blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News flashes

New version of the European Patent Register - SPC information for Unitary Patents.

2024-03-06

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
FAQ - Register Alert
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP2703487

EP2703487 - PEPTIDE FOR INDUCING REGENERATION OF TISSUE AND USE THEREOF [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  03.05.2019
Database last updated on 13.07.2024
FormerThe patent has been granted
Status updated on  25.05.2018
FormerGrant of patent is intended
Status updated on  18.05.2018
FormerExamination is in progress
Status updated on  15.03.2018
FormerGrant of patent is intended
Status updated on  02.11.2017
FormerExamination is in progress
Status updated on  13.12.2016
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK		published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
StemRIM Inc.
7-15, Saito-Asagi 7-chome
Ibaraki-shi
Osaka / JP
For all designated states
Osaka University
1-1 Yamadaoka
Suita-shi, Osaka 565-0871 / JP
[2018/38]
Former [2014/10]For all designated states
Genomix Co., Ltd.
3FL, Saito Biotechnology Incubator 7-15, Saito-Asagi 7-chome Ibaraki-shi
Osaka 567-0085 / JP
For all designated states
Osaka University
1-1 Yamadaoka
Suita-shi, Osaka 565-0871 / JP
Inventor(s)01 / TAMAI, Katsuto
c/o Osaka University
1-1 Yamadaoka
Suita-shi, Osaka 565-0871 / JP
02 / YAMAZAKI, Takehiko
c/o Genomix Co., Ltd.
7-15-306 Saito-Asagi 7-chome
Ibaraki-shi, Osaka 567-0085 / JP
03 / KANEZAKI, Tsutomu
c/o Genomix Co., Ltd.
7-15-306 Saito-Asagi 7-chome
Ibaraki-shi, Osaka 567-0085 / JP
04 / SAKURAI, Shigeru
c/o Genomix Co., Ltd.
7-15-306 Saito-Asagi 7-chome
Ibaraki-shi, Osaka 567-0085 / JP
05 / NOGUCHI, Yukiko
c/o Genomix Co., Ltd.
7-15-306 Saito-Asagi 7-chome
Ibaraki-shi, Osaka 567-0085 / JP
06 / ENDO, Mayumi
c/o Genomix Co., Ltd.
7-15-306 Saito-Asagi 7-chome
Ibaraki-shi, Osaka 567-0085 / JP
07 / HAMABUCHI, Natsumi
c/o Genomix Co., Ltd.
7-15-306 Saito-Asagi 7-chome
Ibaraki-shi, Osaka 567-0085 / JP
08 / NAITO, Kana
c/o Genomix Co., Ltd.
7-15-306 Saito-Asagi 7-chome
Ibaraki-shi, Osaka 567-0085 / JP
 [2014/10]
Representative(s)Zacco GmbH
Bayerstrasse 83
80335 München / DE
[2018/26]
Former [2014/10]Zacco Denmark A/S
Hans Bekkevolds Allé 7
2900 Hellerup / DK
Application number, filing date12777041.003.04.2012
[2018/26]
WO2012JP59113
Priority number, dateJP2011009827026.04.2011         Original published format: JP 2011098270
JP2011021945403.10.2011         Original published format: JP 2011219454
[2014/10]
Filing languageJA
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2012147470
Date:01.11.2012
Language:JA
[2012/44]
Type: A1 Application with search report 
No.:EP2703487
Date:05.03.2014
Language:EN
[2014/10]
Type: B1 Patent specification 
No.:EP2703487
Date:27.06.2018
Language:EN
[2018/26]
Search report(s)International search report - published on:JP01.11.2012
(Supplementary) European search report - dispatched on:EP10.10.2014
ClassificationIPC:C12N15/09, A61K31/711, A61K31/713, A61K35/12, A61K35/28, A61K35/76, A61K38/00, A61K48/00, A61P1/00, A61P1/04, A61P9/00, A61P9/10, A61P17/00, A61P19/00, A61P21/00, C07K14/47, C12N1/15, C12N1/19, C12N1/21, C12N5/10
[2014/10]
CPC:
