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Extract from the Register of European Patents

EP About this file: EP2640853

EP2640853 - MODULATION OF ALPHA SYNUCLEIN EXPRESSION [Right-click to bookmark this link]
StatusPatent revoked
Status updated on  21.10.2024
Database last updated on 03.04.2025
FormerThe patent has been granted
Status updated on  23.11.2018
FormerGrant of patent is intended
Status updated on  18.06.2018
FormerExamination is in progress
Status updated on  08.06.2018
FormerGrant of patent is intended
Status updated on  01.02.2018
FormerExamination is in progress
Status updated on  24.02.2017
Most recent event   Tooltip25.10.2024Revocation of patentpublished on 27.11.2024  [2024/48]
Applicant(s)For all designated states
Ionis Pharmaceuticals, Inc.
2855 Gazelle Court
Carlsbad, CA 92010 / US
[2016/07]
Former [2013/39]For all designated states
Isis Pharmaceuticals, Inc.
2855 Gazelle Court
Carlsbad, CA 92010 / US
Inventor(s)01 / BENNETT, C., Frank
2855 Gazelle Court
Carlsbad, CA 92010 / US
02 / FREIER, Susan, M.
2855 Gazelle Court
Carlsbad, CA 92010 / US
03 / MALLAJOSYULA, Jyothi
1762 Cottonwood Ave
Carlsbad, CA 92011 / US
 [2013/39]
Representative(s)Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[N/P]
Former [2013/39]Chapman, Desmond Mark
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
Application number, filing date11840796.417.11.2011
[2018/52]
WO2011US61245
Priority number, dateUS20100414848P17.11.2010         Original published format: US 414848 P
[2013/39]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2012068405
Date:24.05.2012
Language:EN
[2012/21]
Type: A2 Application without search report 
No.:EP2640853
Date:25.09.2013
Language:EN
The application published by WIPO in one of the EPO official languages on 24.05.2012 takes the place of the publication of the European patent application.
[2013/39]
Type: B1 Patent specification 
No.:EP2640853
Date:26.12.2018
Language:EN
[2018/52]
Search report(s)International search report - published on:US12.07.2012
(Supplementary) European search report - dispatched on:EP04.12.2014
ClassificationIPC:C12Q1/68, C07H21/04, A61K48/00, C12N15/113
[2015/02]
CPC:
C12N15/113 (EP,US); A61P21/00 (EP); A61P25/00 (EP);
A61P25/02 (EP); A61P25/16 (EP); A61P25/28 (EP);
A61P43/00 (EP); C12N2310/11 (EP,US); C12N2310/315 (EP,US);
C12N2310/323 (EP,US); C12N2310/3231 (EP,US); C12N2310/3341 (EP,US);
C12N2310/341 (EP,US); C12N2310/346 (EP,US) (-)
C-Set:
C12N2310/321, C12N2310/3525 (EP,US)
Former IPC [2013/39]C12Q1/68, C07H21/04, A61K48/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2013/39]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:MODULATION VON ALPHA-SYNUKLEINEXPRESSION[2013/39]
English:MODULATION OF ALPHA SYNUCLEIN EXPRESSION[2013/39]
French:MODULATION DE L'EXPRESSION DE L'ALPHA SYNUCLÉINE[2013/39]
Entry into regional phase17.06.2013National basic fee paid 
17.06.2013Search fee paid 
17.06.2013Designation fee(s) paid 
17.06.2013Examination fee paid 
Examination procedure17.06.2013Examination requested  [2013/39]
10.08.2015Despatch of communication that the application is deemed to be withdrawn, reason: reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report not received in time
08.10.2015Amendment by applicant (claims and/or description)
24.02.2017Despatch of a communication from the examining division (Time limit: M06)
06.09.2017Reply to a communication from the examining division
02.02.2018Communication of intention to grant the patent
08.06.2018Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
19.06.2018Communication of intention to grant the patent
29.10.2018Fee for grant paid
29.10.2018Fee for publishing/printing paid
29.10.2018Receipt of the translation of the claim(s)
