blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News Flashes

New version of the European Patent Register – SPC proceedings information in the Unitary Patent Register.

2024-07-24

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
FAQ - Register Alert
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP2689020

EP2689020 - MICROBIAL PRODUCTION OF CHEMICAL PRODUCTS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  22.03.2019
Database last updated on 24.08.2024
FormerThe patent has been granted
Status updated on  13.04.2018
FormerGrant of patent is intended
Status updated on  28.02.2018
FormerExamination is in progress
Status updated on  23.01.2018
FormerGrant of patent is intended
Status updated on  21.09.2017
FormerExamination is in progress
Status updated on  18.11.2016
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
OPX Biotechnologies Inc.
2425 55th Street Suite 100
Boulder, CO 80301 / US
[2018/20]
Former [2014/05]For all designated states
OPX Biotechnologies Inc.
2425 55th Street Suite 100
Boulder, CO 80301 / US
Inventor(s)01 / LYNCH, Michael, D.
2425 55th Street, Suite 100
Boulder, CO 80301 / US
02 / LIPSCOMB, Tanya, E.w.
2425 55th Street, Suite 100
Boulder, CO 80301 / US
03 / TRAHAN, Ashley, D.
2425 55th Street, Suite 100
Boulder, CO 80301 / US
04 / SINGH, Amar
2425 55th Street, Suite 100
Boulder, CO 80301 / US
05 / WOLTER, Travis
2425 55th Street, Suite 100
Boulder, CO 80301 / US
 [2014/05]
Representative(s)Gowshall, Jonathan Vallance
Forresters IP LLP
Skygarden
Erika-Mann-Strasse 11
80636 München / DE
[2018/20]
Former [2014/05]Longland, Emma Louise
avidity IP
Kestrel House
Falconry Court
Baker's Lane
Epping, Essex CM16 5DQ / GB
Application number, filing date12759932.222.03.2012
[2018/20]
WO2012US30209
Priority number, dateUS201161466363P22.03.2011         Original published format: US 201161466363 P
US201161466433P22.03.2011         Original published format: US 201161466433 P
US201161539378P26.09.2011         Original published format: US 201161539378 P
US201161539162P26.09.2011         Original published format: US 201161539162 P
[2014/05]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2012129450
Date:27.09.2012
Language:EN
[2012/39]
Type: A1 Application with search report 
No.:EP2689020
Date:29.01.2014
Language:EN
The application published by WIPO in one of the EPO official languages on 27.09.2012 takes the place of the publication of the European patent application.
[2014/05]
Type: B1 Patent specification 
No.:EP2689020
Date:16.05.2018
Language:EN
[2018/20]
Search report(s)International search report - published on:US27.09.2012
(Supplementary) European search report - dispatched on:EP01.12.2014
ClassificationIPC:C12P1/00
[2014/05]
CPC:
C12P7/6409 (EP,US); C07C53/126 (US); C12N15/70 (US);
C12N9/001 (EP,US); C12N9/1029 (EP,US); C12P13/14 (EP,US);
C12P7/00 (EP,US); C12P7/22 (EP,US); C12P7/42 (EP,US);
C12P7/52 (EP,US); C12P7/625 (EP,US); C12Y103/01 (EP,US);
C12Y203/01041 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/05]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:MIKROBIELLE HERSTELLUNG CHEMISCHER PRODUKTE UND ZUSAMMENSETZUNGEN DARAUS SOWIE VERFAHREN UND SYSTEME DAFÜR[2014/05]
