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Extract from the Register of European Patents

EP About this file: EP2582384

EP2582384 - COMPOSITIONS AND METHODS FOR TREATING CANCER [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  29.09.2017
Database last updated on 15.06.2024
Most recent event   Tooltip10.07.2020Lapse of the patent in a contracting state
New state(s): AL, IS		published on 12.08.2020  [2020/33]
Applicant(s)For all designated states
THE CLEVELAND CLINIC FOUNDATION
9500 Euclid Avenue
Cleveland, OH 44195 / US
[2016/47]
Former [2013/17]For all designated states
The Cleveland Clinic Foundation
9500 Euclid Avenue
Cleveland, OH 44195 / US
Inventor(s)01 / HAZEN, Stanley L.
31650 Gates Mills Boulevard
Pepper Pike, Ohio 44124 / US
02 / DIDONATO, Joseph
25708 Laura Lane
Westlake, Ohio 44145 / US
03 / ZAMANIAN-DARYOUSH, Maryam
17915 Shaker Blvd.
Shaker Heights, Ohio 44120 / US
 [2013/17]
Representative(s)Glawe, Delfs, Moll
Partnerschaft mbB von
Patent- und Rechtsanwälten
Postfach 13 03 91
20103 Hamburg / DE
[N/P]
Former [2016/47]Glawe, Delfs, Moll
Partnerschaft mbB
von Patent- und Rechtsanwälten
Postfach 13 03 91
20103 Hamburg / DE
Former [2013/17]Glawe, Delfs, Moll
Patent- und Rechtsanwälte
Rothenbaumchaussee 58
20148 Hamburg / DE
Application number, filing date11796346.215.06.2011
[2016/47]
WO2011US40471
Priority number, dateUS201161436030P25.01.2011         Original published format: US 201161436030 P
US20100355134P15.06.2010         Original published format: US 355134 P
[2013/17]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2011159771
Date:22.12.2011
Language:EN
[2011/51]
Type: A2 Application without search report 
No.:EP2582384
Date:24.04.2013
Language:EN
The application published by WIPO in one of the EPO official languages on 22.12.2011 takes the place of the publication of the European patent application.
[2013/17]
Type: B1 Patent specification 
No.:EP2582384
Date:23.11.2016
Language:EN
[2016/47]
Search report(s)International search report - published on:KR19.04.2012
(Supplementary) European search report - dispatched on:EP07.02.2014
ClassificationIPC:A61K38/17, A61K38/10, A61K31/711, A61K31/70, A61P35/00, A61K31/7105
[2016/23]
CPC:
A61K31/7105 (EP,US); A61K31/711 (EP,US); A61K38/1709 (EP,US);
A61P35/00 (EP); G01N33/574 (EP,US); G01N33/92 (EP,US);
G01N2800/50 (EP,US) (-)
Former IPC [2014/11]A61K38/16, A61K38/17, A61K38/10, A61K31/711, A61K31/70, A61P35/00, G01N33/574, G01N33/92, A61K31/7105
Former IPC [2013/17]A61K38/16, A61K38/17, A61K38/10, A61K31/711, A61K31/70, A61P35/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2013/17]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:ZUSAMMENSETZUNGEN UND VERFAHREN ZUR BEHANDLUNG VON KREBS[2013/17]
English:COMPOSITIONS AND METHODS FOR TREATING CANCER[2013/17]
French:COMPOSITIONS ET PROCÉDÉS DE TRAITEMENT DU CANCER[2013/17]
