EP2500356 - Dual variable domain immunoglobulin and uses thereof [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 08.01.2016 Database last updated on 14.06.2024 | Most recent event Tooltip | 08.01.2016 | Application deemed to be withdrawn | published on 10.02.2016 [2016/06] | Applicant(s) | For all designated states AbbVie Inc. 1 North Waukegan Road North Chicago, IL 60064 / US | [2013/24] |
Former [2012/38] | For all designated states Abbott Laboratories 100 Abbott Park Road Abbott Park, IL 60064-6008 / US | Inventor(s) | 01 /
Wu, Chengbin 300 Jin Xiu Road, ¤ 14, Apt. 602 Pudong, Shanghai / CN | 02 /
Ghayur, Tariq 1014 Washington Street Holliston, MA 01746 / US | 03 /
Dixon, Richard, W. 19 Nottingham Drive Jefferson, MA 01522 / US | 04 /
Salfeld, Jochen, G. 177 Old Westborough Road North Grafton, MA 01536 / US | [2012/38] | Representative(s) | Modiano, Micaela Nadia, et al Modiano & Partners (DE) Thierschstrasse 11 80538 München / DE | [2012/38] | Application number, filing date | 12161985.2 | 18.08.2006 | [2012/38] | Priority number, date | US20050709911P | 19.08.2005 Original published format: US 709911 P | US20050732892P | 02.11.2005 Original published format: US 732892 P | [2012/38] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | EP2500356 | Date: | 19.09.2012 | Language: | EN | [2012/38] | Type: | A3 Search report | No.: | EP2500356 | Date: | 24.10.2012 | Language: | EN | [2012/43] | Search report(s) | (Supplementary) European search report - dispatched on: | EP | 20.09.2012 | Classification | IPC: | C07K16/24, C07K16/28, C07K16/46, A61K39/395 | [2012/38] | CPC: |
C07K16/241 (EP);
A61K2039/505 (EP);
C07K2317/21 (EP);
C07K2317/31 (EP);
C07K2317/64 (EP);
C07K2317/94 (EP)
| Designated contracting states | AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LI, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR [2012/38] | Extension states | BA | 24.04.2013 | HR | 24.04.2013 | MK | 24.04.2013 | RS | 24.04.2013 | Title | German: | Immunglobuline mit zweifacher variabler Domäne und ihre Verwendung | [2012/38] | English: | Dual variable domain immunoglobulin and uses thereof | [2012/38] | French: | Immunoglobuline à double domaine variable et ses utilisations | [2012/38] | Examination procedure | 24.04.2013 | Examination requested [2013/23] | 07.08.2013 | Amendment by applicant (claims and/or description) | 24.04.2015 | Despatch of a communication from the examining division (Time limit: M04) | 05.09.2015 | Application deemed to be withdrawn, date of legal effect [2016/06] | 29.09.2015 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2016/06] | Parent application(s) Tooltip | EP06813554.0 / EP1928506 | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20060813554) is 23.03.2010 | Request for further processing for: | The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report | 07.08.2013 | Request for further processing filed | 07.08.2013 | Full payment received (date of receipt of payment) Request granted | 23.08.2013 | Decision despatched | Fees paid | Renewal fee | 11.07.2012 | Renewal fee patent year 03 | 11.07.2012 | Renewal fee patent year 04 | 11.07.2012 | Renewal fee patent year 05 | 11.07.2012 | Renewal fee patent year 06 | 08.08.2012 | Renewal fee patent year 07 | 07.08.2013 | Renewal fee patent year 08 | 07.08.2014 | Renewal fee patent year 09 | Penalty fee | Additional fee for renewal fee | 31.08.2015 | 10   M06   Not yet paid |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [I]US2002127231 (SCHNECK JONATHAN [US], et al) [I] 1-19 * figures 1B,1c,1d; claims 1,3,7,8 *; | [I]WO0202781 (VLAAMS INTERUNIV INST BIOTECH [BE], et al) [I] 1-19 * figure 1 *; | [ID]WO0177342 (GENENTECH INC [US]) [ID] 1-19 * figure 4 *; | [I]EP0517024 (BEHRINGWERKE AG [DE]) [I] 1-19 * claim 