English:MICROBIAL PRODUCTION OF CHEMICAL PRODUCTS AND RELATED COMPOSITIONS, METHODS AND SYSTEMS[2014/05]
French:PRODUCTION MICROBIENNE DE PRODUITS CHIMIQUES, ET COMPOSITIONS, PROCÉDÉS ET SYSTÈMES ASSOCIÉS[2014/05]
Entry into regional phase30.09.2013National basic fee paid 
30.09.2013Search fee paid 
30.09.2013Designation fee(s) paid 
30.09.2013Examination fee paid 
Examination procedure30.09.2013Examination requested  [2014/05]
29.06.2015Amendment by applicant (claims and/or description)
30.10.2015Despatch of a communication from the examining division (Time limit: M06)
05.05.2016Reply to a communication from the examining division
19.05.2016Despatch of a communication from the examining division (Time limit: M06)
15.11.2016Reply to a communication from the examining division
19.01.2017Despatch of a communication from the examining division (Time limit: M04)
15.05.2017Reply to a communication from the examining division
22.09.2017Communication of intention to grant the patent
22.01.2018Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
22.01.2018Fee for grant paid
22.01.2018Fee for publishing/printing paid
07.03.2018Communication of intention to grant the patent
04.04.2018Receipt of the translation of the claim(s)
Divisional application(s)EP18172179.6  / EP3385388
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  30.10.2015
Opposition(s)19.02.2019No opposition filed within time limit [2019/17]
Fees paidRenewal fee
12.03.2014Renewal fee patent year 03
10.03.2015Renewal fee patent year 04
10.03.2016Renewal fee patent year 05
10.03.2017Renewal fee patent year 06
13.03.2018Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU22.03.2012
AL16.05.2018
AT16.05.2018
CY16.05.2018
CZ16.05.2018
DK16.05.2018
EE16.05.2018
ES16.05.2018
FI16.05.2018
HR16.05.2018
IT16.05.2018
LT16.05.2018
LV16.05.2018
MC16.05.2018
MK16.05.2018
PL16.05.2018
RO16.05.2018
RS16.05.2018
SE16.05.2018
SI16.05.2018
SK16.05.2018
SM16.05.2018
TR16.05.2018
BG16.08.2018
NO16.08.2018
GR17.08.2018
IS16.09.2018
PT17.09.2018
[2022/31]
Former [2021/32]HU22.03.2012
AL16.05.2018
AT16.05.2018
CY16.05.2018
CZ16.05.2018
DK16.05.2018
EE16.05.2018
ES16.05.2018
FI16.05.2018
HR16.05.2018
IT16.05.2018
LT16.05.2018
LV16.05.2018
MC16.05.2018
PL16.05.2018
RO16.05.2018
RS16.05.2018
SE16.05.2018
SI16.05.2018
SK16.05.2018
SM16.05.2018
TR16.05.2018
BG16.08.2018
NO16.08.2018
GR17.08.2018
IS16.09.2018
PT17.09.2018
Former [2021/31]AL16.05.2018
AT16.05.2018
CY16.05.2018
CZ16.05.2018
DK16.05.2018
EE16.05.2018
ES16.05.2018
FI16.05.2018
HR16.05.2018
IT16.05.2018
LT16.05.2018
LV16.05.2018
MC16.05.2018
PL16.05.2018
RO16.05.2018
RS16.05.2018
SE16.05.2018
SI16.05.2018
SK16.05.2018
SM16.05.2018
TR16.05.2018
BG16.08.2018
NO16.08.2018
GR17.08.2018
IS16.09.2018
PT17.09.2018
Former [2021/26]AL16.05.2018
AT16.05.2018
CY16.05.2018
CZ16.05.2018
DK16.05.2018
EE16.05.2018
ES16.05.2018
FI16.05.2018
HR16.05.2018
IT16.05.2018
LT16.05.2018
LV16.05.2018
MC16.05.2018
PL16.05.2018
RO16.05.2018
RS16.05.2018
SE16.05.2018
SI16.05.2018
SK16.05.2018
SM16.05.2018
TR16.05.2018
BG16.08.2018
NO16.08.2018
GR17.08.2018
PT17.09.2018
Former [2020/29]AL16.05.2018
AT16.05.2018
CZ16.05.2018
DK16.05.2018
EE16.05.2018
ES16.05.2018
