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Extract from the Register of European Patents

EP About this file: EP2726869

EP2726869 - SOMATIC MUTATIONS IN ATRX IN BRAIN CANCER [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  15.06.2018
Database last updated on 27.07.2024
FormerThe patent has been granted
Status updated on  07.07.2017
FormerGrant of patent is intended
Status updated on  21.02.2017
Most recent event   Tooltip17.07.2020Lapse of the patent in a contracting state
New state(s): AL		published on 19.08.2020  [2020/34]
Applicant(s)For all designated states
Duke University
2812 Erwin Road, Suite 306 P.O. Box 90083
Durham, North Carolina 27705 / US
For all designated states
The Johns Hopkins University
3400 N. Charles Street, 5th Floor
Baltimore, MD 21218 / US
[2014/19]
Inventor(s)01 / YAN, Hai
108 Sully Court
Chapel Hill, North Carolina 27514 / US
02 / BIGNER, Darell
5133 Corbett Ridge Road
Mebane, North Carolina 27302 / US
03 / VOGELSTEIN, Bert
3700 Breton Way
Baltimore, Maryland 21208 / US
04 / KINZLER, Kenneth W.
616 Ponte Villas North
Baltimore, Maryland 21030 / US
05 / MEEKER, Alan
827 Cliffedge Road
Pikesville, Maryland 21208-4606 / US
06 / HRUBAN, Ralph
101Dunkirk Road
Baltimore, Maryland 21212 / US
07 / PAPADAPOULOS, Nickolas
606 Horncrest
Towson, Maryland 21204 / US
08 / DIAZ, Luis
5135 Crystal Springs Drive
Ellicott City, Maryland 21043 / US
09 / JIAO, Yuchen
1650 Orleans Street
Baltimore, Maryland 21231 / US
 [2014/19]
Representative(s)Tombling, Adrian George, et al
Withers & Rogers LLP
2 London Bridge
London SE1 9RA / GB
[N/P]
Former [2014/19]Tombling, Adrian George, et al
Withers & Rogers LLP
4 More London Riverside
London SE1 2AU / GB
Application number, filing date12804757.828.06.2012
[2017/32]
WO2012US44631
Priority number, dateUS201161502646P29.06.2011         Original published format: US 201161502646 P
[2014/19]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2013003583
Date:03.01.2013
Language:EN
[2013/01]
Type: A2 Application without search report 
No.:EP2726869
Date:07.05.2014
Language:EN
The application published by WIPO in one of the EPO official languages on 03.01.2013 takes the place of the publication of the European patent application.
[2014/19]
Type: B1 Patent specification 
No.:EP2726869
Date:09.08.2017
Language:EN
[2017/32]
Search report(s)International search report - published on:KR04.04.2013
(Supplementary) European search report - dispatched on:EP11.02.2015
ClassificationIPC:G01N33/53, C12Q1/68, A61K39/00, A61K31/7105
[2014/19]
CPC:
C12Q1/6886 (EP,US); C07K16/40 (US); C12N15/1137 (US);
G01N33/57407 (EP,US); C12Q2600/118 (EP,US); C12Q2600/156 (EP,US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/19]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:SOMATISCHE ATRX-MUTATIONEN BEI HIRNKREBS[2014/19]
English:SOMATIC MUTATIONS IN ATRX IN BRAIN CANCER[2014/19]
French:MUTATIONS SOMATIQUES DE L'ATRX DANS LE CANCER DU CERVEAU[2014/19]
Entry into regional phase17.01.2014National basic fee paid 
17.01.2014Search fee paid 
17.01.2014Designation fee(s) paid 
17.01.2014Examination fee paid 
