EP2668277 - METHOD FOR THE CONSTRUCTION OF SPECIFIC PROMOTERS [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 22.09.2017 Database last updated on 10.07.2024 | Most recent event Tooltip | 17.07.2020 | Lapse of the patent in a contracting state New state(s): AL, IS | published on 19.08.2020 [2020/34] | Applicant(s) | For all designated states Synpromics Ltd. NINE, Edinburgh Bioquarter 9, Little France Road Edinburgh EH16 4UX / GB | [2016/46] |
Former [2013/49] | For all designated states Synpromics Ltd. 1 Newton Village Dalkeith, Midlothian EH22 1SN / GB | Inventor(s) | 01 /
ROBERTS, Michael L. NINE, Edinburgh Bioquarter 9, Little France Road Edinburgh EH16 4UX / GB | [2016/46] |
Former [2013/49] | 01 /
ROBERTS, Michael L. 1 Newton Village Dalkeith EH22 1SN / GB | Representative(s) | HGF Delta House 50 West Nile Street Glasgow G1 2NP / GB | [N/P] |
Former [2016/46] | Drysdale, Douglas Standen HGF Limited Delta House 50 West Nile Street Glasgow G1 2NP / GB | ||
Former [2013/49] | Drysdale, Douglas Standen Harrison Goddard Foote LLP Delta House 50 West Nile Street Glasgow G1 2NP / GB | Application number, filing date | 12704725.6 | 25.01.2012 | [2016/46] | WO2012EP51174 | Priority number, date | EP20110000572 | 25.01.2011 Original published format: EP 11000572 | [2013/49] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2012101191 | Date: | 02.08.2012 | Language: | EN | [2012/31] | Type: | A1 Application with search report | No.: | EP2668277 | Date: | 04.12.2013 | Language: | EN | The application published by WIPO in one of the EPO official languages on 02.08.2012 takes the place of the publication of the European patent application. | [2013/49] | Type: | B1 Patent specification | No.: | EP2668277 | Date: | 16.11.2016 | Language: | EN | [2016/46] | Search report(s) | International search report - published on: | EP | 02.08.2012 | Classification | IPC: | C12N15/79, C12N15/10 | [2013/49] | CPC: |
C12N15/1086 (EP,US);
C12N15/11 (KR);
C12N15/113 (US);
C12N15/63 (KR);
C12N15/79 (EP,US);
C12N15/85 (US)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2013/49] | Extension states | BA | Not yet paid | ME | Not yet paid | Title | German: | VERFAHREN ZUR KONSTRUKTION SPEZIFISCHER PROMOTOREN | [2013/49] | English: | METHOD FOR THE CONSTRUCTION OF SPECIFIC PROMOTERS | [2013/49] | French: | PROCÉDÉ DE CONSTRUCTION DE PROMOTEURS SPÉCIFIQUES | [2013/49] | Entry into regional phase | 20.08.2013 | National basic fee paid | 20.08.2013 | Designation fee(s) paid | 20.08.2013 | Examination fee paid | Examination procedure | 20.08.2013 | Examination requested [2013/49] | 13.03.2014 | Amendment by applicant (claims and/or description) | 24.09.2015 | Despatch of a communication from the examining division (Time limit: M04) | 04.02.2016 | Reply to a communication from the examining division | 08.06.2016 | Communication of intention to grant the patent | 07.10.2016 | Fee for grant paid | 07.10.2016 | Fee for publishing/printing paid | 07.10.2016 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 24.09.2015 | Opposition(s) | 