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Extract from the Register of European Patents

EP About this file: EP2746268

EP2746268 - METHOD FOR CHEMICAL SYNTHESIS OF ANTROCIN [Right-click to bookmark this link]
Former [2014/26]METHOD FOR CHEMICAL SYNTHESIS OF ANTROCIN AND USE THEREOF FOR SUPPRESSING NON-SMALL CELL LUNG CANCER
[2016/18]
StatusNo opposition filed within time limit
Status updated on  13.10.2017
Database last updated on 17.05.2024
FormerThe patent has been granted
Status updated on  04.11.2016
Most recent event   Tooltip17.07.2020Lapse of the patent in a contracting state
New state(s): AL		published on 19.08.2020  [2020/34]
Applicant(s)For all designated states
Yang, Zhen
F202 Peking University Shenzhen Graduate School
Lishui Road
Xili Town
Nanshan District
Shenzhen, Guangdong 518055 / CN
For all designated states
Tzeng, Yewmin
82-2 Wuquan West 5th Street
West District
Taichung, Taiwan 40348 / TW
For all designated states
KAIYEW INVESTMENT CORP.
1st Floor, 82-2 Wuquan West 5th Street
West District
Taichung, 40348
Taiwan / TW
For all designated states
JENISA BIOTECHNOLOGY CORP.
3F., No.87, Xinhu 2nd Road
Neihu District
Taipei City 114, Taiwan / TW
[N/P]
Former [2016/49]For all designated states
Yang, Zhen
F202 Peking University Shenzhen Graduate School
Lishui Road
Xili Town
Nanshan District
Shenzhen, Guangdong 518055 / CN
For all designated states
Tzeng, Yewmin
82-2 Wuquan West 5th Street
West District
Taichung, Taiwan 40348 / TW
For all designated states
KAIYEW INVESTMENT CORP.
1st Floor, 82-2 Wuquan West 5th Street
West District
Taichung, 40348
Taiwan / TW
For all designated states
JENISA BIOTECHNOLOGY CORP.
3F., No.87, Xinhu 2nd Road
Nehu District
Taipei City 114, Taiwan / TW
Former [2015/37]For all designated states
Yang, Zhen
F202 Peking University Shenzhen Graduate School
Lishui Road
Xili Town
Nanshan District
Shenzhen, Guangdong 518055 / CN
For all designated states
Tzeng, Yewmin
82-2 Wuquan West 5th Street
West District
Taichung, Taiwan 40348 / TW
For all designated states
KAIYEW INVESTMENT CORP.
1st Floor, 82-2 Wuquan West 5th Street
West District
Taichung, 40348
Taiwan / TW
For all designated states
JENISA BIOTECHNOLOGY CORP.
7th Floor, 26 Xinhu 2nd Road
Nehu District
Taipei, 114
Taiwan / TW
Former [2014/26]For all designated states
Yang, Zhen
F202 Peking University Shenzhen Graduate School
Lishui Road
Xili Town
Nanshan District
Shenzhen, Guangdong 518055 / CN
For all designated states
Tzeng, Yewmin
82-2 Wuquan West 5th Street
West District
Taichung, Taiwan 40348 / TW
Inventor(s)01 / LI, Chuangchuang
F305 Peking University Shenzhen Graduate School
Lishui Road
Xili Town
Nanshan District
Shenzhen Guangdong 518055 / CN
02 / LUO, Tuoping
276 Watertown St.
Newton Massachusetts 02458 / US
03 / SHI, Hang
F322 Peking University Shenzhen Graduate School
Lishui Road
Xili Town
Nanshan District
Shenzhen Guangdong 518055 / CN
04 / YEH, Chitai
6F No. 22 Lane 66 Wen-Te Road
Neihu District
Taipei Taiwan 11476 / TW
 [2014/26]
Representative(s)Ter Meer Steinmeister & Partner
Patentanwälte mbB
Nymphenburger Straße 4
80335 München / DE
[2016/49]
Former [2014/26]Ter Meer Steinmeister & Partner
Patentanwälte
Mauerkircherstrasse 45
81679 München / DE
Application number, filing date11870667.010.08.2011
[2016/49]
WO2011CN78232
Filing languageZH
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2013020285
Date:14.02.2013
Language:ZH
[2013/07]
Type: A1 Application with search report 
No.:EP2746268
Date:25.06.2014
Language:EN
[2014/26]
Type: B1 Patent specification 
No.:EP2746268
Date:07.12.2016
Language:EN
[2016/49]
Search report(s)International search report - published on:CN14.02.2013
