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Extract from the Register of European Patents

EP About this file: EP2539715

EP2539715 - METHODS FOR PREPARING PEG-HEMOGLOBIN CONJUGATES USING REDUCED REACTANT RATIOS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  28.10.2022
Database last updated on 26.07.2024
FormerThe patent has been granted
Status updated on  19.11.2021
FormerGrant of patent is intended
Status updated on  13.04.2021
FormerRequest for examination was made
Status updated on  13.08.2020
FormerGrant of patent is intended
Status updated on  06.04.2020
FormerRequest for examination was made
Status updated on  18.03.2020
FormerGrant of patent is intended
Status updated on  10.11.2019
FormerRequest for examination was made
Status updated on  29.10.2019
FormerGrant of patent is intended
Status updated on  24.06.2019
FormerRequest for examination was made
Status updated on  05.06.2019
FormerGrant of patent is intended
Status updated on  24.01.2019
FormerRequest for examination was made
Status updated on  08.01.2019
FormerGrant of patent is intended
Status updated on  16.08.2018
FormerRequest for examination was made
Status updated on  30.07.2018
FormerGrant of patent is intended
Status updated on  25.03.2018
Most recent event   Tooltip27.04.2024Lapse of the patent in a contracting state
New state(s): MK		published on 29.05.2024  [2024/22]
Applicant(s)For all designated states
Schindler, William
40 E. Wildflower Dr.
Santa Fe CA NM 87506 / US
[2022/12]
Former [2013/01]For all designated states
Sangart, Inc.
6175 Lusk Boulevard
San Diego, CA 92121 / US
Inventor(s)01 / MALAVALLI, Ashok
9185 Hillery Drive
San Diego, CA 92126 / US
02 / VANDEGRIFF, Kim D.
100 Harbor Drive 1106
San Diego, CA 92101 / US
 [2021/51]
Former [2013/01]01 / MALAVALLI, Ashok
9185 Hillery Drive
San Diego, CA 92126 / US
02 / VANDEGRIFF, Kim D.
100 Harbor Drive 1106
San Diego, CA 92101 / US
Representative(s)Michalski Hüttermann & Partner Patentanwälte mbB
Kaistraße 16A
40221 Düsseldorf / DE
[N/P]
Former [2021/51]Michalski Hüttermann & Partner Patentanwälte mbB
Speditionstraße 21
40221 Düsseldorf / DE
Former [2013/01]Michalski Hüttermann & Partner
Neuer Zollhof 2
40221 Düsseldorf / DE
Application number, filing date11747978.223.02.2011
[2021/51]
WO2011US25888
Priority number, dateUS20100308238P25.02.2010         Original published format: US 308238 P
[2013/01]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2011106396
Date:01.09.2011
Language:EN
[2011/35]
Type: A1 Application with search report 
No.:EP2539715
Date:02.01.2013
Language:EN
The application published by WIPO in one of the EPO official languages on 01.09.2011 takes the place of the publication of the European patent application.
[2013/01]
Type: B1 Patent specification 
No.:EP2539715
Date:22.12.2021
Language:EN
[2021/51]
Search report(s)International search report - published on:US01.09.2011
(Supplementary) European search report - dispatched on:EP01.02.2016
ClassificationIPC:A61K47/60, C07K14/805, C08H1/00, G01N33/72, // A61K38/00
[2018/14]
CPC:
C08H1/00 (EP,KR,US); A61K38/42 (KR); A61K38/00 (EP,KR,US);
A61K47/60 (EP,US); A61P7/00 (EP); A61P7/04 (EP);
C07K14/805 (EP,US); G01N33/72 (KR) (-)
Former IPC [2016/09]G01N33/72, C08H1/00, A61K38/00, A61K47/48, C07K14/805
