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Extract from the Register of European Patents

EP About this file: EP2718444

EP2718444 - IN VIVO DE-GLYCOSYLATION OF RECOMBINANT PROTEINS BY CO-EXPRESSION WITH PNGASE F [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  02.11.2018
Database last updated on 13.07.2024
FormerThe patent has been granted
Status updated on  24.11.2017
FormerGrant of patent is intended
Status updated on  16.07.2017
FormerExamination is in progress
Status updated on  01.02.2017
Most recent event   Tooltip17.07.2020Lapse of the patent in a contracting state
New state(s): AL		published on 19.08.2020  [2020/34]
Applicant(s)For all designated states
iBio, Inc.
9 Innovation Way, Suite 100
Newark, DE 19711 / US
[2014/16]
Inventor(s)01 / MAMMEDOV, Tarlan
6310 Winterhaven Drive
Newark, DE 19702 / US
02 / YUSIBOV, Vidadi
640 Ellis Rd
Havertown, Pennsylvania 19083-1211 / US
 [2014/25]
Former [2014/16]01 / MAMMEDOV, Tarlan
6310 Winterhaven Drive
Newark, DE 19702 / US
02 / YUSIBOV, Vidadi
1808 Manor Road
Havertown, Pennsylvania 19083 / US
Representative(s)Conroy, John, et al
Fish & Richardson P.C.
Highlight Business Towers
Mies-van-der-Rohe-Straße 8
80807 München / DE
[2017/52]
Former [2014/16]Coehn, Markus
Fish & Richardson P.C. Mies-van-der-Rohe-Strasse 8
80807 München / DE
Application number, filing date12730713.007.06.2012
[2017/52]
WO2012US41340
Priority number, dateUS201161494141P07.06.2011         Original published format: US 201161494141 P
US201161564427P29.11.2011         Original published format: US 201161564427 P
[2014/16]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2012170678
Date:13.12.2012
Language:EN
[2012/50]
Type: A1 Application with search report 
No.:EP2718444
Date:16.04.2014
Language:EN
The application published by WIPO in one of the EPO official languages on 13.12.2012 takes the place of the publication of the European patent application.
[2014/16]
Type: B1 Patent specification 
No.:EP2718444
Date:27.12.2017
Language:EN
[2017/52]
Search report(s)International search report - published on:EP13.12.2012
ClassificationIPC:C07K14/32, C12N15/82, C12N9/80, C07K14/445
[2017/30]
CPC:
C12N9/80 (EP,US); C07K14/445 (US); C07K14/32 (US);
C12N15/8242 (EP,US)
Former IPC [2014/16]C12N15/82, C12N9/80
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/16]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:IN-VIVO-DEGLYCOSYLIERUNG REKOMBINANTER PROTEINE DURCH CO-EXPRESSION MIT PNGASE F[2014/16]
English:IN VIVO DE-GLYCOSYLATION OF RECOMBINANT PROTEINS BY CO-EXPRESSION WITH PNGASE F[2014/16]
French:DÉ-GLYCOSYLATION IN VIVO DE PROTÉINES RECOMBINÉES PAR CO-EXPRESSION AVEC LA PNGASE F[2014/16]
Entry into regional phase19.12.2013National basic fee paid 
19.12.2013Designation fee(s) paid 
19.12.2013Examination fee paid 
Examination procedure19.12.2013Examination requested  [2014/16]
21.07.2014Amendment by applicant (claims and/or description)
14.11.2014Despatch of a communication from the examining division (Time limit: M06)