Entry into regional phase10.01.2013National basic fee paid 
10.01.2013Search fee paid 
10.01.2013Designation fee(s) paid 
10.01.2013Examination fee paid 
Examination procedure10.01.2013Examination requested  [2013/17]
21.08.2014Amendment by applicant (claims and/or description)
15.06.2015Despatch of a communication from the examining division (Time limit: M06)
29.10.2015Reply to a communication from the examining division
17.02.2016Despatch of a communication from the examining division (Time limit: M04)
22.03.2016Reply to a communication from the examining division
15.06.2016Communication of intention to grant the patent
13.10.2016Fee for grant paid
13.10.2016Fee for publishing/printing paid
13.10.2016Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  15.06.2015
Opposition(s)24.08.2017No opposition filed within time limit [2017/44]
Fees paidRenewal fee
27.06.2013Renewal fee patent year 03
30.06.2014Renewal fee patent year 04
29.06.2015Renewal fee patent year 05
27.06.2016Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU15.06.2011
AL23.11.2016
AT23.11.2016
BE23.11.2016
CY23.11.2016
CZ23.11.2016
DK23.11.2016
EE23.11.2016
ES23.11.2016
FI23.11.2016
HR23.11.2016
IT23.11.2016
LT23.11.2016
LV23.11.2016
MC23.11.2016
MK23.11.2016
NL23.11.2016
PL23.11.2016
RO23.11.2016
RS23.11.2016
SE23.11.2016
SI23.11.2016
SK23.11.2016
SM23.11.2016
TR23.11.2016
BG23.02.2017
NO23.02.2017
GR24.02.2017
IS23.03.2017
PT23.03.2017
IE15.06.2017
LU15.06.2017
MT15.06.2017
CH30.06.2017
LI30.06.2017
[2020/33]
Former [2020/15]HU15.06.2011
AT23.11.2016
BE23.11.2016
CY23.11.2016
CZ23.11.2016
DK23.11.2016
EE23.11.2016
ES23.11.2016
FI23.11.2016
HR23.11.2016
IT23.11.2016
LT23.11.2016
LV23.11.2016
MC23.11.2016
MK23.11.2016
NL23.11.2016
PL23.11.2016
RO23.11.2016
RS23.11.2016
SE23.11.2016
SI23.11.2016
SK23.11.2016
SM23.11.2016
TR23.11.2016
BG23.02.2017
NO23.02.2017
GR24.02.2017
PT23.03.2017
IE15.06.2017
LU15.06.2017
MT15.06.2017
CH30.06.2017
LI30.06.2017
Former [2019/51]HU15.06.2011
AT23.11.2016
BE23.11.2016
CY23.11.2016
CZ23.11.2016
DK23.11.2016
EE23.11.2016
ES23.11.2016
FI23.11.2016
HR23.11.2016
IT23.11.2016
LT23.11.2016
LV23.11.2016
MC23.11.2016
MK23.11.2016
NL23.11.2016
PL23.11.2016
RO23.11.2016
RS23.11.2016
SE23.11.2016
SI23.11.2016
SK23.11.2016
SM23.11.2016
BG23.02.2017
NO23.02.2017
GR24.02.2017
PT23.03.2017
IE15.06.2017
LU15.06.2017
MT15.06.2017
CH30.06.2017
LI30.06.2017
Former [2019/46]HU15.06.2011
AT23.11.2016
BE23.11.2016
CY23.11.2016
CZ23.11.2016
DK23.11.2016
EE23.11.2016
ES23.11.2016
FI23.11.2016
HR23.11.2016
IT23.11.2016
LT23.11.2016
LV23.11.2016
MC23.11.2016
NL23.11.2016
PL23.11.2016
RO23.11.2016
RS23.11.2016
SE23.11.2016
SI23.11.2016
SK23.11.2016
SM23.11.2016
BG23.02.2017
NO23.02.2017
GR24.02.2017
PT23.03.2017
IE15.06.2017
LU15.06.2017
MT15.06.2017
CH30.06.2017
LI30.06.2017
Former [2019/31]HU15.06.2011
AT23.11.2016
BE23.11.2016
CZ23.11.2016
DK23.11.2016
