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EP2776578
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EP About this file: EP2776578
| EP2776578 - ASSAY FOR THE PREDICTION OF THERAPEUTIC EFFECTIVENESS OR POTENCY OF MESENCHYMAL STEM CELLS, AND METHODS OF USING SAME [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 02.10.2015 Database last updated on 15.06.2024 | Most recent event Tooltip | 02.10.2015 | Application deemed to be withdrawn | published on 04.11.2015 [2015/45] | Applicant(s) | For all designated states Allocure, Inc. 25 Corporate Drive, STE 360 Burlington MA 01803 / US | [2014/38] | Inventor(s) | 01 /
BRENNER, Robert, M. 14 Hitching Post Lane Weston, MA 02493 / US | 02 /
MOHAMED, Ali, S. I8427 Thundercloud Rd. Boyds, MD 20841 / US | 03 /
MINNING, Dena 870 N. Miramar Ave. Suite 227 Indialantic, FL 32903 / US | [2014/38] | Representative(s) | Haley, Stephen Gill Jennings & Every LLP The Broadgate Tower 20 Primrose Street London EC2A 2ES / GB | [2014/38] | Application number, filing date | 12788399.9 | 07.11.2012 | WO2012US63940 | Priority number, date | US201161557616P | 09.11.2011 Original published format: US 201161557616 P | [2014/38] | Filing language | EN | Procedural language | EN | Publication | Type: | A1 Application with search report | No.: | WO2013070765 | Date: | 16.05.2013 | Language: | EN | [2013/20] | Type: | A1 Application with search report | No.: | EP2776578 | Date: | 17.09.2014 | Language: | EN | The application published by WIPO in one of the EPO official languages on 16.05.2013 takes the place of the publication of the European patent application. | [2014/38] | Search report(s) | International search report - published on: | EP | 16.05.2013 | Classification | IPC: | C12Q1/68, C12N5/0775 | [2014/38] | CPC: |
C12N5/0663 (EP,US);
C12Q1/6888 (US);
A61K35/28 (EP,US);
C12Q1/6881 (EP,US);
A61K2035/124 (EP,US);
C12N2502/115 (EP,US);
C12Q2600/156 (EP,US)
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| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2014/38] | Title | German: | ASSAY ZUR VORHERSAGE DER THERAPEUTISCHEN WIRKUNG ODER POTENZ MESENCHYMALER STAMMZELLEN SOWIE VERWENDUNGSVERFAHREN DAFÜR | [2014/38] | English: | ASSAY FOR THE PREDICTION OF THERAPEUTIC EFFECTIVENESS OR POTENCY OF MESENCHYMAL STEM CELLS, AND METHODS OF USING SAME | [2014/38] | French: | DOSAGE PERMETTANT DE PRÉDIRE L'EFFICACITÉ OU LA PUISSANCE THÉRAPEUTIQUE DES CELLULES SOUCHES MÉSENCHYMATEUSES, ET SES PROCÉDÉS D'UTILISATION | [2014/38] | Entry into regional phase | 19.05.2014 | National basic fee paid | 19.05.2014 | Designation fee(s) paid | 19.05.2014 | Examination fee paid | Examination procedure | 19.05.2014 | Examination requested [2014/38] | 17.12.2014 | Amendment by applicant (claims and/or description) | 02.06.2015 | Application deemed to be withdrawn, date of legal effect [2015/45] | 26.06.2015 | Despatch of communication that the application is deemed to be withdrawn, reason: renewal fee not paid in time [2015/45] | Fees paid | Penalty fee | Additional fee for renewal fee | 30.11.2014 | 03 M06 Not yet paid |
