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Extract from the Register of European Patents

EP About this file: EP2500356

EP2500356 - Dual variable domain immunoglobulin and uses thereof [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  08.01.2016
Database last updated on 14.06.2024
Most recent event   Tooltip08.01.2016Application deemed to be withdrawnpublished on 10.02.2016  [2016/06]
Applicant(s)For all designated states
AbbVie Inc.
1 North Waukegan Road
North Chicago, IL 60064 / US
[2013/24]
Former [2012/38]For all designated states
Abbott Laboratories
100 Abbott Park Road
Abbott Park, IL 60064-6008 / US
Inventor(s)01 / Wu, Chengbin
300 Jin Xiu Road, ¤ 14, Apt. 602
Pudong, Shanghai / CN
02 / Ghayur, Tariq
1014 Washington Street
Holliston, MA 01746 / US
03 / Dixon, Richard, W.
19 Nottingham Drive
Jefferson, MA 01522 / US
04 / Salfeld, Jochen, G.
177 Old Westborough Road
North Grafton, MA 01536 / US
 [2012/38]
Representative(s)Modiano, Micaela Nadia, et al
Modiano & Partners (DE)
Thierschstrasse 11
80538 München / DE
[2012/38]
Application number, filing date12161985.218.08.2006
[2012/38]
Priority number, dateUS20050709911P19.08.2005         Original published format: US 709911 P
US20050732892P02.11.2005         Original published format: US 732892 P
[2012/38]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP2500356
Date:19.09.2012
Language:EN
[2012/38]
Type: A3 Search report 
No.:EP2500356
Date:24.10.2012
Language:EN
[2012/43]
Search report(s)(Supplementary) European search report - dispatched on:EP20.09.2012
ClassificationIPC:C07K16/24, C07K16/28, C07K16/46, A61K39/395
[2012/38]
CPC:
C07K16/241 (EP); A61K2039/505 (EP); C07K2317/21 (EP);
C07K2317/31 (EP); C07K2317/64 (EP); C07K2317/94 (EP)
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   NL,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2012/38]
Extension statesBA24.04.2013
HR24.04.2013
MK24.04.2013
RS24.04.2013
TitleGerman:Immunglobuline mit zweifacher variabler Domäne und ihre Verwendung[2012/38]
English:Dual variable domain immunoglobulin and uses thereof[2012/38]
French:Immunoglobuline à double domaine variable et ses utilisations[2012/38]
Examination procedure24.04.2013Examination requested  [2013/23]
07.08.2013Amendment by applicant (claims and/or description)
24.04.2015Despatch of a communication from the examining division (Time limit: M04)
05.09.2015Application deemed to be withdrawn, date of legal effect  [2016/06]
29.09.2015Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2016/06]
Parent application(s)   TooltipEP06813554.0  / EP1928506
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20060813554) is  23.03.2010
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
07.08.2013Request for further processing filed
07.08.2013Full payment received (date of receipt of payment)
Request granted
23.08.2013Decision despatched
Fees paidRenewal fee
11.07.2012Renewal fee patent year 03
11.07.2012Renewal fee patent year 04
11.07.2012Renewal fee patent year 05
11.07.2012Renewal fee patent year 06
08.08.2012Renewal fee patent year 07
07.08.2013Renewal fee patent year 08
07.08.2014Renewal fee patent year 09
Penalty fee
Additional fee for renewal fee
31.08.201510   M06   Not yet paid
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[I]US2002127231  (SCHNECK JONATHAN [US], et al) [I] 1-19 * figures 1B,1c,1d; claims 1,3,7,8 *;
 [I]WO0202781  (VLAAMS INTERUNIV INST BIOTECH [BE], et al) [I] 1-19 * figure 1 *;
 [ID]WO0177342  (GENENTECH INC [US]) [ID] 1-19 * figure 4 *;
 [I]EP0517024  (BEHRINGWERKE AG [DE]) [I] 1-19 * claim 1 *;
