blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News flashes

New version of the European Patent Register - SPC information for Unitary Patents.

2024-03-06

More...
blank Related links

Extract from the Register of European Patents

EP About this file: EP2553086

EP2553086 - REPROGRAMMING CELLS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  23.02.2018
Database last updated on 12.07.2024
FormerThe patent has been granted
Status updated on  17.03.2017
FormerGrant of patent is intended
Status updated on  08.03.2017
Most recent event   Tooltip10.07.2020Lapse of the patent in a contracting state
New state(s): AL
published on 12.08.2020  [2020/33]
Applicant(s)For all designated states
The Scripps Research Institute
Mail Drop TPC-8 10550 North Torrey Pines Road
La Jolla, CA 92037 / US
[2013/06]
Inventor(s)01 / ZHU, Saiyong
10550 North Torrey Pines Road
Mail TPC-8
La Jolla California 92037 / US
02 / DING, Sheng
10550 North Torrey Pines Road
Mail TPC-8
La Jolla California 92037 / US
 [2013/06]
Representative(s)J A Kemp LLP
80 Turnmill Street
London EC1M 5QU / GB
[N/P]
Former [2013/06]Campbell, Patrick John Henry
J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
Application number, filing date11763396.630.03.2011
[2017/16]
WO2011US30598
Priority number, dateUS20100406892P26.10.2010         Original published format: US 406892 P
US20100393724P15.10.2010         Original published format: US 393724 P
US20100319494P31.03.2010         Original published format: US 319494 P
[2013/06]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2011123572
Date:06.10.2011
Language:EN
[2011/40]
Type: A1 Application with search report 
No.:EP2553086
Date:06.02.2013
Language:EN
The application published by WIPO in one of the EPO official languages on 06.10.2011 takes the place of the publication of the European patent application.
[2013/06]
Type: B1 Patent specification 
No.:EP2553086
Date:19.04.2017
Language:EN
[2017/16]
Search report(s)International search report - published on:US06.10.2011
(Supplementary) European search report - dispatched on:EP29.08.2013
ClassificationIPC:C12N5/074
[2016/32]
CPC:
C12N5/0696 (EP,US); C12N2501/065 (EP,US); C12N2501/15 (EP,US);
C12N2501/41 (EP,US); C12N2501/602 (EP,US); C12N2501/603 (EP,US);
C12N2501/604 (EP,US); C12N2501/606 (EP,US); C12N2501/727 (EP,US);
C12N2501/73 (US); C12N2506/03 (US); C12N2506/094 (EP,US);
C12N2506/28 (EP,US) (-)
Former IPC [2013/40]C12N5/071
Former IPC [2013/06]C12N5/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2013/06]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:UMPROGRAMMIERUNG VON ZELLEN[2013/06]
English:REPROGRAMMING CELLS[2013/06]
French:NOUVELLE PROGRAMMATION DE CELLULES[2013/06]
Entry into regional phase17.10.2012National basic fee paid 
17.10.2012Search fee paid 
17.10.2012Designation fee(s) paid 
17.10.2012Examination fee paid 
Examination procedure17.10.2012Examination requested  [2013/06]
27.03.2014Amendment by applicant (claims and/or description)
23.04.2014Despatch of a communication from the examining division (Time limit: M06)
03.11.2014Reply to a communication from the examining division
17.11.2014Despatch of a communication from the examining division (Time limit: M06)
26.05.2015Reply to a communication from the examining division
15.06.2015Despatch of a communication from the examining division (Time limit: M04)
21.10.2015Reply to a communication from the examining division
08.08.2016Communication of intention to grant the patent
03.10.2016Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
27.10.2016Communication of intention to grant the patent
06.03.2017Fee for grant paid
06.03.2017Fee for publishing/printing paid
06.03.2017Receipt of the translation of the claim(s)
Divisional application(s)EP17160894.6  / EP3199623