(Supplementary) European search report - dispatched on:EP19.08.2015
ClassificationIPC:C07D307/88, A61K31/343, A61K31/365, A61P35/00
[2015/05]
CPC:
C07D307/88 (EP,US); A61K31/365 (EP,US); A61P35/00 (EP);
A61P43/00 (EP)
Former IPC [2014/26]C07D307/77, A61K31/343, A61K31/365, A61P35/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/26]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:VERFAHREN ZUR CHEMISCHEN SYNTHESE VON ANTROCIN[2016/18]
English:METHOD FOR CHEMICAL SYNTHESIS OF ANTROCIN[2016/18]
French:PROCÉDÉ POUR LA SYNTHÈSE CHIMIQUE D'ANTROCINE[2016/18]
Former [2014/26]VERFAHREN ZUR CHEMISCHEN SYNTHESE VON ANTROCIN UND VERWENDUNG ZUR UNTERDRÜCKUNG VON NICHT-KLEINZELLIGEM LUNGENKARZINOM
Former [2014/26]METHOD FOR CHEMICAL SYNTHESIS OF ANTROCIN AND USE THEREOF FOR SUPPRESSING NON-SMALL CELL LUNG CANCER
Former [2014/26]PROCÉDÉ POUR LA SYNTHÈSE CHIMIQUE D'ANTROCINE ET SON UTILISATION POUR LA SUPPRESSION DU CANCER BRONCHOPULMONAIRE « NON À PETITES CELLULES »
Entry into regional phase28.02.2014Translation filed 
28.02.2014National basic fee paid 
28.02.2014Search fee paid 
28.02.2014Designation fee(s) paid 
28.02.2014Examination fee paid 
Examination procedure28.02.2014Examination requested  [2014/26]
03.03.2016Amendment by applicant (claims and/or description)
06.05.2016Communication of intention to grant the patent
25.08.2016Fee for grant paid
25.08.2016Fee for publishing/printing paid
25.08.2016Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  06.05.2016
Opposition(s)08.09.2017No opposition filed within time limit [2017/46]
Fees paidRenewal fee
28.02.2014Renewal fee patent year 03
22.08.2014Renewal fee patent year 04
21.08.2015Renewal fee patent year 05
12.08.2016Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU10.08.2011
AL07.12.2016
AT07.12.2016
BE07.12.2016
CY07.12.2016
CZ07.12.2016
DK07.12.2016
EE07.12.2016
ES07.12.2016
FI07.12.2016
HR07.12.2016
IT07.12.2016
LT07.12.2016
LV07.12.2016
MC07.12.2016
MK07.12.2016
NL07.12.2016
PL07.12.2016
RO07.12.2016
RS07.12.2016
SE07.12.2016
SI07.12.2016
SK07.12.2016
SM07.12.2016
TR07.12.2016
BG07.03.2017
NO07.03.2017
GR08.03.2017
IS07.04.2017
PT07.04.2017
IE10.08.2017
LU10.08.2017
MT10.08.2017
CH31.08.2017
LI31.08.2017
[2020/34]
Former [2020/15]HU10.08.2011
AT07.12.2016
BE07.12.2016
CY07.12.2016
CZ07.12.2016
DK07.12.2016
EE07.12.2016
ES07.12.2016
FI07.12.2016
HR07.12.2016
IT07.12.2016
LT07.12.2016
LV07.12.2016
MC07.12.2016
MK07.12.2016
NL07.12.2016
PL07.12.2016
RO07.12.2016
RS07.12.2016
SE07.12.2016
SI07.12.2016
SK07.12.2016
SM07.12.2016
TR07.12.2016
BG07.03.2017
NO07.03.2017
GR08.03.2017
IS07.04.2017
PT07.04.2017
IE10.08.2017
LU10.08.2017
MT10.08.2017
CH31.08.2017
LI31.08.2017
Former [2019/51]HU10.08.2011
AT07.12.2016
BE07.12.2016
CY07.12.2016
CZ07.12.2016
DK07.12.2016
EE07.12.2016
ES07.12.2016
FI07.12.2016
HR07.12.2016
IT07.12.2016
LT07.12.2016
LV07.12.2016
MC07.12.2016
MK07.12.2016
NL07.12.2016
PL07.12.2016
RO07.12.2016
RS07.12.2016
SE07.12.2016
SI07.12.2016
SK07.12.2016
SM07.12.2016
BG07.03.2017
NO07.03.2017
GR08.03.2017
IS07.04.2017
PT07.04.2017
IE10.08.2017
LU10.08.2017
MT10.08.2017
CH31.08.2017
LI31.08.2017
Former [2019/46]HU10.08.2011
AT07.12.2016
BE07.12.2016
CY07.12.2016
CZ07.12.2016
DK07.12.2016
EE07.12.2016
ES07.12.2016
FI07.12.2016
HR07.12.2016
IT07.12.2016
LT07.12.2016
LV07.12.2016
MC07.12.2016
NL07.12.2016
PL07.12.2016
RO07.12.2016
RS07.12.2016
SE07.12.2016
SI07.12.2016
SK07.12.2016
SM07.12.2016
BG07.03.2017
NO07.03.2017
GR08.03.2017
IS07.04.2017
PT07.04.2017
IE10.08.2017
LU10.08.2017
MT10.08.2017
CH31.08.2017
LI31.08.2017
Former [2019/31]HU10.08.2011
AT07.12.2016