 [I]WO9509917  (UNIV CALIFORNIA [US]) [I] 1-19 * figure 3 *;
 [IP]WO2006020258  (IMCLONE SYSTEMS INC [US], et al) [IP] 1-19 * figure 1; claim 1 *;
 [I]  - ALT M ET AL, "NOVEL TETRAVALENT AND BISPECIFIF IGG-LIKE ANTIBODY MOLECULES COMBINING SINGLE-CHAIN DIABODIES WITH THE IMMUNOGLOBULIN GAMMA1 FC OR CH3 REGION", FEBS LETTERS, ELSEVIER, AMSTERDAM, NL, (19990101), vol. 454, no. 1/2, doi:10.1016/S0014-5793(99)00782-6, ISSN 0014-5793, pages 90 - 94, XP000919188 [I] 1-19 * figure 1 *

DOI:   http://dx.doi.org/10.1016/S0014-5793(99)00782-6
 [I]  - LU DAN ET AL, "Di-diabody: A novel tetravalent bispecific antibody molecule by design.", JOURNAL OF IMMUNOLOGICAL METHODS, (200308), vol. 279, no. 1-2, ISSN 0022-1759, pages 219 - 232, XP004455322 [I] 1-19 * figure 1 *

DOI:   http://dx.doi.org/10.1016/S0022-1759(03)00251-5
 [I]  - PARK S S ET AL, "Generation and characterization of a novel tetravalent bispecific antibody that binds to hepatitis B virus surface antigens", MOLECULAR IMMUNOLOGY, PERGAMON, GB, (20001201), vol. 37, no. 18, ISSN 0161-5890, pages 1123 - 1130, XP002266827 [I] 1-19 * figure 1 *

DOI:   http://dx.doi.org/10.1016/S0161-5890(01)00027-X
 [T]  - WU CHENGBIN ET AL, "Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin", NATURE BIOTECHNOLOGY, (200711), vol. 25, no. 11, ISSN 1087-0156, pages 1290 - 1297, XP002542446 [T] 1-19 * the whole document *

DOI:   http://dx.doi.org/10.1038/nbt1345
 [A]  - JIAN YI LI ET AL, "GENETICALLY ENGINEERED BRAIN DRUG DELIVERY VECTORS: CLONING, EXPRESSION AND IN VIVO APPLICATION OF AN ANTI-TRANSFERRIN RECEPTOR SINGLE CHAIN ANTIBODY-STREPTAVIDIN FUSION GENE AND PROTEIN", PROTEIN ENGINEERING, OXFORD UNIVERSITY PRESS, SURREY, GB, (19990901), vol. 12, no. 9, doi:10.1093/PROTEIN/12.9.787, ISSN 0269-2139, pages 787 - 796, XP000984720 [A] 1-19 * the whole document *

DOI:   http://dx.doi.org/10.1093/protein/12.9.787
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    - MILSTEIN, C.; A.C. CUELLO, NATURE, (1983), vol. 305, no. 5934, pages 537 - 40
    - STAERZ, U.D. ET AL., NATURE, (1985), vol. 314, no. 6012, pages 628 - 3 1
    - BRENRAN, M. ET AL., SCIENCE, (1985), vol. 229, no. 4708, pages 81 - 3
    - GLENNIE, M.J. ET AL., J IMMUNOL, (1987), vol. 139, no. 7, pages 2367 - 75
    - KRIANGKUM, J. ET AL., BIOMOL ENG, (2001), vol. 18, no. 2, pages 31 - 40
    - ECONOMIDES, A.N. ET AL., NAT MED, (2003), vol. 9, no. 1, pages 47 - 52
    - NAKANISHI, K. ET AL., ANNU REV IMMUNOL, (2001), vol. 19, pages 423 - 74
    - GRACIE, J. A. ET AL., J CLIN INVEST, (1999), vol. 104, no. 10, pages 1393 - 401
    - LEUNG, B.P. ET AL., J IMMUNOL, (2000), vol. 164, no. 12, pages 6495 - 502
    - ITO, A. ET AL., J INUNUNOL, (2003), vol. 170, no. 9, pages 4802 - 9
    - KARNI, A. ET AL., J NEUROIMMUNOL, (2002), vol. 125, no. 1-2, pages 134 - 40
    - ARNDT, M.; J. KRAUSS, METHODS MOL BIOL, (2003), vol. 207, pages 305 - 21
    - PEIPP, M.; T. VALERIUS, BIOCHEM SOC TRANS, (2002), vol. 30, no. 4, pages 507 - 11
    - MACK, M.; G. RIETHMULLER; P. KUFER, PROC NATL ACAD SCI USA, (1995), vol. 92, no. 15, pages 7021 - 5
    - HOLLIGER, P.; T. PROSPERO; G. WINTER, PROC NATL ACAD SCI USA, (1993), vol. 90, no. 14
    - HOLLIGER, P.; G. WINTER, CANCER IMMUNOL IMMUNOTHER, (1997), vol. 45, no. 3-4, pages 128 - 30
    - WU, A.M. ET AL., IMMUNOTECHNOLOGY, (1996), vol. 2, no. 1, pages 21 - 36
    - PLUCKTHUN, A.; P. PACK, IMMUNOTECHNOLOGY, (1997), vol. 3, no. 2, pages 83 - 105
    - RIDGWAY, J.B. ET AL., PROTEIN ENG, (1996), vol. 9, no. 7, pages 617 - 21
    - LU, D. ET AL., J BIOL CHEM, vol. 279, no. 4, pages 2856 - 65
