EP2608797 - BONE MARROW DERIVED CD271 PRECURSOR CELLS FOR CARDIAC REPAIR [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 29.07.2016 Database last updated on 31.08.2024 | Most recent event Tooltip | 19.10.2018 | Lapse of the patent in a contracting state New state(s): AL | published on 21.11.2018 [2018/47] | Applicant(s) | For all designated states University of Miami Office of Technology Transfer 1400 N.W. 10th Avenue Suite 906 Miami, FL 33136 / US | [2013/27] | Inventor(s) | 01 /
HARE, Joshua, M. 6010 Aqua Path Miami Beach, FL 33141 / US | 02 /
McNIECE, Ian, K. 821 Majorca Avenue Coral Gables, FL 33134 / US | [2013/27] | Representative(s) | Inspicos P/S Agern Allé 24 2970 Hørsholm / DK | [N/P] |
Former [2015/39] | Inspicos A/S Kogle Allé 2 P.O. Box 45 2970 Hørsholm / DK | ||
Former [2013/27] | Inspicos A/S Kogle Allé 2 P.O. Box 45 2970 Hørsholm / DK | Application number, filing date | 11820774.5 | 29.08.2011 | [2015/39] | WO2011US49542 | Priority number, date | US20100377661P | 27.08.2010 Original published format: US 377661 P | [2013/27] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2012027740 | Date: | 01.03.2012 | Language: | EN | [2012/09] | Type: | A1 Application with search report | No.: | EP2608797 | Date: | 03.07.2013 | Language: | EN | The application published by WIPO in one of the EPO official languages on 01.03.2012 takes the place of the publication of the European patent application. | [2013/27] | Type: | B1 Patent specification | No.: | EP2608797 | Date: | 23.09.2015 | Language: | EN | [2015/39] | Search report(s) | International search report - published on: | US | 01.03.2012 | (Supplementary) European search report - dispatched on: | EP | 02.01.2014 | Classification | IPC: | A61K35/12 | [2013/27] | CPC: |
A61K35/28 (EP,US);
A61K35/12 (KR);
A61P9/00 (EP);
A61P9/04 (EP);
A61P9/10 (EP);
A61P9/12 (EP)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2013/27] | Extension states | BA | Not yet paid | ME | Not yet paid | Title | German: | AUS KNOCHENMARK GEWONNENE CD271-VORLÄUFERZELLEN ZUR HERZREPARATUR | [2013/27] | English: | BONE MARROW DERIVED CD271 PRECURSOR CELLS FOR CARDIAC REPAIR | [2013/27] | French: | CELLULES PRÉCURSEUR CD271 ISSUES DE LA MOELLE OSSEUSE POUR UNE RÉPARATION CARDIAQUE | [2013/27] | Entry into regional phase | 27.03.2013 | National basic fee paid | 27.03.2013 | Search fee paid | 27.03.2013 | Designation fee(s) paid | 27.03.2013 | Examination fee paid | Examination procedure | 27.03.2013 | Examination requested [2013/27] | 24.07.2014 | Amendment by applicant (claims and/or description) | 24.10.2014 | Despatch of a communication from the examining division (Time limit: M04) | 26.02.2015 | Reply to a communication from the examining division | 07.04.2015 | Communication of intention to grant the patent | 13.08.2015 | Fee