Divisional application(s)EP18215623.2  / EP3521451
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  24.02.2017
Opposition(s)Opponent(s)01  25.09.2019  30.09.2019  ADMISSIBLE
Hoffmann Eitle Patent- und Rechtsanwälte Partnerschaftsgesellschaft mbB
Arabellastr. 30
81925 München / DE
Opponent's representative
Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
 [N/P]
Former [2019/45]
Opponent(s)01  25.09.2019  30.09.2019  ADMISSIBLE
Hoffman Eitle Patent- und Rechtsanwälte Partnerschaftsgesellschaft mbB
Arabellastr. 30
81925 München / DE
Opponent's representative
Hoffmann Eitle
Patent- und Rechtsanwälte PartmbB
Arabellastraße 30
81925 München / DE
14.10.2019Invitation to proprietor to file observations on the notice of opposition
24.02.2020Reply of patent proprietor to notice(s) of opposition
03.09.2020Cancellation of oral proceeding that was planned for 10.12.2020
28.09.2020Cancellation of oral proceeding that was planned for 14.09.2021
10.12.2020Date of oral proceedings
14.09.2021Date of oral proceedings
05.10.2021Date of oral proceedings
18.10.2021Despatch of minutes of oral proceedings
07.06.2022Date of oral proceedings
21.06.2022Despatch of interlocutory decision in opposition
21.06.2022Despatch of minutes of oral proceedings
16.10.2024Legal effect of revocation of patent [2024/48]
16.10.2024Despatch of communication that the patent will be revoked
Appeal following opposition01.09.2022Appeal received No.  T2044/22
01.09.2022Payment of appeal fee
01.11.2022Statement of grounds filed
11.10.2024Result of appeal procedure: revocation of the patent
16.10.2024Despatch of the decision of the Board of Appeal
31.08.2022Appeal received No.  T2044/22
31.08.2022Payment of appeal fee
31.10.2022Statement of grounds filed
11.10.2024Result of appeal procedure: revocation of the patent
16.10.2024Despatch of the decision of the Board of Appeal
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
08.10.2015Request for further processing filed
08.10.2015Full payment received (date of receipt of payment)
Request granted
21.10.2015Decision despatched
Fees paidRenewal fee
07.11.2013Renewal fee patent year 03
07.11.2014Renewal fee patent year 04
10.11.2015Renewal fee patent year 05
10.11.2016Renewal fee patent year 06
13.11.2017Renewal fee patent year 07
14.11.2018Renewal fee patent year 08
Opt-out from the exclusive  Tooltip
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Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU17.11.2011
AL26.12.2018
AT26.12.2018
CY26.12.2018
CZ26.12.2018
DK26.12.2018
EE26.12.2018
ES26.12.2018
FI26.12.2018
HR26.12.2018
IT26.12.2018
LT26.12.2018
LV26.12.2018
MC26.12.2018
MK26.12.2018
MT26.12.2018
NL26.12.2018
PL26.12.2018
RO26.12.2018
RS26.12.2018
SE26.12.2018
SI26.12.2018
SK26.12.2018
SM26.12.2018
TR26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
IS26.04.2019
PT26.04.2019
IE17.11.2019
LU17.11.2019
BE30.11.2019
CH30.11.2019
LI30.11.2019
[2022/31]
Former [2021/34]HU17.11.2011
AL26.12.2018
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CY26.12.2018
CZ26.12.2018
DK26.12.2018
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FI26.12.2018
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IT26.12.2018
LT26.12.2018
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MC26.12.2018
MT26.12.2018
NL26.12.2018
PL26.12.2018
RO26.12.2018
RS26.12.2018
SE26.12.2018
SI26.12.2018
SK26.12.2018
SM26.12.2018
TR26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
IS26.04.2019
PT26.04.2019
IE17.11.2019
LU17.11.2019
BE30.11.2019
CH30.11.2019
LI30.11.2019
Former [2021/32]HU17.11.2011
AL26.12.2018
AT26.12.2018
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CZ26.12.2018
DK26.12.2018
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FI26.12.2018
