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Extract from the Register of European Patents

EP About this file: EP2531597

EP2531597 - ENGINEERED ENZYMES WITH METHIONINE-GAMMA-LYASE ENZYMES AND PHARMACOLOGICAL PREPARATIONS THEROF [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  12.11.2021
Database last updated on 05.10.2024
FormerThe patent has been granted
Status updated on  04.12.2020
FormerGrant of patent is intended
Status updated on  30.07.2020
FormerExamination is in progress
Status updated on  03.02.2020
Most recent event   Tooltip06.09.2024Lapse of the patent in a contracting state
New state(s): MT		published on 09.10.2024 [2024/41]
Applicant(s)For all designated states
AEMase, Inc.
815-A Brazos Street, No. 101
Austin, TX 78701 / US
[2021/01]
Former [2014/07]For all designated states
AEMase, Inc.
815-A Brazos Street, No. 101
Austin, TX 78701 / US
Former [2013/27]For all designated states
GMA Technologies LLC
6405 Williams Ridge Way
Austin, TX 78731 / US
Former [2012/51]For all designated states
Georgiou, George
6405 Williams Ridge Way
Austin, TX 78731 / US
Former [2012/50]For all designated states
The Board of Regents of The University of Texas System
201 West 7th Street
Austin, TX 78701 / US
Inventor(s)01 / GEORGIOU, George
6405 Williams Riddge Way
Austin, TX 78731 / US
02 / STONE, Everett
7004 Deborah Dr.
Austin, TX 78752-3132 / US
 [2012/50]
Representative(s)Miller Sturt Kenyon
9 John Street
London WC1N 2ES / GB
[2021/01]
Former [2012/50]Rutt, Jason Edward
Rouse Patents
Patents Agency
11th Floor, Exchange Tower
1 Harbour Exchange Square
London E14 9GE / GB
Application number, filing date11740355.003.02.2011
[2021/01]
WO2011US23606
Priority number, dateUS20100301368P04.02.2010         Original published format: US 301368 P
[2012/50]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2011097381
Date:11.08.2011
Language:EN
[2011/32]
Type: A2 Application without search report 
No.:EP2531597
Date:12.12.2012
Language:EN
The application published by WIPO in one of the EPO official languages on 11.08.2011 takes the place of the publication of the European patent application.
[2012/50]
Type: B1 Patent specification 
No.:EP2531597
Date:06.01.2021
Language:EN
[2021/01]
Search report(s)International search report - published on:KR08.12.2011
(Supplementary) European search report - dispatched on:EP26.02.2019
ClassificationIPC:C12N9/88, C12N15/60, A61K38/51, A61P35/00
[2012/50]
CPC:
C12N9/88 (EP,KR,US); C12Q1/527 (US); A61K38/00 (EP,KR,US);
A61K38/51 (KR); A61P35/00 (EP); C12N15/52 (KR);
C12N15/70 (KR); C12N9/96 (EP,KR,US); C12Q1/02 (KR);
C12Q1/10 (US); C12Y404/01001 (KR); C12Y404/01011 (KR);
G01N2333/988 (US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2012/50]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:MANIPULIERTE ENZYME MIT METHIONIN-GAMMA-LYASE-ENZYMEN UND PHARMAKOLOGISCHE PRÄPARATE DARAUS[2012/50]
English:ENGINEERED ENZYMES WITH METHIONINE-GAMMA-LYASE ENZYMES AND PHARMACOLOGICAL PREPARATIONS THEROF[2012/50]
French:ENZYMES GÉNÉTIQUEMENT MODIFIÉES PAR DES ENZYMES MÉTHIONINE-GAMMA-LYASE, ET PRÉPARATIONS PHARMACOLOGIQUES ASSOCIÉES[2012/50]
Entry into regional phase13.08.2012National basic fee paid 
13.08.2012Search fee paid 
13.08.2012Designation fee(s) paid 
13.08.2012Examination fee paid 