C07K14/4702 (EP,CN,US); C12N15/85 (KR,US); C07K14/4705 (CN,US);
A61K35/15 (KR); A61K35/28 (KR); A61K38/1709 (KR,US);
A61K48/00 (KR); A61P1/00 (EP); A61P1/04 (EP);
A61P1/16 (EP); A61P1/18 (EP); A61P11/00 (EP);
A61P13/00 (EP); A61P15/00 (EP); A61P17/00 (EP);
A61P17/02 (EP); A61P17/14 (EP); A61P19/00 (EP);
A61P21/00 (EP); A61P25/00 (EP); A61P43/00 (EP);
A61P9/00 (EP); A61P9/10 (EP); C07K14/4718 (KR);
C12N5/0647 (KR); C12N5/0663 (KR); A61K38/17 (EP,US);
C07K2319/21 (KR,US); C07K2319/50 (KR,US); C12N2510/00 (KR,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/10]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:PEPTIDE ZUR INDUKTION DER REGENERIERUNG VON GEWEBE UND VERWENDUNG DAVON[2014/10]
English:PEPTIDE FOR INDUCING REGENERATION OF TISSUE AND USE THEREOF[2014/10]
French:PEPTIDE PERMETTANT D'INDUIRE LA RÉGÉNÉRATION D'UN TISSU ET SON UTILISATION[2014/10]
Entry into regional phase25.11.2013Translation filed 
25.11.2013National basic fee paid 
25.11.2013Search fee paid 
25.11.2013Designation fee(s) paid 
25.11.2013Examination fee paid 
Examination procedure25.11.2013Examination requested  [2014/10]
15.06.2015Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time
11.08.2015Amendment by applicant (claims and/or description)
20.11.2015Despatch of a communication from the examining division (Time limit: M06)
30.05.2016Reply to a communication from the examining division
08.08.2016Despatch of a communication from the examining division (Time limit: M04)
12.12.2016Reply to a communication from the examining division
20.09.2017Date of oral proceedings
02.10.2017Minutes of oral proceedings despatched
03.11.2017Communication of intention to grant the patent
05.03.2018Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
05.03.2018Fee for grant paid
05.03.2018Fee for publishing/printing paid
17.05.2018Information about intention to grant a patent
17.05.2018Receipt of the translation of the claim(s)
Divisional application(s)EP18160112.1  / EP3358011
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  20.11.2015
Opposition(s)28.03.2019No opposition filed within time limit [2019/23]
Request for further processing for:The application is deemed to be withdrawn due to failure to indicate the wish to proceed further with the application
11.08.2015Request for further processing filed
11.08.2015Full payment received (date of receipt of payment)
Request granted
02.09.2015Decision despatched
The application is deemed to be withdrawn due to failure to reply to the Extended European Search Report/Written Opinion of the International Searching Authority/International Preliminary Examination Report/Supplementary international search report/Supplementary European search report
11.08.2015Request for further processing filed
11.08.2015Full payment received (date of receipt of payment)
Request granted
02.09.2015Decision despatched
Fees paidRenewal fee
21.03.2014Renewal fee patent year 03
21.04.2015Renewal fee patent year 04
29.03.2016Renewal fee patent year 05
21.04.2017Renewal fee patent year 06
26.04.2018Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU03.04.2012
AL27.06.2018
AT27.06.2018
CY27.06.2018
CZ27.06.2018
EE27.06.2018
HR27.06.2018
LT27.06.2018
LV27.06.2018
MC27.06.2018
MK27.06.2018
MT27.06.2018
RS27.06.2018
SI27.06.2018
SK27.06.2018