FI16.05.2018
HR16.05.2018
IT16.05.2018
LT16.05.2018
LV16.05.2018
MC16.05.2018
PL16.05.2018
RO16.05.2018
RS16.05.2018
SE16.05.2018
SI16.05.2018
SK16.05.2018
SM16.05.2018
TR16.05.2018
BG16.08.2018
NO16.08.2018
GR17.08.2018
PT17.09.2018
Former [2020/16]AL16.05.2018
AT16.05.2018
CZ16.05.2018
DK16.05.2018
EE16.05.2018
ES16.05.2018
FI16.05.2018
HR16.05.2018
IT16.05.2018
LT16.05.2018
LV16.05.2018
MC16.05.2018
PL16.05.2018
RO16.05.2018
RS16.05.2018
SE16.05.2018
SI16.05.2018
SK16.05.2018
SM16.05.2018
TR16.05.2018
BG16.08.2018
NO16.08.2018
GR17.08.2018
Former [2019/51]AL16.05.2018
AT16.05.2018
CZ16.05.2018
DK16.05.2018
EE16.05.2018
ES16.05.2018
FI16.05.2018
HR16.05.2018
IT16.05.2018
LT16.05.2018
LV16.05.2018
MC16.05.2018
PL16.05.2018
RO16.05.2018
RS16.05.2018
SE16.05.2018
SI16.05.2018
SK16.05.2018
SM16.05.2018
BG16.08.2018
NO16.08.2018
GR17.08.2018
Former [2019/46]AT16.05.2018
CZ16.05.2018
DK16.05.2018
EE16.05.2018
ES16.05.2018
FI16.05.2018
HR16.05.2018
IT16.05.2018
LT16.05.2018
LV16.05.2018
MC16.05.2018
PL16.05.2018
RO16.05.2018
RS16.05.2018
SE16.05.2018
SI16.05.2018
SK16.05.2018
SM16.05.2018
BG16.08.2018
NO16.08.2018
GR17.08.2018
Former [2019/26]AT16.05.2018
CZ16.05.2018
DK16.05.2018
EE16.05.2018
ES16.05.2018
FI16.05.2018
HR16.05.2018
IT16.05.2018
LT16.05.2018
LV16.05.2018
PL16.05.2018
RO16.05.2018
RS16.05.2018
SE16.05.2018
SI16.05.2018
SK16.05.2018
SM16.05.2018
BG16.08.2018
NO16.08.2018
GR17.08.2018
Former [2019/11]AT16.05.2018
CZ16.05.2018
DK16.05.2018
EE16.05.2018
ES16.05.2018
FI16.05.2018
HR16.05.2018
IT16.05.2018
LT16.05.2018
LV16.05.2018
PL16.05.2018
RO16.05.2018
RS16.05.2018
SE16.05.2018
SK16.05.2018
SM16.05.2018
BG16.08.2018
NO16.08.2018
GR17.08.2018
Former [2019/10]AT16.05.2018
CZ16.05.2018
DK16.05.2018
EE16.05.2018
ES16.05.2018
FI16.05.2018
HR16.05.2018
LT16.05.2018
LV16.05.2018
PL16.05.2018
RO16.05.2018
RS16.05.2018
SE16.05.2018
SK16.05.2018
BG16.08.2018
NO16.08.2018
GR17.08.2018
Former [2019/09]DK16.05.2018
EE16.05.2018
ES16.05.2018
FI16.05.2018
HR16.05.2018
LT16.05.2018
LV16.05.2018
RS16.05.2018
SE16.05.2018
BG16.08.2018
NO16.08.2018
GR17.08.2018
Former [2019/08]DK16.05.2018
ES16.05.2018
FI16.05.2018
HR16.05.2018
LT16.05.2018
LV16.05.2018
RS16.05.2018
SE16.05.2018
BG16.08.2018
NO16.08.2018
GR17.08.2018
Former [2018/52]ES16.05.2018
FI16.05.2018
HR16.05.2018
LT16.05.2018
LV16.05.2018
RS16.05.2018
SE16.05.2018
BG16.08.2018
NO16.08.2018
GR17.08.2018
Former [2018/51]ES16.05.2018
FI16.05.2018
HR16.05.2018
LT16.05.2018
LV16.05.2018
RS16.05.2018
SE16.05.2018
BG16.08.2018
NO16.08.2018
Former [2018/50]ES16.05.2018
FI16.05.2018
HR16.05.2018
LT16.05.2018
SE16.05.2018
BG16.08.2018
NO16.08.2018
Former [2018/49]ES16.05.2018
FI16.05.2018
LT16.05.2018
SE16.05.2018
BG16.08.2018
NO16.08.2018
Former [2018/47]ES16.05.2018
FI16.05.2018
LT16.05.2018
NO16.08.2018
Documents cited:Search[X]WO2007093848  (AFFINIUM PHARM INC [CA], et al) [X] 13,14* figure 10A *;
 [Y]  - XUEFENG LU ET AL, "Overproduction of free fatty acids in E. coli: Implications for biodiesel production", METABOLIC ENGINEERING, (20081101), vol. 10, no. 6, doi:10.1016/j.ymben.2008.08.006, ISSN 1096-7176, pages 333 - 339, XP055100754 [Y] 1-12,15 * the whole document * * figure 1 *

