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Extract from the Register of European Patents

EP About this file: EP2726115

EP2726115 - PROCOAGULANT PEPTIDES AND THEIR DERIVATIVES AND USES THEREFOR [Right-click to bookmark this link]
StatusPatent revoked
Status updated on  28.11.2023
Database last updated on 03.04.2025
FormerThe patent has been granted
Status updated on  11.08.2017
FormerGrant of patent is intended
Status updated on  06.06.2017
Most recent event   Tooltip01.12.2023Revocation of patentpublished on 03.01.2024  [2024/01]
Applicant(s)For all designated states
Ethicon, Inc
P.O. Box 151
U.S. Route 22
Somerville, NJ 08876 / US
[2014/19]
Inventor(s)01 / WANG, Yi-Lan
126 Primrose Court
Belle Mead, NJ 08502 / US
02 / ZHANG, Guanghui
4 Millers Grove Road
Belle Mead, NJ 08502 / US
 [2014/19]
Representative(s)Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[N/P]
Former [2014/19]Kirsch, Susan Edith
Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
Application number, filing date12732896.114.06.2012
[2017/37]
WO2012US42346
Priority number, dateUS20111317301330.06.2011         Original published format: US201113173013
[2014/19]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2013003045
Date:03.01.2013
Language:EN
[2013/01]
Type: A2 Application without search report 
No.:EP2726115
Date:07.05.2014
Language:EN
The application published by WIPO in one of the EPO official languages on 03.01.2013 takes the place of the publication of the European patent application.
[2014/19]
Type: B1 Patent specification 
No.:EP2726115
Date:13.09.2017
Language:EN
[2017/37]
Search report(s)International search report - published on:EP25.04.2013
ClassificationIPC:A61L15/32
[2014/19]
CPC:
A61L24/0015 (EP,US); A61L26/0052 (US); A61K38/39 (EP,US);
A61L24/108 (EP,US); A61L26/009 (US); A61P17/02 (EP);
A61P41/00 (EP); A61P7/04 (EP); A61K38/08 (RU);
A61K38/17 (RU); A61K38/36 (RU); A61L15/32 (RU);
A61L2300/25 (EP,US); A61L2300/252 (US); A61L2300/418 (EP,US);
A61L2400/04 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/19]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:PEPTIDE MIT VORGERINNUNGSAKTIVITÄT, IHRE DERIVATE UND VERWENDUNGEN DAFÜR[2014/19]
English:PROCOAGULANT PEPTIDES AND THEIR DERIVATIVES AND USES THEREFOR[2014/19]
French:PEPTIDES PROCOAGULANTS ET LEURS DÉRIVÉS ET LEURS UTILISATIONS[2014/19]
Entry into regional phase20.01.2014National basic fee paid 
20.01.2014Designation fee(s) paid 
20.01.2014Examination fee paid 
Examination procedure10.01.2013Request for preliminary examination filed
International Preliminary Examining Authority: EP
20.01.2014Examination requested  [2014/19]
18.08.2014Amendment by applicant (claims and/or description)
07.06.2017Communication of intention to grant the patent
02.08.2017Fee for grant paid
02.08.2017Fee for publishing/printing paid
02.08.2017Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  07.06.2017
Opposition(s)Opponent(s)01  13.06.2018  19.06.2018  ADMISSIBLE
Baxter International Inc.
One Baxter Parkway
Deerfield, IL 60015 / US
Opponent's representative
SONN Patentanwälte GmbH & Co KG
Riemergasse 14
1010 Wien / AT
 [N/P]
Former [2018/30]
Opponent(s)01  13.06.2018  19.06.2018  ADMISSIBLE
Baxter International Inc.
One Baxter Parkway
Deerfield, IL 60015 / US
Opponent's representative
Sonn & Partner Patentanwälte
Riemergasse 14
1010 Wien / AT
03.07.2018Invitation to proprietor to file observations on the notice of opposition
13.11.2018Reply of patent proprietor to notice(s) of opposition
15.10.2019Date of oral proceedings
16.12.2019Despatch of interlocutory decision in opposition
16.12.2019Despatch of minutes of oral proceedings
12.10.2023Legal effect of revocation of patent [2024/01]