BE07.12.2016
CZ07.12.2016
DK07.12.2016
EE07.12.2016
ES07.12.2016
FI07.12.2016
HR07.12.2016
IT07.12.2016
LT07.12.2016
LV07.12.2016
MC07.12.2016
NL07.12.2016
PL07.12.2016
RO07.12.2016
RS07.12.2016
SE07.12.2016
SI07.12.2016
SK07.12.2016
SM07.12.2016
BG07.03.2017
NO07.03.2017
GR08.03.2017
IS07.04.2017
PT07.04.2017
IE10.08.2017
LU10.08.2017
MT10.08.2017
CH31.08.2017
LI31.08.2017
Former [2018/43]AT07.12.2016
BE07.12.2016
CZ07.12.2016
DK07.12.2016
EE07.12.2016
ES07.12.2016
FI07.12.2016
HR07.12.2016
IT07.12.2016
LT07.12.2016
LV07.12.2016
MC07.12.2016
NL07.12.2016
PL07.12.2016
RO07.12.2016
RS07.12.2016
SE07.12.2016
SI07.12.2016
SK07.12.2016
SM07.12.2016
BG07.03.2017
NO07.03.2017
GR08.03.2017
IS07.04.2017
PT07.04.2017
IE10.08.2017
LU10.08.2017
MT10.08.2017
CH31.08.2017
LI31.08.2017
Former [2018/34]AT07.12.2016
BE07.12.2016
CZ07.12.2016
DK07.12.2016
EE07.12.2016
ES07.12.2016
FI07.12.2016
HR07.12.2016
IT07.12.2016
LT07.12.2016
LV07.12.2016
MC07.12.2016
NL07.12.2016
PL07.12.2016
RO07.12.2016
RS07.12.2016
SE07.12.2016
SI07.12.2016
SK07.12.2016
SM07.12.2016
BG07.03.2017
NO07.03.2017
GR08.03.2017
IS07.04.2017
PT07.04.2017
IE10.08.2017
LU10.08.2017
CH31.08.2017
LI31.08.2017
Former [2018/21]AT07.12.2016
BE07.12.2016
CZ07.12.2016
DK07.12.2016
EE07.12.2016
ES07.12.2016
FI07.12.2016
HR07.12.2016
IT07.12.2016
LT07.12.2016
LV07.12.2016
MC07.12.2016
NL07.12.2016
PL07.12.2016
RO07.12.2016
RS07.12.2016
SE07.12.2016
SI07.12.2016
SK07.12.2016
SM07.12.2016
BG07.03.2017
NO07.03.2017
GR08.03.2017
IS07.04.2017
PT07.04.2017
CH31.08.2017
LI31.08.2017
Former [2018/18]AT07.12.2016
BE07.12.2016
CZ07.12.2016
DK07.12.2016
EE07.12.2016
ES07.12.2016
FI07.12.2016
HR07.12.2016
IT07.12.2016
LT07.12.2016
LV07.12.2016
MC07.12.2016
NL07.12.2016
PL07.12.2016
RO07.12.2016
RS07.12.2016
SE07.12.2016
SI07.12.2016
SK07.12.2016
SM07.12.2016
BG07.03.2017
NO07.03.2017
GR08.03.2017
IS07.04.2017
PT07.04.2017
Former [2017/52]AT07.12.2016
BE07.12.2016
CZ07.12.2016
DK07.12.2016
EE07.12.2016
ES07.12.2016
FI07.12.2016
HR07.12.2016
IT07.12.2016
LT07.12.2016
LV07.12.2016
NL07.12.2016
PL07.12.2016
RO07.12.2016
RS07.12.2016
SE07.12.2016
SI07.12.2016
SK07.12.2016
SM07.12.2016
BG07.03.2017
NO07.03.2017
GR08.03.2017
IS07.04.2017
PT07.04.2017
Former [2017/38]AT07.12.2016
BE07.12.2016
CZ07.12.2016
EE07.12.2016
ES07.12.2016
FI07.12.2016
HR07.12.2016
IT07.12.2016
LT07.12.2016
LV07.12.2016
NL07.12.2016
PL07.12.2016
RO07.12.2016
RS07.12.2016
SE07.12.2016
SK07.12.2016
SM07.12.2016
BG07.03.2017
NO07.03.2017
GR08.03.2017
IS07.04.2017
PT07.04.2017
Former [2017/36]BE07.12.2016
CZ07.12.2016
EE07.12.2016
ES07.12.2016
FI07.12.2016
HR07.12.2016
LT07.12.2016
LV07.12.2016
NL07.12.2016
PL07.12.2016
RO07.12.2016
RS07.12.2016
SE07.12.2016
SK07.12.2016
NO07.03.2017
GR08.03.2017
IS07.04.2017
Former [2017/31]ES07.12.2016
FI07.12.2016
HR07.12.2016
LT07.12.2016
LV07.12.2016
NL07.12.2016
RS07.12.2016
SE07.12.2016
NO07.03.2017
GR08.03.2017
Former [2017/28]ES07.12.2016
FI07.12.2016
HR07.12.2016
LT07.12.2016
LV07.12.2016
RS07.12.2016
SE07.12.2016
NO07.03.2017
GR08.03.2017
Former [2017/12]LV07.12.2016
Documents cited:Search[Y]US2007116787  (YAO CHIH-JUNG [TW], et al) [Y] 10-15 * abstract * * paragraph [[0027]] *;
 [Y]US2008119565  (LIU SHENG-YUN [TW], et al) [Y] 10-15 * abstract * * paragraphs [[0018]] , [ [0040]]; example 3; claims 11,16; table 2 *
 [T]  - HANG SHI ET AL, "Total Syntheses of Drimane-Type Sesquiterpenoids Enabled by a Gold-Catalyzed Tandem Reaction", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, (20110928), vol. 133, no. 38, doi:10.1021/ja206837j, ISSN 0002-7863, pages 14944 - 14947, XP055159708 [T] 1-9 * the whole document *