26.05.2015Reply to a communication from the examining division
08.12.2015Despatch of a communication from the examining division (Time limit: M04)
07.04.2016Reply to a communication from the examining division
10.10.2016Despatch of a communication from the examining division (Time limit: M04)
31.01.2017Reply to a communication from the examining division
17.07.2017Communication of intention to grant the patent
17.11.2017Fee for grant paid
17.11.2017Fee for publishing/printing paid
17.11.2017Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  14.11.2014
Opposition(s)28.09.2018No opposition filed within time limit [2018/49]
Fees paidRenewal fee
30.06.2014Renewal fee patent year 03
29.06.2015Renewal fee patent year 04
27.06.2016Renewal fee patent year 05
27.06.2017Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU07.06.2012
AL27.12.2017
AT27.12.2017
CY27.12.2017
CZ27.12.2017
DK27.12.2017
EE27.12.2017
ES27.12.2017
FI27.12.2017
HR27.12.2017
IT27.12.2017
LT27.12.2017
LV27.12.2017
MC27.12.2017
MK27.12.2017
NL27.12.2017
PL27.12.2017
PT27.12.2017
RO27.12.2017
RS27.12.2017
SE27.12.2017
SI27.12.2017
SK27.12.2017
SM27.12.2017
TR27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
IS27.04.2018
LU07.06.2018
MT07.06.2018
BE30.06.2018
CH30.06.2018
LI30.06.2018
[2020/34]
Former [2020/31]HU07.06.2012
AT27.12.2017
CY27.12.2017
CZ27.12.2017
DK27.12.2017
EE27.12.2017
ES27.12.2017
FI27.12.2017
HR27.12.2017
IT27.12.2017
LT27.12.2017
LV27.12.2017
MC27.12.2017
MK27.12.2017
NL27.12.2017
PL27.12.2017
PT27.12.2017
RO27.12.2017
RS27.12.2017
SE27.12.2017
SI27.12.2017
SK27.12.2017
SM27.12.2017
TR27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
IS27.04.2018
LU07.06.2018
MT07.06.2018
BE30.06.2018
CH30.06.2018
LI30.06.2018
Former [2020/29]HU07.06.2012
AT27.12.2017
CY27.12.2017
CZ27.12.2017
DK27.12.2017
EE27.12.2017
ES27.12.2017
FI27.12.2017
HR27.12.2017
IT27.12.2017
LT27.12.2017
LV27.12.2017
MC27.12.2017
NL27.12.2017
PL27.12.2017
PT27.12.2017
RO27.12.2017
RS27.12.2017
SE27.12.2017
SI27.12.2017
SK27.12.2017
SM27.12.2017
TR27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
IS27.04.2018
LU07.06.2018
MT07.06.2018
BE30.06.2018
CH30.06.2018
LI30.06.2018
Former [2020/27]HU07.06.2012
AT27.12.2017
CY27.12.2017
CZ27.12.2017
DK27.12.2017
EE27.12.2017
ES27.12.2017
FI27.12.2017
HR27.12.2017
IT27.12.2017
LT27.12.2017
LV27.12.2017
MC27.12.2017
NL27.12.2017
PL27.12.2017
PT27.12.2017
RO27.12.2017
RS27.12.2017
SI27.12.2017
SK27.12.2017
SM27.12.2017
TR27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
IS27.04.2018
LU07.06.2018
MT07.06.2018
BE30.06.2018
CH30.06.2018
LI30.06.2018
Former [2020/16]AT27.12.2017
CY27.12.2017
CZ27.12.2017
DK27.12.2017
EE27.12.2017
ES27.12.2017
FI27.12.2017
HR27.12.2017
IT27.12.2017
LT27.12.2017
LV27.12.2017
MC27.12.2017
NL27.12.2017
PL27.12.2017
RO27.12.2017
RS27.12.2017
SI27.12.2017
SK27.12.2017
SM27.12.2017
TR27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
IS27.04.2018
LU07.06.2018
MT07.06.2018
BE30.06.2018
CH30.06.2018
LI30.06.2018
Former [2020/08]AT27.12.2017