29.11.2023Despatch of communication that the patent will be revoked
Appeal following opposition26.02.2020Appeal received No.  T0451/20
24.04.2020Statement of grounds filed
12.10.2023Result of appeal procedure: revocation of the patent
29.11.2023Despatch of the decision of the Board of Appeal
17.02.2020Appeal received No.  T0451/20
12.10.2023Result of appeal procedure: revocation of the patent
29.11.2023Despatch of the decision of the Board of Appeal
12.10.2023Date of oral proceedings
Fees paidRenewal fee
31.03.2014Renewal fee patent year 03
10.06.2015Renewal fee patent year 04
10.06.2016Renewal fee patent year 05
16.06.2017Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU14.06.2012
AL13.09.2017
CY13.09.2017
CZ13.09.2017
DK13.09.2017
EE13.09.2017
FI13.09.2017
HR13.09.2017
LT13.09.2017
LV13.09.2017
MC13.09.2017
MK13.09.2017
NL13.09.2017
PL13.09.2017
PT13.09.2017
RO13.09.2017
RS13.09.2017
SE13.09.2017
SI13.09.2017
SK13.09.2017
SM13.09.2017
TR13.09.2017
BG13.12.2017
NO13.12.2017
GR14.12.2017
IS13.01.2018
IE14.06.2018
LU14.06.2018
MT14.06.2018
BE30.06.2018
CH30.06.2018
LI30.06.2018
[2020/34]
Former [2020/31]HU14.06.2012
CY13.09.2017
CZ13.09.2017
DK13.09.2017
EE13.09.2017
FI13.09.2017
HR13.09.2017
LT13.09.2017
LV13.09.2017
MC13.09.2017
MK13.09.2017
NL13.09.2017
PL13.09.2017
PT13.09.2017
RO13.09.2017
RS13.09.2017
SE13.09.2017
SI13.09.2017
SK13.09.2017
SM13.09.2017
TR13.09.2017
BG13.12.2017
NO13.12.2017
GR14.12.2017
IS13.01.2018
IE14.06.2018
LU14.06.2018
MT14.06.2018
BE30.06.2018
CH30.06.2018
LI30.06.2018
Former [2020/27]HU14.06.2012
CZ13.09.2017
DK13.09.2017
EE13.09.2017
FI13.09.2017
HR13.09.2017
LT13.09.2017
LV13.09.2017
MC13.09.2017
NL13.09.2017
PL13.09.2017
PT13.09.2017
RO13.09.2017
RS13.09.2017
SE13.09.2017
SI13.09.2017
SK13.09.2017
SM13.09.2017
TR13.09.2017
BG13.12.2017
NO13.12.2017
GR14.12.2017
IS13.01.2018
IE14.06.2018
LU14.06.2018
MT14.06.2018
BE30.06.2018
CH30.06.2018
LI30.06.2018
Former [2020/16]CZ13.09.2017
DK13.09.2017
EE13.09.2017
FI13.09.2017
HR13.09.2017
LT13.09.2017
LV13.09.2017
MC13.09.2017
NL13.09.2017
PL13.09.2017
RO13.09.2017
RS13.09.2017
SE13.09.2017
SI13.09.2017
SK13.09.2017
SM13.09.2017
TR13.09.2017
BG13.12.2017
NO13.12.2017
GR14.12.2017
IS13.01.2018
IE14.06.2018
LU14.06.2018
MT14.06.2018
BE30.06.2018
CH30.06.2018
LI30.06.2018
Former [2020/08]CZ13.09.2017
DK13.09.2017
EE13.09.2017
FI13.09.2017
HR13.09.2017
LT13.09.2017
LV13.09.2017
MC13.09.2017
NL13.09.2017
PL13.09.2017
RO13.09.2017
RS13.09.2017
SE13.09.2017
SI13.09.2017
SK13.09.2017
SM13.09.2017
BG13.12.2017
NO13.12.2017
GR14.12.2017
IS13.01.2018
IE14.06.2018
LU14.06.2018
MT14.06.2018
BE30.06.2018
CH30.06.2018
LI30.06.2018
Former [2019/24]CZ13.09.2017
DK13.09.2017
EE13.09.2017
FI13.09.2017
HR13.09.2017
LT13.09.2017
LV13.09.2017
MC13.09.2017
NL13.09.2017
PL13.09.2017
RO13.09.2017
RS13.09.2017
SE13.09.2017
SI13.09.2017
SK13.09.2017
SM13.09.2017
BG13.12.2017
NO13.12.2017
GR14.12.2017
IS13.01.2018
IE14.06.2018
LU14.06.2018
BE30.06.2018
CH30.06.2018
LI30.06.2018
Former [2019/21]CZ13.09.2017
DK13.09.2017
EE13.09.2017
FI13.09.2017
HR13.09.2017
LT13.09.2017
LV13.09.2017
MC13.09.2017
NL13.09.2017
PL13.09.2017
RO13.09.2017
RS13.09.2017
SE13.09.2017
SI13.09.2017
SK13.09.2017
SM13.09.2017
BG13.12.2017
NO13.12.2017
GR14.12.2017
IS13.01.2018
IE14.06.2018
LU14.06.2018
CH30.06.2018
LI30.06.2018
Former [2019/19]CZ13.09.2017
DK13.09.2017
EE13.09.2017
FI13.09.2017
HR13.09.2017
LT13.09.2017
LV13.09.2017
MC13.09.2017
NL13.09.2017
PL13.09.2017
RO13.09.2017
RS13.09.2017
SE13.09.2017
SI13.09.2017
SK13.09.2017
SM13.09.2017
BG13.12.2017
NO13.12.2017
GR14.12.2017
IS13.01.2018
IE14.06.2018
LU14.06.2018
Former [2019/17]CZ13.09.2017
DK13.09.2017
EE13.09.2017
FI13.09.2017
HR13.09.2017
LT13.09.2017
LV13.09.2017
MC13.09.2017