for grant paid | 13.08.2015 | Fee for publishing/printing paid | 13.08.2015 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 24.10.2014 | Opposition(s) | 24.06.2016 | No opposition filed within time limit [2016/35] | Fees paid | Renewal fee | 02.09.2013 | Renewal fee patent year 03 | 13.08.2014 | Renewal fee patent year 04 | 10.08.2015 | Renewal fee patent year 05 |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 29.08.2011 | AL | 23.09.2015 | AT | 23.09.2015 | BE | 23.09.2015 | BG | 23.09.2015 | CY | 23.09.2015 | CZ | 23.09.2015 | DK | 23.09.2015 | EE | 23.09.2015 | FI | 23.09.2015 | HR | 23.09.2015 | LT | 23.09.2015 | LV | 23.09.2015 | MC | 23.09.2015 | MK | 23.09.2015 | NL | 23.09.2015 | PL | 23.09.2015 | RO | 23.09.2015 | RS | 23.09.2015 | SI | 23.09.2015 | SK | 23.09.2015 | SM | 23.09.2015 | TR | 23.09.2015 | NO | 23.12.2015 | GR | 24.12.2015 | IS | 23.01.2016 | PT | 25.01.2016 | [2018/47] |
Former [2018/38] | HU | 29.08.2011 | |
AT | 23.09.2015 | ||
BE | 23.09.2015 | ||
BG | 23.09.2015 | ||
CY | 23.09.2015 | ||
CZ | 23.09.2015 | ||
DK | 23.09.2015 | ||
EE | 23.09.2015 | ||
FI | 23.09.2015 | ||
HR | 23.09.2015 | ||
LT | 23.09.2015 | ||
LV | 23.09.2015 | ||
MC | 23.09.2015 | ||
MK | 23.09.2015 | ||
NL | 23.09.2015 | ||
PL | 23.09.2015 | ||
RO | 23.09.2015 | ||
RS | 23.09.2015 | ||
SI | 23.09.2015 | ||
SK | 23.09.2015 | ||
SM | 23.09.2015 | ||
TR | 23.09.2015 | ||
NO | 23.12.2015 | ||
GR | 24.12.2015 | ||
IS | 23.01.2016 | ||
PT | 25.01.2016 | ||
Former [2018/31] | HU | 29.08.2011 | |
AT | 23.09.2015 | ||
BE | 23.09.2015 | ||
CY | 23.09.2015 | ||
CZ | 23.09.2015 | ||
DK | 23.09.2015 | ||
EE | 23.09.2015 | ||
FI | 23.09.2015 | ||
HR | 23.09.2015 | ||
LT | 23.09.2015 | ||
LV | 23.09.2015 | ||
MC | 23.09.2015 | ||
MK | 23.09.2015 | ||
NL | 23.09.2015 | ||
PL | 23.09.2015 | ||
RO | 23.09.2015 | ||
RS | 23.09.2015 | ||
SI | 23.09.2015 | ||
SK | 23.09.2015 | ||
SM | 23.09.2015 | ||
TR | 23.09.2015 | ||
NO | 23.12.2015 | ||
GR | 24.12.2015 | ||
IS | 23.01.2016 | ||
PT | 25.01.2016 | ||
Former [2018/29] | HU | 29.08.2011 | |
AT | 23.09.2015 | ||
BE | 23.09.2015 | ||
CY | 23.09.2015 | ||
CZ | 23.09.2015 | ||
DK | 23.09.2015 | ||
EE | 23.09.2015 | ||
FI | 23.09.2015 | ||
HR | 23.09.2015 | ||
LT | 23.09.2015 | ||
LV | 23.09.2015 | ||
MC | 23.09.2015 | ||
MK | 23.09.2015 | ||
NL | 23.09.2015 | ||
PL | 23.09.2015 | ||
RO | 23.09.2015 | ||
RS | 23.09.2015 | ||
SI | 23.09.2015 | ||
SK | 23.09.2015 | ||
SM | 23.09.2015 | ||
TR | 23.09.2015 | ||
NO | 23.12.2015 | ||
GR | 24.12.2015 | ||
IS | 23.01.2016 | ||
PT | 25.01.2016 | ||
Former [2018/28] | HU | 29.08.2011 | |
AT | 23.09.2015 | ||
BE | 23.09.2015 | ||
CY | 23.09.2015 | ||
CZ | 23.09.2015 | ||
DK | 23.09.2015 | ||
EE | 23.09.2015 | ||
FI | 23.09.2015 | ||
HR | 23.09.2015 | ||
LT | 23.09.2015 | ||
LV | 23.09.2015 | ||