DOI:   http://dx.doi.org/10.1016/j.ymben.2008.08.006
 [Y]  - XIN MENG ET AL, "Increasing fatty acid production inby simulating the lipid accumulation of oleaginous microorganisms", JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY ; OFFICIAL JOURNAL OF THE SOCIETY FOR INDUSTRIAL MICROBIOLOGY, SPRINGER, BERLIN, DE, (20101026), vol. 38, no. 8, doi:10.1007/S10295-010-0861-Z, ISSN 1476-5535, pages 919 - 925, XP019928933 [Y] 1-12,15 * the whole document *

DOI:   http://dx.doi.org/10.1007/s10295-010-0861-z
International search[X]  - ZHA ET AL., "Improving cellular malonyl-CoA level in Escherichia coli via metabolic engineering", METAB..ENG., (200905), vol. 11, no. 3, pages 192 - 198, XP026034671

DOI:   http://dx.doi.org/10.1016/j.ymben.2009.01.005
 [A]  - FOWLER ET AL., "Increased Malonyl Coenzyme A Biosynthesis by Tuning the Escherichia coli Metabolic Network and Its Application to Flavanone Production", APPL. ENVIRON. MICROBIOL., (200909), vol. 75, no. 18, pages 5831 - 5839, XP055003952

DOI:   http://dx.doi.org/10.1128/AEM.00270-09
by applicantUS2469701
 US2798053
 US3687885
 US3891591
 US3904685
 US3915921
 US4268641
 US4301266
 US4666983
 US4685915
 US4708997
 US4734478
 US4857610
 US4985518
 US5009653
 US5093472
 US5135677
 US5145906
 US5180798
 US5331059
 US5342899
 US5350799
 US5426199
 US5470928
 US5510307
 US5558656
 US5817870
 US5827255
 US6355412
 WO0242418
 US6509156
 US6534679
 US6593116
 US6709919
 US2005222458
 US6960455
 US2007031918
 US7186856
 US2007219390
 US2008274523
 US2009076297
 US2009111151
 WO2010011874
 US7678869
 US2010291644
 US2011171702
    - BELLION ET AL., Microb. Growth Cl Compd. (Int. Symp.), INTERCEPT, (1993), pages 415 - 32
    - SULTER ET AL., ARCH. MICROBIOL., (1990), vol. 153, pages 485 - 489
    - B. ALBERTS ET AL., Molecular Biology of the Cell, 3rd Ed.,, GARLAND PUBLISHING, (1994), pages 42 - 45,66-74
    - D. L. NELSON; M. M. COX, Principles of Biochemistry 3rd Ed.,, WORTH PUBLISHERS, (2000), pages 527 - 658
    - L. STRYER, Biochemistry, 4th ed.,, W. H. FREEMAN AND CO., (1995), pages 463 - 650
    - DESHPANDE, MUKUND V., APPL. BIOCHEM. BIOTECHNOL., (1992), vol. 36, page 227
    - J. E. BAILEY; D. F. 01 LIS, Biochemical Engineering Fundamentals, 2nd ed, MCGRAW HILL, (1986), pages 533 - 657
    - BOWIE, J. U. ET AL., "Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions", SCIENCE, (1990), vol. 247, doi:doi:10.1126/science.2315699, pages 1306 - 1310, XP002939052