NL13.09.2017
PL13.09.2017
RO13.09.2017
RS13.09.2017
SE13.09.2017
SI13.09.2017
SK13.09.2017
SM13.09.2017
BG13.12.2017
NO13.12.2017
GR14.12.2017
IS13.01.2018
LU14.06.2018
Former [2019/15]CZ13.09.2017
DK13.09.2017
EE13.09.2017
FI13.09.2017
HR13.09.2017
LT13.09.2017
LV13.09.2017
MC13.09.2017
NL13.09.2017
PL13.09.2017
RO13.09.2017
RS13.09.2017
SE13.09.2017
SI13.09.2017
SK13.09.2017
SM13.09.2017
BG13.12.2017
NO13.12.2017
GR14.12.2017
IS13.01.2018
Former [2018/52]CZ13.09.2017
DK13.09.2017
EE13.09.2017
FI13.09.2017
HR13.09.2017
LT13.09.2017
LV13.09.2017
NL13.09.2017
PL13.09.2017
RO13.09.2017
RS13.09.2017
SE13.09.2017
SI13.09.2017
SK13.09.2017
SM13.09.2017
BG13.12.2017
NO13.12.2017
GR14.12.2017
IS13.01.2018
Former [2018/35]CZ13.09.2017
DK13.09.2017
EE13.09.2017
FI13.09.2017
HR13.09.2017
LT13.09.2017
LV13.09.2017
NL13.09.2017
PL13.09.2017
RO13.09.2017
RS13.09.2017
SE13.09.2017
SK13.09.2017
SM13.09.2017
BG13.12.2017
NO13.12.2017
GR14.12.2017
IS13.01.2018
Former [2018/24]CZ13.09.2017
EE13.09.2017
FI13.09.2017
HR13.09.2017
LT13.09.2017
LV13.09.2017
NL13.09.2017
PL13.09.2017
RO13.09.2017
RS13.09.2017
SE13.09.2017
SK13.09.2017
SM13.09.2017
BG13.12.2017
NO13.12.2017
GR14.12.2017
IS13.01.2018
Former [2018/23]CZ13.09.2017
EE13.09.2017
FI13.09.2017
HR13.09.2017
LT13.09.2017
LV13.09.2017
NL13.09.2017
PL13.09.2017
RO13.09.2017
RS13.09.2017
SE13.09.2017
SK13.09.2017
BG13.12.2017
NO13.12.2017
GR14.12.2017
IS13.01.2018
Former [2018/21]CZ13.09.2017
FI13.09.2017
HR13.09.2017
LT13.09.2017
LV13.09.2017
NL13.09.2017
RS13.09.2017
SE13.09.2017
BG13.12.2017
NO13.12.2017
GR14.12.2017
Former [2018/15]FI13.09.2017
HR13.09.2017
LT13.09.2017
LV13.09.2017
NL13.09.2017
RS13.09.2017
SE13.09.2017
BG13.12.2017
NO13.12.2017
GR14.12.2017
Former [2018/12]FI13.09.2017
HR13.09.2017
LT13.09.2017
LV13.09.2017
RS13.09.2017
SE13.09.2017
BG13.12.2017
NO13.12.2017
GR14.12.2017
Former [2018/11]FI13.09.2017
HR13.09.2017
LT13.09.2017
RS13.09.2017
SE13.09.2017
BG13.12.2017
NO13.12.2017
GR14.12.2017
Former [2018/09]FI13.09.2017
LT13.09.2017
SE13.09.2017
NO13.12.2017
Former [2018/08]FI13.09.2017
LT13.09.2017
NO13.12.2017
Former [2018/07]LT13.09.2017
NO13.12.2017
Cited inInternational search[YD]US5399667  (FRAZIER WILLIAM A [US], et al) [YD] 1-27 * column 1, lines 11-50 * * column 2, lines 17-53 *;
 [YD]WO9640033  (CLARION PHARMACEUTICALS INC [US]) [YD] 1-27 * page 5, lines 9-20 * * page 6, lines 4-27 * * page 8, lines 24-28 * * page 9, lines 27-32 * * page 10, line 25 - page 11, line 3 * * page 15, lines 22-27 * * page 17, line 32 - page 18, line 7 ** page 19, lines 15-29 *;
 [Y]WO2007044026  (UNIV JOHNS HOPKINS [US], et al) [Y] 1-27 * page 1, paragraph 3 * * page 2, paragraphs 2-5, 7 * * page 7, paragraphs 4, 6 - page 8, paragraph 2 * * page 22, paragraph 1 * * page 10, paragraph 3 * * page 36, paragraph 5 - page 39, paragraph 3 *;
 [XD]WO2009040034  (MONDOBIOTECH LAB AG [LI], et al) [XD] 1-8,11,22,25 * page 1, lines 6-10 * * page 37, lines 4-10, 20-23 * * page 67, lines 19-24 * * page 68, lines 1-9 * * page 69, lines 1-19 * * page 71, lines 2-6, 20, 21 * * page 75, lines 7-18 * * page 85, lines 17-21 * * page 98, lines 27-30 * * examples 19, 21 *;
 [XY]  - J. CHUNG ET AL., "Thrombospondin-1 Acts Via IAP/CD47 to Synergize With Collagen in alpha2beta1-Mediated Platelet Activation", BLOOD, (19990715), vol. 94, no. 2, pages 642 - 648, XP002691637 [X] 1-4,22,23,25 * the whole document * [Y] 1-27
 [Y]  - TRUMEL C ET AL, "Platelet aggregation induced by the C-terminal peptide of thrombospondin-1 requires the docking protein LAT but is largely independent of alphaIIb/beta3.", MEDLINE, US NATIONAL LIBRARY OF MEDICINE (NLM), BETHESDA, MD, US, (200302), Database accession no. NLM12871507, XP002691638 [Y] 1-27 * abstract *