MC | 23.09.2015 | ||
MK | 23.09.2015 | ||
NL | 23.09.2015 | ||
PL | 23.09.2015 | ||
RO | 23.09.2015 | ||
RS | 23.09.2015 | ||
SI | 23.09.2015 | ||
SK | 23.09.2015 | ||
SM | 23.09.2015 | ||
NO | 23.12.2015 | ||
GR | 24.12.2015 | ||
IS | 23.01.2016 | ||
PT | 25.01.2016 | ||
Former [2017/23] | AT | 23.09.2015 | |
BE | 23.09.2015 | ||
CZ | 23.09.2015 | ||
DK | 23.09.2015 | ||
EE | 23.09.2015 | ||
FI | 23.09.2015 | ||
HR | 23.09.2015 | ||
LT | 23.09.2015 | ||
LV | 23.09.2015 | ||
MC | 23.09.2015 | ||
NL | 23.09.2015 | ||
PL | 23.09.2015 | ||
RO | 23.09.2015 | ||
RS | 23.09.2015 | ||
SI | 23.09.2015 | ||
SK | 23.09.2015 | ||
NO | 23.12.2015 | ||
GR | 24.12.2015 | ||
IS | 23.01.2016 | ||
PT | 25.01.2016 | ||
Former [2017/03] | AT | 23.09.2015 | |
BE | 23.09.2015 | ||
CZ | 23.09.2015 | ||
DK | 23.09.2015 | ||
EE | 23.09.2015 | ||
FI | 23.09.2015 | ||
HR | 23.09.2015 | ||
LT | 23.09.2015 | ||
LV | 23.09.2015 | ||
NL | 23.09.2015 | ||
PL | 23.09.2015 | ||
RO | 23.09.2015 | ||
RS | 23.09.2015 | ||
SI | 23.09.2015 | ||
SK | 23.09.2015 | ||
NO | 23.12.2015 | ||
GR | 24.12.2015 | ||
IS | 23.01.2016 | ||
PT | 25.01.2016 | ||
Former [2016/49] | AT | 23.09.2015 | |
CZ | 23.09.2015 | ||
DK | 23.09.2015 | ||
EE | 23.09.2015 | ||
FI | 23.09.2015 | ||
HR | 23.09.2015 | ||
LT | 23.09.2015 | ||
LV | 23.09.2015 | ||
NL | 23.09.2015 | ||
PL | 23.09.2015 | ||
RO | 23.09.2015 | ||
RS | 23.09.2015 | ||
SI | 23.09.2015 | ||
SK | 23.09.2015 | ||
NO | 23.12.2015 | ||
GR | 24.12.2015 | ||
IS | 23.01.2016 | ||
PT | 25.01.2016 | ||
Former [2016/39] | AT | 23.09.2015 | |
CZ | 23.09.2015 | ||
DK | 23.09.2015 | ||
EE | 23.09.2015 | ||
FI | 23.09.2015 | ||
HR | 23.09.2015 | ||
LT | 23.09.2015 | ||
LV | 23.09.2015 | ||
NL | 23.09.2015 | ||
PL | 23.09.2015 | ||
RO | 23.09.2015 | ||
RS | 23.09.2015 | ||
SK | 23.09.2015 | ||
NO | 23.12.2015 | ||
GR | 24.12.2015 | ||
IS | 23.01.2016 | ||
PT | 25.01.2016 | ||
Former [2016/24] | AT | 23.09.2015 | |
CZ | 23.09.2015 | ||
EE | 23.09.2015 | ||
FI | 23.09.2015 | ||
HR | 23.09.2015 | ||
LT | 23.09.2015 | ||
LV | 23.09.2015 | ||
NL | 23.09.2015 | ||
PL | 23.09.2015 | ||
RO | 23.09.2015 | ||
RS | 23.09.2015 | ||
SK | 23.09.2015 | ||
NO | 23.12.2015 | ||
GR | 24.12.2015 | ||
IS | 23.01.2016 | ||
PT | 25.01.2016 | ||
Former [2016/23] | CZ | 23.09.2015 | |
EE | 23.09.2015 | ||
FI | 23.09.2015 | ||
HR | 23.09.2015 | ||
LT | 23.09.2015 | ||
LV | 23.09.2015 | ||
NL | 23.09.2015 | ||
RO | 23.09.2015 | ||
RS | 23.09.2015 | ||
SK | 23.09.2015 | ||
NO | 23.12.2015 | ||
GR | 24.12.2015 | ||
IS | 23.01.2016 | ||
Former [2016/22] | CZ | 23.09.2015 | |
EE | 23.09.2015 | ||
FI | 23.09.2015 | ||
HR | 23.09.2015 | ||
LT | 23.09.2015 | ||
LV | 23.09.2015 | ||
NL | 23.09.2015 | ||
RS | 23.09.2015 | ||
NO | 23.12.2015 | ||
GR | 24.12.2015 | ||
IS | 23.01.2016 | ||
Former [2016/14] | FI | 23.09.2015 | |
