blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Extract from the Register of European Patents

EP About this file: EP2673375

EP2673375 - COMBINATION OF BIOMARKERS FOR DETECTING AND EVALUATING AN HEPATIC FIBROSIS [Right-click to bookmark this link]
Former [2013/51]COMBINATION OF BIOMARKERS FOR DETECTING AND EVALUATING A HEPATIC FIBROSIS
[2018/20]
StatusNo opposition filed within time limit
Status updated on  23.08.2019
Database last updated on 26.07.2024
FormerThe patent has been granted
Status updated on  14.09.2018
FormerGrant of patent is intended
Status updated on  01.05.2018
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK
published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
Bio-Rad Europe GmbH
Holbeinstrasse 75
4051 Basel / CH
For all designated states
Ariana Pharmaceuticals
43-47 avenue de la Grande Armée
75116 Paris / FR
For all designated states
Institut National de la Santé et de la Recherche Médicale
101, Rue de Tolbiac
75654 Paris Cedex 13 / FR
For all designated states
Assistance Publique - Hôpitaux de Paris
3 Avenue Victoria
75004 Paris / FR
For all designated states
Centre National de la Recherche Scientifique
3, rue Michel Ange
75794 Paris Cedex 16 / FR
[2019/09]
Former [2018/47]For all designated states
Bio-Rad Europe GmbH
Holbeinstrasse 75
4051 Basel / CH
For all designated states
Ariana Pharmaceuticals
28 rue du Docteur Finlay
75015 Paris / FR
For all designated states
Institut National de la Santé et de la Recherche Médicale
101, Rue de Tolbiac
75654 Paris Cedex 13 / FR
For all designated states
Assistance Publique - Hôpitaux de Paris
3 Avenue Victoria
75004 Paris / FR
For all designated states
Centre National de la Recherche Scientifique
3, rue Michel Ange
75794 Paris Cedex 16 / FR
Former [2018/42]For all designated states
Bio-Rad Innovations
3, Boulevard Raymond Poincaré
92430 Marnes-La-Coquette / FR
For all designated states
Ariana Pharmaceuticals
28 rue du Docteur Finlay
75015 Paris / FR
For all designated states
Institut National de la Santé et de la Recherche Médicale
101, Rue de Tolbiac
75654 Paris Cedex 13 / FR
For all designated states
Assistance Publique - Hôpitaux de Paris
3 Avenue Victoria
75004 Paris / FR
For all designated states
Centre National de la Recherche Scientifique
3, rue Michel Ange
75794 Paris Cedex 16 / FR
Former [2013/51]For all designated states
Bio-Rad Innovations
3, Boulevard Raymond Poincaré
92430 Marnes-La-Coquette / FR
For all designated states
Ariana Pharmaceuticals
28 rue du Docteur Finlay
75015 Paris / FR
For all designated states
Institut National de la Santé et de la Recherche Médicale
101, Rue de Tolbiac
75654 Paris Cedex 13 / FR
For all designated states
Assistance Publique - Hôpitaux de Paris
3 Avenue Victoria
75004 Paris / FR
For all designated states
Centre National de la Recherche Scientifique
3, rue Michel-Ange
75794 Paris Cedex 16 / FR
Inventor(s)01 / WATELET, Bénédicte
Les Côteaux du Lac -
4 rue de la Mairie - Villa n° 2
34980 Saint Clement De Riviere / FR
02 / ASSELAH, Tarik
112 avenue du Général Michel Bizot
75012 Paris / FR
03 / BIECHE, Ivan
12 esplanade des Courtieux
92150 Suresnes / FR
04 / BATXELLI, Isabelle, Catherine
N° 7 Lotissement Volte-Basse
Chemin de l'eau noire
30670 Aigues-Vives / FR
05 / JULLIAN, Nathalie
60 rue Gabriel Peri
92120 Montrouge / FR
06 / VIDAUD, Michel
11 rue Squeville
94120 Fontenay Sous Bois / FR
07 / MARCELLIN, Patrick
176 rue Legendre
75017 Paris / FR
08 / LAUNE, Daniel
5 rue Pierre Couder
34790 Grabels / FR
09 / AFSHAR, Mohammad
51 rue du Ranelagh
75016 Paris / FR