1 *; | [I]WO9509917 (UNIV CALIFORNIA [US]) [I] 1-19 * figure 3 *; | [IP]WO2006020258 (IMCLONE SYSTEMS INC [US], et al) [IP] 1-19 * figure 1; claim 1 *; | [I] - ALT M ET AL, "NOVEL TETRAVALENT AND BISPECIFIF IGG-LIKE ANTIBODY MOLECULES COMBINING SINGLE-CHAIN DIABODIES WITH THE IMMUNOGLOBULIN GAMMA1 FC OR CH3 REGION", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, (19990101), vol. 454, no. 1/2, doi:10.1016/S0014-5793(99)00782-6, ISSN 0014-5793, pages 90 - 94, XP000919188 [I] 1-19 * figure 1 * DOI: http://dx.doi.org/10.1016/S0014-5793(99)00782-6 | [I] - LU DAN ET AL, "Di-diabody: A novel tetravalent bispecific antibody molecule by design.", JOURNAL OF IMMUNOLOGICAL METHODS, (200308), vol. 279, no. 1-2, ISSN 0022-1759, pages 219 - 232, XP004455322 [I] 1-19 * figure 1 * DOI: http://dx.doi.org/10.1016/S0022-1759(03)00251-5 | [I] - PARK S S ET AL, "Generation and characterization of a novel tetravalent bispecific antibody that binds to hepatitis B virus surface antigens", MOLECULAR IMMUNOLOGY, PERGAMON, GB, (20001201), vol. 37, no. 18, ISSN 0161-5890, pages 1123 - 1130, XP002266827 [I] 1-19 * figure 1 * DOI: http://dx.doi.org/10.1016/S0161-5890(01)00027-X | [T] - WU CHENGBIN ET AL, "Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin", NATURE BIOTECHNOLOGY, (200711), vol. 25, no. 11, ISSN 1087-0156, pages 1290 - 1297, XP002542446 [T] 1-19 * the whole document * DOI: http://dx.doi.org/10.1038/nbt1345 | [A] - JIAN YI LI ET AL, "GENETICALLY ENGINEERED BRAIN DRUG DELIVERY VECTORS: CLONING, EXPRESSION AND IN VIVO APPLICATION OF AN ANTI-TRANSFERRIN RECEPTOR SINGLE CHAIN ANTIBODY-STREPTAVIDIN FUSION GENE AND PROTEIN", PROTEIN ENGINEERING, OXFORD UNIVERSITY PRESS, SURREY, GB, (19990901), vol. 12, no. 9, doi:10.1093/PROTEIN/12.9.787, ISSN 0269-2139, pages 787 - 796, XP000984720 [A] 1-19 * the whole document * DOI: http://dx.doi.org/10.1093/protein/12.9.787 | by applicant | WO0177342 | US5648260 | US5624821 | WO9005144 | US5641870 | WO0202773 | WO0183525 | US5627052 | WO9202551 | WO9729131 | WO0056772 | US5916771 | US5939598 | US5985615 | US5998209 | US6075181 | US6091001 | US6114598 | US6130364 | WO9110741 | WO9402602 | WO9634096 | WO9633735 | WO9816654 | WO9824893 | WO9850433 | WO9945031 | WO9953049 | WO0009560 | WO0037504 | US5223409 | WO9218619 | WO9117271 | WO9220791 | WO9215679 | WO9301288 | WO9201047 | WO9209690 | US2003186374 | WO9002809 | WO9110737 | WO9311236 | WO9515982 | WO9520401 | US5698426 | US5403484 | US5580717 | US5427908 | US5750753 | US5821047 | US5571698 | US5516637 | US5780 | US225 | US5658727 | US5733743 | US5969108 | WO9222324 | US4946778 | US5258498 | WO9831700 | US6699658 | EP0239400 | WO9109967 | US5225539 | US5530101 | US5585089 | EP0592106 | EP0519596 | US5565352 | WO9014443 | WO9014424 | WO9014430 | EP0229246 | US5565332 | US5723323 | US5976862 | US5824514 | US5817483 | US5814476 | US5763192 | US5766886 | US5714352 | US6204023 | US6180370 | US5693762 | US4816567 | US6258562 | US6914128 | US2005147610 | US5736137 | US5500362 | US5677171 | US4753894 | US4943533 | WO9640210 | US6235883 | US5558864 | WO9520045 | US5891996 | US6506883 | WO0162931 | WO0188138 | WO02072636 | WO03016466 | US5714350 | US6350861 | EP1176195 | WO03035835 | WO9954342 | US2004018590 | US2002137134 | WO2005100584 | US6019968 | US5985320 | US5985309 | US5934272 | US5874064 | US5855913 | US5290540 | US4880078 | WO9219244 | WO9732572 | WO9744013 | WO9831346 | WO9966903 | US5679377 | US5916597 | US5912015 | US5989463 | US5128326 | WO9915154 | WO9920253 | US4526938 | WO9105548 | WO9620698 | US4980286 | WO2004078140 | US2006104968 | WO9925044 | US2005042664 | WO02097048 | WO9524918 | US5780225 | WO0158956 | - MILSTEIN, C.; A.C. CUELLO, NATURE, (1983), vol. 305, no. 5934, pages 537 - 40 | - STAERZ, U.D. ET