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Extract from the Register of European Patents

EP About this file: EP2545928

EP2545928 - CELL PREPARATION CONTAINING MESENCHYMAL STEM CELLS, AND METHOD FOR PRODUCING SAME [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  26.05.2017
Database last updated on 14.06.2024
Most recent event   Tooltip06.03.2020Lapse of the patent in a contracting state
New state(s): TR		published on 08.04.2020  [2020/15]
Applicant(s)For all designated states
Two Cells Co., Ltd
Hiroshima Sangyou Bunka Center Bldg., 11F
16-35, Hijiyamahonmachi
Minami-ku
Hiroshima City
Hiroshima 732-0816 / JP
[2016/28]
Former [2013/03]For all designated states
Two Cells Co., Ltd
4-5-17-501, Danbara Minami-ku
Hiroshima-shi, Hiroshima 732-0811 / JP
Inventor(s)01 / TSUCHIYA, Toshie
3-29-21, Tamagawa, Setagaya-ku.
158 -0094Tokyo / JP
02 / TSUJI, Koichiro
Hiroshima Sangyou Bunka Center Bldg.
11F, 16-35, Hijiyamahonmachi
Minami-ku, Hiroshima City
Hiroshima 732-0816 / JP
03 / KATO, Yukio
c/o Graduate School of Biomedical Sciences
Hiroshima University
1-2-3 Kasumi
Minami-ku
Hiroshima-shi Hiroshima 734-8551 / JP
04 / SHAO, Jin Chang
Hiroshima Sangyou Bunka Center Bldg.
11F, 16-35, Hijiyamahonmachi
Minami-ku, Hiroshima City
Hiroshima 732-0816 / JP
05 / HARA, Maiko
Hiroshima Sangyou Bunka Center Bldg.
11F, 16-35, Hijiyamahonmachi
Minami-ku, Hiroshima City
Hiroshima 732-0816 / JP
 [2016/28]
Former [2013/03]01 / TSUCHIYA, Toshie
3-29-21, Tamagawa, Setagaya-ku.
158 -0094Tokyo / JP
02 / TSUJI, Koichiro
c/o Two Cells Co., Ltd.
4-5-17-501, Danbara, Minami-ku, Hiroshima-shi
732-0811 Hiroshima / JP
03 / KATO, Yukio
c/o Graduate School of Biomedical Sciences
Hiroshima University
1-2-3 Kasumi
Minami-ku
Hiroshima-shi Hiroshima 734-8551 / JP
04 / SHAO, Jin Chang
c/o TWO CELLS Co. Ltd.
4-5-17-501 Danbara
Minami-ku
Hiroshima-shi Hiroshima 732-0811 / JP
05 / HARA, Maiko
c/o TWO CELLS Co. Ltd.
4-5-17-501 Danbara
Minami-ku
Hiroshima-shi Hiroshima 732-0811 / JP
Representative(s)Bittner, Thomas L.
Boehmert & Boehmert
Anwaltspartnerschaft mbB
Pettenkoferstrasse 22
80336 München / DE
[N/P]
Former [2016/29]Bittner, Thomas L.
Boehmert & Boehmert
Anwaltspartnerschaft mbB
Patentanwälte Rechtsanwälte
Pettenkoferstrasse 20-22
80336 München / DE
Former [2013/03]Bittner, Thomas L.