Examination procedure13.08.2012Examination requested  [2012/50]
19.09.2019Amendment by applicant (claims and/or description)
06.02.2020Despatch of a communication from the examining division (Time limit: M04)
16.06.2020Reply to a communication from the examining division
31.07.2020Communication of intention to grant the patent
27.11.2020Fee for grant paid
27.11.2020Fee for publishing/printing paid
27.11.2020Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  06.02.2020
Opposition(s)07.10.2021No opposition filed within time limit [2021/50]
Fees paidRenewal fee
19.02.2013Renewal fee patent year 03
12.02.2014Renewal fee patent year 04
11.02.2015Renewal fee patent year 05
10.02.2016Renewal fee patent year 06
10.02.2017Renewal fee patent year 07
27.02.2018Renewal fee patent year 08
27.02.2019Renewal fee patent year 09
27.02.2020Renewal fee patent year 10
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU03.02.2011
AL06.01.2021
AT06.01.2021
CY06.01.2021
CZ06.01.2021
DK06.01.2021
EE06.01.2021
ES06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
MC06.01.2021
MK06.01.2021
MT06.01.2021
NL06.01.2021
PL06.01.2021
RO06.01.2021
RS06.01.2021
SE06.01.2021
SI06.01.2021
SK06.01.2021
SM06.01.2021
TR06.01.2021
IE03.02.2021
LU03.02.2021
BE28.02.2021
CH28.02.2021
LI28.02.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
IS06.05.2021
PT06.05.2021
[2024/41]
Former [2024/29]HU03.02.2011
AL06.01.2021
AT06.01.2021
CY06.01.2021
CZ06.01.2021
DK06.01.2021
EE06.01.2021
ES06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
MC06.01.2021
MK06.01.2021
NL06.01.2021
PL06.01.2021
RO06.01.2021
RS06.01.2021
SE06.01.2021
SI06.01.2021
SK06.01.2021
SM06.01.2021
TR06.01.2021
IE03.02.2021
LU03.02.2021
BE28.02.2021
CH28.02.2021
LI28.02.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
IS06.05.2021
PT06.05.2021
Former [2024/22]HU03.02.2011
AL06.01.2021
AT06.01.2021
CY06.01.2021
CZ06.01.2021
DK06.01.2021
EE06.01.2021
ES06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
MC06.01.2021
MK06.01.2021
NL06.01.2021
PL06.01.2021
RO06.01.2021
RS06.01.2021
SE06.01.2021
SI06.01.2021
SK06.01.2021
SM06.01.2021
IE03.02.2021
LU03.02.2021
BE28.02.2021
CH28.02.2021
LI28.02.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
IS06.05.2021
PT06.05.2021
Former [2024/08]HU03.02.2011
AL06.01.2021
AT06.01.2021
CY06.01.2021
CZ06.01.2021
DK06.01.2021
EE06.01.2021
ES06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
MC06.01.2021
NL06.01.2021
PL06.01.2021
RO06.01.2021
RS06.01.2021
SE06.01.2021
SI06.01.2021
SK06.01.2021
SM06.01.2021
IE03.02.2021
LU03.02.2021
BE28.02.2021
CH28.02.2021
LI28.02.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
IS06.05.2021
PT06.05.2021
Former [2023/27]HU03.02.2011
AL06.01.2021
AT06.01.2021
CY06.01.2021
CZ06.01.2021
DK06.01.2021
EE06.01.2021
ES06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
MC06.01.2021
NL06.01.2021
PL06.01.2021
RO06.01.2021
RS06.01.2021
SE06.01.2021
SI06.01.2021
SK06.01.2021
SM06.01.2021
IE03.02.2021
LU03.02.2021
BE28.02.2021
CH28.02.2021
LI28.02.2021
BG06.04.2021
GB06.04.2021
NO06.04.2021
GR07.04.2021
IS06.05.2021
PT06.05.2021
Former [2023/24]AL06.01.2021
AT06.01.2021
CY06.01.2021
CZ06.01.2021
DK06.01.2021
EE06.01.2021
ES06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
MC06.01.2021
