EP2635565 - 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS [Right-click to bookmark this link] | Status | The application has been withdrawn Status updated on 12.09.2014 Database last updated on 22.08.2024 | Most recent event Tooltip | 12.09.2014 | Withdrawal of application | published on 15.10.2014 [2014/42] | Applicant(s) | For all designated states Amgen Inc. One Amgen Center Drive Thousand Oaks, California 91320-1799 / US | [2013/37] | Inventor(s) | 01 /
FISHER, Benjamin 411-23rd Avenue San Mateo California 94403 / US | 02 /
JOHNSON, Michael G. 409 Clipper Street San Francsicso California 94114 / US | 03 /
LUCAS, Brian 133 10th Avenue San Francisco California 94118 / US | 04 /
SHIN, Youngsook 64 Loop 22 Emeryville California 94608 / US | 05 /
KAIZERMAN, Jacob . deceased / US | [2013/37] | Representative(s) | Hoffmann Eitle Patent- und Rechtsanwälte PartmbB Arabellastrasse 30 81925 München / DE | [N/P] |
Former [2013/37] | HOFFMANN EITLE Patent- und Rechtsanwälte Arabellastrasse 4 81925 München / DE | Application number, filing date | 11785857.1 | 04.11.2011 | WO2011US59309 | Priority number, date | US20100410278P | 04.11.2010 Original published format: US 410278 P | [2013/37] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2012061696 | Date: | 10.05.2012 | Language: | EN | [2012/19] | Type: | A1 Application with search report | No.: | EP2635565 | Date: | 11.09.2013 | Language: | EN | The application published by WIPO in one of the EPO official languages on 10.05.2012 takes the place of the publication of the European patent application. | [2013/37] | Search report(s) | International search report - published on: | EP | 10.05.2012 | Classification | IPC: | C07D401/12, C07D401/14, C07D473/34, C07D239/48, C07D403/12, A61K31/506, A61K31/52, A61K31/505, A61P29/00, A61P19/02, A61P35/00, A61P37/00 | [2013/37] | CPC: |
C07D239/48 (EP,US);
A61P1/04 (EP);
A61P17/02 (EP);
A61P17/06 (EP);
A61P19/02 (EP);
A61P19/08 (EP);
A61P21/04 (EP);
A61P25/00 (EP);
A61P27/02 (EP);
A61P29/00 (EP);
A61P35/00 (EP);
A61P37/00 (EP);
A61P37/02 (EP);
A61P37/08 (EP);
A61P43/00 (EP);
A61P7/00 (EP);
A61P7/06 (EP);
C07D401/12 (EP,US);
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2013/37] | Extension states | BA | 22.05.2013 | ME | 22.05.2013 | Title | German: | 5 -CYANO-4, 6 -DIAMINOPYRIMIDIN ODER 6 -AMINOPURINDERIVATE ALS PI3K-DELTA-INHIBITOREN | [2013/37] | English: | 5 -CYANO-4, 6 -DIAMINOPYRIMIDINE OR 6 -AMINOPURINE DERIVATIVES AS PI3K- DELTA INHIBITORS | [2013/37] | French: | DÉRIVÉS DE LA 5-CYANO-4,6-DIAMINOPYRIMIDINE OU DE LA 6-AMINOPURINE EN TANT QU'INHIBITEURS DE LA PI3K-DELTA | [2013/37] | Entry into regional phase | 22.05.2013 | National