SM27.06.2018
BG27.09.2018
NO27.09.2018
IS27.10.2018
[2022/31]
Former [2021/34]HU03.04.2012
AL27.06.2018
AT27.06.2018
CY27.06.2018
CZ27.06.2018
EE27.06.2018
HR27.06.2018
LT27.06.2018
LV27.06.2018
MC27.06.2018
MT27.06.2018
RS27.06.2018
SI27.06.2018
SK27.06.2018
SM27.06.2018
BG27.09.2018
NO27.09.2018
IS27.10.2018
Former [2021/32]HU03.04.2012
AL27.06.2018
AT27.06.2018
CY27.06.2018
CZ27.06.2018
EE27.06.2018
HR27.06.2018
LT27.06.2018
LV27.06.2018
MC27.06.2018
RS27.06.2018
SI27.06.2018
SK27.06.2018
SM27.06.2018
BG27.09.2018
NO27.09.2018
IS27.10.2018
Former [2021/26]AL27.06.2018
AT27.06.2018
CY27.06.2018
CZ27.06.2018
EE27.06.2018
HR27.06.2018
LT27.06.2018
LV27.06.2018
MC27.06.2018
RS27.06.2018
SI27.06.2018
SK27.06.2018
SM27.06.2018
BG27.09.2018
NO27.09.2018
IS27.10.2018
Former [2020/02]AL27.06.2018
AT27.06.2018
CZ27.06.2018
EE27.06.2018
HR27.06.2018
LT27.06.2018
LV27.06.2018
MC27.06.2018
RS27.06.2018
SI27.06.2018
SK27.06.2018
SM27.06.2018
BG27.09.2018
NO27.09.2018
IS27.10.2018
Former [2019/51]AL27.06.2018
AT27.06.2018
CZ27.06.2018
EE27.06.2018
HR27.06.2018
LT27.06.2018
LV27.06.2018
RS27.06.2018
SI27.06.2018
SK27.06.2018
SM27.06.2018
BG27.09.2018
NO27.09.2018
IS27.10.2018
Former [2019/37]AT27.06.2018
CZ27.06.2018
EE27.06.2018
HR27.06.2018
LT27.06.2018
LV27.06.2018
RS27.06.2018
SI27.06.2018
SK27.06.2018
SM27.06.2018
BG27.09.2018
NO27.09.2018
IS27.10.2018
Former [2019/12]AT27.06.2018
CZ27.06.2018
EE27.06.2018
HR27.06.2018
LT27.06.2018
LV27.06.2018
RS27.06.2018
SK27.06.2018
SM27.06.2018
BG27.09.2018
NO27.09.2018
IS27.10.2018
Former [2019/10]AT27.06.2018
CZ27.06.2018
EE27.06.2018
HR27.06.2018
LT27.06.2018
LV27.06.2018
RS27.06.2018
SK27.06.2018
BG27.09.2018
NO27.09.2018
IS27.10.2018
Former [2019/09]EE27.06.2018
HR27.06.2018
LT27.06.2018
LV27.06.2018
RS27.06.2018
BG27.09.2018
NO27.09.2018
IS27.10.2018
Former [2019/08]HR27.06.2018
LT27.06.2018
LV27.06.2018
RS27.06.2018
BG27.09.2018
NO27.09.2018
IS27.10.2018
Former [2018/51]HR27.06.2018
LT27.06.2018
LV27.06.2018
RS27.06.2018
BG27.09.2018
NO27.09.2018
Former [2018/50]HR27.06.2018
LT27.06.2018
BG27.09.2018
NO27.09.2018
Former [2018/47]LT27.06.2018
NO27.09.2018
Documents cited:Search[X]WO2004004763  (SAN RAFFAELE CENTRO FOND [IT], et al) [X] 1-15 * figure 9; example -; claim - * * the whole document *;
 US2004031072  [ ] (LA ROSA THOMAS J [US], et al);
 [X]WO2006024547  (CREABILIS THERAPEUTICS SPA [IT], et al) [X] 1-15 * figure 5; claim -; sequences 248,249 * * the whole document *;
 [D]WO2008053892  (GENOMIX CO LTD [JP], et al);
 [XD]EP2055308  (UNIV OSAKA [JP]) [XD] 1-15 * paragraph [[0071]]; example -; claim - *;
 [D]WO2009133939  (GENOMIX CO LTD [JP], et al);
 [D]WO2009133943  (GENOMIX CO LTD [JP], et al);
 [XD]EP2284255  (GENOMIX CO LTD [JP], et al) [XD] 1-15 * paragraph [0066]; claim - * * the whole document *;
 [XD]EP2301559  (GENOMIX CO LTD [JP], et al) [XD] 1-15 * paragraphs [0046] - [0054] - [0072] , [0076]; example -; claim - * * the whole document *;
 [XD]  - PALUMBO ROBERTA ET AL, "Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation", THE JOURNAL OF CELL BIOLOGY : JCB, THE ROCKEFELLER UNIVERSITY PRESS, US, vol. 164, no. 3, doi:10.1083/JCB.200304135, ISSN 0021-9525, (20040202), pages 441 - 449, (20040126), XP002600991 [XD] 1-15 * the whole document * * figure 3 *

