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Extract from the Register of European Patents

EP About this file: EP2694687

EP2694687 - AN IN VITRO METHOD FOR HIGH THROUGHPUT SCREENING OF GENOTOXIC AGENTS IN EUKARYOTIC CELLS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  07.12.2018
Database last updated on 14.09.2024
FormerThe patent has been granted
Status updated on  29.12.2017
FormerGrant of patent is intended
Status updated on  17.08.2017
FormerExamination is in progress
Status updated on  30.12.2016
Most recent event   Tooltip26.06.2020Lapse of the patent in a contracting state
New state(s): CY, MK		published on 29.07.2020  [2020/31]
Applicant(s)For all designated states
Anthem Biosciences Pvt Ltd
49 Canara Bank Road
Bommasandra Industrial Area Phase I
Bommasandra
Hosur Road
Bangalore 56099, Karnataka / IN
[2014/07]
Inventor(s)01 / NAIR, Ayyappan
Amrita School of Biotechnology
Clappana (PO)
Kollam 690525 Kerala / IN
02 / SUBBIAH, Madhuri
Anthem Biosciences Pvt Ltd.
49, Canara Bank Road
Bommasandra Industrial Area Phase I
Bangalore 560099 Karnataka / IN
03 / GUPTA, Gunja
Anthem Biosciences Pvt Ltd.
49, Canara Bank Road
Bommasandra Industrial Area Phase I
Bangalore 56099 Karnataka / IN
04 / RAJAKRISHNA, Lakshmi
Anthem Biosciences Pvt Ltd.
49, Canara Bank Road
Bommasandra Industrial Area Phase I
Bangalore 56099 Karnataka / IN
05 / RAGHAVENDRA, Pradeep Savanoor
Anthem Biosciences Pvt Ltd.
49, Canara Bank Road
Bommasandra Industrial Area Phase I
Bangalore 56099 Karnataka / IN
06 / KARTHIKEYAN, Subbulakshmi
Anthem Biosciences Pvt Ltd.
49, Canara Bank Road
Bommasandra Industrial Area Phase I
Bangalore 560099 Karnataka / IN
07 / UNNI, Salini Krishnan
Anthem Biosciences Pvt Ltd.
49, Canara Bank Road
Bommasandra Industrial Area Phase I
Bangalore 560099 Karnataka / IN
08 / SAMBASIVAM, Ganesh
Anthem Biosciences Pvt Ltd.
49, Canara Bank Road
Bommasandra Industrial Area Phase I
Bangalore 560099 Karnataka / IN
 [2017/37]
Former [2014/07]01 / NAIR, Ayyappan
Amrita School of Biotechnology
Clappana (PO)
Kollam 690525 Kerala / IN
02 / SUBBIAH, Madhuri
Anthem Biosciences Pvt Ltd.
49 Canara Bank Road
Bommasandra Industrial Area Phase I
Bangalore 560099 Karnataka / IN
03 / GUPTA, Gunja
Anthem Biosciences Pvt Ltd.
49 Canara Bank Road
Bommasandra Industrial Area Phase I
Bangalore 56099 Karnataka / IN
04 / RAJAKRISHNA, Lakshmi
Anthem Biosciences Pvt Ltd.
49 Canara Bank Road
Bommasandra Industrial Area Phase I
Bangalore 56099 Karnataka / IN
05 / RAGHAVENDRA, Pradeep Savanoor
Anthem Biosciences Pvt Ltd.
49 Canara Bank Road
Bommasandra Industrial Area Phase I
Bangalore 56099 Karnataka / IN
06 / KARTHIKEYAN, Subbulakshmi
Anthem Biosciences Pvt Ltd.
49 Canara Bank Road
Bommasandra Industrial Area Phase I
Bangalore 560099 Karnataka / IN
07 / UNNI, Salini Krishnan
Anthem Biosciences Pvt Ltd.
49 Canara Bank Road
Bommasandra Industrial Area Phase I
Bangalore 560099 Karnataka / IN
08 / SAMBASIVAM, Ganesh
Anthem Biosciences Pvt Ltd.
49 Canara Bank Road
Bommasandra Industrial Area Phase I
Bangalore 560099 Karnataka / IN
Representative(s)Heinze, Ekkehard, et al
Meissner Bolte Patentanwälte
Rechtsanwälte Partnerschaft mbB
Widenmayerstraße 47
