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EP2533639
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EP About this file: EP2533639
| EP2533639 - PYRAZOLOPYRIDINE, PYRAZOLOPYRAZINE, PYRAZOLOPYRIMIDINE, PYRAZOLOTHIOPHENE AND PYRAZOLOTHIAZOLE COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOUNDS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 10.03.2017 Database last updated on 12.07.2024 | |
| Former | Examination is in progress Status updated on 30.11.2016 | Most recent event Tooltip | 10.03.2017 | Application deemed to be withdrawn | published on 12.04.2017 [2017/15] | Applicant(s) | For all designated states Vanderbilt University 305 Kirkland Hall 2201 West End Avenue Nashville, TN 37240 / US | [N/P] |
| Former [2012/51] | For all designated states Vanderbilt University 305 Kirkland Hall Nashville, Tennessee 37240 / US | Inventor(s) | 01 /
CONN, P., Jeffrey 9012 Grey Point Court Brentwood, Tennessee 37027 / US | 02 /
LINDSLEY, Craig, W. 401 Brierly Court Brentwood, Tennessee 37027 / US | 03 /
HOPKINS, Corey, R. 151 Lodge Hall Road Nolensville, Tennessee 37135 / US | 04 /
NISWENDER, Colleen, M. 9634 Brunswick Drive Brentwood, Tennessee 37027 / US | 05 /
GOGLIOTTI, Rocco, D. 1116B Dog Creek Road Kingston Springs, Tennessee 37082 / US | 06 /
SALOVICH, James, M. 119 Twin Oaks Drive Nashville, Tennessee 37211 / US | 07 /
ENGERS, Darren, W. 4809 Redcastle Ridge Nashville, Tennessee 37211 / US | 08 /
CHEUNG, Yiu-Yin 497 Essex Park Circle Franklin, Tennessee 37069 / US | [2012/51] | Representative(s) | Bailey, Sam Rogerson, et al Mewburn Ellis LLP City Tower 40 Basinghall Street London EC2V 5DE / GB | [N/P] |
| Former [2014/16] | Bailey, Sam Rogerson, et al Mewburn Ellis LLP 33 Gutter Lane London EC2V 8AS / GB | ||
| Former [2014/11] | Murphy, Colm Damien, et al Venner Shipley LLP 200 Aldersgate London EC1A 4HD / GB | ||
| Former [2012/51] | Murphy, Colm Damien, et al Ipulse 126-130-Regent Street London W1B 5SE / GB | Application number, filing date | 11742910.0 | 11.02.2011 | WO2011US24618 | Priority number, date | US20110430521P | 06.01.2011 Original published format: US 430521 P | US20100303481P | 11.02.2010 Original published format: US 303481 P | [2012/51] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2011100607 | Date: | 18.08.2011 | Language: | EN | [2011/33] | Type: | A1 Application with search report | No.: | EP2533639 | Date: | 19.12.2012 | Language: | EN | The application published by WIPO in one of the EPO official languages on 18.08.2011 takes the place of the publication of the European patent application. | [2012/51] | Search report(s) | International search report - published on: | US | 18.08.2011 | (Supplementary) European search report - dispatched on: | EP | 18.07.2013 | Classification | IPC: | A01N43/56, A61K31/415 | [2012/51] | CPC: |
C07D471/04 (EP,US);
A61K31/415 (EP,KR,US);
A61K31/4188 (EP,US);
A61K31/429 (EP,US);
A61K31/437 (EP,US);
A61K31/444 (EP,US);
A61K31/4709 (EP,US);
A61K31/497 (EP,US);
A61K31/4985 (EP,US);
A61K31/506 (EP,US);
A61K31/519 (EP,KR,US);
A61K31/5377 (EP,US);
A61K45/06 (US);
A61P21/00 (EP);
A61P25/00 (EP);
A61P25/08 (EP);
A61P25/16 (EP);
A61P25/18 (EP);
A61P25/22 (EP);
A61P25/24 (EP);
A61P25/28 (EP);
A61P25/32 (EP);
A61P29/00 (EP);
A61P3/00 (EP);
A61P3/04 (EP);
A61P3/10 (EP);
A61P35/00 (EP);
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2012/51] | Title | German: | PYRAZOLOPYRIDIN-, PYRAZOLOPYRAZIN-, PYRAZOLOPYRIMIDIN-, PYRAZOLOTHIOPHEN- UND PYRAZOLOTHIAZOL-VERBINDUNGEN ALS ALLOSTERISCHE MGLUR4-POTENZIERER SOWIE VERBINDUNGEN UND VERFAHREN ZUR BEHANDLUNG NEUROLOGISCHER DYSFUNKTIONEN | [2012/51] | English: | PYRAZOLOPYRIDINE, PYRAZOLOPYRAZINE, PYRAZOLOPYRIMIDINE, PYRAZOLOTHIOPHENE AND PYRAZOLOTHIAZOLE COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOUNDS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION | [2012/51] | French: | COMPOSÉS DE PYRAZOLOPYRIDINE, DE PYRAZOLOPYRAZINE, DE PYRAZOLOPYRIMIDINE, DE PYRAZOLOTHIOPHÈNE ET DE PYRAZOLOTHIAZOLE EN TANT QUE POTENTIALISATEURS ALLOSTÉRIQUES DU SOUS-TYPE 4 DU RÉCEPTEUR DU GLUTAMATE MÉTABOTROPIQUE (MGLUR4), COMPOSÉS ET PROCÉDÉS DE TRAITEMENT DE DYSFONCTIONNEMENTS NEUROLOGIQUES | [2012/51] | Entry into regional phase | 11.09.2012 | National basic