EP21180031.3
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  23.04.2014
Opposition(s)22.01.2018No opposition filed within time limit [2018/13]
Fees paidRenewal fee
11.03.2013Renewal fee patent year 03
12.03.2014Renewal fee patent year 04
10.03.2015Renewal fee patent year 05
10.03.2016Renewal fee patent year 06
10.03.2017Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU30.03.2011
AL19.04.2017
AT19.04.2017
CY19.04.2017
CZ19.04.2017
DK19.04.2017
EE19.04.2017
FI19.04.2017
HR19.04.2017
LT19.04.2017
LV19.04.2017
MC19.04.2017
MK19.04.2017
NL19.04.2017
PL19.04.2017
PT19.04.2017
RO19.04.2017
RS19.04.2017
SE19.04.2017
SI19.04.2017
SK19.04.2017
SM19.04.2017
TR19.04.2017
BG19.07.2017
NO19.07.2017
GR20.07.2017
IS19.08.2017
[2020/33]
Former [2020/31]HU30.03.2011
AT19.04.2017
CY19.04.2017
CZ19.04.2017
DK19.04.2017
EE19.04.2017
FI19.04.2017
HR19.04.2017
LT19.04.2017
LV19.04.2017
MC19.04.2017
MK19.04.2017
NL19.04.2017
PL19.04.2017
PT19.04.2017
RO19.04.2017
RS19.04.2017
SE19.04.2017
SI19.04.2017
SK19.04.2017
SM19.04.2017
TR19.04.2017
BG19.07.2017
NO19.07.2017
GR20.07.2017
IS19.08.2017
Former [2020/27]HU30.03.2011
AT19.04.2017
CZ19.04.2017
DK19.04.2017
EE19.04.2017
FI19.04.2017
HR19.04.2017
LT19.04.2017
LV19.04.2017
MC19.04.2017
NL19.04.2017
PL19.04.2017
PT19.04.2017
RO19.04.2017
RS19.04.2017
SE19.04.2017
SI19.04.2017
SK19.04.2017
SM19.04.2017
TR19.04.2017
BG19.07.2017
NO19.07.2017
GR20.07.2017
IS19.08.2017
Former [2020/15]AT19.04.2017
CZ19.04.2017
DK19.04.2017
EE19.04.2017
FI19.04.2017
HR19.04.2017
LT19.04.2017
LV19.04.2017
MC19.04.2017
NL19.04.2017
PL19.04.2017
RO19.04.2017
RS19.04.2017
SE19.04.2017
SI19.04.2017
SK19.04.2017
SM19.04.2017
TR19.04.2017
BG19.07.2017
NO19.07.2017
GR20.07.2017
IS19.08.2017
Former [2018/52]AT19.04.2017
CZ19.04.2017
DK19.04.2017
EE19.04.2017
FI19.04.2017
HR19.04.2017
LT19.04.2017
LV19.04.2017
MC19.04.2017
NL19.04.2017
PL19.04.2017
RO19.04.2017
RS19.04.2017
SE19.04.2017
SI19.04.2017
SK19.04.2017
SM19.04.2017
BG19.07.2017
NO19.07.2017
GR20.07.2017
IS19.08.2017
Former [2018/25]AT19.04.2017
CZ19.04.2017
DK19.04.2017
EE19.04.2017
FI19.04.2017
HR19.04.2017
LT19.04.2017
LV19.04.2017
NL19.04.2017
PL19.04.2017
RO19.04.2017
RS19.04.2017
SE19.04.2017
SI19.04.2017
SK19.04.2017
SM19.04.2017
BG19.07.2017
NO19.07.2017
GR20.07.2017
IS19.08.2017
Former [2018/11]AT19.04.2017
CZ19.04.2017
DK19.04.2017
EE19.04.2017
FI19.04.2017
HR19.04.2017
LT19.04.2017
LV19.04.2017
NL19.04.2017
PL19.04.2017
RO19.04.2017
RS19.04.2017
SE19.04.2017
SK19.04.2017
SM19.04.2017
BG19.07.2017
NO19.07.2017
GR20.07.2017
IS19.08.2017
Former [2018/10]AT19.04.2017
CZ19.04.2017
DK19.04.2017
EE19.04.2017
FI19.04.2017
HR19.04.2017
LT19.04.2017
LV19.04.2017
NL19.04.2017
PL19.04.2017
RO19.04.2017
RS19.04.2017
SE19.04.2017
SK19.04.2017
BG19.07.2017
NO19.07.2017
GR20.07.2017
IS19.08.2017
Former [2018/09]AT19.04.2017
DK19.04.2017
EE19.04.2017
FI19.04.2017
HR19.04.2017
LT19.04.2017
LV19.04.2017
NL19.04.2017
PL19.04.2017
RS19.04.2017
SE19.04.2017
BG19.07.2017
NO19.07.2017
GR20.07.2017
IS19.08.2017
Former [2017/50]AT19.04.2017
FI19.04.2017
HR19.04.2017
LT19.04.2017
LV19.04.2017
NL19.04.2017
PL19.04.2017
RS19.04.2017
SE19.04.2017
BG19.07.2017
NO19.07.2017
GR20.07.2017
IS19.08.2017
Former [2017/49]AT19.04.2017
FI19.04.2017
HR19.04.2017
LT19.04.2017
NL19.04.2017
NO19.07.2017
GR20.07.2017
IS19.08.2017
Former [2017/48]NL19.04.2017
Documents cited:Search[E]WO2011047300  (SCRIPPS RESEARCH INST [US], et al) [E] 1-16* figure 8; example 3 *;
 [X]  - YAN SHI ET AL, "Induction of Pluripotent Stem Cells from Mouse Embryonic Fibroblasts by Oct4 and Klf4 with Small-Molecule Compounds", CELL STEM CELL, CELL PRESS, US, (20081106), vol. 3, doi:10.1016/J.STEM.2008.10.004, ISSN 1934-5909, pages 568 - 574, XP007913847 [X] 1-16 * the whole document *