NL06.01.2021
PL06.01.2021
RO06.01.2021
RS06.01.2021
SE06.01.2021
SI06.01.2021
SK06.01.2021
SM06.01.2021
IE03.02.2021
LU03.02.2021
BE28.02.2021
CH28.02.2021
LI28.02.2021
BG06.04.2021
GB06.04.2021
NO06.04.2021
GR07.04.2021
IS06.05.2021
PT06.05.2021
Former [2022/36]AL06.01.2021
AT06.01.2021
CZ06.01.2021
DK06.01.2021
EE06.01.2021
ES06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
MC06.01.2021
NL06.01.2021
PL06.01.2021
RO06.01.2021
RS06.01.2021
SE06.01.2021
SI06.01.2021
SK06.01.2021
SM06.01.2021
IE03.02.2021
LU03.02.2021
BE28.02.2021
CH28.02.2021
LI28.02.2021
BG06.04.2021
GB06.04.2021
NO06.04.2021
GR07.04.2021
IS06.05.2021
PT06.05.2021
Former [2022/34]AL06.01.2021
AT06.01.2021
CZ06.01.2021
DK06.01.2021
EE06.01.2021
ES06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
MC06.01.2021
NL06.01.2021
PL06.01.2021
RO06.01.2021
RS06.01.2021
SE06.01.2021
SI06.01.2021
SK06.01.2021
SM06.01.2021
IE03.02.2021
IT03.02.2021
LU03.02.2021
BE28.02.2021
CH28.02.2021
LI28.02.2021
BG06.04.2021
GB06.04.2021
NO06.04.2021
GR07.04.2021
IS06.05.2021
PT06.05.2021
Former [2022/23]AL06.01.2021
AT06.01.2021
CZ06.01.2021
DK06.01.2021
EE06.01.2021
ES06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
MC06.01.2021
NL06.01.2021
PL06.01.2021
RO06.01.2021
RS06.01.2021
SE06.01.2021
SI06.01.2021
SK06.01.2021
SM06.01.2021
IE03.02.2021
IT03.02.2021
LU03.02.2021
CH28.02.2021
LI28.02.2021
FR06.03.2021
BG06.04.2021
GB06.04.2021
NO06.04.2021
GR07.04.2021
IS06.05.2021
PT06.05.2021
Former [2022/21]AL06.01.2021
AT06.01.2021
CZ06.01.2021
DK06.01.2021
EE06.01.2021
ES06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
MC06.01.2021
NL06.01.2021
PL06.01.2021
RO06.01.2021
RS06.01.2021
SE06.01.2021
SI06.01.2021
SK06.01.2021
SM06.01.2021
IE03.02.2021
LU03.02.2021
CH28.02.2021
LI28.02.2021
FR06.03.2021
BG06.04.2021
GB06.04.2021
NO06.04.2021
GR07.04.2021
PT06.05.2021
Former [2022/13]AL06.01.2021
AT06.01.2021
CZ06.01.2021
DK06.01.2021
EE06.01.2021
ES06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
MC06.01.2021
NL06.01.2021
PL06.01.2021
RO06.01.2021
RS06.01.2021
SE06.01.2021
SI06.01.2021
SK06.01.2021
SM06.01.2021
IE03.02.2021
LU03.02.2021
CH28.02.2021
LI28.02.2021
FR06.03.2021
BG06.04.2021
GB06.04.2021
NO06.04.2021
GR07.04.2021
PT06.05.2021
DE01.09.2021
Former [2022/10]AL06.01.2021
AT06.01.2021
CZ06.01.2021
DK06.01.2021
EE06.01.2021
ES06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
MC06.01.2021
NL06.01.2021
PL06.01.2021
RO06.01.2021
RS06.01.2021
SE06.01.2021
SK06.01.2021
SM06.01.2021
IE03.02.2021
LU03.02.2021
CH28.02.2021
LI28.02.2021
FR06.03.2021
BG06.04.2021
GB06.04.2021
NO06.04.2021
GR07.04.2021
PT06.05.2021
DE01.09.2021
Former [2022/08]AL06.01.2021
AT06.01.2021
CZ06.01.2021
DK06.01.2021
EE06.01.2021
ES06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
MC06.01.2021
NL06.01.2021
PL06.01.2021
RO06.01.2021
RS06.01.2021
SE06.01.2021
SK06.01.2021
SM06.01.2021
IE03.02.2021
LU03.02.2021
CH28.02.2021
LI28.02.2021
FR06.03.2021
BG06.04.2021
GB06.04.2021
NO06.04.2021
GR07.04.2021
IS06.05.2021
PT06.05.2021
DE01.09.2021
Former [2022/07]AL06.01.2021
AT06.01.2021
CZ06.01.2021
DK06.01.2021
EE06.01.2021
ES06.01.2021
FI06.01.2021
HR06.01.2021
LT06.01.2021
LV06.01.2021
MC06.01.2021
NL06.01.2021
PL06.01.2021
RO06.01.2021
RS06.01.2021
SE06.01.2021
SK06.01.2021
