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Extract from the Register of European Patents

EP About this file: EP2659501

EP2659501 - QUANTITATION OF INSULIN BY MASS SPECTROMETRY [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  13.07.2018
Database last updated on 28.06.2024
FormerThe patent has been granted
Status updated on  04.08.2017
FormerGrant of patent is intended
Status updated on  24.03.2017
Most recent event   Tooltip17.07.2020Lapse of the patent in a contracting state
New state(s): AL		published on 19.08.2020  [2020/34]
Applicant(s)For all designated states
Quest Diagnostics Investments Incorporated
300 Delaware Avenue
Wilmington, DE 19899 / US
[2013/45]
Inventor(s)01 / CHEN, Zhaohui
57 Rolling Ridge
Las Flores California 92688 / US
02 / CLARKE, Nigel
1689 Avenida Guillermo
Oceanside California 92056 / US
 [2013/45]
Representative(s)Harrison IP Limited
3 Ebor House
Millfield Lane
Nether Poppleton
York YO26 6QY / GB
[N/P]
Former [2017/36]Harrison IP Limited
3 Ebor House
Millfield Lane
Nether Poppleton, York YO26 6QY / GB
Former [2013/45]D'Arcy, Julia
Harrison IP
1st Floor
Box Tree House
Northminster Business Park, Northfield Lane
York, YO26 6QU / GB
Application number, filing date11852467.727.12.2011
[2017/36]
WO2011US67397
Priority number, dateUS201061427749P28.12.2010         Original published format: US 201061427749 P
[2013/45]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2012092281
Date:05.07.2012
Language:EN
[2012/27]
Type: A2 Application without search report 
No.:EP2659501
Date:06.11.2013
Language:EN
The application published by WIPO in one of the EPO official languages on 05.07.2012 takes the place of the publication of the European patent application.
[2013/45]
Type: B1 Patent specification 
No.:EP2659501
Date:06.09.2017
Language:EN
[2017/36]
Search report(s)International search report - published on:US23.08.2012
(Supplementary) European search report - dispatched on:EP14.03.2014
ClassificationIPC:H01J49/00, G01N33/00, G01N33/68
[2014/16]
CPC:
G01N33/74 (EP,CN,US); G01N33/6848 (EP,CN,US); G01N33/49 (EP,US);
G01N2333/62 (EP,US); H01J49/004 (EP,US)
Former IPC [2013/45]H01J49/00, G01N33/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2013/45]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:QUANTIFIZIERUNG VON INSULIN MITTELS MASSENSPEKTROMETRIE[2013/45]
English:QUANTITATION OF INSULIN BY MASS SPECTROMETRY[2013/45]
French:QUANTIFICATION DE L'INSULINE PAR SPECTROMÉTRIE DE MASSE[2013/45]
Entry into regional phase26.07.2013National basic fee paid 
26.07.2013Search fee paid 
26.07.2013Designation fee(s) paid 
26.07.2013Examination fee paid 
Examination procedure26.07.2013Examination requested  [2013/45]
08.10.2014Amendment by applicant (claims and/or description)
08.04.2015Despatch of a communication from the examining division (Time limit: M06)
19.10.2015Reply to a communication from the examining division
10.12.2015Despatch of a communication from the examining division (Time limit: M06)
15.06.2016Reply to a communication from the examining division
31.03.2017Communication of intention to grant the patent
27.07.2017Fee for grant paid
27.07.2017Fee for publishing/printing paid
27.07.2017Receipt of the translation of the claim(s)
Divisional application(s)EP16176190.3  / EP3091562
EP17189034.6  / EP3270407
EP18209927.5  / EP3511973
EP21184018.6  / EP3920207
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  08.04.2015
Opposition(s)07.06.2018No opposition filed within time limit [2018/33]
Fees paidRenewal fee
