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Extract from the Register of European Patents

EP About this file: EP2556058

EP2556058 - RADIOPROTECTOR COMPOUNDS AND METHODS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  20.04.2018
Database last updated on 28.05.2024
FormerThe patent has been granted
Status updated on  12.05.2017
FormerGrant of patent is intended
Status updated on  03.01.2017
Most recent event   Tooltip10.07.2020Lapse of the patent in a contracting state
New state(s): AL		published on 12.08.2020  [2020/33]
Applicant(s)For all designated states
Peter MacCallum Cancer Institute
Smorgon Family Building St Andrew's Place
East Melbourne, VIC 3002 / AU
[2013/07]
Inventor(s)01 / MARTIN, Roger, Francis
10/165 Ford Street
Ivanhoe, Victoria 3079 / AU
02 / WHITE, Jonathan
11 Freeman Street
Wheelers Hill, Victoria 3150 / AU
03 / LOBACHEVSKY, Pavel
3 Reichelt Avenue
Montmorency, Victoria 3094 / AU
04 / WINKLER, David
5/158-160 Wattletree Road
Malvern, Victoria 3144 / AU
05 / SKENE, Colin
1/10 Shirley Avenue
Glen Waverley, Victoria 3150 / AU
06 / MARCUCCIO, Sebastian
5 Sporing Court
Endeavour Hills, Victoria 3802 / AU
 [2013/07]
Representative(s)Goodall, Scott, et al
Sagittarius IP
Marlow International
Parkway
Marlow SL7 1YL / GB
[N/P]
Former [2013/19]Goodall, Scott, et al
Sagittarius IP
Three Globeside
Fieldhouse Lane
Marlow, Buckinghamshire SL7 1HZ / GB
Former [2013/07]Sagittarius IP
Three Globeside
Fieldhouse Lane
Marlow
Buckinghamshire SL7 1HZ / GB
Application number, filing date11764947.506.04.2011
[2017/24]
WO2011AU00392
Priority number, dateUS20100321288P06.04.2010         Original published format: US 321288 P
[2013/07]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2011123890
Date:13.10.2011
Language:EN
[2011/41]
Type: A1 Application with search report 
No.:EP2556058
Date:13.02.2013
Language:EN
The application published by WIPO in one of the EPO official languages on 13.10.2011 takes the place of the publication of the European patent application.
[2013/07]
Type: B1 Patent specification 
No.:EP2556058
Date:14.06.2017
Language:EN
[2017/24]
Search report(s)International search report - published on:AU13.10.2011
(Supplementary) European search report - dispatched on:EP27.08.2013
ClassificationIPC:C07D235/18, A61P39/00, A61K31/4184, A61P43/00
[2013/07]
CPC:
C07D401/14 (EP,US); C07D405/14 (EP,KR,US); A61K31/496 (KR);
A61P39/00 (EP); A61P43/00 (EP); C07D235/18 (EP,KR,US);
C07D403/14 (EP,US); C07D413/04 (EP,US); C07D413/14 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2013/07]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:RADIOPROTEKTORVERBINDUNGEN UND -VERFAHREN[2013/07]
English:RADIOPROTECTOR COMPOUNDS AND METHODS[2013/07]
French:COMPOSÉS RADIOPROTECTEURS ET PROCÉDÉS CORRESPONDANTS[2013/07]
Entry into regional phase05.11.2012National basic fee paid 
05.11.2012Search fee paid 
05.11.2012Designation fee(s) paid 