17.08.2017 | No opposition filed within time limit [2017/43] | Fees paid | Renewal fee | 20.01.2014 | Renewal fee patent year 03 | 29.12.2014 | Renewal fee patent year 04 | 12.01.2016 | Renewal fee patent year 05 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 25.01.2012 | AL | 16.11.2016 | AT | 16.11.2016 | BE | 16.11.2016 | CY | 16.11.2016 | CZ | 16.11.2016 | DK | 16.11.2016 | EE | 16.11.2016 | ES | 16.11.2016 | FI | 16.11.2016 | HR | 16.11.2016 | IT | 16.11.2016 | LT | 16.11.2016 | LV | 16.11.2016 | MC | 16.11.2016 | MK | 16.11.2016 | PL | 16.11.2016 | RO | 16.11.2016 | RS | 16.11.2016 | SI | 16.11.2016 | SK | 16.11.2016 | SM | 16.11.2016 | TR | 16.11.2016 | LU | 25.01.2017 | MT | 25.01.2017 | BG | 16.02.2017 | NO | 16.02.2017 | GR | 17.02.2017 | IS | 16.03.2017 | PT | 16.03.2017 | [2020/33] |
Former [2020/15] | HU | 25.01.2012 | |
AT | 16.11.2016 | ||
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CZ | 16.11.2016 | ||
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TR | 16.11.2016 | ||
LU | 25.01.2017 | ||
MT | 25.01.2017 | ||
BG | 16.02.2017 | ||
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PT | 16.03.2017 | ||
Former [2019/51] | HU | 25.01.2012 | |
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MK | 16.11.2016 | ||
PL | 16.11.2016 | ||
RO | 16.11.2016 | ||
RS | 16.11.2016 | ||
SI | 16.11.2016 | ||
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SM | 16.11.2016 | ||
LU | 25.01.2017 | ||
MT | 25.01.2017 | ||
BG | 16.02.2017 | ||
NO | 16.02.2017 | ||
GR | 17.02.2017 | ||
PT | 16.03.2017 | ||
Former [2019/46] | HU | 25.01.2012 | |
AT | 16.11.2016 | ||
BE | 16.11.2016 | ||
CY | 16.11.2016 | ||
CZ | 16.11.2016 | ||
DK | 16.11.2016 | ||
EE | 16.11.2016 | ||
ES | 16.11.2016 | ||
FI | 16.11.2016 | ||
HR | 16.11.2016 | ||
IT | 16.11.2016 | ||
LT | 16.11.2016 | ||
LV | 16.11.2016 | ||
MC | 16.11.2016 | ||
PL | 16.11.2016 | ||
RO | 16.11.2016 | ||
RS | 16.11.2016 | ||
SI | 16.11.2016 | ||
SK | 16.11.2016 | ||
SM | 16.11.2016 | ||
LU | 25.01.2017 | ||
MT | 25.01.2017 | ||
BG | 16.02.2017 | ||
NO | 16.02.2017 | ||
GR | 17.02.2017 | ||
PT | 16.03.2017 | ||
Former [2019/31] | HU | 25.01.2012 | |
AT | 16.11.2016 | ||
BE | 16.11.2016 | ||
CZ | 16.11.2016 | ||
DK | 16.11.2016 | ||
EE | 16.11.2016 | ||
ES | 16.11.2016 | ||
FI | 16.11.2016 | ||
HR | 16.11.2016 | ||
IT | 16.11.2016 | ||
LT | 16.11.2016 | ||
LV | 16.11.2016 | ||
MC | 16.11.2016 | ||
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SI | 16.11.2016 | ||
SK | 16.11.2016 | ||
SM | 16.11.2016 | ||
LU | 25.01.2017 | ||
MT | 25.01.2017 | ||
BG | 16.02.2017 | ||
NO | 16.02.2017 | ||
GR | 17.02.2017 | ||
PT | 16.03.2017 | ||
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SI | 16.11.2016 | ||
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SM | 16.11.2016 | ||
LU | 25.01.2017 | ||
MT | 25.01.2017 | ||
BG | 16.02.2017 | ||
NO | 16.02.2017 | ||
GR | 17.02.2017 | ||
PT | 16.03.2017 | ||
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SI | 16.11.2016 | ||
SK | 16.11.2016 | ||
SM | 16.11.2016 | ||
LU | 25.01.2017 | ||