Boehmert & Boehmert
Pettenkoferstrasse 20-22
80336 München / DE
Application number, filing date11753445.310.03.2011
[2016/29]
WO2011JP55683
Priority number, dateJP2010005317910.03.2010         Original published format: JP 2010053179
[2013/03]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2011111787
Date:15.09.2011
Language:JA
[2011/37]
Type: A1 Application with search report 
No.:EP2545928
Date:16.01.2013
Language:EN
[2013/03]
Type: B1 Patent specification 
No.:EP2545928
Date:20.07.2016
Language:EN
[2016/29]
Search report(s)International search report - published on:JP15.09.2011
(Supplementary) European search report - dispatched on:EP02.08.2013
ClassificationIPC:C12N5/071, C12N5/0775, A61K35/12, A61K35/28, A61P37/06
[2013/36]
CPC:
C12N5/0663 (EP,US); A61K35/28 (KR); A61K35/12 (EP,KR,US);
A61P37/06 (EP); C12N5/0662 (KR); C12N5/0668 (EP,US);
C12N2500/90 (EP,US); C12N2501/11 (EP,US); C12N2501/115 (EP,US);
C12N2501/12 (EP,US); C12N2501/135 (EP,US); C12N2501/15 (EP,US) (-)
Former IPC [2013/03]A61K35/12, A61K35/28, A61P37/06, C12N5/0775
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2013/03]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:ZELLPRÄPARAT MIT MESENCHYMALEN STAMMZELLEN UND HERSTELLUNGSVERFAHREN DAFÜR[2013/03]
English:CELL PREPARATION CONTAINING MESENCHYMAL STEM CELLS, AND METHOD FOR PRODUCING SAME[2013/03]
French:PRÉPARATION DE CELLULES CONTENANT DES CELLULES SOUCHES MÉSENCHYMATEUSES ET PROCÉDÉ DE PRODUCTION DE CELLES-CI[2013/03]
Entry into regional phase04.10.2012Translation filed 
04.10.2012National basic fee paid 
04.10.2012Search fee paid 
04.10.2012Designation fee(s) paid 
04.10.2012Examination fee paid 
Examination procedure04.10.2012Examination requested  [2013/03]
21.11.2013Amendment by applicant (claims and/or description)
10.12.2013Despatch of a communication from the examining division (Time limit: M04)
15.04.2014Reply to a communication from the examining division
30.04.2014Despatch of a communication from the examining division (Time limit: M04)
04.07.2014Reply to a communication from the examining division
23.07.2014Despatch of a communication from the examining division (Time limit: M04)
01.12.2014Reply to a communication from the examining division
15.02.2016Communication of intention to grant the patent
03.06.2016Fee for grant paid
03.06.2016Fee for publishing/printing paid
03.06.2016Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  10.12.2013
Opposition(s)21.04.2017No opposition filed within time limit [2017/26]
Fees paidRenewal fee
11.03.2013Renewal fee patent year 03
12.03.2014Renewal fee patent year 04
10.03.2015Renewal fee patent year 05
10.03.2016Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU10.03.2011
AL20.07.2016
AT20.07.2016
CY20.07.2016
CZ20.07.2016
EE20.07.2016
ES20.07.2016
HR20.07.2016
IT20.07.2016
LT20.07.2016
LV20.07.2016
MC20.07.2016
MK20.07.2016
PL20.07.2016
RO20.07.2016