12.12.2013Renewal fee patent year 03
11.12.2014Renewal fee patent year 04
10.12.2015Renewal fee patent year 05
13.12.2016Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU27.12.2011
AL06.09.2017
AT06.09.2017
CY06.09.2017
CZ06.09.2017
DK06.09.2017
EE06.09.2017
ES06.09.2017
FI06.09.2017
HR06.09.2017
IT06.09.2017
LT06.09.2017
LV06.09.2017
MC06.09.2017
MK06.09.2017
NL06.09.2017
PL06.09.2017
PT06.09.2017
RO06.09.2017
RS06.09.2017
SE06.09.2017
SI06.09.2017
SK06.09.2017
SM06.09.2017
TR06.09.2017
BG06.12.2017
NO06.12.2017
GR07.12.2017
IE27.12.2017
LU27.12.2017
MT27.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
FR02.01.2018
IS06.01.2018
[2020/34]
Former [2020/27]HU27.12.2011
AT06.09.2017
CY06.09.2017
CZ06.09.2017
DK06.09.2017
EE06.09.2017
ES06.09.2017
FI06.09.2017
HR06.09.2017
IT06.09.2017
LT06.09.2017
LV06.09.2017
MC06.09.2017
MK06.09.2017
NL06.09.2017
PL06.09.2017
PT06.09.2017
RO06.09.2017
RS06.09.2017
SE06.09.2017
SI06.09.2017
SK06.09.2017
SM06.09.2017
TR06.09.2017
BG06.12.2017
NO06.12.2017
GR07.12.2017
IE27.12.2017
LU27.12.2017
MT27.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
FR02.01.2018
IS06.01.2018
Former [2020/16]HU27.12.2011
AT06.09.2017
CY06.09.2017
CZ06.09.2017
DK06.09.2017
EE06.09.2017
ES06.09.2017
FI06.09.2017
HR06.09.2017
IT06.09.2017
LT06.09.2017
LV06.09.2017
MC06.09.2017
MK06.09.2017
NL06.09.2017
PL06.09.2017
RO06.09.2017
RS06.09.2017
SE06.09.2017
SI06.09.2017
SK06.09.2017
SM06.09.2017
TR06.09.2017
BG06.12.2017
NO06.12.2017
GR07.12.2017
IE27.12.2017
LU27.12.2017
MT27.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
FR02.01.2018
IS06.01.2018
Former [2019/51]HU27.12.2011
AT06.09.2017
CY06.09.2017
CZ06.09.2017
DK06.09.2017
EE06.09.2017
ES06.09.2017
FI06.09.2017
HR06.09.2017
IT06.09.2017
LT06.09.2017
LV06.09.2017
MC06.09.2017
MK06.09.2017
NL06.09.2017
PL06.09.2017
RO06.09.2017
RS06.09.2017
SE06.09.2017
SI06.09.2017
SK06.09.2017
SM06.09.2017
BG06.12.2017
NO06.12.2017
GR07.12.2017
IE27.12.2017
LU27.12.2017
MT27.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
FR02.01.2018
IS06.01.2018
Former [2019/46]HU27.12.2011
AT06.09.2017
CY06.09.2017
CZ06.09.2017
DK06.09.2017
EE06.09.2017
ES06.09.2017
FI06.09.2017
HR06.09.2017
IT06.09.2017
LT06.09.2017
LV06.09.2017
MC06.09.2017
NL06.09.2017
PL06.09.2017
RO06.09.2017
RS06.09.2017
SE06.09.2017
SI06.09.2017
SK06.09.2017
SM06.09.2017
BG06.12.2017
NO06.12.2017
GR07.12.2017
IE27.12.2017
LU27.12.2017
MT27.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
FR02.01.2018
IS06.01.2018
Former [2019/31]HU27.12.2011
AT06.09.2017
CZ06.09.2017
DK06.09.2017
EE06.09.2017
ES06.09.2017
FI06.09.2017
HR06.09.2017
IT06.09.2017
LT06.09.2017
LV06.09.2017
MC06.09.2017
NL06.09.2017
PL06.09.2017
RO06.09.2017
RS06.09.2017
SE06.09.2017
SI06.09.2017
SK06.09.2017
SM06.09.2017
BG06.12.2017
NO06.12.2017
GR07.12.2017
IE27.12.2017
LU27.12.2017
MT27.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
FR02.01.2018
IS06.01.2018
Former [2019/30]AT06.09.2017
CZ06.09.2017
DK06.09.2017
EE06.09.2017
ES06.09.2017
FI06.09.2017
HR06.09.2017
IT06.09.2017
LT06.09.2017
LV06.09.2017
MC06.09.2017
NL06.09.2017
PL06.09.2017
RO06.09.2017
RS06.09.2017
SE06.09.2017
SI06.09.2017
SK06.09.2017
SM06.09.2017
BG06.12.2017
NO06.12.2017
GR07.12.2017
IE27.12.2017
LU27.12.2017
MT27.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
FR02.01.2018
IS06.01.2018
Former [2018/52]AT06.09.2017
CZ06.09.2017
DK06.09.2017
EE06.09.2017
ES06.09.2017
FI06.09.2017
HR06.09.2017
IT06.09.2017
LT06.09.2017
LV06.09.2017
NL06.09.2017
PL06.09.2017
RO06.09.2017
RS06.09.2017
