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Extract from the Register of European Patents

EP About this file: EP2661437

EP2661437 - 2,4-DIAMINO-6,7-DIHYDRO-5H-PYRROLO[2,3]PYRIMIDINE DERIVATIVES AS FAK/Pyk2 INHIBITORS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  13.09.2019
Database last updated on 05.10.2024
FormerThe patent has been granted
Status updated on  05.10.2018
FormerGrant of patent is intended
Status updated on  10.05.2018
FormerExamination is in progress
Status updated on  09.12.2016
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
Centaurus BioPharma Co., Ltd.
Building No. 16
Tsinghua Science Park
Yuquan Wisdom Vale
Minzhuang Road No. 3, Haidian District
Beijing 100195 / CN
[2018/45]
Former [2013/46]For all designated states
Centaurus Biopharma Co., Ltd.
Building No. 16
Tsinghua Science Park
Yuquan Wisdom Vale
Minzhuang Road No. 3, Haidian District
Beijing 100195 / CN
Inventor(s)01 / XIAO, Dengming
Building No.16 Tsinghua Science Park
Yuquan Wisdom Vale
Minzhuang Road No. 3
Haidian District
Beijing 100195 / CN
02 / CHENG, Liang
Building No.16 Tsinghua Science Park
Yuquan Wisdom Vale
Minzhuang Road No.3
Haidian District
Beijing 100195 / CN
03 / LIU, Xijie
Building No.16 Tsinghua Science Park
Yuquan Wisdom Vale
Minzhuang Road No.3
Haidian District
Beijing 100195 / CN
04 / HU, Yuandong
Building No.16 Tsinghua Science Park
Yuquan Wisdom Vale
Minzhuang Road No.3
Haidian District
Beijing 100195 / CN
05 / XU, Xinhe
Building No.16 Tsinghua Science Park
Yuquan Wisdom Vale
Minzhuang Road No.3
Haidian District
Beijing 100195 / CN
06 / LIU, Zhihua
Building No.16 Tsinghua Science Park
Yuquan Wisdom Vale
Minzhuang Road No.3
Haidian District
Beijing 100195 / CN
07 / ZHANG, Lipeng
Building No.16 Tsinghua Science Park
Yuquan Wisdom Vale
Minzhuang Road No.3
Haidian District
Beijing 100195 / CN
08 / WU, Wei
Building No.16 Tsinghua Science Park
Yuquan Wisdom Vale
Minzhuang Road No.3
Haidian District
Beijing 100195 / CN
09 / WANG, Shulong
Building No.16 Tsinghua Science Park
Yuquan Wisdom Vale
Minzhuang Road No.3
Haidian District
Beijing 100195 / CN
10 / SHEN, Yu
Building No.16 Tsinghua Science Park
Yuquan Wisdom Vale
Minzhuang Road No.3
Haidian District
Beijing 100195 / CN
11 / LI, Gen
Building No.16 Tsinghua Science Park
Yuquan Wisdom Vale
Minzhuang Road No.3
Haidian District
Beijing 100195 / CN
12 / WANG, Yin
Building No.16 Tsinghua Science Park
Yuquan Wisdom Vale
Minzhuang Road No.3
Haidian District
Beijing 100195 / CN
13 / ZHAO, Sheng
Building No.16 Tsinghua Science Park
Yuquan Wisdom Vale
Minzhuang Road No.3
Haidian District
Beijing 100195 / CN
14 / LI, Chonglong
Building No.16 Tsinghua Science Park
Yuquan Wisdom Vale
Minzhuang Road No.3
Haidian District
Beijing 100195 / CN
15 / TANG, Jia
Building No.16 Tsinghua Science Park
Yuquan Wisdom Vale
Minzhuang Road No.3
Haidian District
Beijing 100195 / CN
16 / YU, Honghao
Building No.16 Tsinghua Science Park
Yuquan Wisdom Vale
Minzhuang Road No.3
Haidian District
Beijing 100195 / CN
 [2013/46]
Representative(s)Høiberg P/S
Adelgade 12
1304 Copenhagen K / DK
[2018/45]
Former [2013/46]Høiberg A/S
St. Kongensgade 59 A
1264 Copenhagen K / DK
Application number, filing date12732345.907.01.2012
[2018/45]
WO2012CN70122
Priority number, dateCN2011100277607.01.2011         Original published format: CN201110002776
US201161457217P02.02.2011         Original published format: US 201161457217 P
[2013/46]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2012092880
Date:12.07.2012
Language:EN
[2012/28]
Type: A1 Application with search report 
No.:EP2661437
Date:13.11.2013
Language:EN
The application published by WIPO in one of the EPO official languages on 12.07.2012 takes the place of the publication of the European patent application.