    - MILLER, K. ET AL., J IMMUNOL, (2003), vol. 170, no. 9, pages 4854 - 61
    - DUROCHER ET AL., NUCLEIC ACIDS RESEARCH, (2002), vol. 30, no. 2
    - MIZUSHIMA, S.; NAGATA, S., NUCLEIC ACIDS RESEARCH, (1990), vol. 18, no. 17
    - HUBER ET AL., NATURE, vol. 264, pages 415 - 20
    - THIES ET AL., J MOL BIOL, (1999), vol. 293, pages 67 - 79
    - DALL'ACQUA, BIOCHEMISTRY, (1998), vol. 37, pages 9266 - 73
    - SELIGMAN, ANN IMMUNOL, (1978), vol. 129, pages 855 - 70
    - BIEWENGA ET AL., CLIN EXP IMMUNOL, (1983), vol. 51, pages 395 - 400
    - WEST ET AL., BIOCHEMISTRY, (2000), vol. 39, pages 9698 - 708
    - KIM ET AL., BUR J IMMUNOL, (1994), vol. 24, pages 542 - 548
    - WARD ET AL., NATURE, (1989), vol. 341, pages 544 - 546
    - BIRD ET AL., SCIENCE, (1988), vol. 242, pages 423 - 426
    - HUSTON ET AL., PROC. NATL. ACAD. SCI. USA, (1988), vol. 85, pages 5879 - 5883
    - HOLLIGER, P. ET AL., PROC. NATL. ACAD. SCI. USA, (1993), vol. 90, pages 6444 - 6448
    - POLJAK, R.J. ET AL., STRUCTURE, (1994), vol. 2, pages 1121 - 1123
    - KONTERMANN AND DUBEL, Antibody Engineering, SPRINGER-VERLAG, (2001), page 790, ISBN 3-540-41354-5
    - ZAPATA ET AL., PROTEIN ENG., (1995), vol. 8, no. 10, pages 1057 - 1062
    - STAERZ, U.D. ET AL., NATURE, (1985), vol. 314, no. 6012, pages 628 - 31
    - HOLLIGER, P. ET AL., PROC. NATD. ACAD. SCI. USA, (1993), vol. 9Q, pages 6444 - 6448
    - HOOGENBOOM H.R., TIB TECH., (1997), vol. 15, pages 62 - 70
    - AZZAZY H.; HIGHSMITH W.E., CLIN. BIOCHEM., (2002), vol. 35, pages 425 - 445
    - GAVILONDO J.V.; LARRICK J.W., BIOTECHNIQUES, (2002), vol. 29, pages 128 - 145
    - HOOGENBOOM H.; CHAMES P., IMMUNOLOGY TODAY, (2000), vol. 21, pages 371 - 378
    - TAYLOR, L. D. ET AL., NUCL. ACIDS RES., (1992), vol. 20, pages 6287 - 6295
    - KELLERMANN S-A.; GREEN L.L., CURRENT OPINION IN BIOTECHNOLOGY, (2002), vol. 13, pages 593 - 597
    - LITTLE M. ET AL., IMMUNOLOGY TODAY, (2000), vol. 21, pages 364 - 370
    - MARKS ET AL., BIDLTECHNOLOGY, (1992), vol. 10, pages 779 - 783
    - BARBAS ET AL., PROC NAT. ACAD. SCI, USA, (1994), vol. 91, pages 3809 - 3813
    - YELTON ET AL., J. IMMUNOL., (1995), vol. 155, pages 1994 - 2004
    - JACKSON ET AL., J. IMMUNOL., (1995), vol. 154, no. 7, pages 3310 - 9
    - HAWKINS ET AL., J. MOL. BIOL, (1992), vol. 226, pages 889 - 896
    - KABAT ET AL., ANN, NY ACAD, SCI., (1971), vol. 190, pages 382 - 391
    - CHOTHIA; LESK, J, MOL. BIOL., (1987), vol. 196, pages 901 - 917
    - CHOTHIA ET AL., NATURE, (1989), vol. 342, pages 877 - 883
    - PADLAN, FASEB J., (1995), vol. 9, pages 133 - 139
    - MACCALLUM, J MOL BIOL, (1996), vol. 262, no. 5, pages 732 - 45
    - SHAPIRO ET AL., CRIT. REV. BNMUNOL., (2002), vol. 22, no. 3, pages 183 - 200
    - MARCHALONIS ET AL., ADV EXP MED BIOL., (2001), vol. 484, pages 13 - 30
    - JANSSON, U. ET AL., ANN. BIOL. CLIN., (1993), vol. 51, pages 19 - 26
    - JÖNSSON, U. ET AL., BIOTECHNIQUES, (1991), vol. 11, pages 620 - 627
    - JOHNSSON, B. ET AL., J. MOL. RECOGNIT., (1995), vol. 8, pages 125 - 131
    - JOHNNSON, B. ET AL., ANAL. BIOCHEM., (1991), vol. 128, pages 268 - 277
    - GIEGE, R.; DUCRUIX, A. BARRETT, Crystallization of Nucleic Acids and Proteins, a Practical Approach, 2nd ed.,, OXFORD UNIVERSITY PRESS, (1999), pages 20 1 - 16
    - HAMMERLING ET AL., Monoclonal Antibodies and T-Cell Hybridomas, ELSEVIER, (1981), pages 563 - 681
    - BABCOCK, J.S. ET AL., PROC. NATL. ACAD. SCI. USA, (1996), vol. 93, pages 7843 - 7848
    - GREEN ET AL., NATURE GENETICS, (1994), vol. 7, pages 13 - 21
    - MENDEZ ET AL., NATURE GENETICS, (1997), vol. 15, pages 146 - 156