DOI:   http://dx.doi.org/10.1016/j.stem.2008.10.004
International search[Y]US2008268533  (DALTON STEPHEN [US], et al);
 [Y]US2009227032  (YAMANAKA SHINYA [JP], et al);
 [Y]  - HINDIE ET AL., "Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1.", NAT CHEM BIOL, (200910), vol. 5, no. 10, pages 758 - 764, XP002641255

DOI:   http://dx.doi.org/10.1038/NCHEMBIO.208
 [Y]  - LI ET AL., "Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors.", CELL STEM CELL, (20090109), vol. 4, no. 1, pages 16 - 19, XP009139066

DOI:   http://dx.doi.org/10.1016/j.stem.2008.11.014
 [Y]  - HUANGFU ET AL., "Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds.", NAT BIOTECHNOL, (200807), vol. 26, no. 7, pages 795 - 797, XP002502536

DOI:   http://dx.doi.org/10.1038/NBT1418
 [A]  - LI ET AL., "Small molecules that modulate embryonic stem cell fate and somatic cell reprogramming.", TRENDS PHARMACOL SCI, (201001), vol. 31, no. 1, pages 36 - 45, XP026822211
 [XP]  - ZHU ET AL., "Reprogramming of human primary somatic cells by OCT4 and chemical compounds.", CELL STEM CELL, (20101203), vol. 7, no. 6, pages 651 - 655, XP055075780

DOI:   http://dx.doi.org/10.1016/j.stem.2010.11.015
ExaminationWO2009117439
    - NAKAGAWA MASATO ET AL, "Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts", NATURE BIOTECHNOLOGY, (200801), vol. 26, no. 1, ISSN 1087-0156, pages 101 - 106
    - KEISUKE KAJI ET AL, "Virus-free induction of pluripotency and subsequent excision of reprogramming factors", NATURE, NATURE PUBLISHING GROUP, UNITED KINGDOM, vol. 458, no. 7239, doi:10.1038/NATURE07864, ISSN 0028-0836, (20090409), pages 771 - 775, (20090301), XP002568858

DOI:   http://dx.doi.org/10.1038/nature07864
    - DIMOS JOHN T ET AL, "Induced pluripotent stem cells generated from patients with ALS can be differentiated into motor neurons", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE, US, (20080829), vol. 321, no. 5893, doi:10.1126/SCIENCE.1158799, ISSN 1095-9203, pages 1218 - 1221, XP002552499

