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Extract from the Register of European Patents

EP About this file: EP2612856

EP2612856 - Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  24.05.2019
Database last updated on 12.07.2024
FormerThe patent has been granted
Status updated on  15.06.2018
FormerGrant of patent is intended
Status updated on  01.02.2018
FormerExamination is in progress
Status updated on  23.01.2018
Most recent event   Tooltip03.07.2020Lapse of the patent in a contracting state
New state(s): CY		published on 05.08.2020  [2020/32]
Applicant(s)For all designated states
Onyx Therapeutics, Inc.
One Amgen Center Drive
Thousand Oaks, CA 91320-1799 / US
[2018/34]
Former [2014/12]For all designated states
Onyx Therapeutics, Inc.
249 East Grand Avenue
South San Francisco, CA 94080 / US
Former [2013/28]For all designated states
Onyx Therapeutics, Inc.
333 Allerton Avenue
South San Francisco, CA 94080 / US
Inventor(s)01 / Phiasivongsa, Pasit
2712 Saint Regis Avenue
Brentwood, CA 94513 / US
02 / Sehl, Louis C.
403 Alameda de la Pulgas
Redwood City, CA 94062 / US
03 / Fuller, William Dean
3085 Driscoll Drive
San Diego, CA 92117 / US
04 / Laidig, Guy J.
329 Waverley Street
Menlo Park, CA 94025 / US
 [2018/29]
Former [2013/28]01 / Phiasivongsa, Pasit
2712 Saint Regis Avenue
Brentwood, CA 94513 / US
02 / Sehl, Louis C.
403 Alameda de la Pulgas
Redwood City, CA 94062 / US
03 / Fuller, William Dean
3085 Driscoll Drive
San Diego, CA 92117 / US
04 / Laidig, Guy J.
329 Waveley Street
Menlo Park, CA 94025 / US
Representative(s)Mewburn Ellis LLP
Aurora Building
Counterslip
Bristol BS1 6BX / GB
[N/P]
Former [2018/29]Carlisle, Julie, et al
Mewburn Ellis LLP
City Tower
40 Basinghall Street
London EC2V 5DE / GB
Former [2013/28]Carlisle, Julie, et al
Mewburn Ellis LLP
33 Gutter Lane
London EC2V 8AS / GB
Application number, filing date12197779.703.10.2008
[2013/28]
Priority number, dateUS20070997613P04.10.2007         Original published format: US 997613 P
US20070008987P20.12.2007         Original published format: US 8987 P
[2018/09]
Former [2013/28]US2007099761304.10.2007
US20070008987P20.12.2007
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report 
No.:EP2612856
Date:10.07.2013
Language:EN
[2013/28]
Type: A3 Search report 
No.:EP2612856
Date:26.03.2014
Language:EN
[2014/13]
Type: B1 Patent specification 
No.:EP2612856
Date:18.07.2018
Language:EN
[2018/29]
Type: B8 Corrected title page of specification 
No.:EP2612856
Date:17.10.2018
[2018/42]
Search report(s)(Supplementary) European search report - dispatched on:EP20.02.2014
ClassificationIPC:A61P19/08, A61P25/28, A61P31/00, A61P33/00, A61P35/00, A61P37/00, A61P37/06, C07D303/36, C07D301/03, C07K5/087
[2018/08]
CPC:
A61P9/10 (EP); C07D413/12 (KR); C07K5/1016 (US);
A61K31/535 (KR); A61K31/5377 (KR); A61P19/00 (EP);
A61P19/08 (EP); A61P25/00 (EP); A61P25/28 (EP);
A61P31/00 (EP); A61P31/04 (EP); A61P31/12 (EP);
