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Extract from the Register of European Patents

EP About this file: EP2635565

EP2635565 - 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS [Right-click to bookmark this link]
StatusThe application has been withdrawn
Status updated on  12.09.2014
Database last updated on 22.08.2024
Most recent event   Tooltip12.09.2014Withdrawal of applicationpublished on 15.10.2014  [2014/42]
Applicant(s)For all designated states
Amgen Inc.
One Amgen Center Drive
Thousand Oaks, California 91320-1799 / US
[2013/37]
Inventor(s)01 / FISHER, Benjamin
411-23rd Avenue
San Mateo California 94403 / US
02 / JOHNSON, Michael G.
409 Clipper Street
San Francsicso California 94114 / US
03 / LUCAS, Brian
133 10th Avenue
San Francisco California 94118 / US
04 / SHIN, Youngsook
64 Loop 22
Emeryville California 94608 / US
05 / KAIZERMAN, Jacob
.
deceased / US
 [2013/37]
Representative(s)Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastrasse 30
81925 München / DE
[N/P]
Former [2013/37]HOFFMANN EITLE
Patent- und Rechtsanwälte
Arabellastrasse 4
81925 München / DE
Application number, filing date11785857.104.11.2011
WO2011US59309
Priority number, dateUS20100410278P04.11.2010         Original published format: US 410278 P
[2013/37]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2012061696
Date:10.05.2012
Language:EN
[2012/19]
Type: A1 Application with search report 
No.:EP2635565
Date:11.09.2013
Language:EN
The application published by WIPO in one of the EPO official languages on 10.05.2012 takes the place of the publication of the European patent application.
[2013/37]
Search report(s)International search report - published on:EP10.05.2012
ClassificationIPC:C07D401/12, C07D401/14, C07D473/34, C07D239/48, C07D403/12, A61K31/506, A61K31/52, A61K31/505, A61P29/00, A61P19/02, A61P35/00, A61P37/00
[2013/37]
CPC:
C07D239/48 (EP,US); A61P1/04 (EP); A61P17/02 (EP);
A61P17/06 (EP); A61P19/02 (EP); A61P19/08 (EP);
A61P21/04 (EP); A61P25/00 (EP); A61P27/02 (EP);
A61P29/00 (EP); A61P35/00 (EP); A61P37/00 (EP);
A61P37/02 (EP); A61P37/08 (EP); A61P43/00 (EP);
A61P7/00 (EP); A61P7/06 (EP); C07D401/12 (EP,US);
C07D401/14 (EP,US); C07D403/12 (EP,US); C07D473/34 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2013/37]
Extension statesBA22.05.2013
ME22.05.2013
TitleGerman:5 -CYANO-4, 6 -DIAMINOPYRIMIDIN ODER 6 -AMINOPURINDERIVATE ALS PI3K-DELTA-INHIBITOREN[2013/37]
English:5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS[2013/37]
French:DÉRIVÉS DE LA 5-CYANO-4,6-DIAMINOPYRIMIDINE OU DE LA 6-AMINOPURINE EN TANT QU'INHIBITEURS DE LA PI3K-DELTA[2013/37]
Entry into regional phase22.05.2013National basic fee paid 
22.05.2013Designation fee(s) paid 
22.05.2013Examination fee paid 
Examination procedure22.05.2013Amendment by applicant (claims and/or description)
22.05.2013Examination requested  [2013/37]
02.09.2014Application withdrawn by applicant  [2014/42]
Fees paidRenewal fee
18.11.2013Renewal fee patent year 03
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Cited inInternational search[X]WO2008118454  (AMGEN INC [US]) [X] 1-5 * scheme p.49;;; examples 3-10,12,25,26; claims 1-10 *;
 [X]WO2008118455  (AMGEN INC [US]) [X] 1-5 * examples 1-6, 9; claims 1-10 *;
 [X]WO2008118468  (AMGEN INC [US]) [X] 1-5 * examples 1-7,9-13,16,17,21,23-27,...; claims 1-10 *;
 [X]WO2009081105  (UCB PHARMA SA [BE], et al) [X] 1-5 * examples 4-8,11-17,19-43,45-47,...; claims 1-5,8,11-15 *;
 [X]WO2010092340  (UCB PHARMA SA [BE], et al) [X] 1-5 * examples 1,3-5,13,16,22,35,...; claims 1-16 *;
 [XP]WO2011075628  (AMGEN INC [US], et al) [XP] 1-5 * examples 1-3,6; claims 1-4 *;
 [XP]WO2011075630  (INCYTE CORP [US], et al) [XP] 1-5 * examples 1,3-10,,12,13,15-57,...; claims 1-82 *;
 [E]WO2012003271  (AMGEN INC [US], et al) [E] 1-5 * examples 1,3,8,13-16,18; claims 1-4 *
 [X]  - HANNAH C. MAYTUM ET AL, "1,4-Butanediol as a reducing agent in transfer hydrogenation reactions", CHEMISTRY - AN ASIAN JOURNAL, (20100301), vol. 5, no. 3, doi:10.1002/asia.200900527, ISSN 1861-4728, pages 538 - 542, XP055016614 [X] 1 * table 3, entries 6, 9 *