[2013/46]
Type: B1 Patent specification 
No.:EP2661437
Date:07.11.2018
Language:EN
[2018/45]
Search report(s)International search report - published on:CN12.07.2012
(Supplementary) European search report - dispatched on:EP03.06.2014
ClassificationIPC:C07D487/04, A61K31/505, A61P35/00, A61P29/00, A61P31/00, A61P37/02
[2013/46]
CPC:
C07D487/04 (EP,KR,US); A61K31/4523 (EP,US); A61K31/519 (EP,KR,US);
A61K31/5377 (EP,US); A61K31/541 (EP,US); A61P29/00 (EP);
A61P31/00 (EP); A61P31/04 (EP); A61P35/00 (EP);
A61P35/02 (EP); A61P35/04 (EP); A61P37/02 (EP);
A61P43/00 (EP); C07D401/12 (EP,US); C07D413/12 (EP,US);
C07D417/12 (EP,US); C07D493/12 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2013/46]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:2,4-DIAMINO-6,7-DIHYDRO-5H-PYRROLO-[2,3-]PYRIMIDINDERIVATE ALS FAK/PYK2-HEMMER[2013/46]
English:2,4-DIAMINO-6,7-DIHYDRO-5H-PYRROLO[2,3]PYRIMIDINE DERIVATIVES AS FAK/Pyk2 INHIBITORS[2013/46]
French:DÉRIVÉS DE 2,4-DIAMINO-6,7-DIHYDRO-5H-PYRROLO[2,3]PYRIMIDINE COMME INHIBITEURS DE FAK/PYK2[2013/46]
Entry into regional phase05.08.2013National basic fee paid 
05.08.2013Search fee paid 
05.08.2013Designation fee(s) paid 
05.08.2013Examination fee paid 
Examination procedure05.08.2013Examination requested  [2013/46]
22.12.2014Amendment by applicant (claims and/or description)
16.07.2015Despatch of a communication from the examining division (Time limit: M04)
26.11.2015Reply to a communication from the examining division
03.02.2016Despatch of a communication from the examining division (Time limit: M04)
13.06.2016Reply to a communication from the examining division
17.08.2016Despatch of a communication from the examining division (Time limit: M06)
15.02.2017Reply to a communication from the examining division
18.05.2017Despatch of a communication from the examining division (Time limit: M04)
20.09.2017Reply to a communication from the examining division
11.05.2018Communication of intention to grant the patent
21.09.2018Fee for grant paid
21.09.2018Fee for publishing/printing paid
21.09.2018Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  16.07.2015
Opposition(s)08.08.2019No opposition filed within time limit [2019/42]
Fees paidRenewal fee
29.01.2014Renewal fee patent year 03
28.01.2015Renewal fee patent year 04
06.01.2016Renewal fee patent year 05
18.01.2017Renewal fee patent year 06
31.01.2018Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU07.01.2012
AL07.11.2018
AT07.11.2018
CY07.11.2018
CZ07.11.2018
DK07.11.2018
EE07.11.2018
ES07.11.2018
FI07.11.2018
HR07.11.2018
IT07.11.2018
LT07.11.2018
LV07.11.2018
MC07.11.2018
MK07.11.2018
NL07.11.2018
PL07.11.2018
RO07.11.2018
RS07.11.2018
SE07.11.2018
SI07.11.2018
SK07.11.2018
SM07.11.2018
TR07.11.2018
FR07.01.2019
IE07.01.2019
LU07.01.2019
MT07.01.2019
BE31.01.2019
CH31.01.2019
LI31.01.2019
BG07.02.2019
GB07.02.2019
NO07.02.2019
GR08.02.2019
IS07.03.2019
PT07.03.2019
DE01.08.2019