DOI:   http://dx.doi.org/10.1083/jcb.200304135
 [XD]  - K. TAMAI ET AL, "PDGFR -positive cells in bone marrow are mobilized by high mobility group box 1 (HMGB1) to regenerate injured epithelia", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES, (20110419), vol. 108, no. 16, doi:10.1073/pnas.1016753108, ISSN 0027-8424, pages 6609 - 6614, XP055044096 [XD] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1073/pnas.1016753108
 [X]  - PALUMBO R ET AL, "High mobility group box 1 protein, a cue for stem cell recruitment", BIOCHEMICAL PHARMACOLOGY, ELSEVIER, US, vol. 68, no. 6, doi:10.1016/J.BCP.2004.03.048, ISSN 0006-2952, (20040915), pages 1165 - 1170, (20040727), XP002600992 [X] 1-15 * page 1166 * * the whole document *

DOI:   http://dx.doi.org/10.1016/J.BCP.2004.03.048
 [X]  - "Glycine max protein SEQ ID NO:211221.", Geneseq, (20071018), Database accession no. AFQ20044, URL: EBI, XP002730227 [X] 1-15 * sequence . *
 [X]  - HUTTUNEN H J ET AL, "RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS-BINDING COOH-TERMINAL MOTIF OF AMPHOTERIN INHIBITS INVASIVE MIGRATION AND METASTASIS", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, (20020815), vol. 62, no. 16, ISSN 0008-5472, pages 4805 - 4811, XP009060835 [X] 1-15 * the whole document *
International search[X]WO2004004763  (SAN RAFFAELE CENTRO FOND [IT], et al);
 [X]WO2008053892  (GENOMIX CO LTD [JP], et al);
 [X]WO2009133939  (GENOMIX CO LTD [JP], et al);
 [X]WO2009133943  (GENOMIX CO LTD [JP], et al);
 [X]  - PALUMBO R. ET AL., "Extracellular HMGB1, a signal of tissue damage, induces mesoangioblast migration and proliferation", J. CELL BIOL., (20040202), vol. 164, no. 3, pages 441 - 449, XP002600991

DOI:   http://dx.doi.org/10.1083/jcb.200304135
 [Y]  - TAMAI K. ET AL., "PDGFRa-positive cells in bone marrow are mobilized by high mobility group box 1 (HMGB1) to regenerate injured epithelia", PROC. NATL. ACAD. SCI., (20110419), vol. 108, no. 16, pages 6609 - 6614, XP055044096

DOI:   http://dx.doi.org/10.1073/pnas.1016753108
ExaminationWO2004044001
 WO2007130725
    - "High mobility group 1 protein (HMGB1) N-terminal peptide.", Geneseq, (20040812), Database accession no. ADO80180, URL: EBI
    - D Tang ET AL, "High-mobility group box 1, oxidative stress, and disease. D,", Antioxid Redox Signal.14(7), doi:10.1089/ars.2010.3356, (20101024), pages 1315 - 1335, URL: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3048826/pdf/ars.2010.3356.pdf, (20130918), XP055079973

DOI:   http://dx.doi.org/10.1089/ars.2010.3356
    - DEGRYSE BERNARD ET AL, "The high mobility group (HMG) boxes of the nuclear protein HMG1 induce chemotaxis and cytoskeleton reorganization in rat smooth muscle cells", THE JOURNAL OF CELL BIOLOGY : JCB, THE ROCKEFELLER UNIVERSITY PRESS, US, (20010319), vol. 152, no. 6, doi:10.1083/JCB.152.6.1197, ISSN 0021-9525, pages 1197 - 1206, XP002202052

DOI:   http://dx.doi.org/10.1083/jcb.152.6.1197
    - Stefania Straino ET AL, "High-Mobility Group Box 1 Protein in Human and Murine Skin: Involvement in Wound Healing", Journal of Investigative Dermatology, US, (20080131), vol. 128, no. 6, doi:10.1038/sj.jid.5701212, ISSN 0022-202X, pages 1545 - 1553, XP055292651

DOI:   http://dx.doi.org/10.1038/sj.jid.5701212
by applicantJP2005537253
 WO2007015546
 WO2008053892
 WO2009133939
 WO2009133943
 WO2009133940
    - BUSTIN ET AL., MOL CELL BIOL, (1999), vol. 19, pages 5237 - 5246
    - HORI ET AL., J. BIOL. CHEM., (1995), vol. 270, pages 25752 - 25761
    - WANG ET AL., SCIENCE, (1999), vol. 285, pages 248 - 251
    - MULLER ET AL., EMBO J, (2001), vol. 20, pages 4337 - 4340
    - GERMANI ET AL., J LEUKOC BIOL., (200701), vol. 81, no. 1, pages 41 - 5
    - PALUMBO ET AL., J. CELL BIOL., (2004), vol. 164, pages 441 - 449
    - MERENMIES ET AL., J. BIOL. CHEM., (1991), vol. 266, pages 16722 - 16729
    - WU Y ET AL., STEM CELLS, (2007), vol. 25, pages 2648 - 2659
    - TAMAI ET AL., PROC NATL ACAD SCI U S A., (20110404), vol. 108, pages 6609 - 6614
    - YANG ET AL., J LEUKOC BIOL., vol. 81, no. 1, pages 59 - 66
    - GENE, (1988), vol. 67, pages 31 - 40
    - BIO/TECHNOLOGY, (1988), vol. 6, pages 47 - 55
    - Remington's Pharmaceutical Science, MARK PUBLISHING COMPANY
    - YANG ET AL., J LEUKOC BIOL., (200701), vol. 81, no. 1, pages 59 - 66
    - YOUN ET AL., J IMMUNOL, (2008), vol. 180, pages 5067 - 5074
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.