Former IPC [2013/01]G01N33/72, C08H1/00, A61K38/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2013/01]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:VERFAHREN ZUR HERSTELLUNG VON PEG-HÄMOGLOBIN-KONJUGATEN MIT REDUZIERTEM REAKTANZIENVERHÄLTNIS[2013/01]
English:METHODS FOR PREPARING PEG-HEMOGLOBIN CONJUGATES USING REDUCED REACTANT RATIOS[2013/01]
French:PROCÉDÉS DE PRÉPARATION DE CONJUGUÉS PEG-HÉMOGLOBINE UTILISANT DES RAPPORTS RÉDUITS DE RÉACTIF[2013/01]
Entry into regional phase24.09.2012National basic fee paid 
24.09.2012Search fee paid 
24.09.2012Designation fee(s) paid 
24.09.2012Examination fee paid 
Examination procedure24.09.2012Examination requested  [2013/01]
29.08.2016Amendment by applicant (claims and/or description)
26.03.2018Communication of intention to grant the patent
24.07.2018Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
17.08.2018Communication of intention to grant the patent
21.12.2018Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
25.01.2019Communication of intention to grant the patent
27.05.2019Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
27.05.2019Receipt of the translation of the claim(s)
25.06.2019Communication of intention to grant the patent
25.10.2019Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
11.11.2019Communication of intention to grant the patent
11.03.2020Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
07.04.2020Communication of intention to grant the patent
10.08.2020Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
15.03.2021Cancellation of oral proceeding that was planned for 30.03.2021
30.03.2021Date of oral proceedings (cancelled)
14.04.2021Communication of intention to grant the patent
22.09.2021Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time
12.11.2021Fee for grant paid
12.11.2021Fee for publishing/printing paid
12.11.2021Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  26.03.2018
Opposition(s)23.09.2022No opposition filed within time limit [2022/48]
Request for further processing for:The application is deemed to be withdrawn due to failure to fulfill actions required for granting the patent
12.11.2021Request for further processing filed
12.11.2021Full payment received (date of receipt of payment)
Request granted
23.11.2021Decision despatched
Fees paidRenewal fee
27.02.2013Renewal fee patent year 03
01.09.2014Renewal fee patent year 04
27.07.2015Renewal fee patent year 05
26.02.2016Renewal fee patent year 06
27.02.2017Renewal fee patent year 07
27.02.2018Renewal fee patent year 08
27.02.2019Renewal fee patent year 09
27.02.2020Renewal fee patent year 10
25.02.2021Renewal fee patent year 11
Penalty fee
Additional fee for renewal fee
28.02.201404   M06   Fee paid on   01.09.2014
28.02.201505   M06   Fee paid on   27.07.2015
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU23.02.2011
AL22.12.2021
AT22.12.2021
CY22.12.2021
CZ22.12.2021
DK22.12.2021
EE22.12.2021
ES22.12.2021
FI22.12.2021
HR22.12.2021
IT22.12.2021
LT22.12.2021
LV22.12.2021
MC22.12.2021
MK22.12.2021
NL22.12.2021
PL22.12.2021
RO22.12.2021
RS22.12.2021
SI22.12.2021
SK22.12.2021
SM22.12.2021
IE23.02.2022
LU23.02.2022
BE28.02.2022
BG22.03.2022
NO22.03.2022
GR23.03.2022
IS22.04.2022
PT22.04.2022
[2024/22]
Former [2024/20]HU23.02.2011
AL22.12.2021
AT22.12.2021
CY22.12.2021
CZ22.12.2021
DK22.12.2021
EE22.12.2021
ES22.12.2021
FI22.12.2021
HR22.12.2021
IT22.12.2021