10 / MATHIEU, Eve, Laure
205 avenue de Fès
Apt C36
34080 Montpellier / FR
 [2013/51]
Representative(s)Desaix, Anne, et al
Ernest Gutmann - Yves Plasseraud S.A.S.
66, rue de la Chaussée d'Antin
75009 Paris / FR
[N/P]
Former [2018/42]Desaix, Anne, et al
Ernest Gutmann - Yves Plasseraud S.A.S. 3, rue Auber
75009 Paris / FR
Former [2013/51]Paris, Fabienne, et al
Ernest Gutmann - Yves Plasseraud S.A.S. 3, rue Auber
75009 Paris / FR
Application number, filing date12702842.109.02.2012
[2018/42]
WO2012EP52234
Priority number, dateFR2011005102209.02.2011         Original published format: FR 1151022
US201161440986P09.02.2011         Original published format: US 201161440986 P
[2013/51]
Filing languageFR
Procedural languageFR
PublicationType: A1 Application with search report
No.:WO2012107530
Date:16.08.2012
Language:FR
[2012/33]
Type: A1 Application with search report 
No.:EP2673375
Date:18.12.2013
Language:FR
The application published by WIPO in one of the EPO official languages on 16.08.2012 takes the place of the publication of the European patent application.
[2013/51]
Type: B1 Patent specification 
No.:EP2673375
Date:17.10.2018
Language:FR
[2018/42]
Type: B8 Corrected title page of specification 
No.:EP2673375
Date:26.12.2018
[2018/52]
Search report(s)International search report - published on:EP16.08.2012
ClassificationIPC:C12Q1/6883, C12Q1/6876, G01N33/576, C12Q1/70
[2018/20]
CPC:
C12Q1/6883 (EP,US); C12Q1/6876 (US); G01N33/576 (EP,US);
C12Q1/706 (EP,US); C12Q2600/106 (EP,US); C12Q2600/112 (EP,US);
C12Q2600/158 (EP,US); G01N2800/085 (EP,US); G01N2800/60 (EP,US);
G01N2800/7052 (EP,US) (-)
Former IPC [2013/51]C12Q1/68
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2013/51]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:KOMBINATION VON BIOMARKERN ZUR DETEKTION UND EVALUIERUNG EINER LEBERFIBROSE[2013/51]
English:COMBINATION OF BIOMARKERS FOR DETECTING AND EVALUATING AN HEPATIC FIBROSIS[2018/20]
French:COMBINAISON DE BIOMARQUEURS POUR LA DÉTECTION ET L'ÉVALUATION D'UNE FIBROSE HÉPATIQUE[2013/51]
Former [2013/51]COMBINATION OF BIOMARKERS FOR DETECTING AND EVALUATING A HEPATIC FIBROSIS
Entry into regional phase22.07.2013National basic fee paid 
22.07.2013Designation fee(s) paid 
22.07.2013Examination fee paid 
Examination procedure22.07.2013Amendment by applicant (claims and/or description)
22.07.2013Examination requested  [2013/51]
23.10.2014Despatch of a communication from the examining division (Time limit: M06)
23.04.2015Reply to a communication from the examining division
21.03.2016Despatch of a communication from the examining division (Time limit: M06)
02.09.2016Reply to a communication from the examining division
28.03.2018Cancellation of oral proceeding that was planned for 11.04.2018
11.04.2018Date of oral proceedings (cancelled)
02.05.2018Communication of intention to grant the patent
10.09.2018Fee for grant paid
10.09.2018Fee for publishing/printing paid
10.09.2018Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  23.10.2014
Opposition(s)18.07.2019No opposition filed within time limit [2019/39]
Fees paidRenewal fee
27.01.2014Renewal fee patent year 03
26.02.2015Renewal fee patent year 04
26.02.2016Renewal fee patent year 05
27.02.2017Renewal fee patent year 06
27.02.2018Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU09.02.2012
AL17.10.2018
AT17.10.2018
CY17.10.2018
CZ17.10.2018
DK17.10.2018
EE17.10.2018
ES17.10.2018
FI17.10.2018
GR17.10.2018
HR17.10.2018
LT17.10.2018
LV17.10.2018
MC17.10.2018
MK17.10.2018
MT17.10.2018
NL17.10.2018
PL17.10.2018
