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EP About this file: EP2547343

EP2547343 - USE OF P2X PURINERGIC RECEPTOR AGONISTS TO ENHANCE INSULIN SECRETION IN PANCREATIC BETA CELLS [Right-click to bookmark this link]
Status	The application is deemed to be withdrawn Status updated on 20.01.2017 Database last updated on 14.06.2024
Most recent event Tooltip	20.01.2017	Application deemed to be withdrawn	published on 22.02.2017 [2017/08]
Applicant(s)	For all designated states The University of Miami 1600 N.W. 10th Avenue Miami, FL 33136 / US
	[2013/04]
Inventor(s)	01 / BERGGREN, Per-Olof c/o UMMSM 1450 NW 10th Avenue Miami, Florida 33109 / US
	02 / CAICEDO, Alejandro Diabetes Research Institute University of Miami 1450 NW 10th Avenue Miami, Florida 33109 / US
	03 / JACQUES-SILVA, M. Caroline 9 Island Avenue Apartment 909 Miami Beach, Florida 33139 / US
	[2013/04]
Representative(s)	Zwicker, Jörk, et al ZSP Patentanwälte PartG mbB Hansastraße 32 80686 München / DE
	[N/P]
Former [2013/04]	Zwicker, Jörk, et al Dr. Volker Vossius Patent- und Rechtsanwaltskanzlei Geibelstrasse 6 81679 München / DE
Application number, filing date	11757131.5	21.03.2011
	WO2011US29260
Priority number, date	US20100315612P	19.03.2010 Original published format: US 315612 P
	[2013/04]
Filing language	EN
Procedural language	EN
Publication	Type:	A2 Application without search report
	No.:	WO2011116392
	Date:	22.09.2011
	Language:	EN
	[2011/38]
	Type:	A2 Application without search report
	No.:	EP2547343
	Date:	23.01.2013
	Language:	EN
	The application published by WIPO in one of the EPO official languages on 22.09.2011 takes the place of the publication of the European patent application.
	[2013/04]
Search report(s)	International search report - published on:	KR	05.04.2012
	(Supplementary) European search report - dispatched on:	EP	17.05.2013
Classification	IPC:	A61K31/7076, A61P3/10	[2013/25]
	CPC:	A61K31/7076 (EP,KR,US); A61K31/70 (KR); A61P3/00 (EP); A61P3/10 (EP); A61P43/00 (EP); A61P5/50 (EP); (+) G01N33/5023 (US); G01N2333/62 (US) (-)
	Former IPC [2013/04]	A61K31/7076
Designated contracting states	AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2013/04]
Title	German:	VERWENDUNG PURINERGER P2X-REZEPTORAGONISTEN FÜR VERSTÄRKTE INSULINAUSSCHEIDUNG IN PANKREAS-BETA-ZELLEN	[2013/04]
	English:	USE OF P2X PURINERGIC RECEPTOR AGONISTS TO ENHANCE INSULIN SECRETION IN PANCREATIC BETA CELLS	[2013/04]
	French:	UTILISATION D'AGONISTES DE RÉCEPTEUR PURINERGIQUE DE TYPE P2X POUR RENFORCER LA SÉCRÉTION D'INSULINE DANS LES CELLULES BÊTA PANCRÉATIQUE	[2013/04]
Entry into regional phase	17.08.2012	National basic fee paid
	17.08.2012	Search fee paid
	17.08.2012	Designation fee(s) paid
	17.08.2012	Examination fee paid
Examination procedure	17.08.2012	Examination requested [2013/04]
	12.08.2013	Amendment by applicant (claims and/or description)
	13.05.2016	Despatch of a communication from the examining division (Time limit: M04)
	24.09.2016	Application deemed to be withdrawn, date of legal effect [2017/08]
	20.10.2016	Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2017/08]
Divisional application(s)	The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 13.05.2016