80538 München / DE
[2018/05]
Former [2014/07]Meissner, Bolte & Partner
Anwaltssozietät GbR Widenmayerstrasse 48
80538 München / DE
Application number, filing date12768664.007.04.2012
[2018/05]
WO2012IB51729
Priority number, dateIN2011CHE123908.04.2011         Original published format: IN 1239CH2011
[2017/16]
Former [2014/07]IN2011CHE123908.04.2011
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2012137186
Date:11.10.2012
Language:EN
[2012/41]
Type: A1 Application with search report 
No.:EP2694687
Date:12.02.2014
Language:EN
The application published by WIPO in one of the EPO official languages on 11.10.2012 takes the place of the publication of the European patent application.
[2014/07]
Type: B1 Patent specification 
No.:EP2694687
Date:31.01.2018
Language:EN
[2018/05]
Search report(s)International search report - published on:AU11.10.2012
(Supplementary) European search report - dispatched on:EP22.10.2014
ClassificationIPC:C12Q1/68, G01N33/52, C12N15/09, G01N33/50
[2014/47]
CPC:
C12Q1/6897 (EP,CN,KR,US); G01N33/5014 (US); C12N15/09 (KR);
C12N15/11 (KR); G01N33/5023 (EP,CN,US); G01N33/52 (KR);
C12Q2600/142 (KR) (-)
Former IPC [2014/07]C12Q1/68, G01N33/52, C12N15/09
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/07]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:IN-VITRO-VERFAHREN ZUM SCREENING GENOTOXISCHER MITTEL IN EUKARYOTISCHEN ZELLEN MIT HOHEM DURCHSATZ[2014/07]
English:AN IN VITRO METHOD FOR HIGH THROUGHPUT SCREENING OF GENOTOXIC AGENTS IN EUKARYOTIC CELLS[2014/07]
French:PROCÉDÉ IN VITRO POUR LE DÉPISTAGE À HAUT DÉBIT D'AGENTS GÉNOTOXIQUES DANS DES CELLULES EUCARYOTES[2014/07]
Entry into regional phase08.10.2013National basic fee paid 
08.10.2013Search fee paid 
08.10.2013Designation fee(s) paid 
08.10.2013Examination fee paid 
Examination procedure08.10.2013Examination requested  [2014/07]
18.05.2015Amendment by applicant (claims and/or description)
01.09.2015Despatch of a communication from the examining division (Time limit: M04)
11.01.2016Reply to a communication from the examining division
20.12.2016Despatch of a communication from the examining division (Time limit: M04)
03.04.2017Reply to a communication from the examining division
18.08.2017Communication of intention to grant the patent
18.12.2017Fee for grant paid
18.12.2017Fee for publishing/printing paid
18.12.2017Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  01.09.2015
Opposition(s)02.11.2018No opposition filed within time limit [2019/02]
Fees paidRenewal fee
28.03.2014Renewal fee patent year 03
29.04.2015Renewal fee patent year 04
16.08.2016Renewal fee patent year 05
28.04.2017Renewal fee patent year 06
Penalty fee
Additional fee for renewal fee
30.04.201605   M06   Fee paid on   16.08.2016
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU07.04.2012
AL31.01.2018
AT31.01.2018
CY31.01.2018
CZ31.01.2018
DK31.01.2018
EE31.01.2018
ES31.01.2018
FI31.01.2018
HR31.01.2018
IT31.01.2018
LT31.01.2018
LV31.01.2018
MC31.01.2018
MK31.01.2018
NL31.01.2018
PL31.01.2018
PT31.01.2018
RO31.01.2018
RS31.01.2018
SE31.01.2018
SI31.01.2018
SK31.01.2018
SM31.01.2018
TR31.01.2018
IE07.04.2018
LU07.04.2018
MT07.04.2018
BE30.04.2018
BG30.04.2018
CH30.04.2018