RO17.10.2018
RS17.10.2018
SE17.10.2018
SI17.10.2018
SK17.10.2018
SM17.10.2018
TR17.10.2018
BG17.01.2019
NO17.01.2019
IE09.02.2019
LU09.02.2019
IS17.02.2019
PT17.02.2019
BE28.02.2019
CH28.02.2019
LI28.02.2019
[2022/31]
Former [2021/33]HU09.02.2012
AL17.10.2018
AT17.10.2018
CY17.10.2018
CZ17.10.2018
DK17.10.2018
EE17.10.2018
ES17.10.2018
FI17.10.2018
GR17.10.2018
HR17.10.2018
LT17.10.2018
LV17.10.2018
MC17.10.2018
MT17.10.2018
NL17.10.2018
PL17.10.2018
RO17.10.2018
RS17.10.2018
SE17.10.2018
SI17.10.2018
SK17.10.2018
SM17.10.2018
TR17.10.2018
BG17.01.2019
NO17.01.2019
IE09.02.2019
LU09.02.2019
IS17.02.2019
PT17.02.2019
BE28.02.2019
CH28.02.2019
LI28.02.2019
Former [2021/30]AL17.10.2018
AT17.10.2018
CY17.10.2018
CZ17.10.2018
DK17.10.2018
EE17.10.2018
ES17.10.2018
FI17.10.2018
GR17.10.2018
HR17.10.2018
LT17.10.2018
LV17.10.2018
MC17.10.2018
MT17.10.2018
NL17.10.2018
PL17.10.2018
RO17.10.2018
RS17.10.2018
SE17.10.2018
SI17.10.2018
SK17.10.2018
SM17.10.2018
TR17.10.2018
BG17.01.2019
NO17.01.2019
IE09.02.2019
LU09.02.2019
IS17.02.2019
PT17.02.2019
BE28.02.2019
CH28.02.2019
LI28.02.2019
Former [2021/26]AL17.10.2018
AT17.10.2018
CY17.10.2018
CZ17.10.2018
DK17.10.2018
EE17.10.2018
ES17.10.2018
FI17.10.2018
HR17.10.2018
LT17.10.2018
LV17.10.2018
MC17.10.2018
MT17.10.2018
NL17.10.2018
PL17.10.2018
RO17.10.2018
RS17.10.2018
SE17.10.2018
SI17.10.2018
SK17.10.2018
SM17.10.2018
TR17.10.2018
BG17.01.2019
NO17.01.2019
IE09.02.2019
LU09.02.2019
IS17.02.2019
PT17.02.2019
BE28.02.2019
CH28.02.2019
LI28.02.2019
Former [2020/29]AL17.10.2018
AT17.10.2018
CZ17.10.2018
DK17.10.2018
EE17.10.2018
ES17.10.2018
FI17.10.2018
HR17.10.2018
LT17.10.2018
LV17.10.2018
MC17.10.2018
MT17.10.2018
NL17.10.2018
PL17.10.2018
RO17.10.2018
RS17.10.2018
SE17.10.2018
SI17.10.2018
SK17.10.2018
SM17.10.2018
TR17.10.2018
BG17.01.2019
NO17.01.2019
IE09.02.2019
LU09.02.2019
IS17.02.2019
PT17.02.2019
BE28.02.2019
CH28.02.2019
LI28.02.2019
Former [2020/17]AL17.10.2018
AT17.10.2018
CZ17.10.2018
DK17.10.2018
EE17.10.2018
ES17.10.2018
FI17.10.2018
HR17.10.2018
LT17.10.2018
LV17.10.2018
MC17.10.2018
NL17.10.2018
PL17.10.2018
RO17.10.2018
RS17.10.2018
SE17.10.2018
SI17.10.2018
SK17.10.2018
SM17.10.2018
TR17.10.2018
BG17.01.2019
NO17.01.2019
IE09.02.2019
LU09.02.2019
IS17.02.2019
PT17.02.2019
BE28.02.2019
CH28.02.2019
LI28.02.2019
Former [2020/12]AL17.10.2018
AT17.10.2018
CZ17.10.2018
DK17.10.2018
EE17.10.2018
ES17.10.2018
FI17.10.2018
HR17.10.2018
LT17.10.2018
LV17.10.2018
MC17.10.2018
NL17.10.2018
PL17.10.2018
RO17.10.2018
RS17.10.2018
SE17.10.2018
SI17.10.2018
SK17.10.2018
SM17.10.2018
BG17.01.2019
NO17.01.2019
IE09.02.2019
LU09.02.2019
IS17.02.2019
PT17.02.2019
BE28.02.2019
CH28.02.2019
LI28.02.2019
Former [2020/09]AL17.10.2018
AT17.10.2018
CZ17.10.2018
DK17.10.2018
EE17.10.2018
ES17.10.2018
FI17.10.2018
HR17.10.2018
LT17.10.2018
LV17.10.2018
MC17.10.2018
NL17.10.2018
PL17.10.2018
RO17.10.2018
RS17.10.2018
SE17.10.2018
SI17.10.2018
SK17.10.2018
SM17.10.2018
BG17.01.2019
NO17.01.2019
IE09.02.2019
LU09.02.2019
IS17.02.2019
PT17.02.2019
CH28.02.2019
LI28.02.2019
Former [2020/04]AL17.10.2018
AT17.10.2018
CZ17.10.2018
DK17.10.2018
EE17.10.2018
ES17.10.2018
FI17.10.2018
HR17.10.2018
LT17.10.2018
LV17.10.2018
MC17.10.2018
NL17.10.2018
PL17.10.2018
RO17.10.2018
RS17.10.2018
SE17.10.2018
SI17.10.2018
SK17.10.2018
SM17.10.2018
BG17.01.2019
NO17.01.2019
LU09.02.2019
IS17.02.2019
PT17.02.2019
CH28.02.2019
LI28.02.2019
Former [2019/50]AL17.10.2018
AT17.10.2018
CZ17.10.2018
DK17.10.2018
EE17.10.2018
ES17.10.2018
FI17.10.2018
HR17.10.2018
LT17.10.2018