SM06.01.2021
IE03.02.2021
LU03.02.2021
CH28.02.2021
LI28.02.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
IS06.05.2021
PT06.05.2021
DE01.09.2021
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FI06.01.2021
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LT06.01.2021
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NL06.01.2021
PL06.01.2021
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SK06.01.2021
SM06.01.2021
LU03.02.2021
CH28.02.2021
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BG06.04.2021
NO06.04.2021
GR07.04.2021
IS06.05.2021
PT06.05.2021
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EE06.01.2021
FI06.01.2021
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LT06.01.2021
LV06.01.2021
MC06.01.2021
NL06.01.2021
PL06.01.2021
RO06.01.2021
RS06.01.2021
SE06.01.2021
SK06.01.2021
SM06.01.2021
LU03.02.2021
CH28.02.2021
LI28.02.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
IS06.05.2021
PT06.05.2021
Former [2021/49]AT06.01.2021
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FI06.01.2021
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LV06.01.2021
MC06.01.2021
NL06.01.2021
PL06.01.2021
RS06.01.2021
SE06.01.2021
SM06.01.2021
LU03.02.2021
CH28.02.2021
LI28.02.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
IS06.05.2021
PT06.05.2021
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MC06.01.2021
NL06.01.2021
PL06.01.2021
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SM06.01.2021
LU03.02.2021
CH28.02.2021
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BG06.04.2021
NO06.04.2021
GR07.04.2021
IS06.05.2021
PT06.05.2021
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LU03.02.2021
CH28.02.2021
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BG06.04.2021
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BG06.04.2021
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GR07.04.2021
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PT06.05.2021
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RS06.01.2021
SE06.01.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
PT06.05.2021
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FI06.01.2021
HR06.01.2021
LT06.01.2021
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NL06.01.2021
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SE06.01.2021
BG06.04.2021
NO06.04.2021
GR07.04.2021
PT06.05.2021
Former [2021/37]AT06.01.2021
FI06.01.2021
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LT06.01.2021
LV06.01.2021
NL06.01.2021
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BG06.04.2021
NO06.04.2021
GR07.04.2021
PT06.05.2021
Former [2021/36]FI06.01.2021
HR06.01.2021
LT06.01.2021
NL06.01.2021
BG06.04.2021
NO06.04.2021
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PT06.05.2021
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PT06.05.2021
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LT06.01.2021
NL06.01.2021
NO06.04.2021
PT06.05.2021
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NO06.04.2021
PT06.05.2021
Documents cited:Search[Y]WO0220807  (SHIONOGI & CO [JP], et al) [Y] 1-19 * claims 1-30 *;
 [Y]WO03106971  (UNIV COLORADO [US]) [Y] 1-19 * claims 1-61 *;
 [A]US2005036984  (HARRISON ROGER G [US], et al) [A] 1-19 * the whole document *;