FR30.04.2018
GB30.04.2018
LI30.04.2018
NO30.04.2018
GR01.05.2018
IS31.05.2018
DE01.11.2018
[2020/31]
Former [2020/27]HU07.04.2012
AL31.01.2018
AT31.01.2018
CZ31.01.2018
DK31.01.2018
EE31.01.2018
ES31.01.2018
FI31.01.2018
HR31.01.2018
IT31.01.2018
LT31.01.2018
LV31.01.2018
MC31.01.2018
NL31.01.2018
PL31.01.2018
PT31.01.2018
RO31.01.2018
RS31.01.2018
SE31.01.2018
SI31.01.2018
SK31.01.2018
SM31.01.2018
TR31.01.2018
IE07.04.2018
LU07.04.2018
MT07.04.2018
BE30.04.2018
BG30.04.2018
CH30.04.2018
FR30.04.2018
GB30.04.2018
LI30.04.2018
NO30.04.2018
GR01.05.2018
IS31.05.2018
DE01.11.2018
Former [2020/16]AL31.01.2018
AT31.01.2018
CZ31.01.2018
DK31.01.2018
EE31.01.2018
ES31.01.2018
FI31.01.2018
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MC31.01.2018
NL31.01.2018
PL31.01.2018
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SE31.01.2018
SI31.01.2018
SK31.01.2018
SM31.01.2018
TR31.01.2018
IE07.04.2018
LU07.04.2018
MT07.04.2018
BE30.04.2018
BG30.04.2018
CH30.04.2018
FR30.04.2018
GB30.04.2018
LI30.04.2018
NO30.04.2018
GR01.05.2018
IS31.05.2018
DE01.11.2018
Former [2020/08]AL31.01.2018
AT31.01.2018
CZ31.01.2018
DK31.01.2018
EE31.01.2018
ES31.01.2018
FI31.01.2018
HR31.01.2018
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MC31.01.2018
NL31.01.2018
PL31.01.2018
RO31.01.2018
RS31.01.2018
SE31.01.2018
SI31.01.2018
SK31.01.2018
SM31.01.2018
IE07.04.2018
LU07.04.2018
MT07.04.2018
BE30.04.2018
BG30.04.2018
CH30.04.2018
FR30.04.2018
GB30.04.2018
LI30.04.2018
NO30.04.2018
GR01.05.2018
IS31.05.2018
DE01.11.2018
Former [2019/23]AL31.01.2018
AT31.01.2018
CZ31.01.2018
DK31.01.2018
EE31.01.2018
ES31.01.2018
FI31.01.2018
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IT31.01.2018
LT31.01.2018
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MC31.01.2018
NL31.01.2018
PL31.01.2018
RO31.01.2018
RS31.01.2018
SE31.01.2018
SI31.01.2018
SK31.01.2018
SM31.01.2018
IE07.04.2018
LU07.04.2018
BE30.04.2018
BG30.04.2018
CH30.04.2018
FR30.04.2018
GB30.04.2018
LI30.04.2018
NO30.04.2018
GR01.05.2018
IS31.05.2018
DE01.11.2018
Former [2019/19]AL31.01.2018
AT31.01.2018
CZ31.01.2018
DK31.01.2018
EE31.01.2018
ES31.01.2018
FI31.01.2018
HR31.01.2018
IT31.01.2018
LT31.01.2018
LV31.01.2018
MC31.01.2018
NL31.01.2018
PL31.01.2018
RO31.01.2018
RS31.01.2018
SE31.01.2018
SI31.01.2018
SK31.01.2018
SM31.01.2018
IE07.04.2018
LU07.04.2018
BE30.04.2018
BG30.04.2018
CH30.04.2018
GB30.04.2018
LI30.04.2018
NO30.04.2018
GR01.05.2018
IS31.05.2018
DE01.11.2018
Former [2019/12]AL31.01.2018
AT31.01.2018
CZ31.01.2018
DK31.01.2018
EE31.01.2018
ES31.01.2018
FI31.01.2018
HR31.01.2018
IT31.01.2018
LT31.01.2018
LV31.01.2018
MC31.01.2018
NL31.01.2018
PL31.01.2018
RO31.01.2018
RS31.01.2018
SE31.01.2018
SI31.01.2018
SK31.01.2018
SM31.01.2018
LU07.04.2018
BE30.04.2018
BG30.04.2018
CH30.04.2018
GB30.04.2018
LI30.04.2018
NO30.04.2018
GR01.05.2018
IS31.05.2018
DE01.11.2018
Former [2019/08]AL31.01.2018
AT31.01.2018
CZ31.01.2018
DK31.01.2018
EE31.01.2018
ES31.01.2018
FI31.01.2018
HR31.01.2018
IT31.01.2018
LT31.01.2018
LV31.01.2018
MC31.01.2018
NL31.01.2018
PL31.01.2018
RO31.01.2018
RS31.01.2018
SE31.01.2018
SK31.01.2018
SM31.01.2018
LU07.04.2018
BG30.04.2018
NO30.04.2018
GR01.05.2018