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| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Cited in | International search | [A]WO2004044142 (BRIGHAM & WOMENS HOSPITAL [US], et al) [A] 1-103 * the whole document *; | [XY] - A. ZARJOU ET AL, "Paracrine effects of mesenchymal stem cells in cisplatin-induced renal injury require heme oxygenase-1", AJP: RENAL PHYSIOLOGY, (20110101), vol. 300, no. 1, doi:10.1152/ajprenal.00594.2010, ISSN 0363-6127, pages F254 - F262, XP055052148 [X] 1,3-5,21,29,30,67-69,89-95 * abstract * * page 255 * * page 261 * [Y] 2,6-20,22-28,31-66,70-88,96-103 DOI: http://dx.doi.org/10.1152/ajprenal.00594.2010 | [Y] - GERBITZ A ET AL, "Influence of Polymorphism within the Heme Oxygenase-I Promoter on Overall Survival and Transplantation-Related Mortality after Allogeneic Stem Cell Transplantation", BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, KLUGE CARDEN JENNINGS PUBLISHING, CHARLOTTESVILLE, VA, US, vol. 14, no. 10, doi:10.1016/J.BBMT.2008.08.002, ISSN 1083-8791, (20081001), pages 1180 - 1189, (20080917), XP025431774 [Y] 2,6-20,22-28,31-66,70-88,96-103 * abstract * * page 1182, column 1, paragraph 2 - column 2, paragraph 2; figure 1; table 2 * DOI: http://dx.doi.org/10.1016/j.bbmt.2008.08.002 | [A] - OLIN D. LIANG ET AL, "Mesenchymal Stromal Cells Expressing Heme Oxygenase-1 Reverse Pulmonary Hypertension", STEM CELLS, (20110101), vol. 29, no. 1, doi:10.1002/stem.548, ISSN 1066-5099, pages 99 - 107, XP055052284 [A] 1-103 * the whole document * DOI: http://dx.doi.org/10.1002/stem.548 | [A] - T. TSUBOKAWA ET AL, "Impact of anti-apoptotic and anti-oxidative effects of bone marrow mesenchymal stem cells with transient overexpression of heme oxygenase-1 on myocardial ischemia", AJP: HEART AND CIRCULATORY PHYSIOLOGY, (20100501), vol. 298, no. 5, doi:10.1152/ajpheart.01330.2008, ISSN 0363-6135, pages H1320 - H1329, XP055052282 [A] 1-103 * the whole document * DOI: http://dx.doi.org/10.1152/ajpheart.01330.2008 | [A] - ZENG BIN ET AL, "Over-expression of HO-1 on mesenchymal stem cells promotes angiogenesis and improves myocardial function in infarcted myocardium", JOURNAL OF BIOMEDICAL SCIENCE, KLUWER ACADEMIC PUBLISHERS, DO, (20101007), vol. 17, no. 1, doi:10.1186/1423-0127-17-80, ISSN 1423-0127, page 80, XP021071263 [A] 1-103 * the whole document * DOI: http://dx.doi.org/10.1186/1423-0127-17-80 | [A] - TANG Y L ET AL, "Improved Graft Mesenchymal Stem Cell Survival in Ischemic Heart With a Hypoxia-Regulated Heme Oxygenase-1 Vector", JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, ELSEVIER, NEW YORK, NY, US, vol. 46, no. 7, ISSN 0735-1097, (20051004), pages 1339 - 1350, (20051004), XP027719420 [A] 1-103 * the whole document * | [A] - D. CHABANNES ET AL, "A role for heme oxygenase-1 in the immunosuppressive effect of adult rat and human mesenchymal stem cells", BLOOD, (20071115), vol. 110, no. 10, doi:10.1182/blood-2007-02-075481, ISSN 0006-4971, pages 3691 - 3694, XP055052299 [A] 1-103 * the whole document * DOI: http://dx.doi.org/10.1182/blood-2007-02-075481 | by applicant | WO2010017216 | - SCHINKOTHE ET AL., STEM CELLS DEV., (2008), vol. 17, pages 199 - 206 | - PORADA ET AL., CURR STEM CELL RES THER., (2006), vol. 1, pages 365 - 9 | - GIORDANO ET AL., J CELL PHYSIOL., (2007), vol. 211, pages 27 - 35 | - HUMPHREYS ET AL., MINERVA UROL NEFROL., (2006), vol. 58, pages 329 - 37 | - T6GET ET AL., AM J PHYSIOL RENAL PHYSIOL., (2007), vol. 292, pages F1626 - 35 | - IMBERTI ET AL., J AM SOC NEPHROL., (2007), vol. 18, pages 2921 - 8 | - BI ET AL., J AM SOC NEPHROL., (2007), vol. 18, pages 2486 - 96 | - LANGE ET AL., CELLULAR THERAPY AND TRANSPLANTATION, (2008), vol. 1, pages 49 - 53 | - FERENBACH ET AL., NEPHRON EXP NEPHROL, (2010), vol. 115, pages E33 - E37 | - SIKORSKI ET AL., AM J. PHYSIOL RENAL PHYSIOL, (2004), vol. 286, pages F425 - 441 | - SIKORSKI ET AL., AM J. PHYSIOL. RENAL PHYSIOL., (2004), vol. 286, pages F424 - F441 | - ZAIJOU ET AL., AM J PHYSIOL RENAL PHYSIOL, (2011), vol. 300, pages F254 - F262 | - EXNER ET AL., FREE RADICAL BIOLOGY & MEDICINE, (2004), vol. 37, no. 