DOI:   http://dx.doi.org/10.1126/science.1158799
    - LOH YUIN-HAN ET AL, "Generation of induced pluripotent stem cells from human blood", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, vol. 113, no. 22, doi:10.1182/BLOOD-2009-02-204800, ISSN 0006-4971, (20090501), pages 5476 - 5479, (20090318), XP002595207

DOI:   http://dx.doi.org/10.1182/BLOOD-2009-02-204800
    - LIU HUA ET AL, "Generation of Endoderm-Derived Human Induced Pluripotent Stem Cells from Primary Hepatocytes", HEPATOLOGY, (201005), vol. 51, no. 5, ISSN 0270-9139, pages 1810 - 1819
    - TAKAHASHI KAZUTOSHI ET AL, "Induction of pluripotent stem cells from adult human fibroblasts by defined factors", CELL, CELL PRESS, US, (20071130), vol. 131, no. 5, doi:10.1016/J.CELL.2007.11.019, ISSN 0092-8674, pages 861 - 872, XP002478584

DOI:   http://dx.doi.org/10.1016/j.cell.2007.11.019
    - LI WENLIN ET AL, "Generation of Rat and Human Induced Pluripotent Stem Cells by Combining Genetic Reprogramming and Chemical Inhibitors", CELL STEM CELL, (200901), vol. 4, no. 1, ISSN 1934-5909(print), pages 16 - 19
    - KIM DOHOON ET AL, "Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins", CELL STEM CELL, ELSEVIER, CELL PRESS, AMSTERDAM, NL, (20090605), vol. 4, no. 6, doi:10.1016/J.STEM.2009.05.005, ISSN 1934-5909, pages 472 - 476, XP002564507

DOI:   http://dx.doi.org/10.1016/j.stem.2009.05.005
    - ZHOU HONGYAN ET AL, "Generation of Induced Pluripotent Stem Cells Using Recombinant Proteins", CELL STEM CELL, ELSEVIER, CELL PRESS, AMSTERDAM, NL, (20090501), vol. 4, no. 5, doi:10.1016/J.STEM.2009.04.005, ISSN 1934-5909, pages 381 - 384, XP002532629