HR | 23.09.2015 | ||
LT | 23.09.2015 | ||
LV | 23.09.2015 | ||
NL | 23.09.2015 | ||
RS | 23.09.2015 | ||
NO | 23.12.2015 | ||
GR | 24.12.2015 | ||
Former [2016/10] | FI | 23.09.2015 | |
HR | 23.09.2015 | ||
LT | 23.09.2015 | ||
LV | 23.09.2015 | ||
RS | 23.09.2015 | ||
NO | 23.12.2015 | ||
GR | 24.12.2015 | ||
Former [2016/09] | FI | 23.09.2015 | |
LT | 23.09.2015 | ||
LV | 23.09.2015 | ||
NO | 23.12.2015 | ||
GR | 24.12.2015 | ||
Former [2016/08] | LT | 23.09.2015 | |
NO | 23.12.2015 | ||
Former [2016/07] | LT | 23.09.2015 | Documents cited: | Search | [X] - QUEVEDO HENRY C ET AL, Allogeneic mesenchymal stem cells restore cardiac function in chronic ischemic cardiomyopathy via trilineage differentiating capacity., PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 18 AUG 2009, VOL. 106, NR. 33, PAGE(S) 14022 - 14027, (20090818), ISSN 1091-6490, XP002717518 [X] 1-16 * the whole document * DOI: http://dx.doi.org/10.1073/PNAS.0903201106 | [I] - AOYAGI KAZUYA ET AL, Significance of CD271 in bone marrow mesenchymal stem cells--changes by cryopreservation., THE JOURNAL OF CRANIOFACIAL SURGERY MAY 2010, VOL. 21, NR. 3, PAGE(S) 666 - 678, (201005), ISSN 1536-3732, XP009174872 [I] 1-16 * abstract * DOI: http://dx.doi.org/10.1097/SCS.0b013e3181d7a792 | [IP] - FLORES-TORALES EDGARDO ET AL, The CD271 expression could be alone for establisher phenotypic marker in Bone Marrow derived mesenchymal stem cells., FOLIA HISTOCHEMICA ET CYTOBIOLOGICA / POLISH ACADEMY OF SCIENCES, POLISH HISTOCHEMICAL AND CYTOCHEMICAL SOCIETY DEC 2010, VOL. 48, NR. 4, PAGE(S) 682 - 686, (201012), ISSN 1897-5631, XP002717520 [IP] 1-16 * abstract * * Conclusions * DOI: http://dx.doi.org/10.2478/VL0042-010-0063-6 | [X] - ISO Y ET AL, "CD271 IDENTIFIES HUMAN BONE MARROW STEM/PROGENITOR CELLS WITH A PROANGIOGENIC POTENTIAL AND CIRCULATING PROGENITOR CELLS MOBILIZED AFTER ACUTE MYOCARDIAL INFARCTION", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, ELSEVIER, NEW YORK, NY, US, vol. 55, no. 10, ISSN 0735-1097, (20100309), (20100309), XP027002485 [X] 1-16 * the whole document * | [X] - BÜHRING HANS-JÖRG ET AL, Novel markers for the prospective isolation of human MSC., ANNALS OF THE NEW YORK ACADEMY OF SCIENCES JUN 2007, VOL. 1106, PAGE(S) 262 - 271, (200706), ISSN 0077-8923, XP002717521 [X] 1-16 * abstract * DOI: http://dx.doi.org/10.1196/ANNALS.1392.000 | [XP] - GHODSIZAD A ET AL, Application of CD271+ human bone marrow-derived: Stem cells for ischaemic heart disease therapy, EUROPEAN CARDIOLOGY 2011 TOUCH BRIEFINGS GBR, VOL. 7, NR. 4, PAGE(S) 280 - 282, (201106), ISSN 1758-3756, XP002717522 [XP] 1-16 * the whole document * DOI: http://dx.doi.org/10.15420/ecr.2011.7.4.280 | International search | [Y]WO2009140452 (UNIV MIAMI [US], et al); | [X]WO2010056341 (UNIV VERMONT [US], et al); | [Y] - DAVANI S. ET