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Extract from the Register of European Patents

EP About this file: EP2697196

EP2697196 - PRODRUGS OF INHIBITORS OF PLASMA KALLIKREIN [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  18.12.2015
Database last updated on 22.08.2024
Most recent event   Tooltip18.12.2015Application deemed to be withdrawnpublished on 20.01.2016  [2016/03]
Applicant(s)For all designated states
Activesite Pharmaceuticals, Inc.
187 Magellan Avenue
San Francisco, CA 94116 / US
[2014/08]
Inventor(s)01 / SINHA, Sukanto
187 Magellan Avenue
San Francisco California 94116 / US
02 / CHILCOTE, Tamie Jo
187 Magellan Avenue
San Francisco California 94116 / US
03 / SURESH, Joghee Raju
c/o Syngene International Ltd.
Biocon Park, Plot 2 & 3
Bommasandra Industrial Estate - Phase-IV
Bommasandra-Jigani Link Road
Bangalore 560 099 / IN
04 / NARASIMHAN, Sriram
c/o Syngene International Ltd.
Biocon Park, Plot 2 & 3
Bommasandra Industrial Estate - Phase-IV
Bommasandra-Jigani Link Road
Bangalore 560 099 / IN
 [2014/09]
Former [2014/08]01 / SINHA, Sukanto
187 Magellan Avenue
San Francisco California 94116 / US
02 / CHILCOTE, Tamie Jo
187 Magellan Avenue
San Francisco California 94116 / US
03 / SURESH, Joghee Raju
Bangalore Karnataka / IN
04 / NARASIMHAN, Sriram
Bangalore Karnataka / IN
Representative(s)Campbell, Patrick John Henry
J A Kemp
14 South Square
Gray's Inn
London WC1R 5JJ / GB
[2014/08]
Application number, filing date12723771.712.04.2012
WO2012US33353
Priority number, dateUS201161517065P13.04.2011         Original published format: US 201161517065 P
[2014/08]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2012142308
Date:18.10.2012
Language:EN
[2012/42]
Type: A1 Application with search report 
No.:EP2697196
Date:19.02.2014
Language:EN
The application published by WIPO in one of the EPO official languages on 18.10.2012 takes the place of the publication of the European patent application.
[2014/08]
Search report(s)International search report - published on:EP18.10.2012
ClassificationIPC:C07D207/34, C07D231/14, A61K31/402, A61K31/415, A61P9/10
[2014/08]
CPC:
C07D207/34 (EP,US); A61P1/00 (EP); A61P11/06 (EP);
A61P13/12 (EP); A61P19/02 (EP); A61P25/00 (EP);
A61P25/16 (EP); A61P25/28 (EP); A61P27/02 (EP);
A61P29/00 (EP); A61P31/00 (EP); A61P35/00 (EP);
A61P7/02 (EP); A61P9/10 (EP); C07D231/14 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/08]
Extension statesBA08.11.2013
ME08.11.2013
TitleGerman:PRODRUGS VON PLASMAKALLIKREINHEMMERN[2014/08]
English:PRODRUGS OF INHIBITORS OF PLASMA KALLIKREIN[2014/08]
French:PROMÉDICAMENTS D'INHIBITEURS DE LA KALLICRÉINE PLASMATIQUE[2014/08]
Entry into regional phase08.11.2013National basic fee paid 
08.11.2013Designation fee(s) paid 
08.11.2013Examination fee paid 
Examination procedure08.11.2013Examination requested  [2014/08]
12.06.2014Amendment by applicant (claims and/or description)
28.08.2014Despatch of a communication from the examining division (Time limit: M04)
07.01.2015Reply to a communication from the examining division
09.03.2015Communication of intention to grant the patent
21.07.2015Application deemed to be withdrawn, date of legal effect  [2016/03]
24.08.2015Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time  [2016/03]
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  28.08.2014
Fees paidRenewal fee
25.03.2014Renewal fee patent year 03
Penalty fee
Additional fee for renewal fee
30.04.201504   M06   Not yet paid
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Cited inInternational search[YD]WO2008016883  (ACTIVESITE PHARMACEUTICALS INC [US], et al) [YD] 1-31 * page 1, paragraph 4 - page 3, paragraph 10; claim -; table 1 *;
 [Y]WO0214270  (ASTRAZENECA AB [SE], et al) [Y] 1-31 * page 11, line 19 - page 12, line 15; claim - *;
 [YP]WO2011075684  (ACTIVESITE PHARMACEUTICALS INC [US], et al) [YP] 1-31 * page 1, paragraph 4; example -; claim - *
 [Y]  - T. WELLER ET. AL., "Orally Active Fibrinogen Receptor Antagonists. 2. Amidoximes as Prodrugs of Amidines.", JOURNAL OF MEDICINAL CHEMISTRY, (19960701), vol. 39, pages 3139 - 3147, XP002185840 [Y] 1-31 * page 3141 - page 3142; tables 1-3 *

DOI:   http://dx.doi.org/10.1021/jm9509298
 [Y]  - M. UCHIDA ET. AL., "Orally active factor Xa inhibitors. Investigation of a novel series of 3-amidinophenylsulfonamide derivatives using an amidoxime prodrug strategy.", BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS, (20080709), vol. 18, pages 4682 - 4687, XP023613449 [Y] 1-31 * table 2 *

DOI:   http://dx.doi.org/10.1016/j.bmcl.2008.07.009
 [Y]  - H. KOSHIO ET. AL., "Orally active factor Xa inhibitor: synthesis and biological activity of masked amidines as prodrugs of novel 1,4-diazepane derivatives.", BIOORGANIC AND MEDICINAL CHEMISTRY, (20040819), vol. 12, pages 5415 - 5426, XP002680255 [Y] 1-31 * tables 1-3 *

DOI:   http://dx.doi.org/10.1016/J.BMC.2004.07.046
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