LV17.10.2018
MC17.10.2018
NL17.10.2018
PL17.10.2018
RO17.10.2018
RS17.10.2018
SE17.10.2018
SI17.10.2018
SK17.10.2018
SM17.10.2018
BG17.01.2019
NO17.01.2019
LU09.02.2019
IS17.02.2019
PT17.02.2019
Former [2019/47]AL17.10.2018
AT17.10.2018
CZ17.10.2018
DK17.10.2018
EE17.10.2018
ES17.10.2018
FI17.10.2018
HR17.10.2018
LT17.10.2018
LV17.10.2018
MC17.10.2018
NL17.10.2018
PL17.10.2018
RO17.10.2018
RS17.10.2018
SE17.10.2018
SK17.10.2018
SM17.10.2018
BG17.01.2019
NO17.01.2019
LU09.02.2019
IS17.02.2019
PT17.02.2019
Former [2019/45]AL17.10.2018
AT17.10.2018
CZ17.10.2018
DK17.10.2018
EE17.10.2018
ES17.10.2018
FI17.10.2018
HR17.10.2018
LT17.10.2018
LV17.10.2018
MC17.10.2018
NL17.10.2018
PL17.10.2018
RO17.10.2018
RS17.10.2018
SE17.10.2018
SK17.10.2018
SM17.10.2018
BG17.01.2019
NO17.01.2019
IS17.02.2019
PT17.02.2019
Former [2019/40]AL17.10.2018
AT17.10.2018
CZ17.10.2018
DK17.10.2018
EE17.10.2018
ES17.10.2018
FI17.10.2018
HR17.10.2018
LT17.10.2018
LV17.10.2018
NL17.10.2018
PL17.10.2018
RO17.10.2018
RS17.10.2018
SE17.10.2018
SK17.10.2018
SM17.10.2018
BG17.01.2019
NO17.01.2019
IS17.02.2019
PT17.02.2019
Former [2019/37]AL17.10.2018
AT17.10.2018
CZ17.10.2018
DK17.10.2018
EE17.10.2018
ES17.10.2018
FI17.10.2018
HR17.10.2018
LT17.10.2018
LV17.10.2018
NL17.10.2018
PL17.10.2018
RO17.10.2018
RS17.10.2018
SE17.10.2018
SM17.10.2018
BG17.01.2019
NO17.01.2019
IS17.02.2019
PT17.02.2019
Former [2019/35]AL17.10.2018
AT17.10.2018
CZ17.10.2018
DK17.10.2018
ES17.10.2018
FI17.10.2018
HR17.10.2018
LT17.10.2018
LV17.10.2018
NL17.10.2018
PL17.10.2018
RS17.10.2018
SE17.10.2018
BG17.01.2019
NO17.01.2019
IS17.02.2019
PT17.02.2019
Former [2019/34]AL17.10.2018
AT17.10.2018
DK17.10.2018
ES17.10.2018
FI17.10.2018
HR17.10.2018
LT17.10.2018
LV17.10.2018
NL17.10.2018
PL17.10.2018
RS17.10.2018
SE17.10.2018
BG17.01.2019
NO17.01.2019
IS17.02.2019
PT17.02.2019
Former [2019/26]AL17.10.2018
AT17.10.2018
ES17.10.2018
FI17.10.2018
HR17.10.2018
LT17.10.2018
LV17.10.2018
NL17.10.2018
PL17.10.2018
RS17.10.2018
SE17.10.2018
BG17.01.2019
NO17.01.2019
IS17.02.2019
PT17.02.2019
Former [2019/25]AT17.10.2018
ES17.10.2018
FI17.10.2018
HR17.10.2018
LT17.10.2018
LV17.10.2018
NL17.10.2018
PL17.10.2018
RS17.10.2018
SE17.10.2018
BG17.01.2019
NO17.01.2019
IS17.02.2019
Former [2019/23]AT17.10.2018
ES17.10.2018
FI17.10.2018
HR17.10.2018
LT17.10.2018
LV17.10.2018
NL17.10.2018
PL17.10.2018
BG17.01.2019
NO17.01.2019
IS17.02.2019
Former [2019/22]FI17.10.2018
LT17.10.2018
NL17.10.2018
PL17.10.2018
BG17.01.2019
NO17.01.2019
IS17.02.2019
Former [2019/21]FI17.10.2018
LT17.10.2018
NL17.10.2018
NO17.01.2019
IS17.02.2019
Former [2019/20]LT17.10.2018
NL17.10.2018
NO17.01.2019
Former [2019/17]NL17.10.2018
Cited inInternational search[XI]US6631330  (POYNARD THIERRY [FR]) [X] 1,2,5,9,18-25 * abstract, col. 1, l. 44-62, col. 2, l. 61-67 jusqu'à col. 4, l. 22, col. 7, l. 3-17, col. 8, l. 34-50) , fig. 4 * [I] 3,4,6-8,10-17;
 [XI]US2007172907  (VOLKER MICHAEL [DE], et al) [X] 1,2,5,9,18-25 * abstract, [0020]-[0047] * [I] 3,4,6-8,10-17;
 [A]US2010041069  (LEDERKREMER GERARDO ZELMAR [IL]) [A] 1-25 * abstract, [0058] *;
 [A]US2010136579  (TSENG TZU-LING [TW], et al) [A] 1-25 * abstract *;
 [A]US2010203553  (ABDEEN SUAD M [KW], et al) [A] 1-25 * abstract, fig. 1, [0010]-[0013], claims 1-18 *;
 [A]  - SHIN HYOUNG DOO ET AL, "SPP1 polymorphisms associated with HBV clearance and HCC occurrence", INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, (200710), vol. 36, no. 5, doi:10.1093/IJE/DYM093, ISSN 0300-5771, pages 1001 - 1008, XP002668356 [A] 1-25 * the whole document *