AL., NATURE, (1985), vol. 314, no. 6012, pages 628 - 3 1 | - BRENRAN, M. ET AL., SCIENCE, (1985), vol. 229, no. 4708, pages 81 - 3 | - GLENNIE, M.J. ET AL., J IMMUNOL, (1987), vol. 139, no. 7, pages 2367 - 75 | - KRIANGKUM, J. ET AL., BIOMOL ENG, (2001), vol. 18, no. 2, pages 31 - 40 | - ECONOMIDES, A.N. ET AL., NAT MED, (2003), vol. 9, no. 1, pages 47 - 52 | - NAKANISHI, K. ET AL., ANNU REV IMMUNOL, (2001), vol. 19, pages 423 - 74 | - GRACIE, J. A. ET AL., J CLIN INVEST, (1999), vol. 104, no. 10, pages 1393 - 401 | - LEUNG, B.P. ET AL., J IMMUNOL, (2000), vol. 164, no. 12, pages 6495 - 502 | - ITO, A. ET AL., J INUNUNOL, (2003), vol. 170, no. 9, pages 4802 - 9 | - KARNI, A. ET AL., J NEUROIMMUNOL, (2002), vol. 125, no. 1-2, pages 134 - 40 | - ARNDT, M.; J. KRAUSS, METHODS MOL BIOL, (2003), vol. 207, pages 305 - 21 | - PEIPP, M.; T. VALERIUS, BIOCHEM SOC TRANS, (2002), vol. 30, no. 4, pages 507 - 11 | - MACK, M.; G. RIETHMULLER; P. KUFER, PROC NATL ACAD SCI USA, (1995), vol. 92, no. 15, pages 7021 - 5 | - HOLLIGER, P.; T. PROSPERO; G. WINTER, PROC NATL ACAD SCI USA, (1993), vol. 90, no. 14 | - HOLLIGER, P.; G. WINTER, CANCER IMMUNOL IMMUNOTHER, (1997), vol. 45, no. 3-4, pages 128 - 30 | - WU, A.M. ET AL., IMMUNOTECHNOLOGY, (1996), vol. 2, no. 1, pages 21 - 36 | - PLUCKTHUN, A.; P. PACK, IMMUNOTECHNOLOGY, (1997), vol. 3, no. 2, pages 83 - 105 | - RIDGWAY, J.B. ET AL., PROTEIN ENG, (1996), vol. 9, no. 7, pages 617 - 21 | - LU, D. ET AL., J BIOL CHEM, vol. 279, no. 4, pages 2856 - 65 | - MILLER, K. ET AL., J IMMUNOL, (2003), vol. 170, no. 9, pages 4854 - 61 | - DUROCHER ET AL., NUCLEIC ACIDS RESEARCH, (2002), vol. 30, no. 2 | - MIZUSHIMA, S.; NAGATA, S., NUCLEIC ACIDS RESEARCH, (1990), vol. 18, no. 17 | - HUBER ET AL., NATURE, vol. 264, pages 415 - 20 | - THIES ET AL., J MOL BIOL, (1999), vol. 293, pages 67 - 79 | - DALL'ACQUA, BIOCHEMISTRY, (1998), vol. 37, pages 9266 - 73 | - SELIGMAN, ANN IMMUNOL, (1978), vol. 129, pages 855 - 70 | - BIEWENGA ET AL., CLIN EXP IMMUNOL, (1983), vol. 51, pages 395 - 400 | - WEST ET AL., BIOCHEMISTRY, (2000), vol. 39, pages 9698 - 708 | - KIM ET AL., BUR J IMMUNOL, (1994), vol. 24, pages 542 - 548 | - WARD ET AL., NATURE, (1989), vol. 341, pages 544 - 546 | - BIRD ET AL., SCIENCE, (1988), vol. 242, pages 423 - 426 | - HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, (1988), vol. 85, pages 5879 - 5883 | - HOLLIGER, P. ET AL., PROC. NATL. ACAD. SCI. USA, (1993), vol. 90, pages 6444 - 6448 | - POLJAK, R.J. ET AL., STRUCTURE, (1994), vol. 2, pages 1121 - 1123 | - KONTERMANN AND DUBEL, Antibody Engineering, SPRINGER-VERLAG, (2001), page 790, ISBN 3-540-41354-5 | - ZAPATA ET AL., PROTEIN ENG., (1995), vol. 8, no. 10, pages 1057 - 1062 | - STAERZ, U.D. ET AL., NATURE, (1985), vol. 314, no. 6012, pages 628 - 31 | - HOLLIGER, P. ET AL., PROC. NATD. ACAD. SCI. USA, (1993), vol. 9Q, pages 6444 - 6448 | - HOOGENBOOM H.R., TIB TECH., (1997), vol. 15, pages 62 - 70 | - AZZAZY H.; HIGHSMITH W.E., CLIN. BIOCHEM., (2002), vol. 35, pages 425 - 445 | - GAVILONDO J.V.; LARRICK J.W., BIOTECHNIQUES, (2002), vol. 29, pages 128 - 145 | - HOOGENBOOM H.; CHAMES P., IMMUNOLOGY TODAY, (2000), vol. 21, pages 371 - 378 | - TAYLOR, L. D. ET AL., NUCL. ACIDS RES., (1992), vol. 20, pages 6287 - 6295 | - KELLERMANN S-A.; GREEN L.L., CURRENT OPINION IN BIOTECHNOLOGY, (2002), vol. 13, pages 593 - 597 | - LITTLE M. ET AL., IMMUNOLOGY TODAY, (2000), vol. 21, pages 364 - 370 | - MARKS ET AL., BIDLTECHNOLOGY, (1992), vol. 10, pages 779 - 783 | - BARBAS ET AL., PROC NAT. ACAD. SCI, USA, (1994), vol. 91, pages 3809 - 3813 | - YELTON ET AL., J. IMMUNOL., (1995), vol. 155, pages 1994 - 2004 | - JACKSON ET AL., J. IMMUNOL., (1995), vol. 154, no. 7, pages 3310 - 9 | - HAWKINS ET AL., J. MOL. BIOL, (1992), vol. 226, pages 