A61P33/00 (EP); A61P35/00 (EP); A61P37/00 (EP);
A61P37/02 (EP); A61P37/06 (EP); A61P43/00 (EP);
A62C3/004 (US); A62C35/68 (US); A62C37/11 (US);
C07C51/412 (US); C07C53/18 (US); C07D301/00 (EP,US);
C07D301/03 (EP,US); C07D303/36 (EP,KR,US); C07K1/1075 (US);
C07K1/306 (US); C07K5/0812 (EP,US); C07K5/1008 (US);
A61K38/00 (EP,US); A62C35/60 (US); A62C35/62 (US);
A62C37/14 (US) (-)
Former IPC [2014/13]C07K5/10, C07K5/107, A61P19/08, A61P25/28, A61P31/00, A61P33/00, A61P35/00, A61P37/00, A61P37/06, C07D303/36, C07D301/03, C07K5/103
Former IPC [2013/28]C07D303/36, C07K5/10, C07K5/107, A61P33/00, A61P19/08, A61P25/28, A61P31/00, A61P37/00, A61P35/00, A61P37/06
Designated contracting statesAT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MT,   NL,   NO,   PL,   PT,   RO,   SE,   SI,   SK,   TR [2018/29]
Former [2013/28]AT,  BE,  BG,  CH,  CY,  CZ,  DE,  DK,  EE,  ES,  FI,  FR,  GB,  GR,  HR,  HU,  IE,  IS,  IT,  LI,  LT,  LU,  LV,  MC,  MT,  NL,  NO,  PL,  PT,  RO,  SE,  SI,  SK,  TR 
TitleGerman:Kristalline Peptidepoxyketone als Proteaseinhibitoren und Synthese von Aminosäureketoepoxiden[2013/28]
English:Crystalline peptide epoxy ketone protease inhibitors and the synthesis of amino acid keto-epoxides[2013/28]
French:Inhibiteurs de protéase époxy-cétone peptidique cristalline, et synthèse de céto-époxydes d'acides aminés[2013/28]
Examination procedure24.09.2014Examination requested  [2014/45]
26.09.2014Amendment by applicant (claims and/or description)
26.04.2016Despatch of a communication from the examining division (Time limit: M04)
30.08.2016Reply to a communication from the examining division
15.01.2018Cancellation of oral proceeding that was planned for 13.02.2018
02.02.2018Communication of intention to grant the patent
13.02.2018Date of oral proceedings (cancelled)
07.06.2018Fee for grant paid
07.06.2018Fee for publishing/printing paid
07.06.2018Receipt of the translation of the claim(s)
Parent application(s)   TooltipEP08834964.2  / EP2207791
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued (EP20080834964) is  09.12.2010
Opposition(s)23.04.2019No opposition filed within time limit [2019/26]
Fees paidRenewal fee
26.02.2013Renewal fee patent year 03
26.02.2013Renewal fee patent year 04
26.02.2013Renewal fee patent year 05
28.10.2013Renewal fee patent year 06
14.10.2014Renewal fee patent year 07
26.10.2015Renewal fee patent year 08
11.10.2016Renewal fee patent year 09
11.10.2017Renewal fee patent year 10
Opt-out from the exclusive  Tooltip
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU03.10.2008
AT18.07.2018
CY18.07.2018
CZ18.07.2018
DK18.07.2018
EE18.07.2018
FI18.07.2018
HR18.07.2018
LT18.07.2018
LV18.07.2018
MC18.07.2018
NL18.07.2018
PL18.07.2018
PT18.07.2018
RO18.07.2018
SE18.07.2018
SI18.07.2018
SK18.07.2018
TR18.07.2018
IE03.10.2018
LU03.10.2018
MT03.10.2018
BG18.10.2018
NO18.10.2018
GR19.10.2018
BE31.10.2018
IS18.11.2018
[2020/32]
Former [2020/30]HU03.10.2008