RS20.07.2016
SI20.07.2016
SK20.07.2016
SM20.07.2016
TR20.07.2016
BG20.10.2016
GR21.10.2016
IS20.11.2016
PT21.11.2016
IE10.03.2017
LU10.03.2017
MT10.03.2017
[2020/15]
Former [2019/51]HU10.03.2011
AL20.07.2016
AT20.07.2016
CY20.07.2016
CZ20.07.2016
EE20.07.2016
ES20.07.2016
HR20.07.2016
IT20.07.2016
LT20.07.2016
LV20.07.2016
MC20.07.2016
MK20.07.2016
PL20.07.2016
RO20.07.2016
RS20.07.2016
SI20.07.2016
SK20.07.2016
SM20.07.2016
BG20.10.2016
GR21.10.2016
IS20.11.2016
PT21.11.2016
IE10.03.2017
LU10.03.2017
MT10.03.2017
Former [2019/46]HU10.03.2011
AL20.07.2016
AT20.07.2016
CY20.07.2016
CZ20.07.2016
EE20.07.2016
ES20.07.2016
HR20.07.2016
IT20.07.2016
LT20.07.2016
LV20.07.2016
MC20.07.2016
PL20.07.2016
RO20.07.2016
RS20.07.2016
SI20.07.2016
SK20.07.2016
SM20.07.2016
BG20.10.2016
GR21.10.2016
IS20.11.2016
PT21.11.2016
IE10.03.2017
LU10.03.2017
MT10.03.2017
Former [2019/31]HU10.03.2011
AL20.07.2016
AT20.07.2016
CZ20.07.2016
EE20.07.2016
ES20.07.2016
HR20.07.2016
IT20.07.2016
LT20.07.2016
LV20.07.2016
MC20.07.2016
PL20.07.2016
RO20.07.2016
RS20.07.2016
SI20.07.2016
SK20.07.2016
SM20.07.2016
BG20.10.2016
GR21.10.2016
IS20.11.2016
PT21.11.2016
IE10.03.2017
LU10.03.2017
MT10.03.2017
Former [2018/46]AL20.07.2016
AT20.07.2016
CZ20.07.2016
EE20.07.2016
ES20.07.2016
HR20.07.2016
IT20.07.2016
LT20.07.2016
LV20.07.2016
MC20.07.2016
PL20.07.2016
RO20.07.2016
RS20.07.2016
SI20.07.2016
SK20.07.2016
SM20.07.2016
BG20.10.2016
GR21.10.2016
IS20.11.2016
PT21.11.2016
IE10.03.2017
LU10.03.2017
MT10.03.2017
Former [2018/43]AT20.07.2016
CZ20.07.2016
EE20.07.2016
ES20.07.2016
HR20.07.2016
IT20.07.2016
LT20.07.2016
LV20.07.2016
MC20.07.2016
PL20.07.2016
RO20.07.2016
RS20.07.2016
SI20.07.2016
SK20.07.2016
SM20.07.2016
BG20.10.2016
GR21.10.2016
IS20.11.2016
PT21.11.2016
IE10.03.2017
LU10.03.2017
MT10.03.2017
Former [2018/13]AT20.07.2016
CZ20.07.2016
EE20.07.2016
ES20.07.2016
HR20.07.2016
IT20.07.2016
LT20.07.2016
LV20.07.2016
MC20.07.2016
PL20.07.2016
RO20.07.2016
RS20.07.2016
SI20.07.2016
SK20.07.2016
SM20.07.2016
BG20.10.2016
GR21.10.2016
IS20.11.2016
PT21.11.2016
IE10.03.2017
LU10.03.2017
Former [2018/10]AT20.07.2016
CZ20.07.2016
EE20.07.2016
ES20.07.2016
HR20.07.2016
IT20.07.2016
LT20.07.2016
LV20.07.2016
MC20.07.2016
PL20.07.2016
RO20.07.2016
RS20.07.2016
SI20.07.2016
SK20.07.2016
SM20.07.2016
BG20.10.2016
GR21.10.2016
IS20.11.2016
PT21.11.2016
LU10.03.2017
Former [2018/01]AT20.07.2016
CZ20.07.2016
EE20.07.2016
ES20.07.2016
HR20.07.2016
IT20.07.2016
LT20.07.2016
LV20.07.2016
MC20.07.2016
PL20.07.2016
RO20.07.2016
RS20.07.2016
SI20.07.2016
SK20.07.2016
SM20.07.2016
BG20.10.2016
GR21.10.2016
IS20.11.2016
PT21.11.2016
Former [2017/37]AT20.07.2016
CZ20.07.2016
EE20.07.2016
ES20.07.2016
HR20.07.2016
IT20.07.2016
LT20.07.2016
LV20.07.2016
PL20.07.2016
RO20.07.2016
RS20.07.2016
SI20.07.2016
SK20.07.2016
SM20.07.2016
BG20.10.2016
GR21.10.2016
IS20.11.2016
PT21.11.2016