DOI:   http://dx.doi.org/10.1016/J.STEM.2009.04.005
by applicantUS5384253
 US5580859
 US5589466
 US5656610
 US5702932
 US5736524
 US5780448
 US5789215
 US5945100
 WO9948490
 US5981274
 US5994624
 WO0058293
 WO0071111
 WO0144216
 WO0183465
 WO0183478
 WO0185706
 WO0185707
 WO0208209
 WO0214312
 WO0246173
 WO0248106
 US6534476
 WO03047626
 WO03049686
 WO03080566
 WO03095438
 US6730293
 WO2004052869
 WO2004063179
 WO2004072066
 WO2005049019
 US2005119203
 WO2005066145
 WO2005084158
 WO2005095418
 WO2005123132
 WO2006016194
 WO2006058923
 WO2006084210
 WO2007006814
 WO2007006760
 WO2007006761
 WO2007031739
 WO2007048717
 WO2007053345
 WO2007061923
 WO2007075847
 WO2007089512
 WO2007104034
 WO2007117381
 WO2007115967
 WO2007115968
 WO2007123667
 WO2007125103
 WO2007125105
 WO2007143434
 US2008004287
 WO2008005964
 WO2008005914
 WO2008006583
 WO2008012227
 WO2008074694
 WO2008079787
 WO2008078674
 WO2008084043
 WO2008084044
 WO2008091770
 WO2008094597
 WO2008104994
 WO2008108741
 WO2008111473
 WO2008116107
 WO2008118718
 WO2008126932
 US2008268533
 EP1992360
 WO2008149382
 WO2008154563
 WO2009018065
 WO2009022179
 WO2009025781
 WO2009042435
 WO2009046784
 WO2009047798
 WO2009046802
 WO2009082152
 WO2009083553
 WO2009106203
 US2009227032
 WO2009117439
 WO2009127544
 WO2009127546
 WO2009140624
 WO2010029461
 WO2010042867
 WO2010056767
 WO2010080333
 WO2010103438
 WO2011047300
    - TAKAHASHI, K.; YAMANAKA, S., CELL, (2006), vol. 126, pages 663 - 676
    - TAKAHASHI ET AL., CELL, (2007), vol. 131, pages 861 - 872
    - YU ET AL., SCIENCE, (2007), vol. 318, pages 1917 - 1920
    - ZHOU ET AL., CELL STEM CELL, (2009), vol. 4, pages 381 - 384
    - KIM ET AL., CELL STEM CELL, (2009), vol. 4, pages 472 - 476
    - MAHERALI, N.; HOCHEDLINGER, K., CELL STEM CELL, (2009), vol. 3, pages 595 - 605
    - DALEY ET AL., CELL STEM CELL, (2009), vol. 4, pages 200 - 201
    - ZHU ET AL., CELL STEM CELL, (2010), vol. 7, pages 651 - 655
    - SAHA, K.; JAENISCH, R., CELL STEM CELL, (2009), vol. 5, pages 584 - 595
    - SHI ET AL., CELL STEM CELL, (2008), vol. 2, pages 525 - 528
    - SHI ET AL., CELL STEM CELL, (2008), vol. 3, pages 568 - 574
    - HUANGFU ET AL., NAT BIOTECHNOL, (2008), vol. 26, pages 795 - 797
    - HUANGFU ET AL., NAT BIOTECHNOL, (2008), vol. 26, pages 1269 - 1275
    - SILVA ET AL., PLOS BIO, (2008), vol. 6, page E253
    - LYSSIOTIS ET AL., PNAS, (2009), vol. 106, pages 8912 - 8917
    - ICHIDA ET AL., CELL STEM CELL, (2009), vol. 5, pages 491 - 503
    - MAHERALI, N.; HOCHEDLINGER, K., CURR BIOL, (2009), vol. 19, pages 1718 - 1723
    - ESTEBAN ET AL., CELL STEM CELL, (2010), vol. 6, pages 71 - 79
    - FENG ET AL., CELL STEM CELL, (2009), vol. 4, pages 301 - 312
    - KIM ET AL., CELL, (2009), vol. 136, pages 411 - 419
    - KIM ET AL., NATURE, (2009), vol. 461, pages 643 - 649
    - NUNES ET AL., NAT MED, (2003), vol. 9, pages 439 - 447
    - RYAN, A.K.; ROSENFELD, M.G., GENES DEV., (1997), vol. 11, pages 1207 - 1225