AL., "Mesenchymal progenitor cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a rat cellular cardiomyoplasty model", CIRCULATION, (20030909), vol. 108, no. SUPP.2, pages 11-253 - 11-258, XP055081258 DOI: http://dx.doi.org/10.1161/01.cir.0000089186.09692.fa | [Y] - SCHULERI K.H. ET AL., "Autologous mesenchymal stem cells produce reverse remodelling in chronic ischaemic cardiomyopathy", EUR HEART J, (200911), vol. 30, no. 22, pages 2722 - 2732, XP055081264 DOI: http://dx.doi.org/10.1093/eurheartj/ehp265 | by applicant | - RATAJCZAK M. Z. ET AL., LEUKEMIA, (2007), vol. 21, no. 5, pages 860 - 867 | - ZUK, P. A. ET AL., TISSUE ENGINEERING, (2001), vol. 7, pages 211 - 216 | - SHACKLETON, M. ET AL., BREAST CANCER R E., (2005), vol. 7, pages 86 - 95 | - ALVAREZ-BULLTA, A. ET AL., BRAIN RES. BULL., (2002), vol. 57, pages 751 - 758 | - MURREL, W. ET AL., DEV. DYN., (2005), vol. 233, pages 496 - 515 | - KOLLET ET AL., J. CLIN. INVEST, (2003), vol. 112, pages 160 - 169 | - LINKE ET AL., PROC. NATL. ACAD. SCI. USA, (2005), vol. 102, pages 8966 - 8971 | - ROSU-MYLES ET AL., J. CELL. SCI., (2005), vol. 118, pages 4343 - 4352 | - URBANEK ET AL., CIRC. RES., (2005), vol. 97, pages 663 - 673 | - KAJSTURA ET AL., DIABETES, (2001), vol. 50, pages 1414 - 1424 | - TORELLA ET AL., CIRC. RES., (2004), vol. 94, pages 514 - 524 | - DAVIS ET AL., PROC. NATL. ACAD. SCI. USA, (2006), vol. 103, pages 8155 - 8160 | - KANEMURA ET AL., CELL TRANSPLANT, (2005), vol. 14, pages 673 - 682 | - KAPLAN ET AL., NATURE, (2005), vol. 438, pages 750 - 751 | - XU ET AL., METHODS MO/. MED., (2005), vol. 121, pages 189 - 202 | - QUINN ET AL., METHODS MOL. MED., (2005), vol. 121, pages 125 - 148 | - ALMEIDA, JBIOL. CHEM, (2005), vol. 280, pages 41342 - 41351 | - BAMABE-HEIDER ET AL., NEURON, (2005), vol. 48, pages 253 - 265 | - MADLAMBAYAN ET AL., EXP HEMATOL, (2005), vol. 33, pages 1229 - 1239 | - KAMANGA-SOLLO ET AL., EXP CELL RES, (2005), vol. 311, pages 167 - 176 | - HEESE ET AL., NEURO-ONCOL., (2005), vol. 7, pages 476 - 484 | - HE ET AL., AM J. PHYSIOL., (2005), vol. 289, pages H968 - H972 | - BEATTIE ET AL., STEM CELLS, (2005), vol. 23, pages 489 - 495 | - SEKIYA ET AL., CELL TISSUE RES, (2005), vol. 320, pages 269 - 276 | - WEIDT, STEM CELLS, (2004), vol. 22, pages 890 - 896 | - ENCABO ET AL., STEM CELLS, (2004), vol. 22, pages 725 - 740 | - BUYTAERI-HOEFEN ET AL., STEM CELLS, (2004), vol. 22, pages 669 - 674 | - SHERMAN, BASIC APPL. MYOL., (2003), vol. 13, pages 11 - 14 | - PATEL ET AL., THE JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, (2005), vol. 130, pages 1631 - 38 | - PERRIN ET AL., CIRCULATION, (2003), vol. 107, pages 2294 - 2302 | - DAWN ET AL., PROC. NATL. ACAD. SCI. USA, (2005), vol. 102, pages 3766 - 3771 | - FIORDALISO ET AL., DIABETES, (2001), vol. 50, pages 2363 - 2375 | - KOBAYASHI