Fees paid	Renewal fee
	27.03.2013	Renewal fee patent year 03
	27.03.2014	Renewal fee patent year 04
	27.03.2015	Renewal fee patent year 05
	31.03.2016	Renewal fee patent year 06
Opt-out from the exclusive Tooltip competence of the Unified Patent Court	See the Register of the Unified Patent Court for opt-out data
	Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:	Search	[I]WO9936539 (ABBOTT LAB [US]) [I] 13-16 * Summary of the Invention; page 3 *
		[XY] - BERTRAND G ET AL, "P2 purinoceptor agonists stimulate somatostatin secretion from dog pancreas", EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER SCIENCE, NL, vol. 182, no. 2, doi:10.1016/0014-2999(90)90296-I, ISSN 0014-2999, (19900703), pages 369 - 373, (19900703), XP023760114 [X] 1,4-6,10-12 * abstract * [Y] 1-16 DOI: http://dx.doi.org/10.1016/0014-2999(90)90296-I
		[XY] - RIBES G ET AL, "Effects of 2-methylthio ATP on insulin secretion in the dog in vivo", EUROPEAN JOURNAL OF PHARMACOLOGY, ELSEVIER SCIENCE, NL, vol. 155, no. 1-2, doi:10.1016/0014-2999(88)90418-9, ISSN 0014-2999, (19881011), pages 171 - 174, (19881011), XP025566070 [X] 1,4-6,10-12 * Discussion; page 173 * [Y] 1-16 DOI: http://dx.doi.org/10.1016/0014-2999(88)90418-9
		[Y] - CLINTORIA RICHARDS-WILLIAMS ET AL, "Extracellular ATP and zinc are co-secreted with insulin and activate multiple P2X purinergic receptor channels expressed by islet beta-cells to potentiate insulin secretion", PURINERGIC SIGNALLING, KLUWER ACADEMIC PUBLISHERS, DO, (20081023), vol. 4, no. 4, doi:10.1007/S11302-008-9126-Y, ISSN 1573-9546, pages 393 - 405, XP019650682 [Y] 1-16 * abstract * DOI: http://dx.doi.org/10.1007/s11302-008-9126-y
		[Y] - RICHARDS-WILLIAMS CLINTORIA LATRICE ET AL, "P2X purinergic receptor channel expression in primary islets and beta-cells", FASEB JOURNAL, & EXPERIMENTAL BIOLOGY 2007 ANNUAL MEETING; WASHINGTON, DC, USA; APRIL 28 -MAY 02, 2007, (200704), vol. 21, no. 6, ISSN 0892-6638, page A1423, XP009169484 [Y] 1-16 * abstract *
		[Y] - DA SILVA MARIA CAROLINE JACQUES ET AL, "Extracellular ATP is a positive autocrine signal for insulin release in the human pancreatic beta-cell", FASEB JOURNAL, & EXPERIMENTAL BIOLOGY 2007 ANNUAL MEETING; WASHINGTON, DC, USA; APRIL 28 -MAY 02, 2007, (200704), vol. 21, no. 6, ISSN 0892-6638, pages A829 - A830, XP009169483 [Y] 1-16 * abstract *
		[Y] - WILLIAMS CLINTORIA RICHARDS ET AL, "Role of P2XR Channel Purinergic Signaling in Insulin Secretion: Implications in the Treatment of Diabetes", FASEB JOURNAL, & EXPERIMENTAL BIOLOGY ANNUAL MEETING; NEW ORLEANS, LA, USA; APRIL 18 -22, 2009, (200904), vol. 23, page 991.10, XP009169482 [Y] 1-16 * abstract *
	International search	[A]US2005065108 (FISCHER BILHA [IL], et al);
		[A]US7598031 (LIEW CHOONG-CHIN [CA]);
		[A]US2009175800 (SCHWIEBERT ERIK [US], et al)
		[X] - PETIT, P. ET AL., "Evidence for two different types of P2 receptors stimulating insulin secretion from pancreatic B cell", BR J PHARMACOL., (199811), vol. 125, no. 6, pages 1368 - 1374, XP008162137 DOI: http://dx.doi.org/10.1038/sj.bjp.0702214

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