    - GREEN; JAKOBOVITS, J. EXP. MED., (1998), vol. 188, pages 483 - 495
    - FUCHS ET AL., BIO/TECHNOLOGY, (1991), vol. 2, pages 1370 - 1372
    - HAY, HUM ANTIBOD HYBRIDOMAS, (1992), vol. 3, pages 81 - 85
    - HUSE ET AL., SCIENCE, (1989), vol. 246, pages 1275 - 1281
    - MCCAFFERTY ET AL., NATURE, (1990), vol. 348, pages 552 - 554
    - GRIFFITHS ET AL., EMBO J, (1993), vol. 12, pages 725 - 734
    - HAWKINS ET AL., J MOL BIOL, (1992), vol. 226, pages 889 - 896
    - CLACKSON ET AL., NATURE, (1991), vol. 352, pages 624 - 628
    - GRAM ET AL., PNAS, (1992), vol. 89, pages 3576 - 3580
    - GARRAD ET AL., BIOTECHNOLOGY, (1991), vol. 9, pages 1373 - 1377
    - HOOGENBOOM ET AL., NUC ACID RES, (1991), vol. 19, pages 4133 - 4137
    - BARBAS ET AL., PNAS, (1991), vol. 88, pages 7978 - 7982
    - BRINKMAN ET AL., J. LMMUNOL. METHODS, (1995), vol. 182, pages 41 - 50
    - AMES ET AL., J. IMMUNOL. METHODS, (1995), vol. 184, pages 177 - 186
    - KETTLEBOROUGH ET AL., EUR. I. IMMUNOL., (1994), vol. 24, pages 952 - 958
    - PERSIC ET AL., GENE, (1997), vol. 187, pages 9 - 18
    - BURTON, ADVANCES IN IMMUNOLOGY, (1994), vol. 57, pages 191 - 280
    - MULLINAX ET AL., BIOTECHNIQUES, (1992), vol. 12, no. 6, pages 864 - 869
    - SAWAI ET AL., AJRI, (1995), vol. 34, pages 26 - 34
    - BETTER ET AL., SCIENCE, (1988), vol. 240, pages 1041 - 1043
    - HUSTON ET AL., METHODS IN ENZYMOLOGY, (1991), vol. 203, pages 46 - 88
    - SHU ET AL., PNAS, (1993), vol. 90, pages 7995 - 7999
    - SKERRA ET AL., SCIENCE, (1988), vol. 240, pages 1038 - 1040
    - ROBERTS, R.W.; SZOSTAK, J.W., PROC. NATL. ACAD. SCI. USA, (1997), vol. 94, pages 12297 - 12302
    - PADLAN, MOLECULAR IMMUNOLOGY, (1991), vol. 28, no. 4/5
    - STUDNICKA ET AL., PROTEIN ENGINEERING, (1994), vol. 7, no. 6, pages 805 - 814
    - ROGUSKA ET AL., PNAS, (1994), vol. 91, pages 969 - 973
    - RIECHMANN ET AL., NATURE, (1988), vol. 332, page 323
    - JONES ET AL., NATURE, (1986), vol. 321, page 522
    - VERHOEYEN ET AL., SCIENCE, (1988), vol. 239, page 1534
    - SIMS ET AL., J. IMMUNOL, (1993), vol. 151, page 2296
    - CHOTHIA; LESK, J. MOL. BIOL, (1987), vol. 196, page 901
    - CARTER ET AL., PROC. NATL. ACAD. SCI. U.S.A., (1992), vol. 89, page 4285
    - PRESTA ET AL., J. IMMUNOL., (1993), vol. 151, page 2623
    - PADLAN, MOLECULAR IMMUNOLOGY, (1991), vol. 28, no. 4/5, pages 489 - 498
    - ROGUSKA. ET AL., PNAS, (1994), vol. 91, pages 969 - 973
    - PRESTA LG., "Selection, design, and engineering of therapeutic antibodies", J ALLERGY CLIN IMMUNOL., vol. 116, (2005), pages 731 - 6, URL: http://www.path.cam.ac.uk/~mrc7/humanisation/antibodies.html
    - MURTHY ET AL., ARCH BIOCHEM BIOPHYS., (1987), vol. 252, no. 2, pages 549 - 60
    - RODECK ET AL., J CELL BIOCHEM., (1987), vol. 35, no. 4, pages 315 - 20
    - KETTLEBOROUGH ET AL., PROTEIN ENG., (1991), vol. 4, no. 7, pages 773 - 83
    - MODJTAHEDI ET AL., J. CELL BIOPHYS., (1993), vol. 22, no. 1-3, pages 129 - 46
    - MODJTAHEDI ET AL., BR J CANCER., (1993), vol. 67, no. 2, pages 247 - 53
    - MODJTAHEDI ET AL., BR J CANCER, (1996), vol. 73, no. 2, pages 228 - 35
    - MODJTAHEDI ET AL., INT J CANCER, (2003), vol. 105, no. 2, pages 273 - 80
    - MATEO ET AL., IMMUNOTECHNOLOGY, (1997), vol. 3, no. 1, pages 71 - 81
    - JUNGBLUTH ET AL., PROC NATL ACAD SCI USA, (2003), vol. 100, no. 2, pages 639 - 44
    - URLAUB; CHASIN, PROC. NATL. ACAD. SCI. USA, (1980), vol. 77, pages 4216 - 4220
    - R.J. KAUFMAN; P.A. SHARP, MOL. BIOL., (1982), vol. 159, pages 601 - 621