fee paid | 11.09.2012 | Search fee paid | 11.09.2012 | Designation fee(s) paid | 11.09.2012 | Examination fee paid | Examination procedure | 11.09.2012 | Examination requested [2012/51] | 14.02.2014 | Amendment by applicant (claims and/or description) | 21.07.2014 | Despatch of a communication from the examining division (Time limit: M06) | 02.02.2015 | Reply to a communication from the examining division | 24.06.2016 | Despatch of a communication from the examining division (Time limit: M04) | 05.11.2016 | Application deemed to be withdrawn, date of legal effect [2017/15] | 01.12.2016 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2017/15] | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 21.07.2014 | Fees paid | Renewal fee | 27.02.2013 | Renewal fee patent year 03 | 27.02.2014 | Renewal fee patent year 04 | 26.02.2015 | Renewal fee patent year 05 | 25.02.2016 | Renewal fee patent year 06 |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [XA]WO2005019171 (ASTRAZENECA AB [SE], et al) [X] 1,3 * The products of step (i) in Example 1 and Example 6 and others. * [A] 2,4-15; | [XA]WO2005054232 (ASTRAZENECA AB [SE], et al) [X] 1,3 * The product of step a) in Example 5 * [A] 2,4-15; | [XAI]WO2008089307 (LEXICON PHARMACEUTICALS INC [US], et al) [X] 1,3,6,7 * The products of Examples 5.11, 5.14 and 5.15 * * page 4, line 3 - page 4, line 6 * * paragraph [04.5] - paragraph [04.5] * * claim 1 * [A] 4,5,8-15 [I] 2; | [XA]WO2009018415 (VERTEX PHARMA [US], et al) [X] 1,3 * compounds III-1, III-3, III-7, III-8, III-9, III-10, III-16 * * compounds III-20, III-27 * [A] 2,4-15; | [XA] - BERNOTAS R C ET AL, "1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines are 5-HT6 receptor ligands", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 19, no. 24, doi:10.1016/J.BMCL.2009.10.067, ISSN 0960-894X, (20091215), pages 6935 - 6938, (20091020), XP026754152 [X] 1-3 * compound 21 * [A] 4-15 DOI: http://dx.doi.org/10.1016/j.bmcl.2009.10.067 | [XA] - LYN H. JONES ET AL, "Novel Indazole Non-Nucleoside Reverse Transcriptase Inhibitors Using Molecular Hybridization Based on Crystallographic Overlays +", JOURNAL OF MEDICINAL CHEMISTRY, (20090226), vol. 52, no. 4, doi:10.1021/jm801322h, ISSN 0022-2623, pages 1219 - 1223, XP055068001 [X] 1,3 * compound 16 * [A] 2,4-15 DOI: http://dx.doi.org/10.1021/jm801322h | [XA] - NORBERTO FARFÁN ET AL, "Preparation, X-ray crystal structure and 13 C- and 1 H-NMR study of 1-methyl-2-( N -methyl- N -phenylglycyl)-3-( N -methylanilino)indole", JOURNAL OF HETEROCYCLIC CHEMISTRY, (19900901), vol. 27, no. 6, doi:10.1002/jhet.5570270644, ISSN 0022-152X, pages 1745 - 1749, XP055068025 [X] 1,3 * compounds 1b, 1c, 1d * [A] 2,4-15 DOI: http://dx.doi.org/10.1002/jhet.5570270644 | [XA] - P. BRUNI ET AL, "Oxidation of aminoindole radical cations", JOURNAL OF HETEROCYCLIC CHEMISTRY, (19790601), vol. 16, no. 4, doi:10.1002/jhet.5570160433, ISSN 0022-152X, pages 779 - 782, XP055068023 [X] 1,3 * compounds 1a-1f * [A] 2,4-15 DOI: http://dx.doi.org/10.1002/jhet.5570160433 | [XA] - LENNART EBERSON ET AL, "Experimental evidence for an electron-transfer mechanism in the reaction between 2-phenyl-3-phenylimino-3H-indole and Grignard reagents: application of the Marcus theory", THE JOURNAL OF ORGANIC CHEMISTRY, (19840601), vol. 49, no. 12, doi:10.1021/jo00186a011, ISSN 0022-3263, pages 2135 - 2139, XP055068022 [X] 1,3 * compounds 3, 4 * [A] 2,4-15 DOI: http://dx.doi.org/10.1021/jo00186a011 | [XA] - YAN-JIN GUO ET AL, "Palladium-Catalyzed Annulation of 2-(1-Alkynyl)benzenamines with Disulfides: Synthesis of 3-Sulfenylindoles", ADVANCED SYNTHESIS & CATALYSIS, (20091101), vol. 351, no. 16, doi:10.1002/adsc.200900055, ISSN 1615-4150, pages 2615 - 2618, XP055068032 [X] 1,3 * Numerous compounds (products) in Tables 2 and 3 * [A] 2,4-15 DOI: http://dx.doi.org/10.1002/adsc.200900055 | [XA] - JHILLU YADAV ET AL, "Iron(III) Chloride: A Versatile Catalyst for the Practical Synthesis of 3-Sulfenylindoles", SYNTHESIS, (20090501), vol. 2009, no. 09, doi:10.1055/s-0028-1088035, ISSN 0039-7881, pages 1520 - 1524, XP055068030 [X] 1,3 * The products in Table 1 * [A] 2,4-15 DOI: http://dx.doi.org/10.1055/s-0028-1088035 | [XA] - A.-B. 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