Former [2017/31]AT20.07.2016
CZ20.07.2016
EE20.07.2016
ES20.07.2016
HR20.07.2016
IT20.07.2016
LT20.07.2016
LV20.07.2016
PL20.07.2016
RO20.07.2016
RS20.07.2016
SK20.07.2016
SM20.07.2016
BG20.10.2016
GR21.10.2016
IS20.11.2016
PT21.11.2016
Former [2017/13]AT20.07.2016
ES20.07.2016
HR20.07.2016
IT20.07.2016
LT20.07.2016
LV20.07.2016
PL20.07.2016
RS20.07.2016
GR21.10.2016
IS20.11.2016
PT21.11.2016
Former [2017/11]AT20.07.2016
ES20.07.2016
HR20.07.2016
IT20.07.2016
LT20.07.2016
PL20.07.2016
RS20.07.2016
GR21.10.2016
IS20.11.2016
PT21.11.2016
Former [2017/09]IT20.07.2016
LT20.07.2016
Former [2017/07]LT20.07.2016
Documents cited:Search[X]EP1988159  (JAPAN SCIENCE & TECH AGENCY [JP], et al) [X] 1-18 * figures 13, 14 * * examples 1, 3,-5, 7, 8, 9 * * claims 1-55 *;
 [Y]WO2009114860  (UNIV ILLINOIS [US], et al) [Y] 1-18 * paragraph [0032]; figure 8 * * claims 1-21 *;
 [Y]WO9947163  (OSIRIS THERAPEUTICS INC [US]) [Y] 1-18 * claims 1-48 *
International search[X]WO2007080919  (JAPAN SCIENCE & TECH AGENCY [JP], et al);
 [Y]JP2007536935  (BECTON, DICKINSON AND CO.)
 [X]  - YUKIO KATO, "Mukessei Baichi de Kan'yokei Kansaibo no STEMNESS Bunshi Kiko o Kasseika suru: Kessei Saisei Iryo kara Mukessei Saisei Iryo eno Tenkan", JAPAN SOCIETY OF PLASTIC AND RECONSTRUCTIVE SURGERY KISO GAKUJUTSU SHUKAI PROGRAM SHOROKUSHU, (2009), vol. 18TH, pages 54 - 55
 [X]  - RUMI SAWADA ET AL., "Hito Kotsuzui Yurai Kan'yokei Kansaibo no in vitro Baiyo-ji ni Okeru Idenshi Hatsugen no Henka ni Tsuite, Mukessei Baichi no Eikyo", REGENERATIVE MEDICINE, (2009), vol. 8, page 248
 [Y]  - CHRISTELLE DOUCET ET AL., "Platelet Lysates Promote Mesenchymal Stem Cell Expansion: A Safety Substitute for Animal Serum in Cell- Based Therapy Applications", JOURNAL OF CELLULAR PHYSIOLOGY, (2005), vol. 205, pages 228 - 236, XP002454867

DOI:   http://dx.doi.org/10.1002/jcp.20391
 [Y]  - PANAGIOTA A. SOTIROPOULOU ET AL., "Characterization of the Optimal Culture Conditions for Clinical Scale Production of Human Mesenchymal Stem Cells", STEM CELLS, (2006), vol. 24, pages 462 - 471, XP009066391

DOI:   http://dx.doi.org/10.1634/stemcells.2004-0331
 [Y]  - MASSIMO DI NICOLA ET AL., "Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli", BLOOD, (2002), vol. 99, no. 10, pages 3838 - 3843, XP002982803

DOI:   http://dx.doi.org/10.1182/blood.V99.10.3838
by applicantWO2007080919
    - KATO YUKIO, Proceedings of Fifth Iryokiki Forum, MEDICAL EQUIPMENT FORUM, (2007), pages 33 - 35
    - KEATING, A., CELL STEM CELL, (2008), vol. 2, pages 106 - 108
    - CORCIONE, A., BLOOD, (2006), vol. 107, pages 367 - 372
    - RAMASAMY, R., TRANSPLANTATION, (2007), vol. 83, pages 71 - 76
    - AGGARWAL, S., BLOOD, (2005), vol. 105, pages 1815 - 1822
    - LE BLANC K., J INTERN MED., (2007), vol. 262, pages 509 - 525
    - DJOUAD, F., BLOOD, (2003), vol. 102, pages 3837 - 3844
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.