blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News flashes

New version of the European Patent Register - SPC information for Unitary Patents.

2024-03-06

More...
blank Related links

Extract from the Register of European Patents

EP About this file: EP2718422

EP2718422 - CULTURE MEDIA FOR STEM CELLS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  13.07.2018
Database last updated on 06.07.2024
FormerThe patent has been granted
Status updated on  04.08.2017
FormerGrant of patent is intended
Status updated on  15.03.2017
Most recent event   Tooltip17.07.2020Lapse of the patent in a contracting state
New state(s): AL
published on 19.08.2020  [2020/34]
Applicant(s)For all designated states
Koninklijke Nederlandse Akademie van Wetenschappen (KNAW)
Hubrecht Institute
Uppsalalaan 8
3584 CT Utrecht / NL
[2014/16]
Inventor(s)01 / CLEVERS, Johannes Carolus
c/o Hubrecht Institute
Uppsalalaan 8
3584 CT Utrecht / NL
02 / SATO, Toshiro
c/o Hubrecht Institute
Uppsalalaan 8
3584 CT Utrecht / NL
03 / HUCH ORTEGA, Meritxell
c/o Hubrecht Institute
Uppsalalaan 8
3584 CT Utrecht / NL
04 / KARTHAUS, Wouter Richard
c/o Hubrecht Institute
Uppsalalaan 8
3584 CT Utrecht / NL
 [2017/36]
Former [2014/16]01 / CLEVERS, Johannes Carolus
c/o Hubrecht Institute
Uppsalalaan 8
NL-3584 CT Utrecht / NL
02 / SATO, Toshiro
c/o Hubrecht Institute
Uppsalalaan 8
NL-3584 CT Utrecht / NL
03 / HUCH ORTEGA, Meritxell
c/o Hubrecht Institute
Uppsalalaan 8
NL-3584 CT Utrecht / NL
04 / KARTHAUS, Wouter Richard
c/o Hubrecht Institute
Uppsalalaan 8
NL-3584 CT Utrecht / NL
Representative(s)Goodfellow, Hugh Robin
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[2014/16]
Application number, filing date12729741.411.06.2012
[2017/36]
WO2012IB52950
Priority number, dateUS201161520569P10.06.2011         Original published format: US 201161520569 P
GB2011001124430.06.2011         Original published format: GB 201111244
US201161571663P30.06.2011         Original published format: US 201161571663 P
US201161513461P29.07.2011         Original published format: US 201161513461 P
US20111319486629.07.2011         Original published format: US201113194866
US201261594295P02.02.2012         Original published format: US 201261594295 P
[2014/16]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2012168930
Date:13.12.2012
Language:EN
[2012/50]
Type: A2 Application without search report 
No.:EP2718422
Date:16.04.2014
Language:EN
The application published by WIPO in one of the EPO official languages on 13.12.2012 takes the place of the publication of the European patent application.
[2014/16]
Type: B1 Patent specification 
No.:EP2718422
Date:06.09.2017
Language:EN
[2017/36]
Search report(s)International search report - published on:EP11.04.2013
ClassificationIPC:C12N5/00, C12N5/071, C12N5/09, G01N33/50
[2017/10]
CPC:
C12N5/067 (EP,IL,US); C12N5/0688 (IL,US); C12N5/0018 (EP,IL,KR,US);
A61P1/04 (EP,IL); A61P1/16 (EP,IL); A61P13/08 (EP,IL);
A61P3/10 (EP,IL); C12N5/0676 (EP,IL,US); C12N5/0679 (EP,IL,KR,US);
C12N5/0683 (EP,IL,US); C12N5/0693 (IL,US); G01N33/5005 (KR);
G01N33/5008 (IL,US); C12N2500/38 (EP,IL,KR,US); C12N2501/02 (EP,IL,KR,US);
C12N2501/119 (EP,IL,KR,US); C12N2501/12 (EP,IL,KR,US); C12N2501/15 (EP,IL,KR,US);
C12N2501/16 (EP,IL,KR,US); C12N2501/345 (EP,IL,KR,US); C12N2501/392 (EP,IL,KR,US);