SE06.09.2017
SI06.09.2017
SK06.09.2017
SM06.09.2017
BG06.12.2017
NO06.12.2017
GR07.12.2017
IE27.12.2017
LU27.12.2017
MT27.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
FR02.01.2018
IS06.01.2018
Former [2018/49]AT06.09.2017
CZ06.09.2017
DK06.09.2017
EE06.09.2017
ES06.09.2017
FI06.09.2017
HR06.09.2017
IT06.09.2017
LT06.09.2017
LV06.09.2017
NL06.09.2017
PL06.09.2017
RO06.09.2017
RS06.09.2017
SE06.09.2017
SI06.09.2017
SK06.09.2017
SM06.09.2017
BG06.12.2017
NO06.12.2017
GR07.12.2017
IE27.12.2017
LU27.12.2017
MT27.12.2017
BE31.12.2017
FR02.01.2018
IS06.01.2018
Former [2018/45]AT06.09.2017
CZ06.09.2017
DK06.09.2017
EE06.09.2017
ES06.09.2017
FI06.09.2017
HR06.09.2017
IT06.09.2017
LT06.09.2017
LV06.09.2017
NL06.09.2017
PL06.09.2017
RO06.09.2017
RS06.09.2017
SE06.09.2017
SI06.09.2017
SK06.09.2017
SM06.09.2017
BG06.12.2017
NO06.12.2017
GR07.12.2017
IE27.12.2017
LU27.12.2017
MT27.12.2017
IS06.01.2018
Former [2018/43]AT06.09.2017
CZ06.09.2017
DK06.09.2017
EE06.09.2017
ES06.09.2017
FI06.09.2017
HR06.09.2017
IT06.09.2017
LT06.09.2017
LV06.09.2017
NL06.09.2017
PL06.09.2017
RO06.09.2017
RS06.09.2017
SE06.09.2017
SI06.09.2017
SK06.09.2017
SM06.09.2017
BG06.12.2017
NO06.12.2017
GR07.12.2017
LU27.12.2017
MT27.12.2017
IS06.01.2018
Former [2018/39]AT06.09.2017
CZ06.09.2017
DK06.09.2017
EE06.09.2017
ES06.09.2017
FI06.09.2017
HR06.09.2017
IT06.09.2017
LT06.09.2017
LV06.09.2017
NL06.09.2017
PL06.09.2017
RO06.09.2017
RS06.09.2017
SE06.09.2017
SI06.09.2017
SK06.09.2017
SM06.09.2017
BG06.12.2017
NO06.12.2017
GR07.12.2017
IS06.01.2018
Former [2018/35]AT06.09.2017
CZ06.09.2017
DK06.09.2017
EE06.09.2017
ES06.09.2017
FI06.09.2017
HR06.09.2017
IT06.09.2017
LT06.09.2017
LV06.09.2017
NL06.09.2017
PL06.09.2017
RO06.09.2017
RS06.09.2017
SE06.09.2017
SK06.09.2017
SM06.09.2017
BG06.12.2017
NO06.12.2017
GR07.12.2017
IS06.01.2018
Former [2018/24]AT06.09.2017
CZ06.09.2017
EE06.09.2017
ES06.09.2017
FI06.09.2017
HR06.09.2017
IT06.09.2017
LT06.09.2017
LV06.09.2017
NL06.09.2017
PL06.09.2017
RO06.09.2017
RS06.09.2017
SE06.09.2017
SK06.09.2017
SM06.09.2017
BG06.12.2017
NO06.12.2017
GR07.12.2017
IS06.01.2018
Former [2018/23]AT06.09.2017
CZ06.09.2017
EE06.09.2017
ES06.09.2017
FI06.09.2017
HR06.09.2017
LT06.09.2017
LV06.09.2017
NL06.09.2017
PL06.09.2017
RO06.09.2017
RS06.09.2017
SE06.09.2017
SK06.09.2017
BG06.12.2017
NO06.12.2017
GR07.12.2017
IS06.01.2018
Former [2018/21]CZ06.09.2017
ES06.09.2017
FI06.09.2017
HR06.09.2017
LT06.09.2017
LV06.09.2017
NL06.09.2017
RS06.09.2017
SE06.09.2017
BG06.12.2017
NO06.12.2017
GR07.12.2017
Former [2018/15]ES06.09.2017
FI06.09.2017
HR06.09.2017
LT06.09.2017
LV06.09.2017
NL06.09.2017
RS06.09.2017
SE06.09.2017
BG06.12.2017
NO06.12.2017
GR07.12.2017
Former [2018/12]ES06.09.2017
FI06.09.2017
HR06.09.2017
LT06.09.2017
LV06.09.2017
RS06.09.2017
SE06.09.2017
BG06.12.2017
NO06.12.2017
GR07.12.2017
Former [2018/11]ES06.09.2017
FI06.09.2017
HR06.09.2017
LT06.09.2017
RS06.09.2017
SE06.09.2017
BG06.12.2017
NO06.12.2017
GR07.12.2017
Former [2018/09]FI06.09.2017
LT06.09.2017
SE06.09.2017
NO06.12.2017
Former [2018/08]FI06.09.2017
LT06.09.2017
NO06.12.2017
Former [2018/07]LT06.09.2017
NO06.12.2017
Documents cited:Search[A]  - MARIO THEVIS ET AL, "Qualitative Determination of Synthetic Analogues of Insulin in Human Plasma by Immunoaffinity Purification and Liquid Chromatography-Tandem Mass Spectrometry for Doping Control Purposes", ANALYTICAL CHEMISTRY, (20050601), vol. 77, no. 11, doi:10.1021/ac050066i, ISSN 0003-2700, pages 3579 - 3585, XP055105086 [A] 1-5,7-10 * the whole document *