EE23.11.2016
ES23.11.2016
FI23.11.2016
HR23.11.2016
IT23.11.2016
LT23.11.2016
LV23.11.2016
MC23.11.2016
NL23.11.2016
PL23.11.2016
RO23.11.2016
RS23.11.2016
SE23.11.2016
SI23.11.2016
SK23.11.2016
SM23.11.2016
BG23.02.2017
NO23.02.2017
GR24.02.2017
PT23.03.2017
IE15.06.2017
LU15.06.2017
MT15.06.2017
CH30.06.2017
LI30.06.2017
Former [2018/43]AT23.11.2016
BE23.11.2016
CZ23.11.2016
DK23.11.2016
EE23.11.2016
ES23.11.2016
FI23.11.2016
HR23.11.2016
IT23.11.2016
LT23.11.2016
LV23.11.2016
MC23.11.2016
NL23.11.2016
PL23.11.2016
RO23.11.2016
RS23.11.2016
SE23.11.2016
SI23.11.2016
SK23.11.2016
SM23.11.2016
BG23.02.2017
NO23.02.2017
GR24.02.2017
PT23.03.2017
IE15.06.2017
LU15.06.2017
MT15.06.2017
CH30.06.2017
LI30.06.2017
Former [2018/23]AT23.11.2016
BE23.11.2016
CZ23.11.2016
DK23.11.2016
EE23.11.2016
ES23.11.2016
FI23.11.2016
HR23.11.2016
IT23.11.2016
LT23.11.2016
LV23.11.2016
MC23.11.2016
NL23.11.2016
PL23.11.2016
RO23.11.2016
RS23.11.2016
SE23.11.2016
SI23.11.2016
SK23.11.2016
SM23.11.2016
BG23.02.2017
NO23.02.2017
GR24.02.2017
PT23.03.2017
IE15.06.2017
LU15.06.2017
CH30.06.2017
LI30.06.2017
Former [2018/21]AT23.11.2016
BE23.11.2016
CZ23.11.2016
DK23.11.2016
EE23.11.2016
ES23.11.2016
FI23.11.2016
HR23.11.2016
IT23.11.2016
LT23.11.2016
LV23.11.2016
MC23.11.2016
NL23.11.2016
PL23.11.2016
RO23.11.2016
RS23.11.2016
SE23.11.2016
SI23.11.2016
SK23.11.2016
SM23.11.2016
BG23.02.2017
NO23.02.2017
GR24.02.2017
PT23.03.2017
LU15.06.2017
CH30.06.2017
LI30.06.2017
Former [2018/11]AT23.11.2016
BE23.11.2016
CZ23.11.2016
DK23.11.2016
EE23.11.2016
ES23.11.2016
FI23.11.2016
HR23.11.2016
IT23.11.2016
LT23.11.2016
LV23.11.2016
MC23.11.2016
NL23.11.2016
PL23.11.2016
RO23.11.2016
RS23.11.2016
SE23.11.2016
SI23.11.2016
SK23.11.2016
SM23.11.2016
BG23.02.2017
NO23.02.2017
GR24.02.2017
PT23.03.2017
Former [2017/52]AT23.11.2016
BE23.11.2016
CZ23.11.2016
DK23.11.2016
EE23.11.2016
ES23.11.2016
FI23.11.2016
HR23.11.2016
IT23.11.2016
LT23.11.2016
LV23.11.2016
NL23.11.2016
PL23.11.2016
RO23.11.2016
RS23.11.2016
SE23.11.2016
SI23.11.2016
SK23.11.2016
SM23.11.2016
BG23.02.2017
NO23.02.2017
GR24.02.2017
PT23.03.2017
Former [2017/38]AT23.11.2016
BE23.11.2016
CZ23.11.2016
DK23.11.2016
EE23.11.2016
ES23.11.2016
FI23.11.2016
HR23.11.2016
IT23.11.2016
LT23.11.2016
LV23.11.2016
NL23.11.2016
PL23.11.2016
RO23.11.2016
RS23.11.2016
SE23.11.2016
SK23.11.2016
SM23.11.2016
BG23.02.2017
NO23.02.2017
GR24.02.2017
PT23.03.2017
Former [2017/37]AT23.11.2016
BE23.11.2016
CZ23.11.2016
DK23.11.2016
EE23.11.2016
ES23.11.2016
FI23.11.2016
HR23.11.2016
IT23.11.2016
LT23.11.2016
LV23.11.2016
NL23.11.2016
PL23.11.2016
RO23.11.2016
RS23.11.2016
SE23.11.2016
SK23.11.2016
SM23.11.2016
NO23.02.2017
GR24.02.2017
PT23.03.2017
Former [2017/36]AT23.11.2016
BE23.11.2016
CZ23.11.2016
DK23.11.2016
EE23.11.2016
ES23.11.2016
FI23.11.2016
HR23.11.2016
LT23.11.2016
LV23.11.2016
NL23.11.2016
PL23.11.2016