    - R. JEFFERIS, BIOLECLMOL. PROG., (2005), vol. 21, pages 11 - 16
    - CO, M.S. ET AL., MOL. IMMUNOL., (1993), vol. 30, page 1361W 1367
    - WALLICK, S.C. ET AL., EXP. MED., (1988), vol. 168, pages 1099 - 1109
    - WRIGHT, A. ET AL., EMBO J., (1991), vol. 10, page 2717 2723
    - SHIELDS, R. L. ET AL., J. BIOL. CHEM., (2002), vol. 277, pages 26733 - 26740
    - UMANA ET AL., NAT. BIOTECH., (1999), vol. 17, pages 176 - 1
    - ZOLA H, "CD molecules 2005: human cell differentiation molecules", BLOOD, (2005), vol. 106, pages 3123 - 6
    - STAMPER, NATURE, (2001), vol. 410, page 608
    - HWANG, JI, (2002), vol. 169, page 633
    - GRIFFIN, JI, (2000), vol. 164, page 4433
    - BURKE, SANDRA E.; KUNTZ, RICHARD E.; SCHWARTZ, LEWIS B., "Zotarolimus (ABT-578) eluting stents.", ADVANCED DRUG DELIVERY REVIEWS, (2006), vol. 58, no. 3, pages 437 - 446
    - HILDEBRAND, H. P.; BLANCHEMAIN, N.; MAYER, G.; CHAI, F; LEFEBVRE, M.; BOSCHIN, F., "Surface coatings for biological activation and functionalization of medical devices", SURFACE AND COATINGS TECHNOLOGY, (2006), vol. 200, no. 22-23, pages 6318 - 6324
    - WU, PENG; GRAINGER, DAVID W., BIOMATERIALS, (2006), vol. 27, no. 11, pages 2450 - 2467
    - MARQUES, A. P.;; HUNT, J. A.; REIS, RUI L., "Mediation of the cytokine network in the implantation of orthopedic devices.", BIODEGRADABLE SYSTEMS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE, (2005), pages 377 - 397
    - AOJI ET AL., J AM COLL CARDIOL., (2005), vol. 45, no. 10, pages 1574 - 9
    - FINOTTO ET AL., INTERNATIONAL IMMUNOLOGY, (2005), vol. 17, no. 8, pages 993 - 1007
    - PADILLA ET AL., JOURNAL OF IMMUNOLOGY, (2005), vol. 174, no. 12, pages 8097 - 8105
    - MCDONNELL ET AL., "Progress in Respiratory Research", NEW DRUGS FOR ASTHMA, ALLERGY AND COPD, (2001), vol. 3 1, pages 247 - 250
    - COFFMAN ET AL., JOURNAL OF EXPERIMENTAL MEDICINE, (2005), vol. 201, no. 12, pages 1875 - 1879
    - LLOYD ET AL., ADVANCES IN IMMUNOLOGY, (2001), vol. 77, pages 263 - 295
    - BOYCE ET AL., JOURNAL OF EXPERIMENTAL MEDICINE, (2005), vol. 201, no. 12, pages 1869 - 1873
    - SNIBSON ET AL., JOURNAL OF THE BRITISH SOCIETY FOR ALLERGY AND CLINICAL IMMUNOLOGY, (2005), vol. 35, no. 2, pages 146 - 52
    - LUSTER ET AL., TOXICOLOGY, (1994), vol. 92, no. 1-3, pages 229 - 43
    - DESCOTES ET AL., DEVELOPMENTS IN BIOLOGICAL STANDARDIZATION, (1992), vol. 77, pages 99 - 102
    - HART ET AL., JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, (2001), vol. 108, no. 2, pages 250 - 257
    - HARRIMAN G; HARPER LK; SCHAIBLE TF., "Summary of clinical trials in rheumatoid arthritis using infliximab, an anti-TNFalpha treatment", ANN RHEUM DIS, (1999), vol. 58, no. 1, pages 161 - 4
    - GENOVESE ME ET AL., "Abatacept for rheumatoid arthritis refractory to tumor necrosis factor alpha inhibition", N ENGL J MED., (2005), vol. 353, pages 1114 - 23
    - OKAMOTO H; KAMATANI N., "Rituximab for rheumatoid arthritis", N ENGL J MED., (2004), vol. 351, page 1909
    - BRAND DD., COMP MED., (2005), vol. 55, no. 2, pages 114 - 22
    - SFIKAKIS PP ET AL., CURR OPIN RHEUMATOL, (2005), vol. 17, pages 550 - 7
    - PENG SL, METHODS MOL MED., (2004), vol. 102, pages 227 - 72
    - STEINMAN L ET AL., TRENDS IMMUNOL., (2005), vol. 26, no. 11, pages 565 - 71
    - LUBLIN FD. ET AL., SPRINGER SEMIN IMMUNOPATHOL., (1985), vol. 8, no. 3, pages 197 - 208
    - GENAIN CP ET AL., J MOL MED., (1997), vol. 75, no. 3, pages 187 - 97
    - TUOHY VK ET AL., J EXP MED., (1999), vol. 189, no. 7, pages 1033 - 42
    - OWENS T ET AL., NEURAL CLIN., (1995), vol. 13, no. 1, pages 51 - 73
