04.2011 | |
AT | 14.12.2016 | ||
BE | 14.12.2016 | ||
CY | 14.12.2016 | ||
CZ | 14.12.2016 | ||
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EE | 14.12.2016 | ||
ES | 14.12.2016 | ||
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MK | 14.12.2016 | ||
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RS | 14.12.2016 | ||
SE | 14.12.2016 | ||
SI | 14.12.2016 | ||
SK | 14.12.2016 | ||
SM | 14.12.2016 | ||
BG | 14.03.2017 | ||
NO | 14.03.2017 | ||
GR | 15.03.2017 | ||
IE | 13.04.2017 | ||
LU | 13.04.2017 | ||
MT | 13.04.2017 | ||
IS | 14.04.2017 | ||
PT | 14.04.2017 | ||
CH | 30.04.2017 | ||
LI | 30.04.2017 | ||
Former [2019/46] | HU | 13.04.2011 | |
AT | 14.12.2016 | ||
BE | 14.12.2016 | ||
CY | 14.12.2016 | ||
CZ | 14.12.2016 | ||
DK | 14.12.2016 | ||
EE | 14.12.2016 | ||
ES | 14.12.2016 | ||
FI | 14.12.2016 | ||
HR | 14.12.2016 | ||
IT | 14.12.2016 | ||
LT | 14.12.2016 | ||
LV | 14.12.2016 | ||
MC | 14.12.2016 | ||
NL | 14.12.2016 | ||
PL | 14.12.2016 | ||
RO | 14.12.2016 | ||
RS | 14.12.2016 | ||
SE | 14.12.2016 | ||
SI | 14.12.2016 | ||
SK | 14.12.2016 | ||
SM | 14.12.2016 | ||
BG | 14.03.2017 | ||
NO | 14.03.2017 | ||
GR | 15.03.2017 | ||
IE | 13.04.2017 | ||
LU | 13.04.2017 | ||
MT | 13.04.2017 | ||
IS | 14.04.2017 | ||
PT | 14.04.2017 | ||
CH | 30.04.2017 | ||
LI | 30.04.2017 | ||
Former [2019/31] | HU | 13.04.2011 | |
AT | 14.12.2016 | ||
BE | 14.12.2016 | ||
CZ | 14.12.2016 | ||
DK | 14.12.2016 | ||
EE | 14.12.2016 | ||
ES | 14.12.2016 | ||
FI | 14.12.2016 | ||
HR | 14.12.2016 | ||
IT | 14.12.2016 | ||
LT | 14.12.2016 | ||
LV | 14.12.2016 | ||
MC | 14.12.2016 | ||
NL | 14.12.2016 | ||
PL | 14.12.2016 | ||
RO | 14.12.2016 | ||
RS | 14.12.2016 | ||
SE | 14.12.2016 | ||
SI | 14.12.2016 | ||
SK | 14.12.2016 | ||
SM | 14.12.2016 | ||
BG | 14.03.2017 | ||
NO | 14.03.2017 | ||
GR | 15.03.2017 | ||
IE | 13.04.2017 | ||
LU | 13.04.2017 | ||
MT | 13.04.2017 | ||
IS | 14.04.2017 | ||
PT | 14.04.2017 | ||
CH | 30.04.2017 | ||
LI | 30.04.2017 | ||
Former [2018/43] | AT | 14.12.2016 | |
BE | 14.12.2016 | ||
CZ | 14.12.2016 | ||
DK | 14.12.2016 | ||
EE | 14.12.2016 | ||
ES | 14.12.2016 | ||
FI | 14.12.2016 | ||
HR | 14.12.2016 | ||
IT | 14.12.2016 | ||
LT | 14.12.2016 | ||
LV | 14.12.2016 | ||
MC | 14.12.2016 | ||
NL | 14.12.2016 | ||
PL | 14.12.2016 | ||
RO | 14.12.2016 | ||
RS | 14.12.2016 | ||
SE | 14.12.2016 | ||
SI | 14.12.2016 | ||
SK | 14.12.2016 | ||
SM | 14.12.2016 | ||
BG | 14.03.2017 | ||
NO | 14.03.2017 | ||
GR | 15.03.2017 | ||
IE | 13.04.2017 | ||
LU | 13.04.2017 | ||
MT | 13.04.2017 | ||
IS | 14.04.2017 | ||
PT | 14.04.2017 | ||
CH | 30.04.2017 | ||
LI | 30.04.2017 | ||
Former [2018/23] | AT | 14.12.2016 | |
BE | 14.12.2016 | ||
CZ | 14.12.2016 | ||
DK | 14.12.2016 | ||
EE | 14.12.2016 | ||
ES | 14.12.2016 | ||
FI | 14.12.2016 | ||
HR | 14.12.2016 | ||