 [X]  - A Bahr, "Q5RFI1", UNIPROT, (20041221), URL: https://www.uniprot.org/uniprot/Q5RFI1.txt, (20181012), XP055514780 [X] 1-9 * the whole document *
 [A]  - WEIDONG ZHU ET AL, "Kinetic Properties of Polymorphic Variants and Pathogenic Mutants in Human Cystathionine [gamma]-Lyase +", BIOCHEMISTRY, US, (20080601), vol. 47, no. 23, doi:10.1021/bi800351a, ISSN 0006-2960, pages 6226 - 6232, XP055515416 [A] 1-19 * the whole document *

DOI:   http://dx.doi.org/10.1021/bi800351a
 [A]  - KRAUS J P ET AL, "Cystathionine @c-lyase: Clinical, metabolic, genetic, and structural studies", MOLECULAR GENETICS AND METABOLISM, ACADEMIC PRESS, AMSTERDAM, NL, vol. 97, no. 4, doi:10.1016/J.YMGME.2009.04.001, ISSN 1096-7192, (20090801), pages 250 - 259, (20090409), XP026282971 [A] 1-19 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.ymgme.2009.04.001
 [A]  - LU Y ET AL, "Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine @c-lyase", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, ELSEVIER, AMSTERDAM, NL, vol. 189, no. 2, doi:10.1016/0006-291X(92)92265-Y, ISSN 0006-291X, (19921215), pages 749 - 758, (19921215), XP024838385 [A] 1-19 * the whole document *

DOI:   http://dx.doi.org/10.1016/0006-291X(92)92265-Y
 [A]  - U. BREITINGER ET AL, "The Three-Dimensional Structure of Cystathionine beta-Lyase from Arabidopsis and Its Substrate Specificity", PLANT PHYSIOLOGY, (20010601), vol. 126, no. 2, doi:10.1104/pp.126.2.631, pages 631 - 642, XP055515421 [A] 1-19 * the whole document *

DOI:   http://dx.doi.org/10.1104/pp.126.2.631
 [T]  - EVERETT STONE ET AL, "De novo Engineering of a Human Cystathionine-y-Lyase for Systemic L-Methionine Depletion Cancer Therapy'", ACS CHEMICAL BIOLOGY, (20121116), vol. 7, no. 11, doi:10.1021/cb300335j, ISSN 1554-8929, pages 1822 - 1829, XP055319839

DOI:   http://dx.doi.org/10.1021/cb300335j
International search[A]US2005036984  (HARRISON ROGER G [US], et al) [A] 4-7, 9-32* See the abstract. *;
 [A]  - ZHU, W. et al., "Kinetic properties of polymorphic variants and pathogenic mutants in human cystathionine gamma-lyase", Biochemistry, (20080514), vol. 47, no. 23, pages 6226 - 6232, XP055515416 [A] 4-7, 9-32 * See the abstract. *

DOI:   http://dx.doi.org/10.1021/bi800351a
 [A]  - KRAUS, J. P et al., "Cystathionine gamma-lyase: Clinical, metabolic, genetic, and structural studies", Molecular Genetics and Metabolism, (20090409), vol. 97, no. 4, pages 250 - 259, XP026282971 [A] 4-7, 9-32 * See the abstract. *

DOI:   http://dx.doi.org/10.1016/j.ymgme.2009.04.001
 [A]  - LU , Y. et al., "Cloning and nucleotide sequence of human liver cDNA encoding for cystathionine gamma-lyase", Biochemical and Biophysical Research communications, (19921215), vol. 189, no. 2, pages 749 - 758, XP024838385 [A] 4-7, 9-32 * See the abstract. *

DOI:   http://dx.doi.org/10.1016/0006-291X(92)92265-Y
 [A]  - BREITINGER, U. et al., "The three-dimensional structure of cystathionine beta -lyase from Arabidopsis and its substrate specificity", Plant Physiology, (20010600), vol. 126, no. 2, pages 631 - 642, XP055515421 [A] 4-7, 9-32 * See the abstract. *

DOI:   http://dx.doi.org/10.1104/pp.126.2.631
by applicantUS5889155
 US2009304666
    - RAO et al., J Nutrition, (19900000), vol. 120, pages 1628 - 1632