DOI:   http://dx.doi.org/10.1093/IJE/DYM093
 [A]  - SCHMILOVITZ-WEISS HEMDA ET AL, "Serum globulin levels in predicting the extent of hepatic fibrosis in patients with recurrent post-transplant hepatitis C infection.", CLINICAL TRANSPLANTATION, (200705), vol. 21, no. 3, ISSN 0902-0063, pages 391 - 397, XP002668362 [A] 1-25 * the whole document *

DOI:   http://dx.doi.org/10.1111/J.1399-0012.2007.00657.X
by applicantUS4376110
 US4683202
 US4683195
 US4965188
 WO0216949
 US6569627
 WO2006082522
 WO2006103570
    - ANASTASIADIS ET AL., "New globally convergent training scheme based on the resilient propagation algorithm.", NEUROCOMPUTING, (2005), vol. 64, doi:doi:10.1016/j.neucom.2004.11.016, pages 253 - 270, XP004940267

DOI:   http://dx.doi.org/10.1016/j.neucom.2004.11.016
    - BEDOSSA, POYNARD, "An algorythm for the grading of activity in chronic hepatitis C.", HEPATOLOGY, (1996), vol. 24, pages 289 - 93
    - BOX; COX, "An analysis of transformations", JOURNAL OF THE ROYAL STATISTICAL SOCIETY, SERIES B, (1964), vol. 26, pages 211 - 243
    - BREIMAN, "Random Forests.", MACHINE LEARNING, (2001), vol. 45, doi:doi:10.1023/A:1010933404324, pages 5 - 32, XP019213368