[2022/31]
Former [2021/33]HU07.01.2012
AL07.11.2018
AT07.11.2018
CY07.11.2018
CZ07.11.2018
DK07.11.2018
EE07.11.2018
ES07.11.2018
FI07.11.2018
HR07.11.2018
IT07.11.2018
LT07.11.2018
LV07.11.2018
MC07.11.2018
NL07.11.2018
PL07.11.2018
RO07.11.2018
RS07.11.2018
SE07.11.2018
SI07.11.2018
SK07.11.2018
SM07.11.2018
TR07.11.2018
FR07.01.2019
IE07.01.2019
LU07.01.2019
MT07.01.2019
BE31.01.2019
CH31.01.2019
LI31.01.2019
BG07.02.2019
GB07.02.2019
NO07.02.2019
GR08.02.2019
IS07.03.2019
PT07.03.2019
DE01.08.2019
Former [2021/26]AL07.11.2018
AT07.11.2018
CY07.11.2018
CZ07.11.2018
DK07.11.2018
EE07.11.2018
ES07.11.2018
FI07.11.2018
HR07.11.2018
IT07.11.2018
LT07.11.2018
LV07.11.2018
MC07.11.2018
NL07.11.2018
PL07.11.2018
RO07.11.2018
RS07.11.2018
SE07.11.2018
SI07.11.2018
SK07.11.2018
SM07.11.2018
TR07.11.2018
FR07.01.2019
IE07.01.2019
LU07.01.2019
MT07.01.2019
BE31.01.2019
CH31.01.2019
LI31.01.2019
BG07.02.2019
GB07.02.2019
NO07.02.2019
GR08.02.2019
IS07.03.2019
PT07.03.2019
DE01.08.2019
Former [2020/29]AL07.11.2018
AT07.11.2018
CZ07.11.2018
DK07.11.2018
EE07.11.2018
ES07.11.2018
FI07.11.2018
HR07.11.2018
IT07.11.2018
LT07.11.2018
LV07.11.2018
MC07.11.2018
NL07.11.2018
PL07.11.2018
RO07.11.2018
RS07.11.2018
SE07.11.2018
SI07.11.2018
SK07.11.2018
SM07.11.2018
TR07.11.2018
FR07.01.2019
IE07.01.2019
LU07.01.2019
MT07.01.2019
BE31.01.2019
CH31.01.2019
LI31.01.2019
BG07.02.2019
GB07.02.2019
NO07.02.2019
GR08.02.2019
IS07.03.2019
PT07.03.2019
DE01.08.2019
Former [2020/17]AL07.11.2018
AT07.11.2018
CZ07.11.2018
DK07.11.2018
EE07.11.2018
ES07.11.2018
FI07.11.2018
HR07.11.2018
IT07.11.2018
LT07.11.2018
LV07.11.2018
MC07.11.2018
NL07.11.2018
PL07.11.2018
RO07.11.2018
RS07.11.2018
SE07.11.2018
SI07.11.2018
SK07.11.2018
SM07.11.2018
TR07.11.2018
FR07.01.2019
IE07.01.2019
LU07.01.2019
BE31.01.2019
CH31.01.2019
LI31.01.2019
BG07.02.2019
GB07.02.2019
NO07.02.2019
GR08.02.2019
IS07.03.2019
PT07.03.2019
DE01.08.2019
Former [2020/11]AL07.11.2018
AT07.11.2018
CZ07.11.2018
DK07.11.2018
EE07.11.2018
ES07.11.2018
FI07.11.2018
HR07.11.2018
IT07.11.2018
LT07.11.2018
LV07.11.2018
MC07.11.2018
NL07.11.2018
PL07.11.2018
RO07.11.2018
RS07.11.2018
SE07.11.2018
SI07.11.2018
SK07.11.2018
SM07.11.2018
FR07.01.2019
IE07.01.2019
LU07.01.2019
BE31.01.2019
CH31.01.2019
LI31.01.2019
BG07.02.2019
GB07.02.2019
NO07.02.2019
GR08.02.2019
IS07.03.2019
PT07.03.2019
DE01.08.2019
Former [2020/09]AL07.11.2018
AT07.11.2018
CZ07.11.2018
DK07.11.2018
EE07.11.2018
ES07.11.2018
FI07.11.2018
HR07.11.2018
IT07.11.2018
LT07.11.2018
LV07.11.2018
MC07.11.2018
NL07.11.2018
PL07.11.2018
RO07.11.2018
RS07.11.2018
SE07.11.2018
SI07.11.2018
SK07.11.2018
SM07.11.2018
FR07.01.2019
IE07.01.2019
LU07.01.2019
BE31.01.2019
CH31.01.2019
LI31.01.2019
BG07.02.2019
NO07.02.2019
GR08.02.2019
IS07.03.2019
PT07.03.2019
DE01.08.2019
Former [2020/04]AL07.11.2018
AT07.11.2018
CZ07.11.2018
DK07.11.2018
EE07.11.2018
ES07.11.2018
FI07.11.2018
HR07.11.2018
IT07.11.2018