8, pages 1097 - 104 | - ZARJOU ET AL., AM J PHYSIOL RENAL PHYSIOL, (2011), vol. 300, pages F254 - F262 | - KUNTER ET AL., J AM SOC NEPHROL, (200706), vol. 18, no. 6, pages 1754 - 64 | - OKUDA ET AL., FEBS LETT., (20071002), vol. 581, no. 24, pages 4754 - 60 | - LIANG ET AL., NATURE GENETICS, (2007), vol. 39, no. 2, pages 178 - 188 | - BUHLER ET AL., MOL CANCER RES., (2005), vol. 3, no. 7, pages 365 - 71 | - ROBERTS ET AL., DNA CELL BIOL., (2002), vol. 21, no. 1, pages 11 - 9 | - HOMBACK-KLONICH ET AL., J MOL MCD (BCRL, (2008), vol. 86, no. 12, pages 1301 - 1314 | - ANKRUM ET AL., TRENDS MOL MED., (2010), vol. 16, no. 5, pages 203 - 09 | - HARE ET AL., J. AM COLL CARDIOL, (2009), pages 2227 - 86 | - CAO ET AL., BIOTECHNOL LETT, (2010), vol. 32, pages 725 - 32 | - TOGEL ET AL., STEM CELLS DEV, (2009), vol. 18, pages 475 - 85 | - ANKRUM ET AL., TRENDS MOL MED, (2010), vol. 16, no. 5, pages 203 - 209 | - KEBRIAEI, BIOL BLOOD MARROW TRANSPLANT., (2009), vol. 15, pages 804 - 11 | - HARE ET AL., J AM COLL CARDIOL, (2009), vol. 54, pages 2227 - 86 | - LEE ET AL., J AM SOC NEPHROL, (2002), vol. 13, pages 2753 - 2761 | - XIE ET AL., J AM SOC NEPHROL, (2006), vol. 17, pages 3336 - 3346 | - LANGE, "Accelerated and safe expansion of human mesenchymal stem cells in animal serum-free medium for transplantation and regenerative medicine", J. CELL. PHYSIOL., (2007), vol. 213, doi:doi:10.1002/jcp.21081, pages 18 - 26, XP002545733 DOI: http://dx.doi.org/10.1002/jcp.21081 | - ZARJOU ET AL., "Paracrine effects of mesenchymal stem cells in cisplatin-induced renal injury require heme oxygenase-1", AM JPHYSIOL RENAL PHYSIOL, (2011), vol. 300, doi:doi:10.1152/ajprenal.00594.2010, pages F254 - F262, XP055052148 DOI: http://dx.doi.org/10.1152/ajprenal.00594.2010 | - FERENBACH ET AL., "Hemeoxygenase-1 and Renal Ischaemia-Reperfusion Injury", NEPHRON EXP NEPHROL, (2010), vol. 115, pages E33 - E37 | - SIKORSKI ET AL., "The story so far: molecular regulation of the heme oxygenase-1 gene in renal injury", AM J PHYSIOL RENAL PHYSIOL, (2004), vol. 286, doi:doi:10.1152/ajprenal.00297.2003, pages F425 - F441, XP009166864 DOI: http://dx.doi.org/10.1152/ajprenal.00297.2003 | - ANKRUM ET AL., "Mesenchymal stem cell therapy: Two steps forward, one step back", TRENDS MOL MED., (2010), vol. 16, no. 5, pages 203 - 209, XP027048782 | - HARE ET AL., "A Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Study of Intravenous Adult Human Mesenchymal Cells (Prochymal) after Acute Myocardial Infarction", JAM COLL CARDIOL., (2009), vol. 54, pages 2227 - 2286 | - CAO ET AL., "Mesenchymal stem cells derived from human umbilical cord ameliorate ischemia/reperfusion-induced acute renal failure in rats", BIOTECHNOL LETT., (2010), vol. 32, pages 725 - 732, XP019787087 | - TÖGEL ET AL., "Autologous and allogeneic marrow stromal cells are safe and effective for the treatment of acute kidney injury", STEM CELLS DEV., (2009), vol. 18, pages 475 - 485 | - KEBRIAE ET AL., "Adult Human Mesenchymal Stem Cells Added to Corticostcroid Therapy for the Treatment of Acute Graft-vcrsus-Host Disease", BIOL BLOOD MARROW TRANSPLANT., (2009), vol. 15, pages 804 - 811 | - EXNER ET AL., "The Role of Heme Oxygenase-1 Promoter Polymorphisms in Human Disease", FREE RADICAL BIOLOGY & MEDICINE, (2004), vol. 37, no. 8, doi:doi:10.1016/j.freeradbiomed.2004.07.008, pages 1097 - 104, XP004580137 DOI: http://dx.doi.org/10.1016/j.freeradbiomed.2004.07.008 | - LANGE ET AL., "Platelet Lysate for Rapid Expansion of Human Mesenchymal Stromal Cells", CELLULAR THERAPY AND TRANSPLANATION, (2008), vol. 1, pages 49 - 53 |