CY27.12.2017
CZ27.12.2017
DK27.12.2017
EE27.12.2017
ES27.12.2017
FI27.12.2017
HR27.12.2017
IT27.12.2017
LT27.12.2017
LV27.12.2017
MC27.12.2017
NL27.12.2017
PL27.12.2017
RO27.12.2017
RS27.12.2017
SI27.12.2017
SK27.12.2017
SM27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
IS27.04.2018
LU07.06.2018
MT07.06.2018
BE30.06.2018
CH30.06.2018
LI30.06.2018
Former [2019/24]AT27.12.2017
CY27.12.2017
CZ27.12.2017
DK27.12.2017
EE27.12.2017
ES27.12.2017
FI27.12.2017
HR27.12.2017
IT27.12.2017
LT27.12.2017
LV27.12.2017
MC27.12.2017
NL27.12.2017
PL27.12.2017
RO27.12.2017
RS27.12.2017
SI27.12.2017
SK27.12.2017
SM27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
IS27.04.2018
LU07.06.2018
BE30.06.2018
CH30.06.2018
LI30.06.2018
Former [2019/21]AT27.12.2017
CY27.12.2017
CZ27.12.2017
DK27.12.2017
EE27.12.2017
ES27.12.2017
FI27.12.2017
HR27.12.2017
IT27.12.2017
LT27.12.2017
LV27.12.2017
MC27.12.2017
NL27.12.2017
PL27.12.2017
RO27.12.2017
RS27.12.2017
SI27.12.2017
SK27.12.2017
SM27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
IS27.04.2018
LU07.06.2018
CH30.06.2018
LI30.06.2018
Former [2019/17]AT27.12.2017
CY27.12.2017
CZ27.12.2017
DK27.12.2017
EE27.12.2017
ES27.12.2017
FI27.12.2017
HR27.12.2017
IT27.12.2017
LT27.12.2017
LV27.12.2017
MC27.12.2017
NL27.12.2017
PL27.12.2017
RO27.12.2017
RS27.12.2017
SI27.12.2017
SK27.12.2017
SM27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
IS27.04.2018
LU07.06.2018
Former [2019/15]AT27.12.2017
CY27.12.2017
CZ27.12.2017
DK27.12.2017
EE27.12.2017
ES27.12.2017
FI27.12.2017
HR27.12.2017
IT27.12.2017
LT27.12.2017
LV27.12.2017
MC27.12.2017
NL27.12.2017
PL27.12.2017
RO27.12.2017
RS27.12.2017
SI27.12.2017
SK27.12.2017
SM27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
IS27.04.2018
Former [2019/13]AT27.12.2017
CY27.12.2017
CZ27.12.2017
DK27.12.2017
EE27.12.2017
ES27.12.2017
FI27.12.2017
HR27.12.2017
IT27.12.2017
LT27.12.2017
LV27.12.2017
NL27.12.2017
PL27.12.2017
RO27.12.2017
RS27.12.2017
SI27.12.2017
SK27.12.2017
SM27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
IS27.04.2018
Former [2018/51]AT27.12.2017
CY27.12.2017
CZ27.12.2017
DK27.12.2017
EE27.12.2017
ES27.12.2017
FI27.12.2017
HR27.12.2017
IT27.12.2017
LT27.12.2017
LV27.12.2017
NL27.12.2017
PL27.12.2017
RO27.12.2017
RS27.12.2017
SK27.12.2017
SM27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
IS27.04.2018
Former [2018/40]AT27.12.2017
CY27.12.2017
CZ27.12.2017
EE27.12.2017
ES27.12.2017
FI27.12.2017
HR27.12.2017
IT27.12.2017
LT27.12.2017
LV27.12.2017
NL27.12.2017
PL27.12.2017
RO27.12.2017
RS27.12.2017
SK27.12.2017
SM27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
IS27.04.2018
Former [2018/39]AT27.12.2017
CY27.12.2017
CZ27.12.2017
EE27.12.2017
ES27.12.2017
FI27.12.2017
HR27.12.2017
IT27.12.2017
LT27.12.2017
LV27.12.2017
NL27.12.2017
PL27.12.2017
RS27.12.2017
SK27.12.2017
SM27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
IS27.04.2018
Former [2018/38]AT27.12.2017
CY27.12.2017
CZ27.12.2017
EE27.12.2017
ES27.12.2017
FI27.12.2017
HR27.12.2017
LT27.12.2017