basic fee paid | 22.05.2013 | Designation fee(s) paid | 22.05.2013 | Examination fee paid | Examination procedure | 22.05.2013 | Amendment by applicant (claims and/or description) | 22.05.2013 | Examination requested [2013/37] | 02.09.2014 | Application withdrawn by applicant [2014/42] | Fees paid | Renewal fee | 18.11.2013 | Renewal fee patent year 03 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Cited in | International search | [X]WO2008118454 (AMGEN INC [US]) [X] 1-5 * scheme p.49;;; examples 3-10,12,25,26; claims 1-10 *; | [X]WO2008118455 (AMGEN INC [US]) [X] 1-5 * examples 1-6, 9; claims 1-10 *; | [X]WO2008118468 (AMGEN INC [US]) [X] 1-5 * examples 1-7,9-13,16,17,21,23-27,...; claims 1-10 *; | [X]WO2009081105 (UCB PHARMA SA [BE], et al) [X] 1-5 * examples 4-8,11-17,19-43,45-47,...; claims 1-5,8,11-15 *; | [X]WO2010092340 (UCB PHARMA SA [BE], et al) [X] 1-5 * examples 1,3-5,13,16,22,35,...; claims 1-16 *; | [XP]WO2011075628 (AMGEN INC [US], et al) [XP] 1-5 * examples 1-3,6; claims 1-4 *; | [XP]WO2011075630 (INCYTE CORP [US], et al) [XP] 1-5 * examples 1,3-10,,12,13,15-57,...; claims 1-82 *; | [E]WO2012003271 (AMGEN INC [US], et al) [E] 1-5 * examples 1,3,8,13-16,18; claims 1-4 * | [X] - HANNAH C. MAYTUM ET AL, "1,4-Butanediol as a reducing agent in transfer hydrogenation reactions", CHEMISTRY - AN ASIAN JOURNAL, (20100301), vol. 5, no. 3, doi:10.1002/asia.200900527, ISSN 1861-4728, pages 538 - 542, XP055016614 [X] 1 * table 3, entries 6, 9 * DOI: http://dx.doi.org/10.1002/asia.200900527 | [X] - A. S. DNEPROVSKII AND I. V. FEDOSOV, "Fragmentation of anion radicals with elimination of aryloxy groups", RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, (2001), vol. 37, no. 10, doi:10.1023/A:1013456112725, ISSN 1070-4280, pages 1438 - 1443, XP055016606 [X] 1 * scheme 4,;; compounds III, XI * DOI: http://dx.doi.org/10.1023/A:1013456112725 | [X] - MOTOI KAWATSURA AND JOHN F. HARTWIG, "Palladium-catalyzed intermolecular hydroamination of vinylarenes using arylamines", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (2000), vol. 122, no. 39, doi:10.1021/JA002284T, ISSN 0002-7863, pages 9546 - 9547, XP002285694 [X] 1 * table 2, entries 10, 13; scheme 1 * DOI: http://dx.doi.org/10.1021/ja002284t | [X] - FRAUKE GAEDCKE ET AL, "Strukturabhängigkeit der antiplasmodischen Wirkung von 3-[N-(4'-Amidosulfonyl)-phenyl]-aminomethyl-chinolin", ARCHIV DER PHARMAZIE, (1980), vol. 313, no. 2, doi:10.1002/ARDP.19803130209, ISSN 0365-6233, pages 166 - 173, XP002542820 [X] 1 * table 1; compounds 4n, 4o * DOI: http://dx.doi.org/10.1002/ardp.19803130209 | [X] - ERICA L. LANNI ET AL, "Synthesis of substituted N-benzyl pyridones via an O- to N-alkyl