889 - 896 | - KABAT ET AL., ANN, NY ACAD, SCI., (1971), vol. 190, pages 382 - 391 | - CHOTHIA; LESK, J, MOL. BIOL., (1987), vol. 196, pages 901 - 917 | - CHOTHIA ET AL., NATURE, (1989), vol. 342, pages 877 - 883 | - PADLAN, FASEB J., (1995), vol. 9, pages 133 - 139 | - MACCALLUM, J MOL BIOL, (1996), vol. 262, no. 5, pages 732 - 45 | - SHAPIRO ET AL., CRIT. REV. BNMUNOL., (2002), vol. 22, no. 3, pages 183 - 200 | - MARCHALONIS ET AL., ADV EXP MED BIOL., (2001), vol. 484, pages 13 - 30 | - JANSSON, U. ET AL., ANN. BIOL. CLIN., (1993), vol. 51, pages 19 - 26 | - JÖNSSON, U. ET AL., BIOTECHNIQUES, (1991), vol. 11, pages 620 - 627 | - JOHNSSON, B. ET AL., J. MOL. RECOGNIT., (1995), vol. 8, pages 125 - 131 | - JOHNNSON, B. ET AL., ANAL. BIOCHEM., (1991), vol. 128, pages 268 - 277 | - GIEGE, R.; DUCRUIX, A. BARRETT, Crystallization of Nucleic Acids and Proteins, a Practical Approach, 2nd ed.,, OXFORD UNIVERSITY PRESS, (1999), pages 20 1 - 16 | - HAMMERLING ET AL., Monoclonal Antibodies and T-Cell Hybridomas, ELSEVIER, (1981), pages 563 - 681 | - BABCOCK, J.S. ET AL., PROC. NATL. ACAD. SCI. USA, (1996), vol. 93, pages 7843 - 7848 | - GREEN ET AL., NATURE GENETICS, (1994), vol. 7, pages 13 - 21 | - MENDEZ ET AL., NATURE GENETICS, (1997), vol. 15, pages 146 - 156 | - GREEN; JAKOBOVITS, J. EXP. MED., (1998), vol. 188, pages 483 - 495 | - FUCHS ET AL., BIO/TECHNOLOGY, (1991), vol. 2, pages 1370 - 1372 | - HAY, HUM ANTIBOD HYBRIDOMAS, (1992), vol. 3, pages 81 - 85 | - HUSE ET AL., SCIENCE, (1989), vol. 246, pages 1275 - 1281 | - MCCAFFERTY ET AL., NATURE, (1990), vol. 348, pages 552 - 554 | - GRIFFITHS ET AL., EMBO J, (1993), vol. 12, pages 725 - 734 | - HAWKINS ET AL., J MOL BIOL, (1992), vol. 226, pages 889 - 896 | - CLACKSON ET AL., NATURE, (1991), vol. 352, pages 624 - 628 | - GRAM ET AL., PNAS, (1992), vol. 89, pages 3576 - 3580 | - GARRAD ET AL., BIOTECHNOLOGY, (1991), vol. 9, pages 1373 - 1377 | - HOOGENBOOM ET AL., NUC ACID RES, (1991), vol. 19, pages 4133 - 4137 | - BARBAS ET AL., PNAS, (1991), vol. 88, pages 7978 - 7982 | - BRINKMAN ET AL., J. LMMUNOL. METHODS, (1995), vol. 182, pages 41 - 50 | - AMES ET AL., J. IMMUNOL. METHODS, (1995), vol. 184, pages 177 - 186 | - KETTLEBOROUGH ET AL., EUR. I. IMMUNOL., (1994), vol. 24, pages 952 - 958 | - PERSIC ET AL., GENE, (1997), vol. 187, pages 9 - 18 | - BURTON, ADVANCES IN IMMUNOLOGY, (1994), vol. 57, pages 191 - 280 | - MULLINAX ET AL., BIOTECHNIQUES, (1992), vol. 12, no. 6, pages 864 - 869 | - SAWAI ET AL., AJRI, (1995), vol. 34, pages 26 - 34 | - BETTER ET AL., SCIENCE, (1988), vol. 240, pages 1041 - 1043 | - HUSTON ET AL., METHODS IN ENZYMOLOGY, (1991), vol. 203, pages 46 - 88 | - SHU ET AL., PNAS, (1993), vol. 90, pages 7995 - 7999 | - SKERRA ET AL., SCIENCE, (1988), vol. 240, pages 1038 - 1040 | - ROBERTS, R.W.; SZOSTAK, J.W., PROC. NATL. ACAD. SCI. USA, (1997), vol. 94, pages 12297 - 12302 | - PADLAN, MOLECULAR IMMUNOLOGY, (1991), vol. 28, no. 4/5 | - STUDNICKA ET AL., PROTEIN ENGINEERING, (1994), vol. 7, no. 6, pages 805 - 814 | - ROGUSKA ET AL., PNAS, (1994), vol. 91, pages 969 - 973 | - RIECHMANN ET AL., NATURE, (1988), vol. 332, page 323 | - JONES ET AL., NATURE, (1986), vol. 321, page 522 | - VERHOEYEN ET AL., SCIENCE, (1988), vol. 239, page 1534 | - SIMS ET AL., J. IMMUNOL, (1993), vol. 151, page 2296 | - CHOTHIA; LESK, J. MOL. BIOL, (1987), vol. 196, page 901 | - CARTER ET AL., PROC. NATL. ACAD. SCI. U.S.A., (1992), vol. 89, page 4285 | - PRESTA ET AL., J. IMMUNOL., (1993), vol. 151, page 2623 | - PADLAN, MOLECULAR IMMUNOLOGY, (1991), vol. 28, no. 4/5, pages 489 - 498 | - ROGUSKA. ET AL., PNAS, (1994), vol. 91, pages 969 - 973 | - PRESTA LG., "Selection, design, and engineering of therapeutic antibodies", J ALLERGY CLIN IMMUNOL., vol. 116, (2005), pages 