LT07.11.2018
LV07.11.2018
MC07.11.2018
NL07.11.2018
PL07.11.2018
RO07.11.2018
RS07.11.2018
SE07.11.2018
SI07.11.2018
SK07.11.2018
SM07.11.2018
FR07.01.2019
LU07.01.2019
BE31.01.2019
CH31.01.2019
LI31.01.2019
BG07.02.2019
NO07.02.2019
GR08.02.2019
IS07.03.2019
PT07.03.2019
DE01.08.2019
Former [2019/50]AL07.11.2018
AT07.11.2018
CZ07.11.2018
DK07.11.2018
EE07.11.2018
ES07.11.2018
FI07.11.2018
HR07.11.2018
IT07.11.2018
LT07.11.2018
LV07.11.2018
MC07.11.2018
NL07.11.2018
PL07.11.2018
RO07.11.2018
RS07.11.2018
SE07.11.2018
SI07.11.2018
SK07.11.2018
SM07.11.2018
FR07.01.2019
LU07.01.2019
BE31.01.2019
BG07.02.2019
NO07.02.2019
GR08.02.2019
IS07.03.2019
PT07.03.2019
DE01.08.2019
Former [2019/49]AL07.11.2018
AT07.11.2018
CZ07.11.2018
DK07.11.2018
EE07.11.2018
ES07.11.2018
FI07.11.2018
HR07.11.2018
IT07.11.2018
LT07.11.2018
LV07.11.2018
MC07.11.2018
NL07.11.2018
PL07.11.2018
RO07.11.2018
RS07.11.2018
SE07.11.2018
SI07.11.2018
SK07.11.2018
SM07.11.2018
FR07.01.2019
LU07.01.2019
BG07.02.2019
NO07.02.2019
GR08.02.2019
IS07.03.2019
PT07.03.2019
DE01.08.2019
Former [2019/44]AL07.11.2018
AT07.11.2018
CZ07.11.2018
DK07.11.2018
EE07.11.2018
ES07.11.2018
FI07.11.2018
HR07.11.2018
IT07.11.2018
LT07.11.2018
LV07.11.2018
MC07.11.2018
NL07.11.2018
PL07.11.2018
RO07.11.2018
RS07.11.2018
SE07.11.2018
SK07.11.2018
SM07.11.2018
LU07.01.2019
BG07.02.2019
NO07.02.2019
GR08.02.2019
IS07.03.2019
PT07.03.2019
Former [2019/40]AL07.11.2018
AT07.11.2018
CZ07.11.2018
DK07.11.2018
EE07.11.2018
ES07.11.2018
FI07.11.2018
HR07.11.2018
IT07.11.2018
LT07.11.2018
LV07.11.2018
MC07.11.2018
NL07.11.2018
PL07.11.2018
RO07.11.2018
RS07.11.2018
SE07.11.2018
SK07.11.2018
SM07.11.2018
BG07.02.2019
NO07.02.2019
GR08.02.2019
IS07.03.2019
PT07.03.2019
Former [2019/37]AL07.11.2018
AT07.11.2018
CZ07.11.2018
DK07.11.2018
EE07.11.2018
ES07.11.2018
FI07.11.2018
HR07.11.2018
IT07.11.2018
LT07.11.2018
LV07.11.2018
NL07.11.2018
PL07.11.2018
RO07.11.2018
RS07.11.2018
SE07.11.2018
SM07.11.2018
BG07.02.2019
NO07.02.2019
GR08.02.2019
IS07.03.2019
PT07.03.2019
Former [2019/35]AL07.11.2018
AT07.11.2018
CZ07.11.2018
DK07.11.2018
ES07.11.2018
FI07.11.2018
HR07.11.2018
IT07.11.2018
LT07.11.2018
LV07.11.2018
NL07.11.2018
PL07.11.2018
RS07.11.2018
SE07.11.2018
BG07.02.2019
NO07.02.2019
GR08.02.2019
IS07.03.2019
PT07.03.2019
Former [2019/34]AL07.11.2018
AT07.11.2018
DK07.11.2018
ES07.11.2018
FI07.11.2018
HR07.11.2018
IT07.11.2018
LT07.11.2018
LV07.11.2018
NL07.11.2018
RS07.11.2018
SE07.11.2018
BG07.02.2019
NO07.02.2019
GR08.02.2019
IS07.03.2019
PT07.03.2019
Former [2019/26]AL07.11.2018
AT07.11.2018
ES07.11.2018
FI07.11.2018
HR07.11.2018
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LV07.11.2018
NL07.11.2018
RS07.11.2018
SE07.11.2018
BG07.02.2019
NO07.02.2019
GR08.02.2019
IS07.03.2019
PT07.03.2019
Former [2019/25]AT07.11.2018
ES07.11.2018
FI07.11.2018
HR07.11.2018
LT07.11.2018
LV07.11.2018
NL07.11.2018
RS07.11.2018
SE07.11.2018