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IT26.12.2018
LT26.12.2018
LV26.12.2018
MC26.12.2018
NL26.12.2018
PL26.12.2018
RO26.12.2018
RS26.12.2018
SE26.12.2018
SI26.12.2018
SK26.12.2018
SM26.12.2018
TR26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
IS26.04.2019
PT26.04.2019
IE17.11.2019
LU17.11.2019
BE30.11.2019
CH30.11.2019
LI30.11.2019
Former [2021/26]AL26.12.2018
AT26.12.2018
CY26.12.2018
CZ26.12.2018
DK26.12.2018
EE26.12.2018
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FI26.12.2018
HR26.12.2018
IT26.12.2018
LT26.12.2018
LV26.12.2018
MC26.12.2018
NL26.12.2018
PL26.12.2018
RO26.12.2018
RS26.12.2018
SE26.12.2018
SI26.12.2018
SK26.12.2018
SM26.12.2018
TR26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
IS26.04.2019
PT26.04.2019
IE17.11.2019
LU17.11.2019
BE30.11.2019
CH30.11.2019
LI30.11.2019
Former [2020/51]AL26.12.2018
AT26.12.2018
CZ26.12.2018
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ES26.12.2018
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IT26.12.2018
LT26.12.2018
LV26.12.2018
MC26.12.2018
NL26.12.2018
PL26.12.2018
RO26.12.2018
RS26.12.2018
SE26.12.2018
SI26.12.2018
SK26.12.2018
SM26.12.2018
TR26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
IS26.04.2019
PT26.04.2019
IE17.11.2019
LU17.11.2019
BE30.11.2019
CH30.11.2019
LI30.11.2019
Former [2020/46]AL26.12.2018
AT26.12.2018
CZ26.12.2018
DK26.12.2018
EE26.12.2018
ES26.12.2018
FI26.12.2018
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IT26.12.2018
LT26.12.2018
LV26.12.2018
MC26.12.2018
NL26.12.2018
PL26.12.2018
RO26.12.2018
RS26.12.2018
SE26.12.2018
SI26.12.2018
SK26.12.2018
SM26.12.2018
TR26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
IS26.04.2019
PT26.04.2019
IE17.11.2019
LU17.11.2019
CH30.11.2019
LI30.11.2019
Former [2020/36]AL26.12.2018
AT26.12.2018
CZ26.12.2018
DK26.12.2018
EE26.12.2018
ES26.12.2018
FI26.12.2018
HR26.12.2018
IT26.12.2018
LT26.12.2018
LV26.12.2018
MC26.12.2018
NL26.12.2018
PL26.12.2018
RO26.12.2018
RS26.12.2018
SE26.12.2018
SI26.12.2018
SK26.12.2018
SM26.12.2018
TR26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
IS26.04.2019
PT26.04.2019
LU17.11.2019
CH30.11.2019
LI30.11.2019
Former [2020/35]AL26.12.2018
AT26.12.2018
CZ26.12.2018
DK26.12.2018
EE26.12.2018
ES26.12.2018
FI26.12.2018
HR26.12.2018
IT26.12.2018
LT26.12.2018
LV26.12.2018
NL26.12.2018
PL26.12.2018
RO26.12.2018
RS26.12.2018
SE26.12.2018
SI26.12.2018
SK26.12.2018
SM26.12.2018
TR26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
IS26.04.2019
PT26.04.2019
LU17.11.2019
CH30.11.2019
LI30.11.2019
Former [2020/34]AL26.12.2018
AT26.12.2018
CZ26.12.2018
DK26.12.2018
EE26.12.2018
ES26.12.2018
FI26.12.2018
HR26.12.2018
IT26.12.2018
LT26.12.2018
LV26.12.2018
NL26.12.2018
PL26.12.2018
RO26.12.2018
RS26.12.2018
SE26.12.2018
SI26.12.2018
SK26.12.2018
SM26.12.2018
TR26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
IS26.04.2019
PT26.04.2019
CH30.11.2019
LI30.11.2019
Former [2020/17]AL26.12.2018
AT26.12.2018
CZ26.12.2018
DK26.12.2018
EE26.12.2018
ES26.12.2018
FI26.12.2018
HR26.12.2018
IT26.12.2018
LT26.12.2018
LV26.12.2018
NL26.12.2018
PL26.12.2018
RO26.12.2018
RS26.12.2018
SE26.12.2018
SI26.12.2018
SK26.12.2018
SM26.12.2018
TR26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
IS26.04.2019
PT26.04.2019
Former [2020/13]AL26.12.2018
AT26.12.2018
CZ26.12.2018
DK26.12.2018
EE26.12.2018
ES26.12.2018
FI26.12.2018
HR26.12.2018
IT26.12.2018
LT26.12.2018
LV26.12.2018
NL26.12.2018
PL26.12.2018
RO26.12.2018
RS26.12.2018
SE26.12.2018
SI26.12.2018
SK26.12.2018
SM26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
IS26.04.2019
PT26.04.2019
Former [2019/48]AL26.12.2018
AT26.12.2018
CZ26.12.2018
DK26.12.2018
EE26.12.2018
ES26.12.2018
FI26.12.2018
HR26.12.2018
IT26.12.2018
LT26.12.2018
LV26.12.2018