731 - 6, URL: http://www.path.cam.ac.uk/~mrc7/humanisation/antibodies.html | - MURTHY ET AL., ARCH BIOCHEM BIOPHYS., (1987), vol. 252, no. 2, pages 549 - 60 | - RODECK ET AL., J CELL BIOCHEM., (1987), vol. 35, no. 4, pages 315 - 20 | - KETTLEBOROUGH ET AL., PROTEIN ENG., (1991), vol. 4, no. 7, pages 773 - 83 | - MODJTAHEDI ET AL., J. CELL BIOPHYS., (1993), vol. 22, no. 1-3, pages 129 - 46 | - MODJTAHEDI ET AL., BR J CANCER., (1993), vol. 67, no. 2, pages 247 - 53 | - MODJTAHEDI ET AL., BR J CANCER, (1996), vol. 73, no. 2, pages 228 - 35 | - MODJTAHEDI ET AL., INT J CANCER, (2003), vol. 105, no. 2, pages 273 - 80 | - MATEO ET AL., IMMUNOTECHNOLOGY, (1997), vol. 3, no. 1, pages 71 - 81 | - JUNGBLUTH ET AL., PROC NATL ACAD SCI USA, (2003), vol. 100, no. 2, pages 639 - 44 | - URLAUB; CHASIN, PROC. NATL. ACAD. SCI. USA, (1980), vol. 77, pages 4216 - 4220 | - R.J. KAUFMAN; P.A. SHARP, MOL. BIOL., (1982), vol. 159, pages 601 - 621 | - R. JEFFERIS, BIOLECLMOL. PROG., (2005), vol. 21, pages 11 - 16 | - CO, M.S. ET AL., MOL. IMMUNOL., (1993), vol. 30, page 1361W 1367 | - WALLICK, S.C. ET AL., EXP. MED., (1988), vol. 168, pages 1099 - 1109 | - WRIGHT, A. ET AL., EMBO J., (1991), vol. 10, page 2717 2723 | - SHIELDS, R. L. ET AL., J. BIOL. CHEM., (2002), vol. 277, pages 26733 - 26740 | - UMANA ET AL., NAT. BIOTECH., (1999), vol. 17, pages 176 - 1 | - ZOLA H, "CD molecules 2005: human cell differentiation molecules", BLOOD, (2005), vol. 106, pages 3123 - 6 | - STAMPER, NATURE, (2001), vol. 410, page 608 | - HWANG, JI, (2002), vol. 169, page 633 | - GRIFFIN, JI, (2000), vol. 164, page 4433 | - BURKE, SANDRA E.; KUNTZ, RICHARD E.; SCHWARTZ, LEWIS B., "Zotarolimus (ABT-578) eluting stents.", ADVANCED DRUG DELIVERY REVIEWS, (2006), vol. 58, no. 3, pages 437 - 446 | - HILDEBRAND, H. P.; BLANCHEMAIN, N.; MAYER, G.; CHAI, F; LEFEBVRE, M.; BOSCHIN, F., "Surface coatings for biological activation and functionalization of medical devices", SURFACE AND COATINGS TECHNOLOGY, (2006), vol. 200, no. 22-23, pages 6318 - 6324 | - WU, PENG; GRAINGER, DAVID W., BIOMATERIALS, (2006), vol. 27, no. 11, pages 2450 - 2467 | - MARQUES, A. P.;; HUNT, J. A.; REIS, RUI L., "Mediation of the cytokine network in the implantation of orthopedic devices.", BIODEGRADABLE SYSTEMS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE, (2005), pages 377 - 397 | - AOJI ET AL., J AM COLL CARDIOL., (2005), vol. 45, no. 10, pages 1574 - 9 | - FINOTTO ET AL., INTERNATIONAL IMMUNOLOGY, (2005), vol. 17, no. 8, pages 993 - 1007 | - PADILLA ET AL., JOURNAL OF IMMUNOLOGY, (2005), vol. 174, no. 12, pages 8097 - 8105 | - MCDONNELL ET AL., "Progress in Respiratory Research", NEW DRUGS FOR ASTHMA, ALLERGY AND COPD, (2001), vol. 3 1, pages 247 - 250 | - COFFMAN ET AL., JOURNAL OF EXPERIMENTAL MEDICINE, (2005), vol. 201, no. 12, pages 1875 - 1879 | - LLOYD ET AL., ADVANCES IN IMMUNOLOGY, (2001), vol. 77, pages 263 - 295 | - BOYCE ET AL., JOURNAL OF EXPERIMENTAL MEDICINE, (2005), vol. 201, no. 12, pages 1869 - 1873 | - SNIBSON ET AL., JOURNAL OF THE BRITISH SOCIETY FOR ALLERGY AND CLINICAL IMMUNOLOGY, (2005), vol. 35, no. 2, pages 146 - 52 | - LUSTER ET AL., TOXICOLOGY, (1994), vol. 92, no. 1-3, pages 229 - 43 | - DESCOTES ET AL., DEVELOPMENTS IN BIOLOGICAL STANDARDIZATION, (1992), vol. 77, pages 99 - 102 | - HART ET AL., JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, (2001), vol. 108, no. 2, pages 250 - 257 | - HARRIMAN G; HARPER LK; SCHAIBLE TF., "Summary of clinical trials in rheumatoid arthritis using infliximab, an anti-TNFalpha treatment", ANN RHEUM DIS, (1999), vol. 58, no. 1, pages 161 - 4 | - GENOVESE ME ET AL., "Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition", N ENGL J MED., (2005), vol. 353, pages 1114 - 23 | - OKAMOTO H; KAMATANI