BG07.02.2019
NO07.02.2019
GR08.02.2019
IS07.03.2019
Former [2019/24]AT07.11.2018
ES07.11.2018
FI07.11.2018
HR07.11.2018
LT07.11.2018
LV07.11.2018
NL07.11.2018
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BG07.02.2019
NO07.02.2019
GR08.02.2019
IS07.03.2019
Former [2019/23]AT07.11.2018
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FI07.11.2018
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LT07.11.2018
LV07.11.2018
NL07.11.2018
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NO07.02.2019
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LT07.11.2018
BG07.02.2019
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NO07.02.2019
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NO07.02.2019
Documents cited:Search[Y]WO03000695  (AVENTIS PHARMA LTD [GB], et al) [Y] 1-14* claims 1-15, 17, 18, 22-25 *;
 [Y]WO2005080393  (IRM LLC [US], et al) [Y] 1-14 * claims 1-5, 7-10 *;
 [Y]WO2007140222  (NOVARTIS AG [CH], et al) [Y] 1-14 * claims 1-7, 11-15, 17, 18, 22-24, 28-43 *;
 [Y]US2010160356  (HEINRICH TIMO [DE], et al) [Y] 1-14 * paragraphs [0008] , [ 0016] , [ 0188] , [ 0189]; claims 1-3, 5-12; table 1 *
International search[X]WO2004043367  (SQUIBB BRISTOL MYERS CO [US], et al);
 [A]WO2009131687  (PORTOLA PHARM INC [US], et al);
 [XP]CN102093364  (BEIJING SAILINTAI PHARMACEUTICAL TECHNOLOGY CO LTD);
 [A]  - DAVID HECHT ET AL., "A Novel In Silico Approach to Drug Discovery via Computational Intelligence.", J. CHEM. INF. MODEL., (2009), vol. 49, no. 4, pages 1105 - 1121, XP055091733

DOI:   http://dx.doi.org/10.1021/ci9000647
by applicantWO03000695
 WO2004043367
 WO2005080393
 WO2007140222
 WO2009131687
 US2010160356
    - BEVIGLIA ET AL., BIOCHEM J., (2003), vol. 373, pages 201 - 210
    - SMITH ET AL., MELANOMA RES., (2005), vol. 15, pages 357 - 362
    - HAIDER ET AL., CLIN. CANCER RES., (2005), vol. 11, pages 8829 - 8836
    - VAN NIMWEGEN ET AL., CANCER RES., (2005), vol. 65, pages 4698 - 4706
    - MITRA ET AL., ONCOGENE, (2006), vol. 25, pages 4429 - 4440
    - XU ET AL., CELL GROWTH AND DIFF., (1996), vol. 7, pages 413 - 418
    - CAREY; SUNDBERG, ADVANCED ORGANIC CHEMISTRY, (2000), vol. A
    - ADVANCED ORGANIC CHEMISTRY, PLENUM PRESS, (2001), vol. B
    - VOGEL'S ENCYCLOPEDIA OF PRACTICAL ORGANIC CHEMISTRY, LONGMAN SCIENTIFIC AND TECHNICAL LTD., (1991), pages 809 - 816
    - HELLER, ACC. CHEM. RES., (1990), vol. 23, page 128
    - GOODMAN; GILMAN, The Pharmacological Basis of Therapeutics, PERGAMON
    - Remington's, Pharmaceutical Sciences, MACK PUBLISHING CO.
    - BERGE ET AL., J. PHARM. SCI., (1977), vol. 66, pages 1 - 19
    - Method in Enzymology, ACADEMIC, (1985), vol. 42, pages 309 - 396
    - "Design and Application of Prodrugs", BUNDGAARD, H., A Textbook ofDrug Design and Development, (1991), pages 113 - 191
    - BUNDGAARD, H., ADVANCED DRUG DELIVERY REVIEW, (1992), vol. 8, pages 1 - 38
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.