migration", THE JOURNAL OF ORGANIC CHEMISTRY, (2008), vol. 73, no. 16, doi:10.1021/jo800866w, ISSN 0022-3263, pages 6425 - 6428, XP055016575 [X] 1 * table 1; compound 2n * DOI: http://dx.doi.org/10.1021/jo800866w | [X] - EDUARDO BUSTO ET AL, "Optically active macrocyclic hexaazapyridinophanes decorated at the periphery: synthesis and applications in the NMR enantiodiscrimination of carboxylic acids", TETRAHEDRON, vol. 66, no. 32, ISSN 0040-4020, (20100807), pages 6070 - 6077, (20100610), XP027142127 [X] 1 * scheme 3, compound 9c * | [X] - KOHFUKU KOHDA ET AL, "Potentiation of the cytotoxicity of chloroethylnitrosourea by O6-arylmethylguanines", BIOLOGICAL & PHARMACEUTICAL BULLETIN (OF JAPAN), (1995), vol. 18, no. 3, ISSN 0918-6158, pages 424 - 430, XP000926768 [X] 1,5 * figure 1; tables I, II; compound 11 * | by applicant | US5858753 | US5822910 | US5985589 | WO9746688 | WO9625488 | EP0039051 | WO2007051982 | EP0041181 | - RAMEH ET AL., J. BIOL CHEM, (1999), vol. 274, pages 8347 - 8350 | - PANAYOTOU ET AL., TRENDS CELL BIOL, (1992), vol. 2, pages 358 - 60 | - CANTLEY, SCIENCE, (2002), vol. 296, pages 1655 - 1657 | - VANHAESEBROECK ET AL., ANNU.REV.BIOCHEM, (2001), vol. 70, pages 535 - 602 | - PARKER ET AL., CURRENT BIOLOGY, (1995), vol. 5, pages 577 - 99 | - YAO ET AL., SCIENCE, (1995), vol. 267, pages 2003 - 05 | - STEMMARK ET AL., J CELL SCI, (1999), vol. 112, pages 4175 - 83 | - LEM -MON ET AL., TRENDS CELL BIOL, (1997), vol. 7, pages 237 - 42 | - SCHAEFFER, SCHWARTZBERG, CURR.OPIN.IMMUNOL., (2000), vol. 12, pages 282 - 288 | - DEANE, FRUMAN, ANNU.REV.IMMUNOL., (2004), vol. 22, pages 563 - 598 | - BURGERING ET AL., NATURE, (1995), vol. 376, pages 599 - 602 | - OTSU ET AL., CELL, (1991), vol. 65, pages 91 - 104 | - HILES ET AL., CELL, (1992), vol. 70, pages 419 - 29 | - HU ET AL., MOL CELL BIOL, (1993), vol. 13, pages 7677 - 88 | - CHANTRY ET AL., J BIOL CHEM, (1997), vol. 272, pages 19236 - 41 | - AL-ALWAN, JI, (2007), vol. 178, pages 2328 - 2335 | - OKKENHAUG ET AL., JI, (2006), vol. 177, pages 5122 - 5128 | - LEE ET AL., PNAS, (2006), vol. 103, pages 1289 - 1294 | - VOGT ET AL., VIROLOGY, (2006), vol. 344, pages 131 - 138 | - SAWYER ET AL., CANCER RES., (2003), vol. 63, pages 1667 - 1675 | - VANHACSCBROCCK, PROC NAT. ACAD SCI USA, (1997), vol. 94, pages 4330 - 5 | - RAMEH ET AL., CELL, (1995), vol. 83, pages 821 - 30 | - VOLINIA ET AL., ONCOGENE, (1992), vol. 7, pages 789 - 93 | - STOYANOV ET AL., SCIENCE, (1995), vol. 269, pages 690 - 93 | - KRUGMANN ET AL., J BIOL CHEM, (1999), vol. 274, pages 17152 - 8 | - VOIGT ET AL., JBC, (2006), vol. 281, pages 9977 - 9986 | - SUIRE ET AL., CURR.BIOL., (2005), vol. 15, pages 566 - 570 | - KLIPPEL