N., "Rituximab for rheumatoid arthritis", N ENGL J MED., (2004), vol. 351, page 1909 | - BRAND DD., COMP MED., (2005), vol. 55, no. 2, pages 114 - 22 | - SFIKAKIS PP ET AL., CURR OPIN RHEUMATOL, (2005), vol. 17, pages 550 - 7 | - PENG SL, METHODS MOL MED., (2004), vol. 102, pages 227 - 72 | - STEINMAN L ET AL., TRENDS IMMUNOL., (2005), vol. 26, no. 11, pages 565 - 71 | - LUBLIN FD. ET AL., SPRINGER SEMIN IMMUNOPATHOL., (1985), vol. 8, no. 3, pages 197 - 208 | - GENAIN CP ET AL., J MOL MED., (1997), vol. 75, no. 3, pages 187 - 97 | - TUOHY VK ET AL., J EXP MED., (1999), vol. 189, no. 7, pages 1033 - 42 | - OWENS T ET AL., NEURAL CLIN., (1995), vol. 13, no. 1, pages 51 - 73 | - T HART BA ET AL., J IMMUNOL, (2005), vol. 175, no. 7, pages 4761 - 8 | - JONES R., "Rovelizumab (ICOS Corp", LDRUGS, (2000), vol. 3, no. 4, pages 442 - 6 | - BURAS JA ET AL., NAT REV DRUG DISCOV., (2005), vol. 4, no. 10, pages 854 - 65 | - CALANDRA T ET AL., NAT MED., (2000), vol. 6, no. 2, pages 164 - 70 | - NELSON RB., CURR PHARM DES., (2005), vol. 11, page 3335 | - WILLIAM L. KLEIN., NEUROCHEM INT., (2002), vol. 41, page 345 | - MICHELLE C JANELSINS ET AL., J NEUROINFLAMMATION., (2005), vol. 2, page 23 | - SOLOMAN B., CURR ALZHEIMER RES., (2004), vol. 1, page 149 | - IGOR KLYUBIN ET AL., NAT MED., (2005), vol. 11, pages 556 - 61 | - ARANCIO 0 ET AL., EMBO JOURNAL, (2004), pages 1 - 10 | - BORNEMANN KD ET AL., AM J PATHOL., (2001), vol. 158, page 63 | - DEANE R ET AL., NAT MED., (2003), vol. 9, pages 907 - 13 | - ELIEZER MASLIAH ET AL., NEURON., (2005), vol. 46, page 857 | - MCGEE AW ET AL., TRENDS NEUROSCI., (2003), vol. 26, page 193 | - MARCO DOMENICONI ET AL., J NEUROL SCI., (2005), vol. 233, page 43 | - MILAN MAKWANAL ET AL., FEBS J., (2005), vol. 272, page 2628 | - BARRY J. DICKSON, SCIENCE, (2002), vol. 298, page 1959 | - FELICIA YU; HSUAN TENG ET AL., J NEUROSCI RES., (2005), vol. 79, page 273 | - TARA KAMEZIS ET AL., NATURE NEUROSCIENCE, (2004), vol. 7, page 736 | - GANG XU ET AL., J, NEUROCHEM., (2004), vol. 91, page 1018 | - VON MEHREN M, "Monoclonal antibody therapy for cancer", ANNU REV MED., (2003), vol. 54, pages 343 - 69 | - WU; WU, J. BIOL. CHEM., (1987), vol. 262 | - SEFTON, CRC CRIT. REF. BIOMED. ENG., (1987), vol. 14, page 20 | - BUCHWALD ET AL., SURGERY, (1980), vol. 88, page 507 | - SAUDEK ET AL., N. BNGL. J. MED., (1989), vol. 321, page 574 | - RANGER; PEPPAS, J., MACROMOL. SCI. REV. MACROMOL. CHEM., (1983), vol. 23, page 61 | - LEVY ET AL., SCIENCE, (1985), vol. 228, page 190 | - DURING ET AL., ANN. NEUROL., (1989), vol. 25, page 351 | - HOWARD ET AL., J. NEUROSURG., (1989), vol. 7 1, page 105 | - GOODSON, MEDICAL APPLICATIONS OF CONTROLLED RELEASE, (1984), vol. 2, pages 115 - 138 | - LANGER, SCIENCE, (1990), vol. 249, pages 1527 - 1533 | - NING ET AL., "Intratumoral Radioimmunotheraphy of a Human Colon Cancer Xenograft Using a Sustained-Release Gel", RADIOTHERAPY &ONCOLOGY, (1996), vol. 39, pages 179 - 189 | - SONG ET AL., "Antibody Mediated Lung Targeting of Long- Circulating Emulsions", PDA JOURNAL OF PHARMACEUTICAL SCIENCE &TECHNOLOGY, (1995), vol. 50, pages 372 - 397 | - CLEEK ET AL., "Biodegradable Polymeric Carriers for a bFGF Antibody for Cardiovascular Application", PRO. INT'L. SYMP. CONTROL. REL. BIOACT. MATER., (1997), vol. 24, pages 853 - 854 | - LAM ET AL., "Microencapsulation of Recombinant Humanized Monoclonal Antibody for Local Delivery", PROC. INT'L. SYMP. CONTROL REL. BIOACT. MATER., (1997), vol. 24, pages 759 - 760 | - JOLIOT ET AL., PROC. NATL. ACAD. SCI. USA, (1991), vol. 88, pages 1864 - 1868 | - GOLDSPIEL ET AL., CLINICAL PHARMACY, (1993), vol. 12, pages 488 - 505 | - WU; WU, BIOTHERAPY, (1991), vol. 3, pages 87 - 95 | - TOLSTOSHEV, ANN. REV. PHARMACOL. TOXICOL., (1993), vol. 32, pages 573 - 596 | - MULLIGAN, SCIENCE, (1993), vol. 260, pages 926 - 932 | - MORGAN; ANDERSON, ANN. REV. BIOCHEM., (1993), vol. 62, pages 191 - 217 | - MAY, TIBTECH, (1993), vol. 11, no. S, pages 155 - 215 | - ARTHRITIS & RHEUMATISM, (1994), vol. 37, page S295 | - J. INVEST. MED., (1996), vol. 44, page 235A | - ARTHRITIS & RHEUMATISM, (1995), vol. 38, page S185 | - ARTHRITIS & RHEUMATISM, (1993), vol. 36, page 1223 | - ARTHRITIS & RHEUMATISM, (1996), vol. 39, no. 9, page S284 | - AMER J. PLAYSIOL. - HEART AND CIRCULATORY PHYSIOLOGY, (1995), vol. 268, pages 37 - 42 | - ARTHRITIS & RHEUMATISM, (1996), vol. 39, no. 9, page S282 | - ARTHRITIS & RHEUMATISM, (1996), vol. 39, no. 9, page S81 | - ARTHRITIS & RHEUMATISM, (1996), vol. 39, no. 9, page S82 | - ARTHRITIS & RHEUMATISM, (1996), vol. 39, no. 9, page S131 | - INFLAMMATION RESEARCH, (1996), vol. 45, pages 103 - 107 | - ARTHRITIS & RHEUMATISM, (1996), vol. 39, no. 9, page S280 | - NEURO REPORT, (1996), vol. 7, pages 1209 - 1213 | - ARTHRITIS & RHEUMATISM, (1996), vol. 39, no. 9, page 8281 | - ARTHRITIS & RHEUMATISM, (1996), vol. 39, no. 9, page S281 | - ARTHRITIS & RHEUMATISM, (1996), vol. 39, no. 9, page 5296 | - ARTHRITIS & RHEUMATISM, (1996), vol. 39, no. 9, page S308 | - ARTHRITIS & RHEUMATISM, (1996), vol. 39, no. 9, page S120 | - DELUCA ET AL., RHEUM. DIS. CLIN. NORTH AM., (1995), vol. 21, pages 759 - 777 | - AUSUBEL, F.M. ET AL., Short Protocols In Molecular Biology(4th Ed.), JOHN WILEY & SONS, (1999), ISBN 0-471-32938-X | - loning and Expression Vectors for Gene Function Analysis, BIOTECHNIQUES PRESS, (2001), page 298 | - OLD, R.W.; S.B. PRIMROSE, Principles of Gene Manipulation: An Introduction To Genetic Engineering, BLACKWELL SCIENTIFIC PUBLICATIONS, vol. 2, page 409 | - SAMBROOK, J. ET AL,, Molecular Cloning: A Laboratory Manual 2d Ed., COLD SPRING HARBOR LABORATORY PRESS, vol. 1-3, ISBN 0-87969-309-6 | - AUSUBEL, F.M. ET AL., Sustained and Controlled Release Drug Delivery Systems 4th Ed.,, MARCEL DEKKER, INC., (1978), ISBN 0-471-32938-X | - WINNACKER, E.L., From Genes To Clones; Introduction To Gene Technology, VCH PUBLISHERS, (1987), page 634, ISBN 0-89573-614-4 | - BRENNAN, M. ET AL., SCIENCE, (1985), vol. 229, no. 4708, pages 81 - 3 | - BRINKMAN ET AL., J. IMMUNOL. METHODS, (1995), vol. 182, pages 41 - 50 | - BURKE, SANDRA E. ET AL., ADVANCED DRUG DELIVERY REVIEWS, (2006), vol. 58, no. 3, pages 437 - 446 | - BURTON ET AL., ADVANCES IN IMMUNOLOGY, (1994), vol. 57, pages 191 - 280 | - CHOTHIA; LESK, J. MOL. BIOL., (1987), vol. 196, pages 901 - 917 | - CLEEK ET AL., PRO. INT'1. SYMP. CONTROL. REL. BIOACT. MATER., (1997), vol. 24, pages 853 - 854 | - CO, M.S. ET AL., MOL. IMMUNOL., (1993), vol. 30, pages 1361 - 1367 | - D'ANDREA, A. ET AL., J EXP MED, (1992), vol. 176, no. 5, pages 1387 - 98 | - DESCOTES J ET AL., DEVELOPMENTS IN BIOLOGICAL STANDARDIZATION, (1992), vol. 77, pages 99 - 102 | - DINARELLO, C. A.; K. MUEGGE; S. K. DURUM., CURRENT PROTOCOLS IN IMMUNOLOGY, (2000), vol. 6, page 1 | - FELICIA YU HSUAN TENG ET AL., J NEUROSCI RES., (2005), vol. 79, page 273 | - FUCHS ET AL., BIO/TECHNOLOGY, (1991), vol. 9, pages 1370 - 1372 | - GANG XU ET AL., J. NEUROCHEM., (2004), vol. 91, page 1018 | - GARRAD ET AL., BIO/TECHNOLOGY, (1991), vol. 2, pages 1373 - 1377 | - GENOVESE MC ET AL., N ENGL J MED., (2005), vol. 353, pages 1114 - 23 | - GRACIE, J.A. ET AL., J CLIN INVEST, (1999), vol. 104, no. 10, pages 1393 - 401 | - HARRIMAN G; HARPER LK; SCHAIBLE TF., ANN RHEUM DIS, (1999), vol. 58, no. 1, pages 161 - 4 | - HAY ET AL., HUM ANTIBOD HYBRIDOMAS, (1992), vol. 3, pages 81 - 85 | - HILDEBRAND, H. F., SURFACE AND COATINGS TECHNOLOGY, (2006), vol. 200, no. 22-23, pages 6318 - 6324 | - HOLLIGER, P.; T. PROSPERO; G. WINTER, PROC NATL ACAD SCI USA, (1993), vol. 