blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News flashes

New version of the European Patent Register - SPC information for Unitary Patents.

2024-03-06

More...
blank Related links

Release notes
European Patent Register Assistant
European Patent Register Resource Book
European Patent Register – pocket guide
FAQ - European Patent Register
FAQ - Register Alert
Federated Register (Flyer)
Global Dossier (Flyer)
Register events
Deep link coverage
Federated Register content
The Patent Information Tour
Fair use charter

Extract from the Register of European Patents

EP About this file: EP2714909

EP2714909 - METHOD OF PRODUCING FACTOR VIII PROTEINS BY RECOMBINANT METHODS [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  27.11.2015
Database last updated on 15.06.2024
Most recent event   Tooltip27.11.2015Application deemed to be withdrawnpublished on 30.12.2015  [2015/53]
Applicant(s)For all designated states
The Regents of The University of Michigan
1600 Huron Parkway, 2nd Floor
Ann Arbor, MI 48109-2590 / US
For all designated states
Cangene Corporation
115 Innovation Drive
Winnipeg, Manitoba R3T 5Y3 / CA
[2014/31]
Former [2014/15]For all designated states
The Regents of The University of Michigan
1600 Huron Parkway, 2nd Floor
Ann Arbor, MI 48109-2590 / US
For all designated states
Inspiration Biopharmaceuticals, Inc.
28202 Cabot Road, Suite 300
Laguna Niguel, CA 92677 / US
Inventor(s)01 / KAUFMAN, Randal, J.
14019 CaminitoVistana
San Diego, CA 92130 / US
02 / PIPE, Steven, W.
1216 Cascade Lane
Ypsilanti, MI 48197 / US
03 / GRIFFITH, Michael
28761 via Buena Vista
San Juan Capistrano, CA 92675 / US
 [2014/15]
Representative(s)Gates, Marie Christina Esther, et al
Tomkins & Co.
5 Dartmouth Road
Dublin 6 / IE
[2014/15]
Application number, filing date12796718.001.06.2012
WO2012US40376
Priority number, dateUS20111315304003.06.2011         Original published format: US201113153040
[2014/15]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2012170289
Date:13.12.2012
Language:EN
[2012/50]
Type: A1 Application with search report 
No.:EP2714909
Date:09.04.2014
Language:EN
The application published by WIPO in one of the EPO official languages on 13.12.2012 takes the place of the publication of the European patent application.
[2014/15]
Search report(s)International search report - published on:KR13.12.2012
(Supplementary) European search report - dispatched on:EP17.11.2014
ClassificationIPC:C12N15/12, C12Q1/68, C07K14/755, A61K38/37, A61P7/04
[2014/15]
CPC:
C07K14/755 (EP); A61P7/04 (EP); A61K38/00 (EP)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/15]
TitleGerman:VERFAHREN ZUR HERSTELLUNG VON FAKTOR-VIII-PROTEINEN DURCH REKOMBINATIONSVERFAHREN[2014/15]
English:METHOD OF PRODUCING FACTOR VIII PROTEINS BY RECOMBINANT METHODS[2014/15]
French:PROCÉDÉ DE PRODUCTION DE PROTÉINES DU FACTEUR VIII PAR DES PROCÉDÉS RECOMBINANTS[2014/15]
Entry into regional phase16.12.2013National basic fee paid 
16.12.2013Search fee paid 
16.12.2013Designation fee(s) paid 
16.12.2013Examination fee paid 
Examination procedure16.12.2013Amendment by applicant (claims and/or description)
16.12.2013Examination requested  [2014/15]
16.06.2015Application deemed to be withdrawn, date of legal effect  [2015/53]
30.07.2015Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2015/53]
Fees paidRenewal fee
30.06.2014Renewal fee patent year 03
Penalty fee
Additional fee for renewal fee
30.06.201504   M06   Not yet paid
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[Y]WO2008005847  (UNIV MICHIGAN [US], et al) [Y] 1-9,11,16-18 * page 3 - page 5 * * figures 31,32 *;
 [XY]  - KERRY L. DOORISS ET AL, "Comparison of Factor VIII Transgenes Bioengineered for Improved Expression in Gene Therapy of Hemophilia A", HUMAN GENE THERAPY, (20090501), vol. 20, no. 5, doi:10.1089/hum.2008.150, ISSN 1043-0342, pages 465 - 478, XP055136766 [X] 10,12-15 * the whole document * [Y] 1-9,11,16-18

DOI:   http://dx.doi.org/10.1089/hum.2008.150
 [XY]  - N. J. WARD ET AL, "Codon optimization of human factor VIII cDNAs leads to high-level expression", BLOOD, (20110120), vol. 117, no. 3, doi:10.1182/blood-2010-05-282707, ISSN 0006-4971, pages 798 - 807, XP055052195 [X] 10,12-15 * the whole document * [Y] 1-9,11,16-18

DOI:   http://dx.doi.org/10.1182/blood-2010-05-282707
 [A]  - MIAO HONGZHI Z ET AL, "Bioengineering of coagulation factor VIII for improved secretion", BLOOD, AMERICAN SOCIETY OF HEMATOLOGY, US, (20040501), vol. 103, no. 9, doi:10.1182/BLOOD-2003-10-3591, ISSN 0006-4971, pages 3412 - 3419, XP002452857 [A] 1-18 * the whole document *

DOI:   http://dx.doi.org/10.1182/blood-2003-10-3591
International search[Y]  - DOORISS, K. L. ET AL., "Comparison of factor VIII transgenes bioengineered for improved expression in gene therapy of hemophilia A", HUMAN GENE THERAPY, (200905), vol. 20, no. 5, pages 465 - 478, XP055136766

DOI:   http://dx.doi.org/10.1089/hum.2008.150
 [Y]  - RUNNING DEER, J. ET AL., "High-level expression of proteins in mammalian cells using transcription regulatory sequences from the Chinese hamster EF-lalpha gene", BIOTECHNOLOGY PROGRESS, (200405), vol. 20, no. 3, pages 880 - 889, XP055017662

DOI:   http://dx.doi.org/10.1021/bp034383r
 [A]  - MIAO, H. Z. ET AL., "Bioengineering of coagulation factor VIII for improved secretion", BLOOD, (20040115), vol. 103, no. 9, pages 3412 - 3419, XP002557336
 [A]  - WARD, N. J. ET AL., "Codon optimization of human factor VIII cDNAs leads to high-level expression", BLOOD, (20101101), vol. 117, no. 3, pages 798 - 807, XP055052195

DOI:   http://dx.doi.org/10.1182/blood-2010-05-282707
 [A]  - HERLITSCHKA, S. E. ET AL., "High expression of a B-domain deleted factor VIII gene in a human hepatic cell line", JOURNAL OF BIOTECHNOLOGY, (19980513), vol. 61, no. 3, pages 165 - 173, XP004128067

DOI:   http://dx.doi.org/10.1016/S0168-1656(98)00035-2
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.