LT22.12.2021
LV22.12.2021
MC22.12.2021
NL22.12.2021
PL22.12.2021
RO22.12.2021
RS22.12.2021
SI22.12.2021
SK22.12.2021
SM22.12.2021
IE23.02.2022
LU23.02.2022
BE28.02.2022
BG22.03.2022
NO22.03.2022
GR23.03.2022
IS22.04.2022
PT22.04.2022
Former [2024/18]HU23.02.2011
AL22.12.2021
AT22.12.2021
CZ22.12.2021
DK22.12.2021
EE22.12.2021
ES22.12.2021
FI22.12.2021
HR22.12.2021
IT22.12.2021
LT22.12.2021
LV22.12.2021
MC22.12.2021
NL22.12.2021
PL22.12.2021
RO22.12.2021
RS22.12.2021
SI22.12.2021
SK22.12.2021
SM22.12.2021
IE23.02.2022
LU23.02.2022
BE28.02.2022
BG22.03.2022
NO22.03.2022
GR23.03.2022
IS22.04.2022
PT22.04.2022
Former [2023/27]AL22.12.2021
AT22.12.2021
CZ22.12.2021
DK22.12.2021
EE22.12.2021
ES22.12.2021
FI22.12.2021
HR22.12.2021
IT22.12.2021
LT22.12.2021
LV22.12.2021
MC22.12.2021
NL22.12.2021
PL22.12.2021
RO22.12.2021
RS22.12.2021
SI22.12.2021
SK22.12.2021
SM22.12.2021
IE23.02.2022
LU23.02.2022
BE28.02.2022
BG22.03.2022
NO22.03.2022
GR23.03.2022
IS22.04.2022
PT22.04.2022
Former [2023/10]AL22.12.2021
AT22.12.2021
CZ22.12.2021
DK22.12.2021
EE22.12.2021
ES22.12.2021
FI22.12.2021
HR22.12.2021
LT22.12.2021
LV22.12.2021
MC22.12.2021
NL22.12.2021
PL22.12.2021
RO22.12.2021
RS22.12.2021
SI22.12.2021
SK22.12.2021
SM22.12.2021
IE23.02.2022
LU23.02.2022
BE28.02.2022
BG22.03.2022
NO22.03.2022
GR23.03.2022
IS22.04.2022
PT22.04.2022
Former [2023/09]AL22.12.2021
AT22.12.2021
CZ22.12.2021
DK22.12.2021
EE22.12.2021
ES22.12.2021
FI22.12.2021
HR22.12.2021
LT22.12.2021
LV22.12.2021
MC22.12.2021
NL22.12.2021
PL22.12.2021
RO22.12.2021
RS22.12.2021
SK22.12.2021
SM22.12.2021
IE23.02.2022
LU23.02.2022
BG22.03.2022
NO22.03.2022
GR23.03.2022
IS22.04.2022
PT22.04.2022
Former [2022/49]AL22.12.2021
AT22.12.2021
CZ22.12.2021
DK22.12.2021
EE22.12.2021
ES22.12.2021
FI22.12.2021
HR22.12.2021
LT22.12.2021
LV22.12.2021
MC22.12.2021
NL22.12.2021
PL22.12.2021
RO22.12.2021
RS22.12.2021
SK22.12.2021
SM22.12.2021
LU23.02.2022
BG22.03.2022
NO22.03.2022
GR23.03.2022
IS22.04.2022
PT22.04.2022
Former [2022/47]AT22.12.2021
CZ22.12.2021
DK22.12.2021
EE22.12.2021
ES22.12.2021
FI22.12.2021
HR22.12.2021
LT22.12.2021
LV22.12.2021
MC22.12.2021
NL22.12.2021
PL22.12.2021
RO22.12.2021
RS22.12.2021
SK22.12.2021
SM22.12.2021
LU23.02.2022
BG22.03.2022
NO22.03.2022
GR23.03.2022
IS22.04.2022
PT22.04.2022
Former [2022/46]AT22.12.2021
CZ22.12.2021
DK22.12.2021
EE22.12.2021
ES22.12.2021
FI22.12.2021
HR22.12.2021
LT22.12.2021
LV22.12.2021
MC22.12.2021
NL22.12.2021
PL22.12.2021
RO22.12.2021
RS22.12.2021
SK22.12.2021
SM22.12.2021
BG22.03.2022
NO22.03.2022
GR23.03.2022
IS22.04.2022
PT22.04.2022
Former [2022/44]AT22.12.2021
CZ22.12.2021
EE22.12.2021
ES22.12.2021
FI22.12.2021
HR22.12.2021
LT22.12.2021
LV22.12.2021
MC22.12.2021
NL22.12.2021
PL22.12.2021
RO22.12.2021
RS22.12.2021
SK22.12.2021
SM22.12.2021
BG22.03.2022
NO22.03.2022
GR23.03.2022
IS22.04.2022
PT22.04.2022
Former [2022/42]AT22.12.2021
CZ22.12.2021
EE22.12.2021
ES22.12.2021
FI22.12.2021
HR22.12.2021
LT22.12.2021
LV22.12.2021
NL22.12.2021
PL22.12.2021
RO22.12.2021
RS22.12.2021
SK22.12.2021
SM22.12.2021
BG22.03.2022
NO22.03.2022
GR23.03.2022
IS22.04.2022
PT22.04.2022
Former [2022/36]AT22.12.2021
CZ22.12.2021
EE22.12.2021
ES22.12.2021
FI22.12.2021
HR22.12.2021
LT22.12.2021
LV22.12.2021
NL22.12.2021
PL22.12.2021
RO22.12.2021
RS22.12.2021
SK22.12.2021
SM22.12.2021
BG22.03.2022
NO22.03.2022