DOI:   http://dx.doi.org/10.1023/A:1010933404324
    - CASTERA ET AL., "Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C", GASTROENTEROLOGY, (2005), vol. 128, doi:doi:10.1053/j.gastro.2004.11.018, pages 343 - 50, XP005313375

DOI:   http://dx.doi.org/10.1053/j.gastro.2004.11.018
    - COLE ET AL., PROC. NATL. ACAD. SCI. USA, (1983), vol. 80, pages 2026 - 2030
    - COLE ET AL., Monoclonal Antibodies And Cancer Therapy, ALAN R. LISS, INC., (1985), pages 77 - 96
    - GOODMAN, "Grading and staging systems for inflammation and fibrosis in chronic liver diseases.", JOURNAL OF HEPATOLOGY, (2007), vol. 47, doi:doi:10.1016/j.jhep.2007.07.006, pages 598 - 607, XP022222974

DOI:   http://dx.doi.org/10.1016/j.jhep.2007.07.006
    - HECHENBICHLER; SCHLIEP, "weighed k-nearest-neighbor techniques and ordinal classification.", SONDERFORSCHUNGSBEREICH, (2004), vol. 386, page 399
    - IKATA; GENTLEMAN, "R : a language for data analysis and graphics.", JOURNAL OF COMPUTATIONAL AND GRAPHICAL STATISTICS, (1996), vol. 5, pages 299 - 314
    - INTRATOR; INTRATOR, Using Neural Nets for Interpretation of Nonlinear Models. Proceedings of the Statistical Computing Section, AMERICAN STATISTICAL SOCIETY, (1993), pages 244 - 249
    - KÖHLER; MILSTEIN, NATURE, (1975), vol. 256, pages 495 - 497
    - KOSBOR ET AL., IMMUNOLOGY TODAY, (1983), vol. 4, page 72
    - KRAMAR ET AL., "Critères ROC généralisés pour l'évaluation de plusieurs marqueurs tumoraux", REVUE D'EPIDéMIOLOGIE ET SANTé PUBLIQUE, (1999), vol. 47, pages 376 - 383
    - KRAMAR ET AL., "mROC: a computer program for combining tumour markers in predicting disease states.", COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE, (2001), vol. 66, pages 199 - 207
    - LIAW; WIENER, "Classification and regression by Random Forest.", R. NEWS, (2002), vol. 2.3, pages 18 - 22, XP055305332
    - LIVAK; SCHMITTGEN, "Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.", METHODS, (2001), vol. 25, pages 402 - 408
    - RIEDMILLER; BRAUN, "A direct adaptive method for faster backpropagation learning: the RPROP algorithm.", PROCEEDINGS OF THE IEEE INTERNATIONAL CONFERENCE ON NEURAL NETWORKS (ICNN, (1993), doi:doi:10.1109/ICNN.1993.298623, pages 586 - 591, XP010111589

DOI:   http://dx.doi.org/10.1109/ICNN.1993.298623
    - REISER; FARAGGI, "Confidence intervals for the generalized ROC criterion.", BIOMETRICS, (1997), vol. 53, pages 644 - 652
    - SCHMITTEN; LIVAK, "Analyzing real-time PCR data by the comparative Ct method.", NATURE PROTOCOLS, (2008), vol. 3, no. 6, doi:doi:10.1038/nprot.2008.73, pages 1101 - 1108, XP055137608

DOI:   http://dx.doi.org/10.1038/nprot.2008.73
    - SHAHEEN ET AL., "FibroTest a.nd FibroScan for the prediction of hepatitis C-related fibrosis : a review of diagnostic test accuracy;", AM. J. GASTROENTEROL., (2007), vol. 102, no. 11, doi:doi:10.1111/j.1572-0241.2007.01466.x, pages 2589 - 2600, XP002563341

DOI:   http://dx.doi.org/10.1111/j.1572-0241.2007.01466.x
    - SHAPIRO, "The interpretation of diagnostic tests.", STATISTICAL METHODS IN MEDICAL RESEARCH, (1999), vol. 8, pages 113 - 134
    - SU; LIU, "Linear combinations of multiple diagnostic markers.", JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, (1993), vol. 88, pages 1350 - 1355
    - SWETS, "Measuring the accuracy of diagnostic systems.", SCIENCE, (1988), vol. 240, pages 1285 - 1293
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.