05.11.2012Examination fee paid 
Examination procedure05.11.2012Examination requested  [2013/07]
31.03.2014Amendment by applicant (claims and/or description)
19.02.2015Despatch of a communication from the examining division (Time limit: M06)
30.07.2015Reply to a communication from the examining division
20.11.2015Despatch of a communication from the examining division (Time limit: M06)
06.05.2016Reply to a communication from the examining division
04.01.2017Communication of intention to grant the patent
04.05.2017Fee for grant paid
04.05.2017Fee for publishing/printing paid
04.05.2017Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  19.02.2015
Opposition(s)15.03.2018No opposition filed within time limit [2018/21]
Fees paidRenewal fee
12.06.2013Renewal fee patent year 03
25.03.2014Renewal fee patent year 04
10.04.2015Renewal fee patent year 05
11.04.2016Renewal fee patent year 06
10.04.2017Renewal fee patent year 07
Penalty fee
Additional fee for renewal fee
30.04.201303   M06   Fee paid on   12.06.2013
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU06.04.2011
AL14.06.2017
AT14.06.2017
CY14.06.2017
CZ14.06.2017
DK14.06.2017
EE14.06.2017
ES14.06.2017
FI14.06.2017
HR14.06.2017
IT14.06.2017
LT14.06.2017
LV14.06.2017
MC14.06.2017
MK14.06.2017
NL14.06.2017
PL14.06.2017
PT14.06.2017
RO14.06.2017
RS14.06.2017
SE14.06.2017
SI14.06.2017
SK14.06.2017
SM14.06.2017
TR14.06.2017
BG14.09.2017
NO14.09.2017
GR15.09.2017
IS14.10.2017
[2020/33]
Former [2020/31]HU06.04.2011
AT14.06.2017
CY14.06.2017
CZ14.06.2017
DK14.06.2017
EE14.06.2017
ES14.06.2017
FI14.06.2017
HR14.06.2017
IT14.06.2017
LT14.06.2017
LV14.06.2017
MC14.06.2017
MK14.06.2017
NL14.06.2017
PL14.06.2017
PT14.06.2017
RO14.06.2017
RS14.06.2017
SE14.06.2017
SI14.06.2017
SK14.06.2017
SM14.06.2017
TR14.06.2017
BG14.09.2017
NO14.09.2017
GR15.09.2017
IS14.10.2017
Former [2020/27]HU06.04.2011
AT14.06.2017
CZ14.06.2017
DK14.06.2017
EE14.06.2017
ES14.06.2017
FI14.06.2017
HR14.06.2017
IT14.06.2017
LT14.06.2017
LV14.06.2017
MC14.06.2017
NL14.06.2017
PL14.06.2017
PT14.06.2017
RO14.06.2017
RS14.06.2017
SE14.06.2017
SI14.06.2017
SK14.06.2017
SM14.06.2017
TR14.06.2017
BG14.09.2017
NO14.09.2017
GR15.09.2017
IS14.10.2017
Former [2020/15]AT14.06.2017
CZ14.06.2017
DK14.06.2017
EE14.06.2017
ES14.06.2017
FI14.06.2017
HR14.06.2017
IT14.06.2017
LT14.06.2017
LV14.06.2017
MC14.06.2017
NL14.06.2017
PL14.06.2017
RO14.06.2017
RS14.06.2017
SE14.06.2017
SI14.06.2017
SK14.06.2017
SM14.06.2017
TR14.06.2017
BG14.09.2017
NO14.09.2017
GR15.09.2017
IS14.10.2017
Former [2018/52]AT14.06.2017
CZ14.06.2017
DK14.06.2017
EE14.06.2017
ES14.06.2017
FI14.06.2017
HR14.06.2017
IT14.06.2017
LT14.06.2017
LV14.06.2017
MC14.06.2017
NL14.06.2017
PL14.06.2017
RO14.06.2017
RS14.06.2017
SE14.06.2017
SI14.06.2017
SK14.06.2017
SM14.06.2017
BG14.09.2017
NO14.09.2017
GR15.09.2017
IS14.10.2017
Former [2018/39]AT14.06.2017
CZ14.06.2017
DK14.06.2017