BG | 16.02.2017 | ||
NO | 16.02.2017 | ||
GR | 17.02.2017 | ||
PT | 16.03.2017 | ||
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SM | 16.11.2016 | ||
BG | 16.02.2017 | ||
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SM | 16.11.2016 | ||
BG | 16.02.2017 | ||
NO | 16.02.2017 | ||
GR | 17.02.2017 | ||
PT | 16.03.2017 | ||
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SM | 16.11.2016 | ||
NO | 16.02.2017 | ||
GR | 17.02.2017 | ||
PT | 16.03.2017 | ||
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RS | 16.11.2016 | ||
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NO | 16.02.2017 | ||
GR | 17.02.2017 | ||
PT | 16.03.2017 | ||
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BE | 31.01.2017 | ||
NO | 16.02.2017 | ||
GR | 17.02.2017 | ||
PT | 16.03.2017 | ||
Former [2017/26] | AT | 16.11.2016 | |
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FI | 16.11.2016 | ||
HR | 16.11.2016 | ||
LT | 16.11.2016 | ||
LV | 16.11.2016 | ||
PL | 16.11.2016 | ||
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BE | 31.01.2017 | ||
NO | 16.02.2017 | ||
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Former [2017/12] | LV | 16.11.2016 | Cited in | International search | [I]US2005227246 (HAHM SUNG HO [US]) [I] 1-14,20-25 * paragraphs [0044] - [0047]; examples 1-4; claims 1-19 *; | [I]WO2008107725 (REGULON S A [GR], et al) [I] 1-14,20-25 * page 7, line 14 - page 14, line 5 * * page 14, line 7 - page 16, line 13 * * page 18, line 20 - page 19, line 16; figure 1; claims 1-23 *; | [Y] - RHODES DANIEL R ET AL, Mining for regulatory programs in the cancer transcriptome, NATURE GENETICS, VOL. 37, NR. 6, PAGE(S) 579-583, (200506), ISSN 1061-4036, XP002671801 [Y] 1-25 * the whole document * DOI: http://dx.doi.org/10.1038/ng1578 | [Y] - SEGAL E ET AL, "Module networks: identifying regulatory modules and their condition-specific regulators from gene expression data", NATURE GENETICS, NATURE PUBLISHING GROUP, NEW YORK, US, (20030601), vol. 34, no. 2, doi:10.1038/NG1165, ISSN 1061-4036, pages 166 - 176, XP007904843 [Y] 1-25 * the whole document * DOI: http://dx.doi.org/10.1038/ng1165 | [Y] - SEGAL E ET AL, "A module map showing conditional activity of expression modules in cancer", NATURE GENETICS, NATURE PUBLISHING GROUP, NEW YORK, US, (20041001), vol. 36, no. 10, doi:10.1038/NG1434, ISSN 1061-4036, pages 1090 - 1098, XP007903052 [Y] 1-25 * the whole document * DOI: http://dx.doi.org/10.1038/ng1434 | [A] - EDELMAN GERALD M ET AL, "Synthetic promoter elements obtained by nucleotide sequence variation and selection for activity", PROC NATL ACAD SCI (US), WASHINGTON, DC; US, (20000328), vol. 97, no. 7, doi:10.1073/PNAS.040569897, ISSN 0027-8424, pages 3038 - 3043, XP002465447 [A] 1-25 * the whole document * DOI: http://dx.doi.org/10.1073/pnas.040569897 | [A] - ZHAO FANG ET AL, TRED: a Transcriptional Regulatory Element Database and a platform for in silico gene regulation studies, NUCLEIC ACIDS RESEARCH, VOL. 33, NR. JANUARY 1, PAGE(S) D103-D107, (20050101), ISSN 0305-1048, XP002671802 [A] 1-25 * the whole document * DOI: http://dx.doi.org/10.1093/nar/gki004 | by applicant | - LI, X.; EASTMAN, E. M.; SCHWARTZ, R. J.; DRAGHIA-AKLI, R., "Synthetic muscle promoters: activities exceeding naturally occurring regulatory sequences", NAT.BIOTECHNOL., (1999), vol. 17, pages 241 - 245 | - DAI, C.; MCANINCH, R. E.; SUTTON, R. E., "Identification of synthetic endothelial cell-specific promoters by use of a high-throughput screen", J.VIROL., (2004), vol. 78, doi:doi:10.1128/JVI.78.12.6209-6221.2004, pages 6209 - 6221, XP002465449 DOI: http://dx.doi.org/10.1128/JVI.78.12.6209-6221.2004 | - RHODES, D. R. ET AL., "Mining for regulatory programs in the cancer transcriptome", NAT.GENET., (2005), vol. 37, doi:doi:10.1038/ng1578, pages 579 - 583, XP002671801 DOI: http://dx.doi.org/10.1038/ng1578 | - SEGAL, E.; FRIEDMAN, N.; KOLLER, D.; REGEV, A., "A module map showing conditional activity of expression modules in cancer", NAT.GENET., (2004), vol. 36, doi:doi:10.1038/ng1434, pages 1090 - 1098, XP007903052 DOI: http://dx.doi.org/10.1038/ng1434 | - SEGAL, E. ET AL., "Module networks: identifying regulatory modules and their condition-specific regulators from gene expression data", NAT.GENET., (2003), vol. 34, doi:doi:10.1038/ng1165, pages 166 - 176, XP007904843 DOI: http://dx.doi.org/10.1038/ng1165 | - WINGENDER, E., "Compilation of transcription regulating proteins", NUCLEIC ACIDS RES, (1988), vol. 16, pages 1879 - 1902 | - KEL-MARGOULIS, 0. V.; KEL, A. E.; REUTER, I.; DEINEKO, I. V.; WINGENDER, E., "TRANSCompel: a database on composite regulatory elements in eukaryotic genes", NUCLEIC ACIDS RES, (2002), vol. 30, pages 332 - 334 | - BLANCO, E.; FARRE, D.; ALBA, M. M.; MESSEGUER, X.; GUIGO, R., "ABS: a database of Annotated regulatory Binding Sites from orthologous promoters", NUCLEIC ACIDS RES, (2006), vol. 34, pages D63 - D67 | - SANDELIN, A.; ALKEMA, W.; ENGSTROM, P.; WASSERMAN, W. W.; LENHARD, B., "JASPAR: an open-access database for eukaryotic transcription factor binding profiles", NUCLEIC ACIDS RES, (2004), vol. 32, pages D91 - D94 | - JAGANNATHAN, V.; ROULET, E.; DELORENZI, M.; BUCHER, P., "HTPSELEX--a database of high-throughput SELEX libraries for transcription factor binding sites", NUCLEIC ACIDS RES, (2006), vol. 34, pages D90 - D94 | - MATYS, V. ET AL., "TRANSFAC: transcriptional regulation, from patterns to profiles", NUCLEIC ACIDS RES, (2003), vol. 31, pages 374 - 378 | - ZHAO, F.; XUAN, Z.; LIU, L.; ZHANG, M. Q., "TRED: a Transcriptional Regulatory Element Database and a platform for in silico gene regulation studies", NUCLEIC ACIDS RES, (2005), vol. 33, doi:doi:10.1093/nar/gki004, pages D103 - D107, XP002671802 DOI: http://dx.doi.org/10.1093/nar/gki004 | - SINHA, S.; TOMPA, M., "YMF: A program for discovery of novel transcription factor binding sites by statistical overrepresentation", NUCLEIC ACIDS RES, (2003), vol. 31, pages 3586 - 3588 | - SINHA, S.; TOMPA, M., "Discovery of novel transcription factor binding sites by statistical overrepresentation.", NUCLEIC ACIDS RES, (2002), vol. 30, pages 5549 - 5560 | - REBEIZ, M.; REEVES, N. L.; POSAKONY, J. W., "SCORE: a computational approach to the identification of cis-regulatory modules and target genes in whole-genome sequence data. Site clustering over random expectation", PROC.NAT:1.ACAD.SCI.U.S.A, (2002), vol. 99, pages 9888 - 9893 | - SUZUKI, Y.; YAMASHITA, R.; SUGANO, S.; NAKAI, K., "DBTSS, DataBase of Transcriptional Start Sites: progress report", NUCLEIC ACIDS RES, (2004), vol. 32, pages D78 - D81 | - SUZUKI, Y.; YAMASHITA, R.; NAKAI, K.; SUGANO, S., "DBTSS: DataBase of human Transcriptional Start Sites and full-length cDNAs", NUCLEIC ACIDS RES, (2002), vol. 30, pages 328 - 331 | - DAVULURI, R. V.; GROSSE, I.; ZHANG, M. Q., "Computational identification of promoters and first exons in the human genome", NAT.GENET., (2001), vol. 29, pages 412 - 417 | - ROTH, F. P.; HUGHES, J. D.; ESTEP, P. W.; CHURCH, G. M., "Finding DNA regulatory motifs within unaligned noncoding sequences clustered by whole-genome mRNA quantitation", NAT.BIOTECHNOL., (1998), vol. 16, doi:doi:10.1038/nbt1098-939, pages 939 - 945, XP002153325 DOI: http://dx.doi.org/10.1038/nbt1098-939 | - BUSSEMAKER, H. J.; LI, H.; SIGGIA, E. D., "Regulatory element detection using correlation with expression", NAT.GENET., (2001), vol. 27, doi:doi:10.1038/84792, pages 167 - 171, XP002953908 DOI: http://dx.doi.org/10.1038/84792 | - JENSEN, L. J.; KNUDSEN, S., "Automatic discovery of regulatory patterns in promoter regions based on whole cell expression data and functional annotation", BIOINFORMATICS, (2000), vol. 16, pages 326 - 333 | - JEGGA, A. G. ET AL., "Detection and visualization of compositionally similar cis-regulatory element clusters in orthologous and coordinately controlled genes", GENOME RES, (2002), vol. 12, pages 1408 - 1417 | - DIETERICH, C.; WANG, H.; RATEITSCHAK, K.; LUZ, H.; VINGRON, M., "CORG: a database for COmparative Regulatory Genomics", NUCLEIC ACIDS RES, (2003), vol. 31, pages 55 - 57 | - LENHARD, B. ET AL., "Identification of conserved regulatory elements by comparative genome analysis", J.BIOL., (2003), vol. 2, doi:doi:10.1186/1475-4924-2-13, page 13, XP021018009 DOI: http://dx.doi.org/10.1186/1475-4924-2-13 | - KARANAM, S.; MORENO, C. S., "CONFAC: automated application of comparative genomic promoter analysis to DNA microarray datasets", NUCLEIC ACIDS RES, (2004), vol. 32, pages W475 - W484 | - LA ROSA, P. ET AL., "VAMP: visualization and analysis of array-CGH, transcriptome and other molecular profiles", BIOINFORMATICS, (2006), vol. 22, doi:doi:10.1093/bioinformatics/btl359, pages 2066 - 2073, XP055197802 DOI: http://dx.doi.org/10.1093/bioinformatics/btl359 | - JEGGA, A. G. ET AL., "CisMols Analyzer: identification of compositionally similar cis-element clusters in ortholog conserved regions of coordinately expressed genes", NUCLEIC ACIDS RES, (2005), vol. 33, doi:doi:10.1093/nar/gki486, pages W408 - W411, XP002369632 DOI: http://dx.doi.org/10.1093/nar/gki486 | - BLANCHETTE, M. ET AL., "Genome-wide computational prediction of transcriptional regulatory modules reveals new