ET AL., HYPERTENS. RES., (2006), vol. 29, pages 449 - 455 | - LERI ET AL., J. CLIN. INVEST., (1998), vol. 101, pages 1326 - 1342 | - MCMURRAY ET AL., LANCET, (2003), vol. 362, pages 767 - 771 | - LLOYD-JONES D; ADAMS R; CARNETHON M; DE SG; FERGUSON TB; FLEGAL K; FORD E; FURIE K; GO A; GREENLUND K, "Heart disease and stroke statistics--2009 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee", CIRCULATION, (2009), vol. 119, no. 3, pages 480 - 486 | - FANG J; MENSAH GA; CROFT JB; KEENAN NL., "Heart failure-related hospitalization in the U.S., 1979 to 2004", JAM COLL CARDIOL, (2008), vol. 52, no. 6, pages 428 - 434 | - VERMA A; MERIS A; SKALI H; GHALI JK; ARNOLD JM; BOURGOUN M; VELAZQUEZ EJ; MCMURRAY JJ; KOBER L; PFEFFER MA, "Prognostic implications of left ventricular mass and geometry following myocardial infarction: the VALIANT (VALsartan In Acute myocardial iNfarcTion) Echocardiographic Study", JACC CARDIOVASC IMAGING, (2008), vol. 1, no. 5, pages 582 - 591 | - KRAUSE K; JAQUET K; SCHNEIDER C; HAUPT S; LIOZNOV MV; OTTE KM; KUCK KH., "Percutaneous intramyocardial stem cell injection in patients with acute myocardial infarction: first-in-man study", HEART, (2009), vol. 95, no. 14, pages 1145 - 1152 | - HIRSCH A; NIJVELDT R; VAN D, V; TIO RA; VAN DER GIESSEN WJ; MARQUES KM; DOEVENDANS PA; WALTENBERGER J; TEN BERG JM; AENGEVAEREN WR, "Intracoronary infusion of autologous mononuclear bone marrow cells in patients with acute myocardial infarction treated with primary PCI: Pilot study of the multicenter HEBE trial.", CATHETER CARDIOVASC INTERV, (2008), vol. 71, no. 3, pages 273 - 281 | - HARE JM., "Translational development of mesenchymal stem cell therapy for cardiovascular diseases", TEX HEART INST J, (2009), vol. 36, no. 2, pages 145 - 147 | - QUEVEDO HC; HATZISTERGOS KE; OSKOUEI BN; FEIGENBAUM GS; RODRIGUEZ JE; VALDES D; PATTANY PM; ZAMBRANO JP; HU Q; MCNIECE I, "Allogeneic mesenchymal stem cells restore cardiac function in chronic ischemic cardiomyopathy via trilineage differentiating capacity", PROC NATL ACAD SCI USA, (2009), vol. 106, no. 33, pages 14022 - 14027 | - SCHULERI KH; FEIGENBAUM GS; CENTOLA M; WEISS ES; ZIMMET JM; TURNEY J; KELLNER J; ZVIMAN MM; HATZISTERGOS KE; DETRICK B, "Autologous mesenchymal stem cells produce reverse remodelling in chronic ischaemic cardiomyopathy", EUR HEART J, (2009), vol. 30, no. 22, pages 2722 - 2732 | - SCHULERI KH; BOYLE AJ; CENTOLA M; AMADO LC; EVERS R; ZIMMET JM; EVERS KS; OSTBYE KM; SCORPIO DG; HARE JM, "The adult Gottingen minipig as a model for chronic heart failure after myocardial infarction: focus on cardiovascular imaging and regenerative therapies.", COMP MED, (2008), vol. 58, no. 6, pages 568 - 579 | - AVISON DL; DEFARIA W; TRYPHONOPOULOS P; TEKIN A; ATTIA GR; TAKAHASHI H; JIN Y; PALAIOS E; PARARAS N; CARRENO