    - DANG, D.T.; PEVSNER, J.; YANG, V.W., CELL BIOL., (2000), vol. 32, pages 1103 - 1121
    - NAKAGAWA ET AL., NATURE BIOTECHNOLOGY, (2007), vol. 26, pages 101 - 106
    - ADHIKARY, S.; EILERS, M., NAT. REV. MOL. CELL BIOL., (2005), vol. 6, pages 635 - 645
    - DANG, D.T. ET AL., INT. J. BIOCHEM. CELL BIOL., (2000), vol. 32, pages 1103 - 1121
    - KUBICEK ET AL., MOL. CELL, (2007), pages 473 - 481
    - RUTHENBURG ET AL., MOL. CELL, (2007), vol. 25, pages 15 - 30
    - BATZER ET AL., NUCLEIC ACID RES., (1991), vol. 19, page 5081
    - OHTSUKA ET AL., J. BIOL. CHEM., (1985), vol. 260, pages 2605 - 2608
    - ROSSOLINI ET AL., MOL. CELL. PROBES, (1994), vol. 8, pages 91 - 98
    - PEARL ET AL., CURR. OPIN. STRUCT. BIOL., (2002), vol. 12, pages 761 - 767
    - BIONDI ET AL., BIOCHEM. J., (2003), vol. 372, pages 1 - 13
    - NEWTON ET AL., CHEM. REV., (2001), vol. 101, pages 2353 - 2364
    - KING ET AL., JOURNAL OF BIOLOGICAL CHEMISTRY, (2000), vol. 275, pages 18108 - 18113
    - HINDIE ET AL., NATURE CHEMICAL BIOLOGY, (2009), vol. 5, pages 758 - 764
    - HUSE; KURIYAN, CELL, (2002), vol. 109, pages 275 - 282
    - JOHNSON; LEWIS, CHEM. REV., (2001), vol. 101, pages 2209 - 2242
    - ENGEL ET AL., EMBO J., (2006), vol. 25, pages 5469 - 5480
    - STROBA ET AL., J. MED. CHEM., (2009), vol. 52, pages 4683 - 4693
    - BROCKLEHURST ET AL., DIABETES, (2004), vol. 53, pages 535 - 541
    - GRIMSBY ET AL., SCIENCE, (2003), vol. 301, pages 370 - 373
    - KAMATA ET AL., STRUCTURE, (2004), vol. 12, pages 429 - 438
    - EFANOV ET AL., ENDOCRINOLOGY, (2005), vol. 146, pages 3696 - 3701
    - OGURA ET AL., JOURNAL OF ENDOCRINOLOGY, (2000), vol. 164, pages 171 - 178
    - FONG ET AL., CELLULAR SIGNALLING, (1996), vol. 8, pages 179 - 183
    - MOLECULAR BRAIN RESEARCH, (1992), vol. 15, pages 221 - 226
    - MOLE ET AL., BIOORG MED CHEM LETT., (2003), vol. 13, pages 2677 - 80
    - IVAN ET AL., PROC NATL ACAD SCI USA, (2002), vol. 99, pages 13459 - 13464
    - DERY ET AL., INT JBIOCHEM CELL BIO., (2004), vol. 37, pages 535 - 540
    - PAGE ET AL., JBIOL CHEM., (2002), vol. 277, pages 48403 - 48409
    - LI ET AL., NAT MED, (2000), vol. 6, pages 49 - 55
    - MARANCHIE ET AL., CANCER CELL, (2002), vol. 1, pages 247 - 255
    - ADCOCK, BRITISH JOURNAL OF PHARMACOLOGY, (2007), vol. 150, pages 829 - 831
    - MUNSTER ET AL., JOURNAL OF CLINICAL ONCOLOGY, (2007), vol. 25, no. 18S, page 1065
    - HAN ET AL., IMMUNOLOGY LETTERS, (2007), vol. 108, pages 143 - 150
    - KELLY ET AL., NATURE CLINICAL PRACTICE ONCOLOGY, (2005), vol. 2, pages 150 - 157
    - GORE ET AL., CANCER RESEARCH, (2006), vol. 66, pages 6361 - 6369
    - ZHU ET AL., CURRENT MEDICINAL CHEMISTRY, (2003), vol. 3, no. 3, pages 187 - 199
    - FURUMAI ET AL., PNAS, (2001), vol. 98, no. 1, pages 87 - 92
    - INMAN ET AL., MOLECULAR PHARMACOLOGY, (2002), vol. 62, no. 1, pages 65 - 74
    - TOJO ET AL., CANCER SCIENCE, (2005), vol. 96, no. 11, pages 791 - 800
    - GELLIBERT ET AL., JOURNAL OFMEDICINAL CHEMISTRY, (2006), vol. 49, no. 7, pages 2210 - 2221