EE14.06.2017
ES14.06.2017
FI14.06.2017
HR14.06.2017
IT14.06.2017
LT14.06.2017
LV14.06.2017
NL14.06.2017
PL14.06.2017
RO14.06.2017
RS14.06.2017
SE14.06.2017
SI14.06.2017
SK14.06.2017
SM14.06.2017
BG14.09.2017
NO14.09.2017
GR15.09.2017
IS14.10.2017
Former [2018/21]AT14.06.2017
CZ14.06.2017
DK14.06.2017
EE14.06.2017
ES14.06.2017
FI14.06.2017
HR14.06.2017
IT14.06.2017
LT14.06.2017
LV14.06.2017
NL14.06.2017
PL14.06.2017
RO14.06.2017
RS14.06.2017
SE14.06.2017
SK14.06.2017
SM14.06.2017
BG14.09.2017
NO14.09.2017
GR15.09.2017
IS14.10.2017
Former [2018/11]AT14.06.2017
CZ14.06.2017
EE14.06.2017
ES14.06.2017
FI14.06.2017
HR14.06.2017
IT14.06.2017
LT14.06.2017
LV14.06.2017
NL14.06.2017
PL14.06.2017
RO14.06.2017
RS14.06.2017
SE14.06.2017
SK14.06.2017
SM14.06.2017
BG14.09.2017
NO14.09.2017
GR15.09.2017
IS14.10.2017
Former [2018/10]AT14.06.2017
CZ14.06.2017
EE14.06.2017
ES14.06.2017
FI14.06.2017
HR14.06.2017
LT14.06.2017
LV14.06.2017
NL14.06.2017
RO14.06.2017
RS14.06.2017
SE14.06.2017
SK14.06.2017
BG14.09.2017
NO14.09.2017
GR15.09.2017
Former [2018/09]EE14.06.2017
ES14.06.2017
FI14.06.2017
HR14.06.2017
LT14.06.2017
LV14.06.2017
NL14.06.2017
RS14.06.2017
SE14.06.2017
BG14.09.2017
NO14.09.2017
GR15.09.2017
Former [2017/52]ES14.06.2017
FI14.06.2017
HR14.06.2017
LT14.06.2017
LV14.06.2017
NL14.06.2017
RS14.06.2017
SE14.06.2017
BG14.09.2017
NO14.09.2017
GR15.09.2017
Former [2017/50]ES14.06.2017
FI14.06.2017
HR14.06.2017
LT14.06.2017
LV14.06.2017
RS14.06.2017
SE14.06.2017
BG14.09.2017
NO14.09.2017
GR15.09.2017
Former [2017/49]ES14.06.2017
FI14.06.2017
HR14.06.2017
LT14.06.2017
NO14.09.2017
GR15.09.2017
Documents cited:Search[XA]WO2007045096  (UNIV SASKATCHEWAN [CA], et al) [X] 1,5,12,16 * 1-methyl-5-[6-(4-methyl-1-piperazinyl)[2,6'-bi-1H-benzimidazol]-2'-yl]-1H-Pyrrol-3-amine with Registry Number RN 934993-01-8 1-methyl-4-[[(1-methyl-1H-imidazol-2-yl)carbonyl]amino]-N-[1-methyl-5-[6-(4-methyl-1-piperazinyl)[2,6'-bi-1H-benzimidazol]-2'-yl]-1H-pyrrol-3-yl]-1H-Imidazole-2-carboxamide with Registry number 934992-57-1 1-methyl-N-[1-methyl-5-[6-(4-methyl-1-piperazinyl)[2,6'-bi-1H-benzimidazol]-2'-yl]-1H-pyrrol-3-yl]-1H-Imidazole-2-carboxamide with Registry number 934992-56-0 * * figure 4 * * the whole document * [A] 2-4,6-11,13-15;
 [XI]  - SINGH M P ET AL, "synthetic utility of catalytic Fe(III)/Fe(II) redox cycling towards fused heterocycles : A FACILE ACCESS TO SUBSTITUTED BENZIMIDAZOLE, BISBENZIMIDAZOLE AND IMIDAZOPYRIDINE DERIVATIVES", SYNTHESIS, GEORG THIEME VERLAG, STUTTGART, DE, (20000101), no. 10, doi:10.1055/S-2000-7111, ISSN 0039-7881, pages 1380 - 1390, XP002340033 [X] 1,5,12 * compounds 12, 14, 15 * * the whole document * [I] 2-4,6-11,13-16

DOI:   http://dx.doi.org/10.1055/s-2000-7111