DOI:   http://dx.doi.org/10.1021/ac050066i
 [X]  - MARIO THEVIS ET AL, "Current role of LC-MS(/MS) in doping control", ANALYTICAL AND BIOANALYTICAL CHEMISTRY, SPRINGER, BERLIN, DE, (20070130), vol. 388, no. 7, doi:10.1007/S00216-007-1131-4, ISSN 1618-2650, pages 1351 - 1358, XP019537454 [X] 1-3,5,7 * figure 1 *

DOI:   http://dx.doi.org/10.1007/s00216-007-1131-4
 [X]  - MARIO THEVIS ET AL, "Doping Control Analysis of Intact Rapid-Acting Insulin Analogues in Human Urine by Liquid Chromatography-Tandem Mass Spectrometry", ANALYTICAL CHEMISTRY, (20060301), vol. 78, no. 6, doi:10.1021/ac052095z, ISSN 0003-2700, pages 1897 - 1903, XP055105122 [X] 1-3,5-7 * the whole document *

DOI:   http://dx.doi.org/10.1021/ac052095z
 [X]  - TIIA KUURANNE ET AL, "Insulins in equine urine: qualitative analysis by immunoaffinity purification and liquid chromatography/tandem mass spectrometry for doping control purposes in horse-racing", RAPID COMMUNICATIONS IN MASS SPECTROMETRY, (20080215), vol. 22, no. 3, doi:10.1002/rcm.3360, ISSN 0951-4198, pages 355 - 362, XP055105124 [X] 1-3,5-7 * the whole document *

DOI:   http://dx.doi.org/10.1002/rcm.3360
International search[Y]US2006219558  (HAFEMAN DEAN G [US], et al);
 [X]  - THEVIS ET AL., "Mass spectrometric determination of insulins and their degradation products in sports drug testing.", MASS SPECTROMETRY REVIEWS, vol. 27, no. 1, (200801), pages 53 - 50, URL: http://onlinelibrary.wiley.com/doi/10.1002/mas.20154/pdf, (20120608), XP055105038

DOI:   http://dx.doi.org/10.1002/mas.20154
 [Y]  - UYTFANGHE ET AL., "New liquid chromatography/electrospray ionization tandem mass spectrometry measurement procedure for quantitative analysis of human insulin in serum.", RAPID COMMUNICATIONS IN MASS SPECTROMETRY, vol. 21, no. 5, (2007), pages 819 - 821, URL: http://www.ncbi.nlm.nih.gov/ pubmed/17279601, (20120618), XP055105039

DOI:   http://dx.doi.org/10.1002/rcm.2889
 [Y]  - MANNERING ET AL., "The insulin A-chain epitope recognized by human T cells is posttranslationally modified.", THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 202, no. 9, (20051031), pages 1191 - 1197, URL: http:/em.rupress.org/content/202/9/1191.full, (20120620), XP055105041

DOI:   http://dx.doi.org/10.1084/jem.20051251
by applicantUS5772874
 US5795469
 US5919368
 US5968367
 US6107623
 US6124137
 US6204500
 US6268144
 US6995364
 US2008118932
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    - DARBY, S.M. ET AL., J. ANAL TOXICOL, (2001), vol. 25, pages 8 - 14
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    - THEVIS, M. ET AL., ANAL..CHEM., (2005), vol. 77, pages 3579 - 85
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    - THOMAS, A. ET AL., ANAL. CHEM., (2007), vol. 79, pages 2518 - 24
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    - ZIMMER ET AL., J CHROMATOGR A, (1999), vol. 854, pages 23 - 35
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    - AMADEO R. FERNANDEZ-ALBA,, "Chapter 8", AMADEO R. FERNANDEZ-ALBA,, E. MICHAEL THURMAN ET AL., Chromatographic-Mass Spectrometric Food Analysis for Trace Determination of Pesticide Residues, ELSEVIER, (2005), page 387
    - THEVIS, MASS SPECTROM. REVIEWS, (2008), vol. 27, pages 35 - 50
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.