IT | 14.12.2016 | ||
LT | 14.12.2016 | ||
LV | 14.12.2016 | ||
MC | 14.12.2016 | ||
NL | 14.12.2016 | ||
PL | 14.12.2016 | ||
RO | 14.12.2016 | ||
RS | 14.12.2016 | ||
SE | 14.12.2016 | ||
SI | 14.12.2016 | ||
SK | 14.12.2016 | ||
SM | 14.12.2016 | ||
BG | 14.03.2017 | ||
NO | 14.03.2017 | ||
GR | 15.03.2017 | ||
IE | 13.04.2017 | ||
LU | 13.04.2017 | ||
IS | 14.04.2017 | ||
PT | 14.04.2017 | ||
CH | 30.04.2017 | ||
LI | 30.04.2017 | ||
Former [2018/13] | AT | 14.12.2016 | |
BE | 14.12.2016 | ||
CZ | 14.12.2016 | ||
DK | 14.12.2016 | ||
EE | 14.12.2016 | ||
ES | 14.12.2016 | ||
FI | 14.12.2016 | ||
HR | 14.12.2016 | ||
IT | 14.12.2016 | ||
LT | 14.12.2016 | ||
LV | 14.12.2016 | ||
MC | 14.12.2016 | ||
NL | 14.12.2016 | ||
PL | 14.12.2016 | ||
RO | 14.12.2016 | ||
RS | 14.12.2016 | ||
SE | 14.12.2016 | ||
SI | 14.12.2016 | ||
SK | 14.12.2016 | ||
SM | 14.12.2016 | ||
BG | 14.03.2017 | ||
NO | 14.03.2017 | ||
GR | 15.03.2017 | ||
LU | 13.04.2017 | ||
IS | 14.04.2017 | ||
PT | 14.04.2017 | ||
CH | 30.04.2017 | ||
LI | 30.04.2017 | ||
Former [2018/06] | AT | 14.12.2016 | |
BE | 14.12.2016 | ||
CZ | 14.12.2016 | ||
DK | 14.12.2016 | ||
EE | 14.12.2016 | ||
ES | 14.12.2016 | ||
FI | 14.12.2016 | ||
HR | 14.12.2016 | ||
IT | 14.12.2016 | ||
LT | 14.12.2016 | ||
LV | 14.12.2016 | ||
MC | 14.12.2016 | ||
NL | 14.12.2016 | ||
PL | 14.12.2016 | ||
RO | 14.12.2016 | ||
RS | 14.12.2016 | ||
SE | 14.12.2016 | ||
SK | 14.12.2016 | ||
SM | 14.12.2016 | ||
BG | 14.03.2017 | ||
NO | 14.03.2017 | ||
GR | 15.03.2017 | ||
IS | 14.04.2017 | ||
PT | 14.04.2017 | ||
Former [2018/01] | AT | 14.12.2016 | |
BE | 14.12.2016 | ||
CZ | 14.12.2016 | ||
DK | 14.12.2016 | ||
EE | 14.12.2016 | ||
ES | 14.12.2016 | ||
FI | 14.12.2016 | ||
HR | 14.12.2016 | ||
IT | 14.12.2016 | ||
LT | 14.12.2016 | ||
LV | 14.12.2016 | ||
NL | 14.12.2016 | ||
PL | 14.12.2016 | ||
RO | 14.12.2016 | ||
RS | 14.12.2016 | ||
SE | 14.12.2016 | ||
SK | 14.12.2016 | ||
SM | 14.12.2016 | ||
BG | 14.03.2017 | ||
NO | 14.03.2017 | ||
GR | 15.03.2017 | ||
IS | 14.04.2017 | ||
PT | 14.04.2017 | ||
Former [2017/41] | AT | 14.12.2016 | |
BE | 14.12.2016 | ||
CZ | 14.12.2016 | ||
EE | 14.12.2016 | ||
ES | 14.12.2016 | ||
FI | 14.12.2016 | ||
HR | 14.12.2016 | ||
IT | 14.12.2016 | ||
LT | 14.12.2016 | ||
LV | 14.12.2016 | ||
NL | 14.12.2016 | ||
PL | 14.12.2016 | ||
RO | 14.12.2016 | ||
RS | 14.12.2016 | ||
SE | 14.12.2016 | ||
SK | 14.12.2016 | ||
SM | 14.12.2016 | ||
BG | 14.03.2017 | ||
NO | 14.03.2017 | ||
GR | 15.03.2017 | ||
IS | 14.04.2017 | ||
PT | 14.04.2017 | ||
Former [2017/35] | CZ | 14.12.2016 | |
EE | 14.12.2016 | ||
FI | 14.12.2016 | ||
HR | 14.12.2016 | ||
LT | 14.12.2016 | ||
LV | 14.12.2016 | ||
NL | 14.12.2016 | ||
RO | 14.12.2016 | ||
RS | 14.12.2016 | ||
SE | 14.12.2016 | ||
NO | 14.03.2017 | ||
GR | 15.03.2017 | ||
Former [2017/31] | FI | 14.12.2016 | |