LV27.12.2017
NL27.12.2017
PL27.12.2017
RS27.12.2017
SK27.12.2017
SM27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
IS27.04.2018
Former [2018/37]CY27.12.2017
CZ27.12.2017
EE27.12.2017
ES27.12.2017
FI27.12.2017
HR27.12.2017
LT27.12.2017
LV27.12.2017
NL27.12.2017
PL27.12.2017
RS27.12.2017
SK27.12.2017
SM27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
Former [2018/34]FI27.12.2017
HR27.12.2017
LT27.12.2017
LV27.12.2017
NL27.12.2017
RS27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
Former [2018/25]FI27.12.2017
HR27.12.2017
LT27.12.2017
LV27.12.2017
RS27.12.2017
BG27.03.2018
NO27.03.2018
GR28.03.2018
Former [2018/23]FI27.12.2017
HR27.12.2017
LT27.12.2017
RS27.12.2017
NO27.03.2018
GR28.03.2018
Former [2018/22]FI27.12.2017
LT27.12.2017
NO27.03.2018
Cited inInternational search[A]US5238821  (BARSOMIAN GARY D [US], et al) [A] 1-24 * claim 1 ** column 3, line 47 - line 52 *;
 [Y]WO0000624  (CROPTECH DEV CORP [US], et al) [Y] 1-9,11,12,15-24 * claim 5 * * page 29, line 16 - line 34 * * page 18, line 31 - page 19, line 8 *;
 [XY]  - SU ET AL, "Engineered yeast with PNGase F on cell surface for releasing of N-glycans from glycoproteins", ENZYME AND MICROBIAL TECHNOLOGY, STONEHAM, MA, US, (20070329), vol. 40, no. 6, doi:10.1016/J.ENZMICTEC.2006.10.029, ISSN 0141-0229, pages 1496 - 1502, XP022003974 [X] 10 * abstract * [Y] 1-9,11-24

DOI:   http://dx.doi.org/10.1016/j.enzmictec.2006.10.029
 [Y]  - LEMP D ET AL, "MOLECULAR CLONING AND HETEROLOGOUS EXPRESSION OF N-GLYCOSIDASE F FROM FLAVOBACTERIUM MENINGOSEPTICUM", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY FOR BIOCHEMISTRY AND MOLECULAR BIOLOGY, US, (19900915), vol. 265, no. 26, ISSN 0021-9258, pages 15606 - 15610, XP000151167 [Y] 7,8,13,14,17,21,22 * abstract *
 [A]  - TEKOAH Y ET AL, "Controlled glycosylation of therapeutic antibodies in plants", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, ACADEMIC PRESS, US, (20040615), vol. 426, no. 2, doi:10.1016/J.ABB.2004.02.034, ISSN 0003-9861, pages 266 - 278, XP004509803 [A] 1-24 * abstract *

DOI:   http://dx.doi.org/10.1016/j.abb.2004.02.034
 [A]  - SAURABH AGARWAL ET AL, "Expression of modified gene encoding functional human Î+--1-antitrypsin protein in transgenic tomato plants", TRANSGENIC RESEARCH, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NE, (20080305), vol. 17, no. 5, ISSN 1573-9368, pages 881 - 896, XP019616152 [A] 1-24 * abstract *
ExaminationEP0448511
    - MAMEDOV T ET AL, "Production of non-glycosylated recombinant proteins in Nicotiana benthamiana plants by co-expressing bacterial PNGase F", PLANT BIOTECHNOLOGY JOURNAL, BLACKWELL PUB, GB, vol. 10, no. 7, doi:10.1111/J.1467-7652.2012.00694.X, ISSN 1467-7644, (20120901), pages 773 - 782, (20120423), XP002759749

DOI:   http://dx.doi.org/10.1111/j.1467-7652.2012.00694.x
by applicantWO9602555
 US5580859
 US5589466
 US5888789
 WO0020612
 US6500644
 US2004092470
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The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.