C12N2501/415 (EP,IL,KR,US); C12N2501/727 (EP,IL,KR,US); C12N2503/02 (KR) (-)
Former IPC [2014/16]C12N5/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/16]
Extension statesBA09.01.2014
ME09.01.2014
TitleGerman:KULTURMEDIEN FÜR STAMMZELLEN[2014/16]
English:CULTURE MEDIA FOR STEM CELLS[2014/16]
French:MILIEU DE CULTURE POUR DES CELLULES SOUCHES[2014/16]
Entry into regional phase09.01.2014National basic fee paid 
09.01.2014Designation fee(s) paid 
09.01.2014Examination fee paid 
Examination procedure09.01.2014Examination requested  [2014/16]
21.08.2014Amendment by applicant (claims and/or description)
09.10.2014Despatch of a communication from the examining division (Time limit: M06)
20.04.2015Reply to a communication from the examining division
06.05.2015Despatch of a communication from the examining division (Time limit: M06)
15.12.2015Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
01.02.2016Reply to a communication from the examining division
16.03.2017Communication of intention to grant the patent
26.07.2017Fee for grant paid
26.07.2017Fee for publishing/printing paid
26.07.2017Receipt of the translation of the claim(s)
Divisional application(s)EP17189470.2  / EP3318627
EP23205567.3
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  09.10.2014
Opposition(s)07.06.2018No opposition filed within time limit [2018/33]
Request for further processing for:The application is deemed to be withdrawn due to failure to reply to the examination report
01.02.2016Request for further processing filed
01.02.2016Full payment received (date of receipt of payment)
Request granted
12.02.2016Decision despatched
Fees paidRenewal fee
31.03.2014Renewal fee patent year 03
10.06.2015Renewal fee patent year 04
10.06.2016Renewal fee patent year 05
16.06.2017Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipAL06.09.2017
CY06.09.2017
EE06.09.2017
LT06.09.2017
LV06.09.2017
MC06.09.2017
MK06.09.2017
RO06.09.2017
RS06.09.2017
SI06.09.2017
SM06.09.2017
BG06.12.2017
[2020/34]
Former [2020/31]CY06.09.2017
EE06.09.2017
LT06.09.2017
LV06.09.2017
MC06.09.2017
MK06.09.2017
RO06.09.2017
RS06.09.2017
SI06.09.2017
SM06.09.2017
BG06.12.2017
Former [2019/15]EE06.09.2017
LT06.09.2017
LV06.09.2017
MC06.09.2017
RO06.09.2017
RS06.09.2017
SI06.09.2017
SM06.09.2017
BG06.12.2017
Former [2018/39]EE06.09.2017
LT06.09.2017
LV06.09.2017
RO06.09.2017
RS06.09.2017
SI06.09.2017
SM06.09.2017
BG06.12.2017
Former [2018/26]EE06.09.2017
LT06.09.2017
LV06.09.2017
RO06.09.2017
RS06.09.2017
SM06.09.2017
BG06.12.2017
Former [2018/23]EE06.09.2017
LT06.09.2017
LV06.09.2017
RO06.09.2017
RS06.09.2017
BG06.12.2017
Former [2018/13]LT06.09.2017
LV06.09.2017
RS06.09.2017
BG06.12.2017
Former [2018/11]LT06.09.2017
RS06.09.2017
BG06.12.2017
Former [2018/07]LT06.09.2017
Cited inInternational search[XDY]WO2010090513  (KONINK NL AKADEMIE VAN WETENSC [NL], et al) [XD] 1-62 * the whole document * [Y] 1-62;
 [XP]WO2012014076  (KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN [NL], et al) [XP] 1-62 * the whole document *;
 [XP]  - TOSHIRO SATO ET AL, "Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium", GASTROENTEROLOGY, ELSEVIER, PHILADELPHIA, PA, vol. 141, no. 5, doi:10.1053/J.GASTRO.2011.07.050, ISSN 0016-5085, (20110727), pages 1762 - 1772, (20110902), XP028325676 [XP] 1-62 * the whole document *