MR, "Heterotopic uterus transplantation in a swine model", TRANSPLANTATION, (2009), vol. 88, no. 4, pages 465 - 469 | - ISHIKAWA Y; HIRAKATA A; GRIESEMER AD; ETTER J; MORAN S; WEINER J; SHIMIZU A; YAMADA K., "Tolerance and Long-Lasting Peripheral Chimerism After Allogeneic Intestinal Transplantation in MGH Miniature Swine", TRANSPLANTATION, (2010), vol. 89, no. 4, pages 417 - 426 | - PIJNAPPELS DA; SCHALIJ MJ; RAMKISOENSING AA; VAN TJ; DE VRIES AA; VAN DER LA; YPEY DL; ATSMA DE., "Forced alignment of mesenchymal stem cells undergoing cardiomyogenic differentiation affects functional integration with cardiomyocyte cultures", CIRC RES, (2008), vol. 103, no. 2, pages 167 - 176 | - KRUGLYAKOV PV; SOKOLOVA IB; ZIN'KOVA NN; VIIDE SK; ALEKSANDROV GV; PETROV NS; POLYNTSEV DG., "In vitro and in vivo differentiation of mesenchymal stem cells in the cardiomyocyte direction", BULL EXP BIOL MED, (2006), vol. 142, no. 4, pages 503 - 506 | - SILVA GV; LITOVSKY S; ASSAD JA; SOUSA AL; MARTIN BJ; VELA D; COULTER SC; LIN J; OBER J; VAUGHN WK, "Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model", CIRCULATION, (2005), vol. 111, no. 2, pages 150 - 156 | - AMADO LC; SALIARIS AP; SCHULERI KH; ST JM; XIE JS; CATTANEO S; DURAND DJ; FITTON T; KUANG JQ; STEWART G, "Cardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction", PROC NATL ACAD SCI USA, (2005), vol. 102, no. 32, pages 11474 - 11479 | - AMADO LC; SCHULERI KH; SALIARIS AP; BOYLE AJ; HELM R; OSKOUEI B; CENTOLA M; ENEBOE V; YOUNG R; LIMA JA, "Multimodality noninvasive imaging demonstrates in vivo cardiac regeneration after mesenchymal stem cell therapy", JAM COLL CARDIOL, (2006), vol. 48, no. 10, pages 2116 - 2124 | - SCHULERI KH; AMADO LC; BOYLE AJ; CENTOLA M; SALIARIS AP; GUTMAN MR; HATZISTERGOS KE; OSKOUEI BN; ZIMMET JM; YOUNG RG, "Early improvement in cardiac tissue perfusion due to mesenchymal stem cells", AM J PHYSIOL HEART CIRC PHYSIOL, (2008), vol. 294, no. 5, pages H2002 - H2011 | - HARE JM; TRAVERSE JH; HENRY TD; DIB N; STRUMPF RK; SCHULMAN SP; GERSTENBLITH G; DEMARIA AN; DENKTAS AE; GAMMON RS, "A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction", JAM COLL CARDIOL, (2009), vol. 54, no. 24, pages 2277 - 2286 | - AMADO LC; GERBER BL; GUPTA SN; RETTMANN DW; SZARF G; SCHOCK R; NASIR K; KRAITCHMAN DL; LIMA JA., "Accurate and objective infarct sizing by contrast-enhanced magnetic resonance imaging in a canine myocardial infarction model.", JAM CALL CARDIO1, (2004), vol. 44, no. 12, pages 2383 - 2389 | - SCHULERI KH; CENTOLA M; GEORGE RT; AMADO LC; EVERS KS; KITAGAWA K; VAVERE AL; EVERS R; HARE JM; COX C, "Characterization of peri-infarct zone heterogeneity by contrast-enhanced multidetector computed tomography: a comparison with magnetic resonance imaging", J AM CO// CARDIOL, (2009), vol. 53, no. 18, pages 1699 - 1707 |