    - SUZUKI ET AL., CANCER RESEARCH, (2007), vol. 67, no. 5, pages 2351 - 2359
    - KIM ET AL., XENOBIOTICA, (2008), vol. 38, no. 3, pages 325 - 339
    - DE GOUVILLE ET AL., DRUG NEWS PERSPECTIVE, (2006), vol. 19, no. 2, pages 85 - 90
    - DACOSTA ET AL., MOLECULAR PHARMACOLOGY, (2004), vol. 65, no. 3, pages 744 - 752
    - WRZESINSKI ET AL., CLINICAL CANCER RESEARCH, (2007), vol. 13, no. 18, pages 5262 - 5270
    - KAMINSKA ET AL., ACTA BIOCHIMICA POLONICA, (2005), vol. 52, no. 2, pages 329 - 337
    - CHANG ET AL., FRONTIERS IN BIOSCIENCE, (2007), vol. 12, pages 4393 - 4401
    - INMAN ET AL., J, MOL. PHAMACOL., (2002), vol. 62, no. 1, pages 65 - 74
    - SHIMANUKI ET AL., ONCOGENE, (2007), vol. 26, pages 3311 - 3320
    - CUI ET AL., ONCOGENE, (2005), vol. 24, pages 3864 - 3874
    - ZHAO ET AL., MOLECULAR BIOLOGY OF THE CELL, (2006), vol. 17, pages 3819 - 3831
    - RINEHART ET AL., JOURNAL OF CLINICAL ONCOLOGY, (2004), vol. 22, pages 4456 - 4462
    - KLEIN ET AL., NEOPLASIA, (2006), vol. 8, pages 1 - 8
    - MATTINGLY ET AL., THE JOURNAL OFPHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, (2006), vol. 316, pages 456 - 465
    - RINEHART ET AL., JOURNAL OF CLINICAL ONCOLOGY, (2004), vol. 22, no. 22, pages 4456 - 4462
    - ENGLISH ET AL., TRENDS IN PHARMACEUTICAL SCIENCES, (2002), vol. 23, no. 1, pages 40 - 45
    - CHOW ET AL., CYTOMETRY (COMMUNICATIONS IN CLINICAL CYTOMETRY), (2001), vol. 46, pages 72 - 78
    - OKITA, K.; ICHISAKA, T.; YAMANAKA, S., NATURE, (2007), vol. 448, pages 313 - 317
    - WERNIG, M. ET AL., NATURE, (2007), vol. 448, pages 318 - 324
    - MAHERALI, N. ET AL., CELL STEM CELL, (2007), vol. 1, pages 55 - 70
    - MEISSNER, A.; WERNIG, M.; JAENISCH, R., NATURE BIOTECHNOL., (2007), vol. 25, pages 1177 - 1181
    - TAKAHASHI, K. ET AL., CELL, (2007), vol. 131, pages 861 - 872
    - YU, J. ET AL., SCIENCE, (2007), vol. 318, pages 1917 - 1920
    - NAKAGAWA, M. ET AL., NATURE BIOTECHNOL., (2007), vol. 26, pages 101 - 106
    - WERNIG, M.; MEISSNER, A.; CASSADY, J. P.; JAENISCH, R., CELL STEM CELL, (2008), vol. 2, pages 10 - 12
    - HOCKEMEYER ET AL., CELL STEM CELL., (20071211), vol. 3, no. 3, pages 346 - 53
    - LOWRY ET AL., PROC NATL ACAD SCI USA., (2008), vol. 105, no. 8, pages 2883 - 8
    - PARK ET AL., NATURE, (2008), vol. 451, no. 7175, pages 141 - 6
    - NAKAGAWA ET AL., NAT BIOTECHNOL., (200801), vol. 26, no. 1, pages 101 - 6
    - TAKAHASHI ET AL., CELL, (2007), vol. 131, no. 5, pages 861 - 72
    - YU ET AL., SCIENCE, (2007), vol. 318, no. 5858, pages 1917 - 20
    - STADTFELD, M. ET AL., SCIENCE, (2008), vol. 322, pages 945 - 949
    - OKITA, K. ET AL., SCIENCE, (2008), vol. 322, pages 949 - 953
    - WOLTJEN, K. ET AL., NATURE, (2009), vol. 458, pages 766 - 770
    - YUSA ET AL., NAT. METHODS, (2009), vol. 6, pages 363 - 369
    - KAJI, K. ET AL., NATURE, (2009), vol. 458, pages 771 - 775
    - SOLDNER, F. ET AL., CELL, (2009), vol. 136, pages 964 - 977