DOI:   http://dx.doi.org/10.1046/j.1538-7836.2003.00068.x
    [ ] - TRUMEL C ET AL, "Platelet aggregation induced by the C-terminal peptide of thrombospondin-1 requires the docking protein LAT but is largely independent of alphaIIb/beta3.", JOURNAL OF THROMBOSIS AND HAEMOSTASIS : JTH FEB 2003, (200302), vol. 1, no. 2, ISSN 1538-7933, pages 320 - 329
 [YD]  - D.J. DORAHY ET AL., "Stimulation of Platelet Activation and Aggregation by a Carboxyl-terminal Peptide from Thrombospondin Binding to the Integrin-associated Protein Receptor", THE JOURNAL OF BIOLOGICAL CHEMISTRY, (19970110), vol. 272, no. 2, XP002691639 [YD] 1-27 * the whole document *

DOI:   http://dx.doi.org/10.1074/jbc.272.2.1323
by applicantUS5190920
 US5399667
 WO9640033
 US6045570
 US7285580
 WO2009040034
    - BONNEFOY ET AL., "The evolving role of thrombospondin-1(TSP1) in hemostasis and vascular biology", CELL. MOL. LIFE SCI., (2008), vol. 65, pages 713 - 727, XP019583924
    - TRUMEL ET AL., "Platelet aggregation induced by the C-terminal peptide of thrombospondin- requires the docking protein LAT but is largely independent of alphallb/beta3", JOURNAL OF THROMBOSIS AND HAEMOSTASIS, (200302), vol. 1, no. 2, pages 320 - 9
    - CHUNG ET AL., "Thrombspondin Acts via Integrin-associated Protein to Activate the Platelet Integrin aIIbb3", J BIOL CHEM, (19970606), vol. 272, no. 23, pages 14740 - 14746
    - TUSZYNSKI ET AL., "Thrombospondin promotes platelet aggregation", BLOOD, (1988), vol. 72, pages 109 - 115
    - CHUNG ET AL., "Thrombospondin-1 acts via IAP/CD47 to synergize with collagen in alpha2betal-mediated platelet activation", BLOOD, (19990715), vol. 94, no. 2, pages 642 - 8, XP002691637
    - DORAHY ET AL., "Stimulation of platelet activation and aggregation by a carboxyl-terminal peptide from thrombospondin binding to the integrin-associated protein receptor", J. BIOL CHEM, (1997), vol. 272, doi:doi:10.1074/jbc.272.2.1323, pages 1323 - 1330, XP002691639