    - T HART BA ET AL., J IMMUNOL, (2005), vol. 175, no. 7, pages 4761 - 8
    - JONES R., "Rovelizumab (ICOS Corp", LDRUGS, (2000), vol. 3, no. 4, pages 442 - 6
    - BURAS JA ET AL., NAT REV DRUG DISCOV., (2005), vol. 4, no. 10, pages 854 - 65
    - CALANDRA T ET AL., NAT MED., (2000), vol. 6, no. 2, pages 164 - 70
    - NELSON RB., CURR PHARM DES., (2005), vol. 11, page 3335
    - WILLIAM L. KLEIN., NEUROCHEM INT., (2002), vol. 41, page 345
    - MICHELLE C JANELSINS ET AL., J NEUROINFLAMMATION., (2005), vol. 2, page 23
    - SOLOMAN B., CURR ALZHEIMER RES., (2004), vol. 1, page 149
    - IGOR KLYUBIN ET AL., NAT MED., (2005), vol. 11, pages 556 - 61
    - ARANCIO 0 ET AL., EMBO JOURNAL, (2004), pages 1 - 10
    - BORNEMANN KD ET AL., AM J PATHOL., (2001), vol. 158, page 63
    - DEANE R ET AL., NAT MED., (2003), vol. 9, pages 907 - 13
    - ELIEZER MASLIAH ET AL., NEURON., (2005), vol. 46, page 857
    - MCGEE AW ET AL., TRENDS NEUROSCI., (2003), vol. 26, page 193
    - MARCO DOMENICONI ET AL., J NEUROL SCI., (2005), vol. 233, page 43
    - MILAN MAKWANAL ET AL., FEBS J., (2005), vol. 272, page 2628
    - BARRY J. DICKSON, SCIENCE, (2002), vol. 298, page 1959
    - FELICIA YU; HSUAN TENG ET AL., J NEUROSCI RES., (2005), vol. 79, page 273
    - TARA KAMEZIS ET AL., NATURE NEUROSCIENCE, (2004), vol. 7, page 736
    - GANG XU ET AL., J, NEUROCHEM., (2004), vol. 91, page 1018
    - VON MEHREN M, "Monoclonal antibody therapy for cancer", ANNU REV MED., (2003), vol. 54, pages 343 - 69
    - WU; WU, J. BIOL. CHEM., (1987), vol. 262
    - SEFTON, CRC CRIT. REF. BIOMED. ENG., (1987), vol. 14, page 20
    - BUCHWALD ET AL., SURGERY, (1980), vol. 88, page 507
    - SAUDEK ET AL., N. BNGL. J. MED., (1989), vol. 321, page 574
    - RANGER; PEPPAS, J., MACROMOL. SCI. REV. MACROMOL. CHEM., (1983), vol. 23, page 61
    - LEVY ET AL., SCIENCE, (1985), vol. 228, page 190
    - DURING ET AL., ANN. NEUROL., (1989), vol. 25, page 351
    - HOWARD ET AL., J. NEUROSURG., (1989), vol. 7 1, page 105
    - GOODSON, MEDICAL APPLICATIONS OF CONTROLLED RELEASE, (1984), vol. 2, pages 115 - 138
    - LANGER, SCIENCE, (1990), vol. 249, pages 1527 - 1533
    - NING ET AL., "Intratumoral Radioimmunotheraphy of a Human Colon Cancer Xenograft Using a Sustained-Release Gel", RADIOTHERAPY &ONCOLOGY, (1996), vol. 39, pages 179 - 189
    - SONG ET AL., "Antibody Mediated Lung Targeting of Long- Circulating Emulsions", PDA JOURNAL OF PHARMACEUTICAL SCIENCE &TECHNOLOGY, (1995), vol. 50, pages 372 - 397
    - CLEEK ET AL., "Biodegradable Polymeric Carriers for a bFGF Antibody for Cardiovascular Application", PRO. INT'L. SYMP. CONTROL. REL. BIOACT. MATER., (1997), vol. 24, pages 853 - 854
    - LAM ET AL., "Microencapsulation of Recombinant Humanized Monoclonal Antibody for Local Delivery", PROC. INT'L. SYMP. CONTROL REL. BIOACT. MATER., (1997), vol. 24, pages 759 - 760
    - JOLIOT ET AL., PROC. NATL. ACAD. SCI. USA, (1991), vol. 88, pages 1864 - 1868
    - GOLDSPIEL ET AL., CLINICAL PHARMACY, (1993), vol. 12, pages 488 - 505
    - WU; WU, BIOTHERAPY, (1991), vol. 3, pages 87 - 95
    - TOLSTOSHEV, ANN. REV. PHARMACOL. TOXICOL., (1993), vol. 32, pages 573 - 596
    - MULLIGAN, SCIENCE, (1993), vol. 260, pages 926 - 932
    - MORGAN; ANDERSON, ANN. REV. BIOCHEM., (1993), vol. 62, pages 191 - 217
    - MAY, TIBTECH, (1993), vol. 11, no. S, pages 155 - 215
    - ARTHRITIS & RHEUMATISM, (1994), vol. 37, page S295
    - J. INVEST. MED., (1996), vol. 44, page 235A
    - ARTHRITIS & RHEUMATISM, (1995), vol. 38, page S185
    - ARTHRITIS & RHEUMATISM, (1993), vol. 36, page 1223