DOI:   http://dx.doi.org/10.1053/j.gastro.2011.07.050
 [Y]  - SAIYONG ZHU ET AL, "Chemical Strategies for Stem Cell Biology and Regenerative Medicine", ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, (20110420), vol. 13, no. 1, doi:10.1146/annurev-bioeng-071910-124715, ISSN 1523-9829, pages 73 - 90, XP055047409 [Y] 1-62 * the whole document *

DOI:   http://dx.doi.org/10.1146/annurev-bioeng-071910-124715
by applicantWO2009022907
 WO2010016766
 WO2010090513
    - BJERKNES; CHENG, METHODS ENZYMOL., (2006), vol. 419, pages 337 - 83
    - BAKKEBO M; HUSE K; HILDEN VI; SMELAND EB; OKSVOLD MP, "TGF-beta-induced growth inhibition in B-cell lymphoma correlates with Smadl/5 signalling and constitutively active p38 MAPK", BMC IMMUNOL., (2010), vol. 11, page 57
    - DE GOUVILLE ET AL., BR J PHARMACOL., (200505), vol. 145, no. 2, pages 166 - 177
    - DREW A E ET AL., "Comparison of 2 Cell-Based Phosphoprotein Assays to Support Screening and Development of an ALK Inhibitor", J BIOMOL SCREEN, (2011), vol. 16, no. 2, pages 164 - 173
    - KORINEK ET AL., SCIENCE, (1997), vol. 275, pages 1784 - 1787
    - KIRIKOSHI H ET AL., BIOCHEM BIOPHYS RES COM, (2001), vol. 283, pages 798 - 805
    - KESTUTIS PLANUTIS ET AL., BMC CELL BIOL, (2007), vol. 8, page 12
    - LM ET AL., ANGEW CHEM INT ED ENGL, (2005), vol. 44, pages 1987 - 90
    - LEOST, M ET AL., Eur J Biochem, BIOMOL INTERNATIONAL, (2000), vol. 267, pages 5983 - 5994
    - MEYER, L ET AL., CHEM BIOL, (2003), vol. 10, pages 1255 - 1266
    - MEIJER ET AL., TRENDS IN PHARMACOLOGICAL SCIENCES, (2004), vol. 25, pages 471 - 480
    - LIAO ET AL., ENDOCRINOLOGY, (2004), vol. 145, no. 6, pages 2941 - 2949
    - DONTU ET AL., BREAST CANCER RES, (2004), vol. 6, pages R605 - R615
    - HSIEH ET AL., MOL CELL. BIOL., (1996), vol. 16, pages 952 - 959
    - ROY PETTIPHER; TREVOR T. HANSEL; RICHARD ARMER, NATURE REVIEWS DRUG DISCOVERY, (200704), vol. 6, pages 313 - 325
    - MIROCHNIK ET AL., PLOS ONE, (2012), vol. 7, no. 3, page E31052
    - NIU ET AL., ONCOGENE, (2010), vol. 29, pages 3593 - 3604
    - BOTTENSTEIN; SATO, PNAS, (1979), vol. 76, no. 1, pages 514 - 517
    - BREWER ET AL., J NEUROSCI RES., (1993), vol. 35, no. 5, pages 567 - 76
    - GREGOREFF; CLEVERS, GENES DEV, (2005), vol. 19, pages 877 - 90
    - BJERKNES; CHENG, GASTROENTEROLOGY, (1999), vol. 1, no. 16, pages 7 - 14
    - CLARKE ET AL., CANCER RES., (2006), vol. 66, pages 9339 - 44
    - SATO, T ET AL., "Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche", NATURE, (2009), vol. 459, pages 262 - 265
    - BARKER ET AL., "Identification of stem cells in small intestine and colon by marker gene Lgr5", NATURE, (20071025), vol. 449, no. 7165, pages 1003 - 7
    - SATO T ET AL., "Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts", NATURE, vol. 469, pages 415 - 418
    - CANCER RES, (2001), vol. 61, pages 8164 - 8170
    - ROBINTON ET AL., NATURE, (2012), vol. 481, page 295
    - MACCHIARINI ET AL., THE LANCET, (2008), vol. 372, no. 9655, pages 2023 - 2030
    - SAHA ET AL., CURR OPIN CHEM BIOL, (2007), vol. 1 1, no. 4, pages 381 - 387
    - SAHA ET AL., BIOPHYSICAL JOURNAL, (2008), vol. 95, pages 4426 - 4438
    - LITTLE ET AL., CHEM REV, (2008), vol. 108, pages 1787 - 1796
    - EVANS GS ET AL., J CELL SCI, (1992), vol. 101, no. 1, pages 219 - 31