DOI:   http://dx.doi.org/10.1074/jbc.272.2.1323
    - FUJIMOTO ET AL., "Thrombospondin-bound integrin-associated protein (CD47) physically and functionally modifies integrin alphallbbeta3 by its extracellular domain", J BIOL CHEM, (2003), vol. 278, pages 26655 - 26665
    - TULASNE ET AL., "C-terminal peptide of thrombospondin-1 induces platelet aggregation through the Fc receptor chain-associated signaling pathway and by agglutination", BLOOD, (2001), vol. 98, doi:doi:10.1182/blood.V98.12.3346, pages 3346 - 3352, XP055309984

DOI:   http://dx.doi.org/10.1182/blood.V98.12.3346
    - VOIT ET AL., "The C-terminal peptide of thrombospondin- stimulates distinct signaling pathways but induces an activation-independent agglutination of platelets and other cells", FEBS LETTERS, (2003), vol. 544, doi:doi:10.1016/S0014-5793(03)00472-1, pages 240 - 245, XP004427900

DOI:   http://dx.doi.org/10.1016/S0014-5793(03)00472-1
    - BONNEFOY ET AL., "A model of platelet aggregation involving multiple interactions of thrombospondin-1, fibrinogen, and GPIIbIIIa receptor", J BIOL CHEM, (2001), vol. 276, pages 5605 - 5612
OppositionUS5399667
 WO9808550
 WO2004028404
 WO2008076407
 WO2009040034
 US2010092467
    - TULASNE et al., "C-terminal peptide of thrombospondin-1 induces platelet aggregation through the Fc receptor gamma -chain-associated signaling pathway and by agglutination", Blood, (20010000), vol. 98, no. 12, pages 3346 - 3352, XP055309984

DOI:   http://dx.doi.org/10.1182/blood.V98.12.3346
    - CHUNG et al., "Thrombospondin-1 Acts Via IAP/CD47 to Synergize With Collagen in .alpha.2.beta.1-Mediated Platelet Activation", Blood, (19990000), vol. 94, pages 642 - 648, XP002691637
    - TRUMEL et al., "Platelet aggregation induced by the C‐terminal peptide of thrombospondin‐1 requires the docking protein LAT but is largely independent of αIIb/β3", J. Thromb. Hemost., (20030000), vol. 1, pages 320 - 329, XP055609057

DOI:   http://dx.doi.org/10.1046/j.1538-7836.2003.00068.x
    - DORAHNY et al., "Stimulation of Platelet Activation and Aggregation by a Carboxyl-terminal Peptide from Thrombospondin Binding to the Integrin-associated Protein Receptor", JBC, (19970000), vol. 272, pages 1323 - 1330, XP002691639

DOI:   http://dx.doi.org/10.1074/jbc.272.2.1323
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.