DOI:   http://dx.doi.org/10.1002/asia.200900527
 [X]  - A. S. DNEPROVSKII AND I. V. FEDOSOV, "Fragmentation of anion radicals with elimination of aryloxy groups", RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, (2001), vol. 37, no. 10, doi:10.1023/A:1013456112725, ISSN 1070-4280, pages 1438 - 1443, XP055016606 [X] 1 * scheme 4,;; compounds III, XI *

DOI:   http://dx.doi.org/10.1023/A:1013456112725
 [X]  - MOTOI KAWATSURA AND JOHN F. HARTWIG, "Palladium-catalyzed intermolecular hydroamination of vinylarenes using arylamines", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (2000), vol. 122, no. 39, doi:10.1021/JA002284T, ISSN 0002-7863, pages 9546 - 9547, XP002285694 [X] 1 * table 2, entries 10, 13; scheme 1 *

DOI:   http://dx.doi.org/10.1021/ja002284t
 [X]  - FRAUKE GAEDCKE ET AL, "Strukturabhängigkeit der antiplasmodischen Wirkung von 3-[N-(4'-Amidosulfonyl)-phenyl]-aminomethyl-chinolin", ARCHIV DER PHARMAZIE, (1980), vol. 313, no. 2, doi:10.1002/ARDP.19803130209, ISSN 0365-6233, pages 166 - 173, XP002542820 [X] 1 * table 1; compounds 4n, 4o *

DOI:   http://dx.doi.org/10.1002/ardp.19803130209
 [X]  - ERICA L. LANNI ET AL, "Synthesis of substituted N-benzyl pyridones via an O- to N-alkyl migration", THE JOURNAL OF ORGANIC CHEMISTRY, (2008), vol. 73, no. 16, doi:10.1021/jo800866w, ISSN 0022-3263, pages 6425 - 6428, XP055016575 [X] 1 * table 1; compound 2n *

DOI:   http://dx.doi.org/10.1021/jo800866w
 [X]  - EDUARDO BUSTO ET AL, "Optically active macrocyclic hexaazapyridinophanes decorated at the periphery: synthesis and applications in the NMR enantiodiscrimination of carboxylic acids", TETRAHEDRON, vol. 66, no. 32, ISSN 0040-4020, (20100807), pages 6070 - 6077, (20100610), XP027142127 [X] 1 * scheme 3, compound 9c *
 [X]  - KOHFUKU KOHDA ET AL, "Potentiation of the cytotoxicity of chloroethylnitrosourea by O6-arylmethylguanines", BIOLOGICAL & PHARMACEUTICAL BULLETIN (OF JAPAN), (1995), vol. 18, no. 3, ISSN 0918-6158, pages 424 - 430, XP000926768 [X] 1,5 * figure 1; tables I, II; compound 11 *
by applicantUS5858753
 US5822910
 US5985589
 WO9746688
 WO9625488
 EP0039051
 WO2007051982
 EP0041181
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