    - ARTHRITIS & RHEUMATISM, (1996), vol. 39, no. 9, page S284
    - AMER J. PLAYSIOL. - HEART AND CIRCULATORY PHYSIOLOGY, (1995), vol. 268, pages 37 - 42
    - ARTHRITIS & RHEUMATISM, (1996), vol. 39, no. 9, page S282
    - ARTHRITIS & RHEUMATISM, (1996), vol. 39, no. 9, page S81
    - ARTHRITIS & RHEUMATISM, (1996), vol. 39, no. 9, page S82
    - ARTHRITIS & RHEUMATISM, (1996), vol. 39, no. 9, page S131
    - INFLAMMATION RESEARCH, (1996), vol. 45, pages 103 - 107
    - ARTHRITIS & RHEUMATISM, (1996), vol. 39, no. 9, page S280
    - NEURO REPORT, (1996), vol. 7, pages 1209 - 1213
    - ARTHRITIS & RHEUMATISM, (1996), vol. 39, no. 9, page 8281
    - ARTHRITIS & RHEUMATISM, (1996), vol. 39, no. 9, page S281
    - ARTHRITIS & RHEUMATISM, (1996), vol. 39, no. 9, page 5296
    - ARTHRITIS & RHEUMATISM, (1996), vol. 39, no. 9, page S308
    - ARTHRITIS & RHEUMATISM, (1996), vol. 39, no. 9, page S120
    - DELUCA ET AL., RHEUM. DIS. CLIN. NORTH AM., (1995), vol. 21, pages 759 - 777
    - AUSUBEL, F.M. ET AL., Short Protocols In Molecular Biology(4th Ed.), JOHN WILEY & SONS, (1999), ISBN 0-471-32938-X
    - loning and Expression Vectors for Gene Function Analysis, BIOTECHNIQUES PRESS, (2001), page 298
    - OLD, R.W.; S.B. PRIMROSE, Principles of Gene Manipulation: An Introduction To Genetic Engineering, BLACKWELL SCIENTIFIC PUBLICATIONS, vol. 2, page 409
    - SAMBROOK, J. ET AL,, Molecular Cloning: A Laboratory Manual 2d Ed., COLD SPRING HARBOR LABORATORY PRESS, vol. 1-3, ISBN 0-87969-309-6
    - AUSUBEL, F.M. ET AL., Sustained and Controlled Release Drug Delivery Systems 4th Ed.,, MARCEL DEKKER, INC., (1978), ISBN 0-471-32938-X
    - WINNACKER, E.L., From Genes To Clones; Introduction To Gene Technology, VCH PUBLISHERS, (1987), page 634, ISBN 0-89573-614-4
    - BRENNAN, M. ET AL., SCIENCE, (1985), vol. 229, no. 4708, pages 81 - 3
    - BRINKMAN ET AL., J. IMMUNOL. METHODS, (1995), vol. 182, pages 41 - 50
    - BURKE, SANDRA E. ET AL., ADVANCED DRUG DELIVERY REVIEWS, (2006), vol. 58, no. 3, pages 437 - 446
    - BURTON ET AL., ADVANCES IN IMMUNOLOGY, (1994), vol. 57, pages 191 - 280
    - CHOTHIA; LESK, J. MOL. BIOL., (1987), vol. 196, pages 901 - 917
    - CLEEK ET AL., PRO. INT'1. SYMP. CONTROL. REL. BIOACT. MATER., (1997), vol. 24, pages 853 - 854
    - CO, M.S. ET AL., MOL. IMMUNOL., (1993), vol. 30, pages 1361 - 1367
    - D'ANDREA, A. ET AL., J EXP MED, (1992), vol. 176, no. 5, pages 1387 - 98
    - DESCOTES J ET AL., DEVELOPMENTS IN BIOLOGICAL STANDARDIZATION, (1992), vol. 77, pages 99 - 102
    - DINARELLO, C. A.; K. MUEGGE; S. K. DURUM., CURRENT PROTOCOLS IN IMMUNOLOGY, (2000), vol. 6, page 1
    - FELICIA YU HSUAN TENG ET AL., J NEUROSCI RES., (2005), vol. 79, page 273
    - FUCHS ET AL., BIO/TECHNOLOGY, (1991), vol. 9, pages 1370 - 1372
    - GANG XU ET AL., J. NEUROCHEM., (2004), vol. 91, page 1018
    - GARRAD ET AL., BIO/TECHNOLOGY, (1991), vol. 2, pages 1373 - 1377
    - GENOVESE MC ET AL., N ENGL J MED., (2005), vol. 353, pages 1114 - 23
    - GRACIE, J.A. ET AL., J CLIN INVEST, (1999), vol. 104, no. 10, pages 1393 - 401
    - HARRIMAN G; HARPER LK; SCHAIBLE TF., ANN RHEUM DIS, (1999), vol. 58, no. 1, pages 161 - 4
    - HAY ET AL., HUM ANTIBOD HYBRIDOMAS, (1992), vol. 3, pages 81 - 85
    - HILDEBRAND, H. F., SURFACE AND COATINGS TECHNOLOGY, (2006), vol. 200, no. 22-23, pages 6318 - 6324
    - HOLLIGER, P.; T. PROSPERO; G. WINTER, PROC NATL ACAD SCI USA, (1993), vol. 90, no. 14, pages 6444 - 8
    - ITO, A. ET AL., J IMMUNOL, (2003), vol. 170, no. 9, pages 4802 - 9
    - JOHNNSON, B. ET AL., ANAL. BIOCHEM., (1991), vol. 198, pages 268 - 277