RO23.11.2016
RS23.11.2016
SE23.11.2016
SK23.11.2016
NO23.02.2017
GR24.02.2017
PT23.03.2017
Former [2017/35]AT23.11.2016
CZ23.11.2016
DK23.11.2016
EE23.11.2016
ES23.11.2016
FI23.11.2016
HR23.11.2016
LT23.11.2016
LV23.11.2016
NL23.11.2016
PL23.11.2016
RO23.11.2016
RS23.11.2016
SE23.11.2016
NO23.02.2017
GR24.02.2017
PT23.03.2017
Former [2017/33]AT23.11.2016
DK23.11.2016
ES23.11.2016
FI23.11.2016
HR23.11.2016
LT23.11.2016
LV23.11.2016
NL23.11.2016
PL23.11.2016
RS23.11.2016
SE23.11.2016
NO23.02.2017
GR24.02.2017
PT23.03.2017
Former [2017/26]AT23.11.2016
ES23.11.2016
FI23.11.2016
HR23.11.2016
LT23.11.2016
LV23.11.2016
NL23.11.2016
PL23.11.2016
RS23.11.2016
SE23.11.2016
NO23.02.2017
GR24.02.2017
PT23.03.2017
Former [2017/12]LV23.11.2016
Documents cited:Search[XI]US2006172919  (HORNICK CONRAD A [US], et al) [X] 1-4 * paragraphs [0016] , [0 43] , [0 45]; example 6; claims 1,5,7 * [I] 5,7,8;
 [A]WO2009055538  (CLEVELAND CLINIC FOUNDATION [US]) [A] 1-5,7,8 * paragraph [0037] *;
 [X]CA2727811  (PROYECTO BIOMEDICINA CIMA SL [ES]) [X] 1-5,7,8 * page 27, paragraph 2; example 15; claims 1,2,12,16,20,21,25 * * page 9, paragraph 4 *;
 [X]  - HAN CUNZHI ET AL, "Serum levels of leptin, insulin, and lipids in relation to breast cancer in China", ENDOCRINE, HUMANA PRESS, US, (20050201), vol. 26, no. 1, ISSN 0969-711X, pages 19 - 24, XP009175427 [X] 1,2 * page 19, column 1 * * page 22, column 1 - column 2 *

DOI:   http://dx.doi.org/10.1385/ENDO:26:1:019
 [A]  - H. DUEZ, "Regulation of Human ApoA-I by Gemfibrozil and Fenofibrate Through Selective Peroxisome Proliferator-Activated Receptor Modulation", ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY, (20050301), vol. 25, no. 3, doi:10.1161/01.ATV.0000154140.73570.00, ISSN 1079-5642, pages 585 - 591, XP055095620 [A] 1 * abstract *

DOI:   http://dx.doi.org/10.1161/01.ATV.0000154140.73570.00
International search[A]US5192264  (FOSSEL ERIC T [US]);
 [X]US2006172429  (NILSSON ERIK J [US], et al);
 [A]  - RENANA SHOR ET AL., "Low HDL levels and the risk of death, sepsis and malignancy", CLIN. RES. CARDIOL., (2008), vol. 97, no. 4, pages 227 - 233, XP019589025
 [A]  - MASASHI UEDA ET AL., "Establishment and evaluation of 2 monoclonal antibodies against oxidized apolipoprotein A-I (apoA-I) and its application to determine blood oxidized apoA-I levels", CLINICA CHIMICA ACTA, (2007), vol. 378, no. 1/2, pages 105 - 111, XP005891495

DOI:   http://dx.doi.org/10.1016/j.cca.2006.11.002
 [A]  - DOROTHEE WEIHRAUCH ET AL., "Effects of D-4F on vasodilation, oxidative stress, angiostatin, myocardial inflammation, and angiogenic potential in tight-skin mice", AM. J. PHYSIOL. HEART CIRC. PHYSIOL., (2007), vol. 293, no. 3, pages H1432 - H1441, XP055073117

DOI:   http://dx.doi.org/10.1152/ajpheart.00038.2007
by applicantWO8304053
 US5391723
 US2009149390
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