AT18.07.2018
CZ18.07.2018
DK18.07.2018
EE18.07.2018
FI18.07.2018
HR18.07.2018
LT18.07.2018
LV18.07.2018
MC18.07.2018
NL18.07.2018
PL18.07.2018
PT18.07.2018
RO18.07.2018
SE18.07.2018
SI18.07.2018
SK18.07.2018
TR18.07.2018
IE03.10.2018
LU03.10.2018
MT03.10.2018
BG18.10.2018
NO18.10.2018
GR19.10.2018
BE31.10.2018
IS18.11.2018
Former [2020/27]AT18.07.2018
CZ18.07.2018
DK18.07.2018
EE18.07.2018
FI18.07.2018
HR18.07.2018
LT18.07.2018
LV18.07.2018
MC18.07.2018
NL18.07.2018
PL18.07.2018
PT18.07.2018
RO18.07.2018
SE18.07.2018
SI18.07.2018
SK18.07.2018
TR18.07.2018
IE03.10.2018
LU03.10.2018
MT03.10.2018
BG18.10.2018
NO18.10.2018
GR19.10.2018
BE31.10.2018
IS18.11.2018
Former [2020/16]AT18.07.2018
CZ18.07.2018
DK18.07.2018
EE18.07.2018
FI18.07.2018
HR18.07.2018
LT18.07.2018
LV18.07.2018
MC18.07.2018
NL18.07.2018
PL18.07.2018
RO18.07.2018
SE18.07.2018
SI18.07.2018
SK18.07.2018
TR18.07.2018
IE03.10.2018
LU03.10.2018
MT03.10.2018
BG18.10.2018
NO18.10.2018
GR19.10.2018
BE31.10.2018
IS18.11.2018
Former [2020/08]AT18.07.2018
CZ18.07.2018
DK18.07.2018
EE18.07.2018
FI18.07.2018
HR18.07.2018
LT18.07.2018
LV18.07.2018
MC18.07.2018
NL18.07.2018
PL18.07.2018
RO18.07.2018
SE18.07.2018
SI18.07.2018
SK18.07.2018
IE03.10.2018
LU03.10.2018
MT03.10.2018
BG18.10.2018
NO18.10.2018
GR19.10.2018
BE31.10.2018
IS18.11.2018
Former [2019/48]AT18.07.2018
CZ18.07.2018
DK18.07.2018
EE18.07.2018
FI18.07.2018
HR18.07.2018
LT18.07.2018
LV18.07.2018
MC18.07.2018
NL18.07.2018
PL18.07.2018
RO18.07.2018
SE18.07.2018
SI18.07.2018
SK18.07.2018
IE03.10.2018
LU03.10.2018
BG18.10.2018
NO18.10.2018
GR19.10.2018
BE31.10.2018
IS18.11.2018
Former [2019/38]AT18.07.2018
CZ18.07.2018
DK18.07.2018
EE18.07.2018
FI18.07.2018
HR18.07.2018
LT18.07.2018
LV18.07.2018
MC18.07.2018
NL18.07.2018
PL18.07.2018
RO18.07.2018
SE18.07.2018
SI18.07.2018
SK18.07.2018
LU03.10.2018
BG18.10.2018
NO18.10.2018
GR19.10.2018
BE31.10.2018
IS18.11.2018
Former [2019/37]AT18.07.2018
CZ18.07.2018
DK18.07.2018
EE18.07.2018
FI18.07.2018
HR18.07.2018
LT18.07.2018
LV18.07.2018
MC18.07.2018
NL18.07.2018
PL18.07.2018
RO18.07.2018
SE18.07.2018
SI18.07.2018
SK18.07.2018
LU03.10.2018
BG18.10.2018
NO18.10.2018
GR19.10.2018
IS18.11.2018
Former [2019/30]AT18.07.2018
CZ18.07.2018
DK18.07.2018
EE18.07.2018
FI18.07.2018
HR18.07.2018
LT18.07.2018
LV18.07.2018
MC18.07.2018
NL18.07.2018
PL18.07.2018
RO18.07.2018
SE18.07.2018
SK18.07.2018
LU03.10.2018
BG18.10.2018
NO18.10.2018
GR19.10.2018
IS18.11.2018
Former [2019/28]AT18.07.2018
CZ18.07.2018
DK18.07.2018
EE18.07.2018
FI18.07.2018
HR18.07.2018
LT18.07.2018
LV18.07.2018
MC18.07.2018
NL18.07.2018
PL18.07.2018
RO18.07.2018
SE18.07.2018
SK18.07.2018
BG18.10.2018
NO18.10.2018
GR19.10.2018
IS18.11.2018
Former [2019/26]AT18.07.2018
CZ18.07.2018
DK18.07.2018
EE18.07.2018
FI18.07.2018
HR18.07.2018
LT18.07.2018
LV18.07.2018
NL18.07.2018
PL18.07.2018
RO18.07.2018
SE18.07.2018
SK18.07.2018
BG18.10.2018
NO18.10.2018
GR19.10.2018
IS18.11.2018