ET AL., MOL CELL BIOL, (1994), vol. 14, pages 2675 - 85 | - HUNTER, CELL, (1995), vol. 83, pages 1 - 4 | - PAGES ET AL., NATURE, (1994), vol. 369, pages 327 - 29 | - RUDD, IMMUNITY, (1996), vol. 4, pages 527 - 34 | - FRASER ET AL., SCIENCE, (1991), vol. 251, pages 313 - 16 | - FRUMAN ET AL., ANN REV BIOCHEM, (1998), vol. 67, pages 481 - 507 | - THELEN ET AL., PROC NATL ACAD SCI USA, (1994), vol. 91, pages 4960 - 64 | - BI ET AL., MAMM.GENOME, (2002), vol. 13, pages 169 - 172 | - BI ET AL., J.BIOL.CHEM., (1999), vol. 274, pages 10963 - 10968 | - FOUKAS, NATURE, (2006), vol. 441, pages 366 - 370 | - LI ET AL., SCIENCE, (2000), vol. 287, pages 1046 - 1049 | - SASAKI ET AL., SCIENCE, (2000), vol. 287, pages 1040 - 1046 | - PATRUCCO ET AL., CELL, (2004), vol. 118, pages 375 - 387 | - CLAYTON ET AL., J.EXP.MED., (2002), vol. 196, pages 753 - 763 | - OKKENHAUG ET AL., SCIENCE, (2002), vol. 297, pages 1031 - 1034 | - OKKENHAUG ET AL., J.IMMUNOL., (2006), vol. 177, pages 5122 - 5128 | - JOU ET AL., INT.J.IMMUNOGENET, (2006), vol. 33, pages 361 - 369 | - ITO ET AL., J. PHARM. EXP. THERAPEUT., (2007), vol. 321, pages 1 - 8 | - HENNESSY ET AL., NATURE REVIEWS, (2005), vol. 4, pages 988 - 1004 | - ITO ET AL., J.PHARM.EXP.THERAPEUT., (2007), vol. 321, pages 1 - 8 | - JACKSON ET AL., NATURE MED., (2005), vol. 11, pages 507 - 514 | - RUECKLE ET AL., NATURE REVIEWS, (2006), vol. 5, pages 903 - 918 | - CAMPS, NATURE MEDICINE, (2005), vol. 11, pages 936 - 943 | - BARBER ET AL., NATURE MEDICINE, (2005), vol. 11, pages 933 - 935 | - KNIGHT ET AL., CELL, (2006), vol. 125, pages 733 - 747 | - CONDLIFFE ET AL., BLOOD, (2005), vol. 106, pages 1432 - 1440 | - ALI ET AL., NATURE, (2002), vol. 431, pages 1007 - 1011 | - ALI, NATURE, (2002), vol. 431, pages 1007 - 1011 | - LEE ET AL., FASEB, (2006), vol. 20, pages 455 - 465 | - NASHED ET AL., EUR.J.IMMUNOL., (2007), vol. 37, pages 416 - 424 | - BERGE ET AL., J. PHARM. SCI., (1977), vol. 66, page 1 | - SVENSSON, TUNEK, DRUG METABOLISM REVIEWS, (1988), page 165 | - BUNGAARD, J. MED. CHEM., (1989), page 2503 | - JOURNAL OF MEDICINAL CHEMISTRY, (2006), vol. 49, no. # 21, pages 6351 - 6363 | - JOURNAL OJ MEDICINAL CHEMISTRY, (1993), vol. 36, no. #11, pages 1669 - 1673 | - TETRAHEDRON LETTERS, (1995), vol. 36, no. 31, pages 5461 - 4 | - SHU, XING-ZHONG, ZHAO, SHU-CHUN, JI, KE-GONG, ZHENG, ZHAO-JING, LIU, XUE-YUAN, LIANG, YONG-MIN, EUR. J. ORG. CHEM., (2009), vol. 1, page 117 | - INDIAN JOURNAL OF CHEMISTRY, (199707), vol. 36B, pages 541 - 44 | - BIOORGANIC & MEDICINAL CHEMISTRY, (2003), vol. 11, no. # 23, pages 5259 - 5272 | - BRISCOE, M.R., FORS, B.P., BUCHWALD, S.L., J. AM. CHEM. SOC., (2008), vol. 130, page 6686 |