DOI:   http://dx.doi.org/10.1021/ja206837j
 [A]  - HIDENORI WATANABE, "Synthesis and determination of the absolute configuration of fudecalone", ARKIVOC, (20030217), vol. 2003, no. 8, doi:10.3998/ark.5550190.0004.826, ISSN 1551-7004, page 267, XP055159719 [A] 1-9 * the whole document *

DOI:   http://dx.doi.org/10.3998/ark.5550190.0004.826
 [A]  - YOSHIKAZU SUZUKI ET AL, "Total Synthesis of (-)-Mniopetal E, a Novel Biologically Intriguing Drimane Sesquiterpenoid", THE JOURNAL OF ORGANIC CHEMISTRY, (20001201), vol. 65, no. 25, doi:10.1021/jo001004p, ISSN 0022-3263, pages 8595 - 8607, XP055159790 [A] 1-9 * the whole document *

DOI:   http://dx.doi.org/10.1021/jo001004p
 [Y]  - JENG-FENG CHIOU ET AL, "A Preclinical Evaluation of Antrodia camphorata Alcohol Extracts in the Treatment of Non-Small Cell Lung Cancer Using Non-Invasive Molecular Imaging", EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, (20110101), vol. 12, no. 3, doi:10.1158/1535-7163.MCT-07-0180, ISSN 1741-427X, pages 5902 - 12, XP055206829 [Y] 10-15 * abstract * * page 2, column left, paragraph 3rd *

DOI:   http://dx.doi.org/10.1093/ecam/nep228
International search[E]CN102204902  (UNIV CHAOYANG TECHNOLOGY);
 [E]US2011263700  (TZENG YEW-MIN [TW], et al);
 [X]  - RAO, YERRA KOTESWARA ET AL., "Identification of Antrocin from Antrodia Camphorata as a Selective and Novel Class of Small Molecule Inhibitor of Akt/mTOR Signaling in Metastatic Breast Cancer MDA-MB-231 Cells.", CHEMICAL RESEARCH IN TOXICOLOGY, (20101215), vol. 24, no. 2, pages 238 - 245, XP055143239

DOI:   http://dx.doi.org/10.1021/tx100318m
 [A]  - CHIANG, HUNG-CHEN ET AL., "A Sesquiterpene Lactone, Phenyl and Biphenyl Compounds from Antrodia Cinnamomea.", PHYTOCHEMISTRY, (199506), vol. 39, no. 3, pages 613 - 616, XP008138393

DOI:   http://dx.doi.org/10.1016/0031-9422(95)00025-3
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