    - JONES R., IDRUGS, (2000), vol. 3, no. 4, pages 442 - 6
    - JÖNSSON, U. ET AL., ANN. BIOL. CLIN., (1993), vol. 51, pages 19 - 26
    - JOOSTEN, L.A. ET AL., ARTHRITIS RHEUM, (1996), vol. 39, no. 5, pages 797 - 809
    - JUNGBLUTH ET AL., PROC NATL ACAD SCI USA., (2003), vol. 100, no. 2, pages 639 - 44
    - KABAT ET AL., ANN. NY ACAD, SCI., (1971), vol. 190, pages 382 - 391
    - KETTLEBOROUGH ET AL., EUR. J. IMMUNOL., (1994), vol. 24, pages 952 - 958
    - KIM ET AL., EUR J IMMUNOL, (1994), vol. 24, pages 542 - 548
    - KIPRIYANOV, S.M. ET AL., INT J CANCER, (1998), vol. 77, no. 5, pages 763 - 72
    - KONISHI, K. ET AL., J IMMUNOL METHODS, (1997), vol. 209, no. 2, pages 187 - 91
    - KOSTELNY, S.A.; M.S. COLE; J.Y. TSO, J IMMUNOL, (1992), vol. 148, no. 5, pages 1547 - 53
    - LAM ET AL., PROC. INT'L. SYMP. CONTROL REL. BIOACT. MATER., (1997), vol. 24, pages 759 - 760
    - LE GALL, F. ET AL., FEBS LETT, (1999), vol. 453, no. 1-2, pages 164 - 8
    - LE GALL, F. ET AL., J IMMUNOL METHODS, (2004), vol. 285, no. 1, pages 111 - 27
    - LLOYD, CLARE M. ET AL., ADVANCES IN IMMUNOLOGY, (2001), vol. 77, pages 263 - 295
    - LU, D. ET AL., J BIOL CHEM, (2004), vol. 279, no. 4, pages 2856 - 65
    - LUBLIN FD. ET AL., SPRINGER SEMIN IRAMUNOPATHOL., (1985), vol. 8, no. 3, pages 197 - 208
    - MACK, M. ET AL., PROC NATL ACAD SCI USA, (1995), vol. 92, no. 15, pages 7021 - 5
    - MARKS ET AL., BIOTECHNOLOGY, (1992), vol. 10, pages 779 - 783
    - MARQUES, A. P., BIODEGRADABLE SYSTEMS IN TISSUE ENGINEERING AND REGENERATIVE MEDICINE, (2005), pages 377 - 397
    - MATEO, IMMUNOTECHNOLOGY, (1997), vol. 3, no. 1, pages 71 - 81
    - MAY, TIBTECH, (1993), vol. 11, no. 5, pages 155 - 215
    - MCDONNELL ET AL., PROGRESS IN RESPIRATORY RESEARCH, (2001), vol. 31, pages 247 - 250
    - MCINTOSH, J.K. ET AL., J IMMUNOL, (1989), vol. 143, no. 1, pages 162 - 7
    - MERCHANT, A.M. ET AL., NAT BIOTECHNOL, (1998), vol. 16, no. 7, pages 677 - 81
    - MICHELLE C JANELSINS ET AL., J NEUROINFLAMMATION, (2005), vol. 2, page 23
    - MODJTAHEDI ET AL., J. CELL BIOPHYS, (1993), vol. 22, no. 1-3, pages 129 - 46
    - NELSON RB, CURR PHARM DES., (2005), vol. 11, page 3335
    - NING ET AL., RADIOTHERAPY &ONCOLOGY, (1996), vol. 39, pages 179 - 189
    - OKAMOTO H; KAMATANI N., N ENGL J MED., (2004), vol. 351, page 1909
    - OWENS T ET AL., NEUROL CLIN., (1995), vol. 13, no. 1, pages 51 - 73
    - PRESTA LG., J ALLERGY CLIN IMMUNOL., (2005), vol. 116, pages 731 - 6
    - R. JEFFERIS, BIOTECHNOL. PROG., (2005), vol. 21, pages 11 - 16
    - ROBERTS, R.W.; SZOSTAK, J.W., PROC. NATL. ACAD, SCI. USA, (1997), vol. 94, pages 12297 - 12302
    - SAUDEK ET AL., N. ENGL. J. MED., (1989), vol. 321, page 574
    - SCHIER ET AL., GENE, (1995), vol. 169, pages 147 - 155
    - SHAPIRO ET AL., CRIT. REV. IMMUNOL., (2002), vol. 22, no. 3, pages 183 - 200
    - SIMS ET AL., J. IMMUNOL., (1993), vol. 151, page 2296
    - SNIBSON K J ET AL., JOURNAL OF THE BRITISH SOCIETY FOR ALLERGY AND CLINICAL IMMUNOLOGY, (2005), vol. 35, no. 2, pages 146 - 52
    - SOLOMAN B, CURR ALZHEIMER RES., (2004), vol. 1, page 149
    - SONG ET AL., PDA JOURNAL OF PHARMACEUTICAL SCIENCE &TECHNOLOGY, (1995), vol. 50, pages 372 - 397
    - TARA KARNEZIS ET AL., NATURE NEUROSCIENCE, (2004), vol. 7, page 736
    - VON MEHREN M ET AL., ANNU REV MED., (2003), vol. 54, pages 343 - 69
    - WILLIAM L. KLEIN, NEUROCHEM INT., (2002), vol. 41, page 345
    - WU; WU, J. BIOL. CHEM., (1987), vol. 262, pages 4429 - 4432
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