insights into human gene expression", GENOME RES, (2006), vol. 16, pages 656 - 668 | - FERRETTI, V. ET AL., "PReMod: a database of genome-wide mammalian cis-regulatory module predictions", NUCLEIC ACIDS RES, (2007), vol. 35, pages D122 - D126 | - SHAROV, A. A.; DUDEKULA, D. B.; KO, M. S., "CisView: a browser and database of cis-regulatory modules predicted in the mouse genome", DNA RES, (2006), vol. 13, pages 123 - 134 | - VEGA, V. B.; BANGARUSAMY, D. K.; MILLER, L. D.; LIU, E. T.; LIN, C. Y., "BEARR: Batch Extraction and Analysis of cis-Regulatory Regions", NUCLEIC ACIDS RES, (2004), vol. 32, pages W257 - W260 | - DUBCHAK, I.; RYABOY, D. V.; VISTA FAMILY OF COMPUTATIONAL TOOLS FOR COMPARATIVE ANALYSIS OF DNA SEQUENCES AND WHOLE GENOMES, METHODS MOL.BIOL., (2006), vol. 338, pages 69 - 89 | - LARDENOIS, A. ET AL., "PromAn: an integrated knowledge-based web server dedicated to promoter analysis", NUCLEIC ACIDS RES, (2006), vol. 34, pages W578 - W583 | - LIU, C. C. ET AL., "CRSD: a comprehensive web server for composite regulatory signature discovery", NUCLEIC ACIDS RES, (2006), vol. 34, pages W571 - W577 | - SUN, H. ET AL., "MPromDb: an integrated resource for annotation and visualization of mammalian gene promoters and ChIP-chip experimental data", NUCLEIC ACIDS RES, (2006), vol. 34, pages D98 - 103 | - NEEDLEMAN-WUNSCH, J. MOL. BIOL., (1970), vol. 48, pages 443 - 453 | - RHODES ET AL., PNAS, (2004), vol. 101, pages 9309 - 14 | - EDELMAN ET AL., PNAS, (2000), vol. 97, no. 7, pages 3038 - 43 | - ZHAO, F.; XUAN, Z.; LIU, L.; ZHANG, M., "Q. TRED: a Transcriptional Regulatory Element Database and a platform for in silico gene regulation studies", NUCLEIC ACIDS RES, (2005), vol. 33, doi:doi:10.1093/nar/gki004, pages D103 - D107, XP002671802 DOI: http://dx.doi.org/10.1093/nar/gki004 | - SINHA, S.; TOMPA, M., "Discovery of novel transcription factor binding sites by statistical overrepresentation", NUCLEIC ACIDS RES, (2002), vol. 30, pages 5549 - 5560 | - REBEIZ, M.; REEVES, N. L.; POSAKONY, J. W., "SCORE: a computational approach to the identification of cis-regulatory modules and target genes in whole-genome sequence data. Site clustering over random expectation", P-ROC.NATL.ACAD.SCI.U.S.A, (2002), vol. 99, pages 9888 - 9893 | - SUZUKI, Y.; YAMASHITA, R.; SUGANO, S.; NAKAI, K., "DBTSS, DataBase of Transcriptional Start Sites: progress report 2004", NUCLEIC ACIDS RES, (2004), vol. 32, pages D78 - D81 | - DIETERICH, C.; WANG, H.; RATEITSCHAK, K.; LUZ, H.; VINGRON, M., "CORG: a database for Comparative Regulatory Genomics", NUCLEIC ACIDS RES, (2003), vol. 31, pages 55 - 57 | - LA ROSA, P. ET AL., "VAMP: visualization and analysis of array-CGH, transcriptome and other molecular profiles", BIOINFORMATICS., (2006), vol. 22, doi:doi:10.1093/bioinformatics/btl359, pages 2066 - 2073, XP055197802 DOI: http://dx.doi.org/10.1093/bioinformatics/btl359 | - DUBCHAK, I.; RYABOY, D. V., "VISTA family of computational tools for comparative analysis of DNA sequences and whole genomes", METHODS MOL.BIOL., (2006), vol. 338, pages 69 - 89 |