IS31.05.2018
DE01.11.2018
Former [2019/07]AL31.01.2018
AT31.01.2018
CZ31.01.2018
DK31.01.2018
EE31.01.2018
ES31.01.2018
FI31.01.2018
HR31.01.2018
IT31.01.2018
LT31.01.2018
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MC31.01.2018
NL31.01.2018
PL31.01.2018
RO31.01.2018
RS31.01.2018
SE31.01.2018
SK31.01.2018
SM31.01.2018
BG30.04.2018
NO30.04.2018
GR01.05.2018
IS31.05.2018
DE01.11.2018
Former [2018/52]AL31.01.2018
AT31.01.2018
CZ31.01.2018
DK31.01.2018
EE31.01.2018
ES31.01.2018
FI31.01.2018
HR31.01.2018
IT31.01.2018
LT31.01.2018
LV31.01.2018
MC31.01.2018
NL31.01.2018
PL31.01.2018
RO31.01.2018
RS31.01.2018
SE31.01.2018
SK31.01.2018
SM31.01.2018
BG30.04.2018
NO30.04.2018
GR01.05.2018
IS31.05.2018
Former [2018/51]AL31.01.2018
AT31.01.2018
CZ31.01.2018
DK31.01.2018
EE31.01.2018
ES31.01.2018
FI31.01.2018
HR31.01.2018
IT31.01.2018
LT31.01.2018
LV31.01.2018
NL31.01.2018
PL31.01.2018
RO31.01.2018
RS31.01.2018
SE31.01.2018
SK31.01.2018
BG30.04.2018
NO30.04.2018
GR01.05.2018
IS31.05.2018
Former [2018/50]AL31.01.2018
AT31.01.2018
CZ31.01.2018
EE31.01.2018
ES31.01.2018
FI31.01.2018
HR31.01.2018
IT31.01.2018
LT31.01.2018
LV31.01.2018
NL31.01.2018
PL31.01.2018
RO31.01.2018
RS31.01.2018
SE31.01.2018
SK31.01.2018
BG30.04.2018
NO30.04.2018
GR01.05.2018
IS31.05.2018
Former [2018/47]AL31.01.2018
AT31.01.2018
ES31.01.2018
FI31.01.2018
HR31.01.2018
IT31.01.2018
LT31.01.2018
LV31.01.2018
NL31.01.2018
PL31.01.2018
RS31.01.2018
SE31.01.2018
BG30.04.2018
NO30.04.2018
GR01.05.2018
IS31.05.2018
Former [2018/46]AL31.01.2018
AT31.01.2018
ES31.01.2018
FI31.01.2018
HR31.01.2018
LT31.01.2018
LV31.01.2018
NL31.01.2018
PL31.01.2018
RS31.01.2018
SE31.01.2018
BG30.04.2018
NO30.04.2018
GR01.05.2018
IS31.05.2018
Former [2018/40]AT31.01.2018
ES31.01.2018
FI31.01.2018
HR31.01.2018
LT31.01.2018
LV31.01.2018
NL31.01.2018
PL31.01.2018
RS31.01.2018
SE31.01.2018
BG30.04.2018
NO30.04.2018
GR01.05.2018
IS31.05.2018
Former [2018/39]AT31.01.2018
ES31.01.2018
FI31.01.2018
HR31.01.2018
LT31.01.2018
LV31.01.2018
NL31.01.2018
PL31.01.2018
RS31.01.2018
SE31.01.2018
NO30.04.2018
GR01.05.2018
IS31.05.2018
Former [2018/37]ES31.01.2018
FI31.01.2018
HR31.01.2018
LT31.01.2018
NL31.01.2018
PL31.01.2018
NO30.04.2018
GR01.05.2018
Former [2018/36]ES31.01.2018
FI31.01.2018
HR31.01.2018
LT31.01.2018
NL31.01.2018
PL31.01.2018
NO30.04.2018
Former [2018/35]FI31.01.2018
HR31.01.2018
LT31.01.2018
NL31.01.2018
NO30.04.2018
Documents cited:Search[XI]WO2010112821  (GENTRONIX LTD [GB], et al) [X] 15 * abstract * [I] 1-14;
 [XI]WO0244427  (HARVARD COLLEGE [US], et al) [X] 15 * examples 1-2; claim 1 * [I] 1-14;
 [A]  - W Kimryn Rathmell ET AL, "DNA-dependent Protein Kinase Is Not Required for Accumulation of P53 or Cell Cycle Arrest after DNA Damage", Cancer Research Vol. 57, (19970101), pages 68 - 74, URL: http://cancerres.aacrjournals.org/content/57/1/68.full.pdf, (20141009), XP055145351 [A] 1-15 * abstract *
International search[Y]US6344324  (HOWELL STEPHEN B [US], et al);
 [Y]  - ZAGER, V. ET AL., "Development of human cell biosensor system for genotoxicity detection based on DNA damage-induced gene expression", RADIOLOGY AND ONCOLOGY., (201003), vol. 44, no. 1, pages 42 - 51, XP002638472