    - ASHE et al., Biochem. Biophys. Res. Commun., (19740000), vol. 57, page 417
    - DATSENKOWANNER, Proc. Natl. Acad. Sci. US4, (20000000), vol. 97, no. 12, pages 6640 - 5
    - ESAKISODA, Methods Enzymol., (19870000), vol. 143, page 459
    - GILLVON RIPPEL, Anal. Biochem., (19890000), vol. 182, pages 319 - 326
    - GOYER et al., Plant and cell Physiology, (20070000), vol. 48, no. 2, page 232
    - GRIMMINGERFELDNER, J Bacteriology., (19740000), vol. 118, no. 2, page 753
    - HALPERN et al., Proc. Natl. Acad. Sci., (19740000), vol. 71, pages 1133 - 1136
    - HARKKI et al., Bio Technology, (19890000), vol. 7, pages 596 - 603
    - HOOVER et al., J Biol. Chem., (20020000), vol. 277, pages 37647 - 37654
    - HORI et al., Cancer Res., (19960000), vol. 56, pages 2116 - 2122
    - HUCHEUNG, Intl. J Cancer, (20090000), vol. 124, no. 7
    - ITO et al., J Biochem., (19760000), vol. 79, page 1263
    - KREISGOODENOW, Cancer Res., (19780000), vol. 38, pages 2259 - 2262
    - KREIS et al., Cancer Res., (19800000), vol. 40, pages 634 - 641
    - KREIS, Cancer Treatment Rpts., (19790000), vol. 63, page 1069
    - KUDOU et al., J Biochem., (20070000), vol. 141, page 535
    - LISHKO et al., Anticancer Res., (19930000), vol. 13, pages 1465 - 1468
    - LOPESLAWTHER, Gene(Amsterdam), (19890000), vol. 76, no. 2, pages 255 - 269
    - LORDANESCU, J Bacterial, (19750000), vol. 12, page 597 601
    - LU et al., Biochem. Biophys. Res. Comm., (19920000), vol. 189, pages 749 - 758
    - MELLOR et al., Gene, (19830000), vol. 24, pages 1 - 14
    - NAKAMURA et al., Anal. Biochem., (19840000), vol. 138, pages 421 - 424
    - PENTTILA et al., Gene, (19870000), vol. 61, pages 155 - 164
    - Remington's Pharmaceutical Sciences, Mack Printing Company, (19900000), pages 1289 - 1329
    - ROOPENIANAKILESH, Nat. Rev. Immunol., (20070000), vol. 7, pages 715 - 725
    - SIBAKOV et al., Eur. J Biochem., (19840000), vol. 145, page 567 572
    - SRIDHAR et al., Acta Cry stal!. Section D: Biolog, Crystal!., (20000000), vol. 56, pages 1665 - 1667
    - STEEGBOM et al., J Biolog. Chem., (19990000), vol. 274, page 12675
    - SUN et al., Anticancer Res., (20050000), vol. 25, no. 1A, pages 59 - 62
    - TAKAKURA et al., Analytical Biochem., (20040000), vol. 327, pages 233 - 240
    - TAN et al., Anticancer Res., (19960000), vol. 16, pages 3931 - 3936
    - TAN, Protein Express. Purif., (19970000), vol. 9, pages 233 - 245
    - TAN, Anticancer Res., (20070000), vol. 17, pages 3857 - 3860
    - VOLKER SCHELLENBERGERL, Nature Biotech., (20090000), vol. 27, pages 1186 - 1190
    - WARD, Proc, Embo-Alko Workshop on Molecular Biology of Filamentous Fungi, (19890000), pages 119 - 128
    - WAWRZYNCZAKTHORPE, Immunoconjugates, Antibody Conuugates In Radio imaging And Therapy Of Cancer, Oxford University Press, (19870000), vol. 28
    - YANG et al., "PEGylation confers greatly extended half-life and attenuated immunogenicity to recombinant methioninase in primates", AACR, (20040000), pages 6673 - 6678
    - YANG et al., "Pharmacokinetics, methionine depletion, and antigenicity of recombinant methioninase in primates", AACR, (20040000), pages 2131 - 2138
    - YOSHIOKA et al., Cancer Res., (19980000), vol. 58, pages 2583 - 2587
 US19680613013
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