    - FUKAMACHI H. J, CELL SCI, (1992), vol. 103, no. 2, pages 511 - 9
    - PERREAULT N; JEAN-FRANCOIS B, EXP CELL RES, (1996), vol. 224, pages 354 - 64
    - WHITEHEAD RH ET AL., GASTROENTEROLOGY, (1999), vol. 117, pages 858 - 65
    - OOTANI A ET AL., NAT, (2009), vol. 15, pages 701 - 6
    - KORINEK V ET AL., NAT GENET, (1998), vol. 19, pages 379 - 83
    - PINTO D ET AL., GENES DEV, (2003), vol. 17, pages 1709 - 13
    - KUHNERT F ET AL., PROC NATL ACAD SCI USA, (2004), vol. 101, pages 266 - 71
    - KIM KA ET AL., SCIENCE, (2005), vol. 309, pages 1256 - 9
    - DIGNASS AU; STURM A, EUR J GASTROENTEROL HEPATOL, (2001), vol. 13, pages 763 - 70
    - HARAMIS AP ET AL., SCIENCE, (2004), vol. 303, pages 1684 - 6
    - HOFMANN C ET AL., GASTROENTEROLOGY, (2007), vol. 132, pages 587 - 600
    - SASAKI T ET AL., EXP CELL RES, (2002), vol. 275, page 185
    - STINGL J ET AL., BREAST CANCER RES TREAT, (2001), vol. 67, pages 93 - 109
    - ROGLER G ET AL., SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, (2001), vol. 36, pages 389 - 98
    - BUSET M ET AL., IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY: JOURNAL OF THE TISSUE CULTURE ASSOCIATION, (1987), vol. 23, pages 403 - 12
    - WHITEHEAD RH ET AL., IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY: JOURNAL OF THE TISSUE CULTURE ASSOCIATION, (1987), vol. 23, pages 436 - 42
    - DEVENEY CW ET AL., THE JOURNAL OF SURGICAL RESEARCH, (1996), vol. 64, pages 161 - 9
    - PANG G ET AL., GASTROENTEROLOGY, (1996), vol. 111, pages 8 - 18
    - LATELLA G ET AL., INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, (1996), vol. 11, pages 76 - 83
    - PANJA A., LABORATORY INVESTIGATION; A JOURNAL OF TECHNICAL METHODS AND PATHOLOGY, (2000), vol. 80, pages 1473 - 5
    - GROSSMANN J ET AL., EUROPEAN JOURNAL OF CELL BIOLOGY, (2003), vol. 82, pages 262 - 70
    - GREGORIEFF A ET AL., GASTROENTEROLOGY, (2005), vol. 129, pages 626 - 38
    - SATO T ET AL., NATURE, vol. 469, pages 415 - 8
    - LUSTIG B ET AL., MOL CELL BIOL, (2002), vol. 22, pages 1184 - 93
    - BARKER NET, NATURE, (2007), vol. 449, pages 1003 - 7
    - SATO T ET AL., NATURE, (2009), vol. 459, pages 262 - 5
    - VAN DE WETERING M ET AL., CELL, (2002), vol. 111, pages 241 - 50
    - DENU JM, TRENDS BIOCHEM SCI, (2005), vol. 30, pages 479 - 83
    - OTSUKA M., GASTROENTEROLOGY, (2010), vol. 138, pages 1255 - 65,1265 EL-9
    - VAN ES JH ET AL., NATURE, (2005), vol. 435, pages 959 - 63
    - BARKER N ET AL., GENES DEV, (2008), vol. 22, pages 1856 - 64
    - ODZE RD, NAT REV GASTROENTEROL HEPATOL, (2009), vol. 6, pages 478 - 90
    - MENKE V ET AL., DISEASE MODELS & MECHANISMS, (2010), vol. 3, pages 104 - 10
    - SATO T ET AL., NATURE, (2011), vol. 469, pages 415 - 8
    - DEY D ET AL., PLOS ONE, (2009), vol. 4, page E5329
    - GARRAWAY IP ET AL., THE PROSTATE, (2010), vol. 70, pages 491 - 501
    - WALEN KH, "In vitro cellular & developmental biology", ANIMAL, (2004), vol. 40, pages 150 - 8
    - HAYFLICK L., THE JOURNAL OF INVESTIGATIVE DERMATOLOGY, (1979), vol. 73, pages 8 - 14
    - BARKER N ET AL., NATURE, (2007), vol. 449, pages 1003 - 7
    - SANSOM OJ ET AL., GENES DEV, (2004), vol. 18, pages 1385 - 90
    - GREGORIEFF A, GASTROENTEROLOGY, (2005), vol. 129, pages 626 - 638
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.