DOI:   http://dx.doi.org/10.1126/science.2315699
    - BRUTLAG ET AL., COMP. APP. BIOSCI., (1990), vol. 6, pages 237 - 245
    - Laboratory Manual Third Edition, COLD SPRING HARBOR LABORATORY PRESS, (2001), vol. 1-3
    - EPPINK ET AL., J MOL. BIOL., (1999), vol. 292, no. 1, pages 87 - 96
    - HALL; TOMSETT, MICROBIOLOGY, (2000), vol. 146, pages 1399 - 406
    - DOHR ET AL., PROC. NATL. ACAD. SCI., (2001), vol. 98, no. 1, pages 81 - 86
    - RICHARD J. HEATH; CHARLES 0. ROCK, "Enoyl-Acyl Carrier Protein (fabl) Plays a Determinant Role in Completing Cycles of Fatty Acid Elongation in Escherichia coli", J. BIOL. CHEM., (1995), vol. 270, no. 44, pages 26538 - 26543, XP001319003
    - MICROBIOLOGICAL REVIEWS, (199309), vol. 57, no. 3, pages 522 - 542
    - K. MAGNUSON ET AL., Regulation of Fatty Acid Biosynthesis in Escherichia coli, AMERICAN SOCIETY FOR MICROBIOLOGY
    - W. ZHA ET AL., "Improving cellular malonyl-CoA level in Escherichia coli via metabolic engineering", METABOLIC ENGINEERING, (2009), vol. 11, doi:doi:10.1016/j.ymben.2009.01.005, pages 192 - 198, XP026034671

DOI:   http://dx.doi.org/10.1016/j.ymben.2009.01.005
    - BEGUIN, P; AUBERT, J-P, FEMS MICROBIAL. REV., (1994), vol. 13, pages 25 - 58
    - OHIMA, K. ET AL., BIOTECHNOL. GENET. ENG. REV., (1997), vol. 14, page 365414
    - LEE ET AL., CELL, (2006), vol. 126, pages 691 - 699
    - CRONAN, CELL, (2006), page 126
    - OKAMURA ET AL., PNAS, (2010), vol. 107, page 25
    - JOONG KYUN KIM ET AL., "Extractive Recovery of Products from Fermentation Broths", BIOTECHNOL. BIOPROCESS ENG., (1999), doi:doi:10.1007/BF02931905, pages 1 - 11, XP002725590

DOI:   http://dx.doi.org/10.1007/BF02931905
    - LAMBERT ET AL., AEM, vol. 73, no. 4, pages 1126 - 1135
    - SAMBROOK; RUSSELL, Molecular Cloning: A Laboratory Manual, Third Edition, COLD SPRING HARBOR LABORATORY PRESS, (2001), vol. 1-3
    - COWAN, P.J. ET AL., J. BACTERIOL., (1991), vol. 173, pages 7464 - 7470
    - "Membrane Separations in the Recovery of Biofuels and Biochemicals - An Update Review", STEPHEN A. LEEPER, Separation and Purification Technology, MARCEL DEKKER, (1992), pages 99 - 194
 US20090246141
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.