Former [2019/24]AT18.07.2018
CZ18.07.2018
EE18.07.2018
FI18.07.2018
HR18.07.2018
LT18.07.2018
LV18.07.2018
NL18.07.2018
PL18.07.2018
RO18.07.2018
SE18.07.2018
SK18.07.2018
BG18.10.2018
NO18.10.2018
GR19.10.2018
IS18.11.2018
Former [2019/22]AT18.07.2018
CZ18.07.2018
FI18.07.2018
HR18.07.2018
LT18.07.2018
LV18.07.2018
NL18.07.2018
PL18.07.2018
RO18.07.2018
SE18.07.2018
BG18.10.2018
NO18.10.2018
GR19.10.2018
IS18.11.2018
Former [2019/12]AT18.07.2018
FI18.07.2018
HR18.07.2018
LT18.07.2018
LV18.07.2018
NL18.07.2018
PL18.07.2018
SE18.07.2018
BG18.10.2018
NO18.10.2018
GR19.10.2018
IS18.11.2018
Former [2019/11]AT18.07.2018
FI18.07.2018
HR18.07.2018
LT18.07.2018
NL18.07.2018
PL18.07.2018
SE18.07.2018
BG18.10.2018
NO18.10.2018
GR19.10.2018
IS18.11.2018
Former [2019/10]AT18.07.2018
FI18.07.2018
LT18.07.2018
NL18.07.2018
PL18.07.2018
SE18.07.2018
BG18.10.2018
NO18.10.2018
GR19.10.2018
IS18.11.2018
Former [2019/08]FI18.07.2018
LT18.07.2018
NL18.07.2018
NO18.10.2018
IS18.11.2018
Former [2019/07]LT18.07.2018
NL18.07.2018
Former [2019/04]NL18.07.2018
Documents cited:Search[I]US2005245435  (SMYTH MARK S [US], et al) [I] 6-8 * Scheme 6;; paragraph [0252]; compound 6 *;
 [I]WO2006017842  (PROTEOLIX INC [US], et al) [I] 6-8 * Scheme 7;; page 47, line 15 - line 25; compound 8 *;
 [IA]  - SIN N ET AL, "Total synthesis of the potent proteasome inhibitor epoxomicin: a useful tool for understanding proteasome biology", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, (19990802), vol. 9, no. 15, doi:10.1016/S0960-894X(99)00376-5, ISSN 0960-894X, pages 2283 - 2288, XP004174176 [I] 1,2,4 * Scheme 1;; page 2285, line 24 - line 28 * * Scheme 1(f); page 2285 * [A] 3,5,9-15

DOI:   http://dx.doi.org/10.1016/S0960-894X(99)00376-5
 [I]  - VERDOES MARTIJN ET AL, "Mixing of peptides and electrophilic traps gives rise to potent, broad-spectrum proteasome inhibitors", ORGANIC & BIOMOLECULAR CHEMISTRY, ROYAL SOCIETY OF CHEMISTRY, GB, (20070507), vol. 5, no. 9, doi:10.1039/B702268A, ISSN 1477-0520, pages 1416 - 1426, XP009106919 [I] 1,2,4 * page 1423, column 2, line 26 - line 33 * * page 1423, column 2, line 48 - line 52 * * page 1424, column 1, line 8 - line 13 * * page 1424, column 1, line 39 - line 47 *

DOI:   http://dx.doi.org/10.1039/b702268a
 [A]  - HO ET AL, "LMP2-Specific Inhibitors: Chemical Genetic Tools for Proteasome Biology", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, (20070427), vol. 14, no. 4, doi:10.1016/J.CHEMBIOL.2007.03.008, ISSN 1074-5521, pages 419 - 430, XP022047028 [A] 9-15 * figure 3 *

DOI:   http://dx.doi.org/10.1016/j.chembiol.2007.03.008
by applicantWO9810779
 US2005256324
 US7232818
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DOI:   http://dx.doi.org/10.1002/jps.2600660104
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    - BERGE ET AL., "Phannaceutical Salts", J. PHANN. SCI., (1977), vol. 66, pages 1 - 19
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.