DOI:   http://dx.doi.org/10.2478/V10019-010-0010-3
 [Y]  - POTRATZ, JC. ET AL., "In vivo analyses of UV-irradiation-induced p53 promoter binding using a novel quantitative real-time PCR assay", INTERNATIONAL JOURNAL OF ONCOLOGY., (200502), vol. 26, no. 2, pages 493 - 498
 [Y]  - BRAASTAD, CD. ET AL., "Constitutive DNase I hypersensitivity of p53-regulated promoters", THE JOURNAL OF BIOLOGICAL CHEMISTRY, (200303), vol. 278, no. 10, pages 8261 - 8268, XP055125382

DOI:   http://dx.doi.org/10.1074/jbc.M204256200
 [Y]  - EIZIRIK, DL. ET AL., "Genotoxic agents increase expression of growrth arrest and DNA damage--inducible genes gadd 153 and gadd 45 in rat pancreatic islets", DIABETES., (199305), vol. 42, no. 5, pages 738 - 745, XP055125388

DOI:   http://dx.doi.org/10.2337/diabetes.42.5.738
 [Y]  - TULLY, DB. ET AL., "Effects of arsenic, cadmium, chromium, and lead on gene expression regulated by a battery of 13 different promoters in recombinant HepG2 cells", TOXICOLOGY AND APPLIED PHARMACOLOGY., (200010), vol. 168, no. 2, pages 79 - 90, XP002324134

DOI:   http://dx.doi.org/10.1006/taap.2000.9014
 [Y]  - TCHOUNWOU, PB. ET AL., "Differential cytotoxicity and gene expression in human liver carcinoma (Hepg2) cells exposed to arsenic trioxide, and monosodium acid methanearsonate (MSMA)", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES., (200211), vol. 3, no. 11, pages 1117 - 1132, XP003030192

DOI:   http://dx.doi.org/10.3390/i3111117
 [Y]  - DELESCLUSE, C. ET AL., "Induction of cytochrome P450 1 A1 gene expression, oxidative stress, and genotoxicity by carbaryl and thiabendazole in transfected human HepG2 and lymphoblastoid cells", BIOCHEMICAL PHARMACOLOGY., (200102), vol. 61, no. 4, pages 399 - 407, XP003013240

DOI:   http://dx.doi.org/10.1016/S0006-2952(00)00562-1
 [A]  - BONDEROFF, J. ET AL., "Time-dependent increase in ribosome processivity", (201011), vol. 38, no. 20, pages 7054 - 7067, XP055125406

DOI:   http://dx.doi.org/10.1093/nar/gkq566
by applicantWO2010112821
 WO0244427
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