    - ZHOU H ET AL., CELL STEM CELL, (20090508), vol. 4, no. 5, pages 381 - 4
    - JOLIOT ET AL., NEW BIOL., (1991), vol. 3, pages 1121 - 34
    - JOLIOT ET AL., PROC. NATL. ACAD. SCI. USA, (1991), vol. 88, pages 1864 - 8
    - LE ROUX ET AL., PROC. NATL. ACAD. SCI. USA, (1993), vol. 90, pages 9120 - 4
    - ELLIOTT; O'HARE, CELL, (1997), vol. 88, pages 223 - 33
    - GREEN; LOEWENSTEIN, CELL, (1988), vol. 55, pages 1179 - 1188
    - FRANKEL; PABO, CELL, (1988), vol. 55, no. 1, pages 289 - 1193
    - STADTFELD; HOCHEDLINGER, NATURE METHODS, (2009), vol. 6, no. 5, pages 329 - 330
    - WOLTJEN ET AL., NATURE, (20090409), vol. 458, pages 766 - 770
    - WILSON ET AL., SCIENCE, (1989), vol. 244, pages 1344 - 1346
    - NABEL; BALTIMORE, NATURE, (1987), vol. 326, pages 711 - 713
    - HARLAND; WEINTRAUB, J. CELL BIOL., (1985), vol. 101, pages 1094 - 1099
    - TUR-KASPA ET AL., MOL. CELL BIOL., (1986), vol. 6, pages 716 - 718
    - POTTER ET AL., PROC. NAT'L ACAD. SCI. USA, (1984), vol. 81, pages 7161 - 7165
    - GRAHAM; VAN DER EB, VIROLOGY, (1973), vol. 52, pages 456 - 467
    - CHEN; OKAYAMA, MOL. CELL BIOL., (1987), vol. 7, no. 8, pages 2745 - 2752
    - RIPPE ET AL., MOL. CELL BIOL., (1990), vol. 10, pages 689 - 695
    - GOPAL, MOL. CELL BIOL., (1985), vol. 5, pages 1188 - 1190
    - FECHHEIMER ET AL., PROC. NAT'L ACAD. SCI. USA, (1987), vol. 84, pages 8463 - 8467
    - NICOLAU; SENE, BIOCHIM. BIOPHYS. ACTA, (1982), vol. 721, pages 185 - 190
    - FRALEY ET AL., PROC. NAT'L ACAD. SCI. USA, (1979), vol. 76, pages 3348 - 3352
    - NICOLAU ET AL., METHODS ENZYMOL., (1987), vol. 149, pages 157 - 176
    - WONG ET AL., GENE, (1980), vol. 10, pages 87 - 94
    - KANEDA ET AL., SCIENCE, (1989), vol. 243, pages 375 - 378
    - KATO ET AL., JBIOL. CHEM.,, (1991), vol. 266, pages 3361 - 3364
    - WU; WU, BIOCHEMISTRY, (1988), vol. 27, pages 887 - 892
    - WU; WU, J. BIOL. CHEM., (1987), vol. 262, pages 4429 - 4432
    - AASEN, T. ET AL., NAT BIOTECHNOL, (2008), vol. 26, pages 1276 - 1284
    - MAHERALI, N. ET AL., CELL STEM CELL, (2008), vol. 3, pages 340 - 345
    - LIN, T. ET AL., NAT METHODS, (2009), vol. 6, pages 805 - 808
    - LI, W. ET AL., STEM CELLS, (2009), vol. 27, pages 2992 - 3000
    - HINDIE, V. ET AL., NAT CHEM BIOL, (2009), vol. 4, pages 758 - 764
    - MANNING, B. D.; CANTLEY, CELL, (2007), vol. 129, pages 1261 - 1274
    - KONDOH, H. ET AL., ANTIOXID REDOX SIGNAL, (2007), vol. 9, pages 293 - 299
    - HEIDEN, M. G. V. ET AL., SCIENCE, (2009), vol. 324, pages 1029 - 1033
    - YOSHIDA, Y. ET AL., CELL STEM CELL, (2009), vol. 5, pages 237 - 241
    - GORDAN, J. D. ET AL., CANCER CELL, (2007), vol. 12, pages 108 - 113
    - DEBERARDINIS, R. J. ET AL., CELL METABOLISM, (2008), vol. 7, pages 11 - 20
    - HEWITSON, K. S.; SCHOFIELD, C. J., DRUG DISCOV TODAY, (2004), vol. 9, pages 704 - 711
    - PELICANO, H. ET AL., ONCOGENE, (2006), vol. 25, pages 4633 - 4646
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.