HR | 14.12.2016 | ||
LT | 14.12.2016 | ||
LV | 14.12.2016 | ||
NL | 14.12.2016 | ||
RS | 14.12.2016 | ||
SE | 14.12.2016 | ||
NO | 14.03.2017 | ||
GR | 15.03.2017 | ||
Former [2017/28] | FI | 14.12.2016 | |
HR | 14.12.2016 | ||
LT | 14.12.2016 | ||
LV | 14.12.2016 | ||
RS | 14.12.2016 | ||
SE | 14.12.2016 | ||
NO | 14.03.2017 | ||
GR | 15.03.2017 | ||
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SASAKI ET AL, "The Neuroblastoma-Associated F1174L ALK Mutation Causes Resistance to an ALK Kinase Inhibitor in ALK-Translocated Cancers", CANCER RESEARCH, (20101215), vol. 70, no. 24, doi:10.1158/0008-5472.CAN-10-2956, ISSN 0008-5472, pages 10038 - 10043, XP055004136 [XP] 1-23 * the whole document * [I] 24-38,53-65 DOI: http://dx.doi.org/10.1158/0008-5472.CAN-10-2956 | [IP] - YOUNG LIM CHOI ET AL, "EML4-ALK Mutations in Lung Cancer That Confer Resistance to ALK Inhibitors", NEW ENGLAND JOURNAL OF MEDICINE, (20101028), vol. 363, no. 18, doi:10.1056/NEJMoa1007478, ISSN 0028-4793, pages 1734 - 1739, XP055004205 [IP] 1-65 * Whole document, especially figure 2 * DOI: http://dx.doi.org/10.1056/NEJMoa1007478 | by applicant | EP0075444 | US4522811 | US4683195 | US4683202 | US4736866 | US4800159 | US4816567 | US4870009 | US4873192 | US4873191 | US4946778 | WO9011354 | US4965188 | WO9101140 | WO9200968 | US5107065 | WO9304169 | US5223409 | US5225539 | US5225326 | US5260203 | US5270184 | US5283317 | WO9410300 | US5403484 | US5455030 | US5455166 | US5475610 | US5514548 | US5538871 | US5545403 | US5545405 | US5545524 | US5571698 | US5585089 | US5602756 | US5605793 | WO9707668 | WO9707669 | US5612473 | US5693761 | US5693762 | US5710029 | US5750105 | US5756096 | US5800992 | US5814447 | US5837458 | US5856456 | US5859205 | US5877397 | US5925517 | US5928862 | US5939598 | US5998144 | US6004552 | US6020135 | US6033860 | US6040138 | US6075181 | US6091001 | US6114598 | US6121489 | US6150097 | US6180370 | US6303305 | US6344316 | US6453242 | US6534274 | US6541205 | US6573043 | US2005042638 | US2005214851 | US2008051419 | US2008090776 | US2008171769 | US2009099193 | - MORRIS ET AL., SCIENCE, (1994), vol. 263, pages 1281 - 1284 | - MORRIS ET AL., ONCOGENE, (1997), vol. 14, pages 2175 - 2188 | - WEBB ET AL., EXPERT REV ANTICANCER THER, (2009), vol. 9, pages 331 - 356 | - GEORGE ET AL., NATURE, (2008), vol. 455, pages 975 - 979 | - O'HARE ET AL., BLOOD, (2007), vol. 110, pages 2242 - 2249 | - ENGELMAN, SETTLEMAN, CURR OPIN GENET DEV, (2008), vol. 18, pages 1 - 7 | - BIKKER ET AL., J MED CHEM, (2009), vol. 52, pages 1493 - 1509 | - BIKKER ET AL., JMED CHEM, (2009), vol. 52, pages 1493 - 1509 | - LAGISETTI ET AL., JMED CHEM, (2009), vol. 52, pages 6979 - 6990 | - SHIOTA ET AL., ONCOGENE, (1994), vol. 9, pages 1567 - 1574 | - MATHEW ET AL., CYTOGENET. 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