90, no. 14, pages 6444 - 8 | - ITO, A. ET AL., J IMMUNOL, (2003), vol. 170, no. 9, pages 4802 - 9 | - JOHNNSON, B. ET AL., ANAL. BIOCHEM., (1991), vol. 198, pages 268 - 277 | - JONES R., IDRUGS, (2000), vol. 3, no. 4, pages 442 - 6 | - JÖNSSON, U. ET AL., ANN. BIOL. CLIN., (1993), vol. 51, pages 19 - 26 | - JOOSTEN, L.A. ET AL., ARTHRITIS RHEUM, (1996), vol. 39, no. 5, pages 797 - 809 | - JUNGBLUTH ET AL., PROC NATL ACAD SCI USA., (2003), vol. 100, no. 2, pages 639 - 44 | - KABAT ET AL., ANN. NY ACAD, SCI., (1971), vol. 190, pages 382 - 391 | - KETTLEBOROUGH ET AL., EUR. J. IMMUNOL., (1994), vol. 24, pages 952 - 958 | - KIM ET AL., EUR J IMMUNOL, (1994), vol. 24, pages 542 - 548 | - KIPRIYANOV, S.M. ET AL., INT J CANCER, (1998), vol. 77, no. 5, pages 763 - 72 | - KONISHI, K. ET AL., J IMMUNOL METHODS, (1997), vol. 209, no. 2, pages 187 - 91 | - KOSTELNY, S.A.; M.S. COLE; J.Y. TSO, J IMMUNOL, (1992), vol. 148, no. 5, pages 1547 - 53 | - LAM ET AL., PROC. INT'L. SYMP. CONTROL REL. BIOACT. MATER., (1997), vol. 24, pages 759 - 760 | - LE GALL, F. ET AL., FEBS LETT, (1999), vol. 453, no. 1-2, pages 164 - 8 | - LE GALL, F. ET AL., J IMMUNOL METHODS, (2004), vol. 285, no. 1, pages 111 - 27 | - LLOYD, CLARE M. ET AL., ADVANCES IN IMMUNOLOGY, (2001), vol. 77, pages 263 - 295 | - LU, D. ET AL., J BIOL CHEM, (2004), vol. 279, no. 4, pages 2856 - 65 | - LUBLIN FD. ET AL., SPRINGER SEMIN IRAMUNOPATHOL., (1985), vol. 8, no. 3, pages 197 - 208 | - MACK, M. ET AL., PROC NATL ACAD SCI USA, (1995), vol. 92, no. 15, pages 7021 - 5 | - MARKS ET AL., BIOTECHNOLOGY, (1992), vol. 10, pages 779 - 783 | - MARQUES, A. P., BIODEGRADABLE SYSTEMS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE, (2005), pages 377 - 397 | - MATEO, IMMUNOTECHNOLOGY, (1997), vol. 3, no. 1, pages 71 - 81 | - MAY, TIBTECH, (1993), vol. 11, no. 5, pages 155 - 215 | - MCDONNELL ET AL., PROGRESS IN RESPIRATORY RESEARCH, (2001), vol. 31, pages 247 - 250 | - MCINTOSH, J.K. ET AL., J IMMUNOL, (1989), vol. 143, no. 1, pages 162 - 7 | - MERCHANT, A.M. ET AL., NAT BIOTECHNOL, (1998), vol. 16, no. 7, pages 677 - 81 | - MICHELLE C JANELSINS ET AL., J NEUROINFLAMMATION, (2005), vol. 2, page 23 | - MODJTAHEDI ET AL., J. CELL BIOPHYS, (1993), vol. 22, no. 1-3, pages 129 - 46 | - NELSON RB, CURR PHARM DES., (2005), vol. 11, page 3335 | - NING ET AL., RADIOTHERAPY &ONCOLOGY, (1996), vol. 39, pages 179 - 189 | - OKAMOTO H; KAMATANI N., N ENGL J MED., (2004), vol. 351, page 1909 | - OWENS T ET AL., NEUROL CLIN., (1995), vol. 13, no. 1, pages 51 - 73 | - PRESTA LG., J ALLERGY CLIN IMMUNOL., (2005), vol. 116, pages 731 - 6 | - R. JEFFERIS, BIOTECHNOL. PROG., (2005), vol. 21, pages 11 - 16 | - ROBERTS, R.W.; SZOSTAK, J.W., PROC. NATL. ACAD, SCI. USA, (1997), vol. 94, pages 12297 - 12302 | - SAUDEK ET AL., N. ENGL. J. MED., (1989), vol. 321, page 574 | - SCHIER ET AL., GENE, (1995), vol. 169, pages 147 - 155 | - SHAPIRO ET AL., CRIT. REV. IMMUNOL., (2002), vol. 22, no. 3, pages 183 - 200 | - SIMS ET AL., J. IMMUNOL., (1993), vol. 151, page 2296 | - SNIBSON K J ET AL., JOURNAL OF THE BRITISH SOCIETY FOR ALLERGY AND CLINICAL IMMUNOLOGY, (2005), vol. 35, no. 2, pages 146 - 52 | - SOLOMAN B, CURR ALZHEIMER RES., (2004), vol. 1, page 149 | - SONG ET AL., PDA JOURNAL OF PHARMACEUTICAL SCIENCE &TECHNOLOGY, (1995), vol. 50, pages 372 - 397 | - TARA KARNEZIS ET AL., NATURE NEUROSCIENCE, (2004), vol. 7, page 736 | - VON MEHREN M ET AL., ANNU REV MED., (2003), vol. 54, pages 343 - 69 | - WILLIAM L. KLEIN, NEUROCHEM INT., (2002), vol. 41, page 345 | - WU; WU, J. BIOL. CHEM., (1987), vol. 262, pages 4429 - 4432 | WO1991GB01134 | WO1998US16280 | WO1996US18978 | WO1991US09630 | WO1991US05939 | WO1994US01234 | GB19890001334 | WO1992GB01755 | US20050172317 | US19990428082 | WO2003US40426 |