 [A]  - KELLY D P ET AL, "DNA BINDING COMPOUNDS. VI SYNTHESIS AND CHARACTERIZATION OF 2,5'-DISUBSTITUTED BIBENZIMIDAZOLES RELATED TO THE DNA MINOR GROOVEBINDER HOECHST 33258", AUSTRALIAN JOURNAL OF CHEMISTRY, CSIRO - COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANIZATION, AUSTRALIA, (19940101), vol. 47, no. 9, ISSN 0004-9425, pages 1751 - 1769, XP000826532 [A] 1-16 * the whole document *
International search[A]WO9704776  (PETER MACCALLUM CANCER INST [AU], et al);
 [A]WO2004063170  (UNIV DELHI [IN], et al);
 [A]WO2008074091  (PETER MACCALLUM CANCER INST [AU], et al);
 [A]  - TAWAR, U. ET AL., "Influence of Phenyl Ring Disubstitution on Bisbenzimidazole and Terbenzimidazole Cytotoxicity: Synthesis and Biological Evaluation as Radioprotectors", JOURNAL OF MEDICINAL CHEMISTRY, (2003), vol. 46, no. 18, pages 3785 - 3792, XP002288100

DOI:   http://dx.doi.org/10.1021/jm030114w
by applicantWO9704776
 WO0220500
 WO2005070906
 WO2008074091
    - METZ ET AL., CLIN CANCER RES., (2004), vol. 10, pages 6411 - 17
    - BURDELYA ET AL., SCIENCE, (2008), vol. 320, pages 226 - 30
    - Remington's Pharmaceutical Sciences, MACK PUBLISHING CO
    - KELLY ET AL., AUST. J. CHEM., (1994), vol. 47, pages 247 - 262
    - WHITTAKER, J. CHEM. SOC., (1951), page 1565
    - J. MED. CHEM., (2007), vol. 50, no. 15, pages 3561 - 3572
    - WASELENKO, J. K.; MACVITTIE, T. J.; BLAKELY, W. F.; PESIK, N.; WILEY, A. L.; DICKERSON, W. E.; TSU, H.; CONFER, D. L.; COLEMAN, C., "Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group", ANN INTERN MED, (2004), vol. 140, doi:doi:10.7326/0003-4819-140-12-200406150-00015, pages 1037 - 1051, XP002683131

DOI:   http://dx.doi.org/10.7326/0003-4819-140-12-200406150-00015
    - SMITH, P.J.; ANDERSON, C.O., INT. J. RADIAT. BIOL., (1984), vol. 46, page 331
    - YOUNG, S.D.; HILL, R.P., BRIT. J. CANCER, (1989), vol. 60, pages 715 - 721
    - MARTIN RF; BROADHURST S; REUM ME; SQUIRE CJ; CLARK GR; LOBACHEVSKY PN; WHITE JM; CLARK C; SY D; SPOTHEIM-MAURIZOT M, "In vitro studies with methylproamine: a potent new radioprotector", CANCER RES., (2004), vol. 64, no. 3, doi:doi:10.1158/0008-5472.CAN-03-2423, pages 1067 - 70, XP002517081

DOI:   http://dx.doi.org/10.1158/0008-5472.CAN-03-2423
    - KELLY, D. P.; BATEMAN, S. A.; HOOK, R. J.; MARTIN, R. F.; REUM, M. E.; ROSE, M.; WHITTAKER, A. R. D, AUST. J. CHEM., (1994), vol. 47, pages 1751 - 1769
    - SMITH PP; BRYANT EM; KAUR P; MCDOUGALL JK, "Cytogenetic analysis of eight human papillomavirus immortalized human keratinocyte cell lines", INT. J. CANCER, (19891215), vol. 44, no. 6, pages 1124 - 31
    - KELLY, D. P.; BATEMAN, S. A.; MARTIN, R. F.; ROSE, M.; WHITTAKER, A. R. D., AUST. J. CHEM., (1994), vol. 47, pages 247 - 262
    - KUZNETSOV ET AL., ZH. ORG. KHIM., (1986), vol. 22, pages 455 - 6
    - RENHOWE ET AL., J. MED. CHEM., (2009), vol. 52, pages 278 - 292
    - OKUMURA ET AL., BULL. CHEM. SOC. JAP., (1960), vol. 33, pages 1471 - 1472
    - RAM ET AL., J. HETEROCYCLIC CHEM., (1989), vol. 26, pages 1053 - 1059
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.