GR23.03.2022
PT22.04.2022
Former [2022/35]CZ22.12.2021
EE22.12.2021
ES22.12.2021
FI22.12.2021
HR22.12.2021
LT22.12.2021
LV22.12.2021
NL22.12.2021
RO22.12.2021
RS22.12.2021
SK22.12.2021
SM22.12.2021
BG22.03.2022
NO22.03.2022
GR23.03.2022
PT22.04.2022
Former [2022/34]EE22.12.2021
ES22.12.2021
FI22.12.2021
HR22.12.2021
LT22.12.2021
LV22.12.2021
NL22.12.2021
RO22.12.2021
RS22.12.2021
SM22.12.2021
BG22.03.2022
NO22.03.2022
GR23.03.2022
PT22.04.2022
Former [2022/33]FI22.12.2021
HR22.12.2021
LT22.12.2021
LV22.12.2021
NL22.12.2021
RS22.12.2021
SM22.12.2021
BG22.03.2022
NO22.03.2022
GR23.03.2022
Former [2022/30]FI22.12.2021
HR22.12.2021
LT22.12.2021
LV22.12.2021
NL22.12.2021
RS22.12.2021
BG22.03.2022
NO22.03.2022
GR23.03.2022
Former [2022/25]FI22.12.2021
HR22.12.2021
LT22.12.2021
LV22.12.2021
RS22.12.2021
BG22.03.2022
NO22.03.2022
GR23.03.2022
Former [2022/24]FI22.12.2021
HR22.12.2021
LT22.12.2021
LV22.12.2021
RS22.12.2021
BG22.03.2022
GR23.03.2022
Former [2022/22]FI22.12.2021
LT22.12.2021
RS22.12.2021
BG22.03.2022
Former [2022/21]RS22.12.2021
BG22.03.2022
Former [2022/19]BG22.03.2022
Documents cited:Search[A]US2006135753  (ACHARYA SEETHARAMA A [US], et al) [A] 1-10 * paragraphs [0037] - [0039] - [0044] , [0045] , [0047] *;
 [A]US5585484  (ACHARYA A SEETHARAMA [US], et al) [A] 1-10 * example 9 *;
 [A]WO2008136888  (EINSTEIN COLL MED [US], et al) [A] 1-10 * paragraphs [0171] , [0172] *
 [A]  - DONGXIA LI ET AL, "Extension Arm Facilitated PEGylation of Hemoglobin: Correlation of the Properties with the Extent of PEGylation", JOURNAL OF PROTEIN CHEMISTRY, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE, (20060523), vol. 25, no. 4, doi:10.1007/S10930-006-9010-Y, ISSN 1573-4943, pages 263 - 274, XP019435869 [A] 1-10 * page 265, section "2.1. PEGylation of HbA" * * page 266, section "3.1. Size Exclusion Chromotographic Analysis of PEGylated HbA" * * figure 1 *

DOI:   http://dx.doi.org/10.1007/s10930-006-9010-y
 [A]  - BELUR N MANJULA ET AL, "Conjugation of Multiple Copies of Polyethylene Glycol to Hemoglobin Facilitated Through Thiolation: Influence on Hemoglobin Structure and Function", JOURNAL OF PROTEIN CHEMISTRY, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE, (20050401), vol. 24, no. 3, ISSN 1573-4943, pages 133 - 146, XP019284384 [A] 1-10 * the whole document *
 [A]  - ACHARYA SEETHARAMA A ET AL, "Enhanced molecular volume of conservatively Pegylated Hb : (SP-PEG5K)6-HbA is non-hypertensive", ARTIFICIAL CELLS, BLOOD SUBSTITUTES, AND IMMOBILIZATION BIOTECHNOLOGY, MARCEL DEKKER INC, US, vol. 33, no. 3, doi:10.1081/BIO-200066365, ISSN 1073-1199, (20050101), pages 239 - 255, (20090711), XP008178702 [A] 1-10 * the whole document *

DOI:   http://dx.doi.org/10.1081/BIO-200066365
International search[Y]US2006135753  (ACHARYA SEETHARAMA A [US], et al);
 [Y]US5585484  (ACHARYA A SEETHARAMA [US], et al);
 [Y]WO2008136888  (EINSTEIN COLL MED [US], et al);
 [Y]US2006111275  (ACHARYA SEETHARAMA A [US], et al);
 [Y]US2005159339  (ACHARYA SEETHARAMA A [US], et al)
by applicant   - "Extension Arm Facilitated PEGylation of Hemoglobin: Correlation of the Properties with the Extent of PEGylation", DONGXIA LI ET AL., Journal Of Protein Chemistry, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, (20060523), vol. 25, pages 263 - 274
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.