NL26.12.2018
PL26.12.2018
RO26.12.2018
RS26.12.2018
SE26.12.2018
SK26.12.2018
SM26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
IS26.04.2019
PT26.04.2019
Former [2019/46]AL26.12.2018
AT26.12.2018
CZ26.12.2018
EE26.12.2018
ES26.12.2018
FI26.12.2018
HR26.12.2018
IT26.12.2018
LT26.12.2018
LV26.12.2018
NL26.12.2018
PL26.12.2018
RO26.12.2018
RS26.12.2018
SE26.12.2018
SK26.12.2018
SM26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
IS26.04.2019
PT26.04.2019
Former [2019/39]AL26.12.2018
CZ26.12.2018
EE26.12.2018
ES26.12.2018
FI26.12.2018
HR26.12.2018
IT26.12.2018
LT26.12.2018
LV26.12.2018
NL26.12.2018
PL26.12.2018
RO26.12.2018
RS26.12.2018
SE26.12.2018
SK26.12.2018
SM26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
IS26.04.2019
PT26.04.2019
Former [2019/37]AL26.12.2018
CZ26.12.2018
EE26.12.2018
ES26.12.2018
FI26.12.2018
HR26.12.2018
IT26.12.2018
LT26.12.2018
LV26.12.2018
NL26.12.2018
PL26.12.2018
RO26.12.2018
RS26.12.2018
SE26.12.2018
SM26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
PT26.04.2019
Former [2019/35]AL26.12.2018
CZ26.12.2018
ES26.12.2018
FI26.12.2018
HR26.12.2018
IT26.12.2018
LT26.12.2018
LV26.12.2018
NL26.12.2018
PL26.12.2018
RS26.12.2018
SE26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
PT26.04.2019
Former [2019/34]AL26.12.2018
FI26.12.2018
HR26.12.2018
IT26.12.2018
LT26.12.2018
LV26.12.2018
NL26.12.2018
RS26.12.2018
SE26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
PT26.04.2019
Former [2019/33]AL26.12.2018
FI26.12.2018
HR26.12.2018
LT26.12.2018
LV26.12.2018
NL26.12.2018
RS26.12.2018
SE26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
PT26.04.2019
Former [2019/30]AL26.12.2018
FI26.12.2018
HR26.12.2018
LT26.12.2018
LV26.12.2018
NL26.12.2018
RS26.12.2018
SE26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
Former [2019/26]AL26.12.2018
FI26.12.2018
HR26.12.2018
LT26.12.2018
LV26.12.2018
RS26.12.2018
SE26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
Former [2019/25]FI26.12.2018
HR26.12.2018
LT26.12.2018
LV26.12.2018
RS26.12.2018
SE26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
Former [2019/24]FI26.12.2018
HR26.12.2018
LT26.12.2018
LV26.12.2018
SE26.12.2018
BG26.03.2019
NO26.03.2019
GR27.03.2019
Former [2019/23]FI26.12.2018
HR26.12.2018
LT26.12.2018
LV26.12.2018
BG26.03.2019
NO26.03.2019
Former [2019/22]FI26.12.2018
LT26.12.2018
BG26.03.2019
NO26.03.2019
Former [2019/21]FI26.12.2018
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NO26.03.2019
Former [2019/20]LT26.12.2018
NO26.03.2019
Documents cited:Search[A]WO2007135426  (ISIS INNOVATION [GB], et al);
 [XI]WO2009079399  (ALNYLAM PHARMACEUTICALS INC [US], et al);
International search[Y]US5102785  (LIVAK KENNETH J [US], et al);
 [Y]US6833361  (HONG ZHI [US], et al);
 [Y]US2007225209  (ROCH JEAN-MARC [US], et al);
 [X]US2008003570  (ROGERS JACK [US], et al);
 [Y]US2009092981  (SWAYZE ERIC E [US], et al);
 [Y]US7750141  (CROOKE ROSANNE M [US], et al);
 [Y]US2010204306  (TAN PAMELA [DE])
by applicantWO9414226
 WO9839352
 WO9914226
 US6268490
 WO03004602
 US6525191
 US6670461
 US6770748
 US2004171570
 US6794499
 WO2004106356
 WO2005021570
 US2005130923
 US7034133
 US7053207
 US2007213366
 WO2007134181
 US2007287831
 US2008039618
 US7399845
 WO2008101157
 US7427672
 US2008300204
 US2008306143
 WO2008150729
 WO2008154401
 WO2009006478
 US2009123575
 WO2009079399
 US2009286745
 US2010031377
 US2010036122
 US2010056622
 US7727957
 US2010179223
 US7763747
 US2010261753
 US2010278814
 US20080915408
 US20080026995
 US20080086231
 US20080097787
 US20070989574
 US20080026998
 WO2008US64591
 US20080056564
 WO2008US66154
 WO2008US68922
 US20080099844
OppositionWO2006034348
 US2008003570
 WO2009079399
 WO2012068405
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.