Examination procedure17.01.2014Examination requested  [2014/19]
03.09.2015Amendment by applicant (claims and/or description)
22.02.2017Communication of intention to grant the patent
08.06.2017Fee for grant paid
08.06.2017Fee for publishing/printing paid
08.06.2017Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  22.02.2017
Opposition(s)11.05.2018No opposition filed within time limit [2018/29]
Fees paidRenewal fee
24.06.2014Renewal fee patent year 03
29.06.2015Renewal fee patent year 04
27.06.2016Renewal fee patent year 05
27.06.2017Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU28.06.2012
AL09.08.2017
AT09.08.2017
CY09.08.2017
CZ09.08.2017
DK09.08.2017
EE09.08.2017
ES09.08.2017
FI09.08.2017
HR09.08.2017
IT09.08.2017
LT09.08.2017
LV09.08.2017
MC09.08.2017
MK09.08.2017
NL09.08.2017
PL09.08.2017
PT09.08.2017
RO09.08.2017
RS09.08.2017
SE09.08.2017
SI09.08.2017
SK09.08.2017
SM09.08.2017
TR09.08.2017
BG09.11.2017
NO09.11.2017
GR10.11.2017
IS09.12.2017
[2020/34]
Former [2020/31]HU28.06.2012
AT09.08.2017
CY09.08.2017
CZ09.08.2017
DK09.08.2017
EE09.08.2017
ES09.08.2017
FI09.08.2017
HR09.08.2017
IT09.08.2017
LT09.08.2017
LV09.08.2017
MC09.08.2017
MK09.08.2017
NL09.08.2017
PL09.08.2017
PT09.08.2017
RO09.08.2017
RS09.08.2017
SE09.08.2017
SI09.08.2017
SK09.08.2017
SM09.08.2017
TR09.08.2017
BG09.11.2017
NO09.11.2017
GR10.11.2017
IS09.12.2017
Former [2020/28]HU28.06.2012
AT09.08.2017
CZ09.08.2017
DK09.08.2017
EE09.08.2017
ES09.08.2017
FI09.08.2017
HR09.08.2017
IT09.08.2017
LT09.08.2017
LV09.08.2017
MC09.08.2017
NL09.08.2017
PL09.08.2017
PT09.08.2017
RO09.08.2017
RS09.08.2017
SE09.08.2017
SI09.08.2017
SK09.08.2017
SM09.08.2017
TR09.08.2017
BG09.11.2017
NO09.11.2017
GR10.11.2017
IS09.12.2017
Former [2020/15]AT09.08.2017
CZ09.08.2017
DK09.08.2017
EE09.08.2017
ES09.08.2017
FI09.08.2017
HR09.08.2017
IT09.08.2017
LT09.08.2017
LV09.08.2017
MC09.08.2017
NL09.08.2017
PL09.08.2017
RO09.08.2017
RS09.08.2017
SE09.08.2017
SI09.08.2017
SK09.08.2017
SM09.08.2017
TR09.08.2017
BG09.11.2017
NO09.11.2017
GR10.11.2017
IS09.12.2017
Former [2019/15]AT09.08.2017
CZ09.08.2017
DK09.08.2017
EE09.08.2017
ES09.08.2017
FI09.08.2017
HR09.08.2017
IT09.08.2017
LT09.08.2017
LV09.08.2017
MC09.08.2017
NL09.08.2017
PL09.08.2017
RO09.08.2017
RS09.08.2017
SE09.08.2017
SI09.08.2017
SK09.08.2017
SM09.08.2017
BG09.11.2017
NO09.11.2017
GR10.11.2017
IS09.12.2017
Former [2018/39]AT09.08.2017
CZ09.08.2017
DK09.08.2017
EE09.08.2017
ES09.08.2017
FI09.08.2017
HR09.08.2017
IT09.08.2017
LT09.08.2017
LV09.08.2017
NL09.08.2017
PL09.08.2017
RO09.08.2017
RS09.08.2017
SE09.08.2017
SI09.08.2017
SK09.08.2017
SM09.08.2017
BG09.11.2017
NO09.11.2017
GR10.11.2017
IS09.12.2017
Former [2018/24]AT09.08.2017
CZ09.08.2017
DK09.08.2017
EE09.08.2017
ES09.08.2017
FI09.08.2017
HR09.08.2017
IT09.08.2017
LT09.08.2017
LV09.08.2017
NL09.08.2017
PL09.08.2017
RO09.08.2017
RS09.08.2017
SE09.08.2017
SK09.08.2017
SM09.08.2017
BG09.11.2017
NO09.11.2017
GR10.11.2017
IS09.12.2017
Former [2018/23]AT09.08.2017
CZ09.08.2017
DK09.08.2017
EE09.08.2017
ES09.08.2017
FI09.08.2017
HR09.08.2017
LT09.08.2017
LV09.08.2017
NL09.08.2017
PL09.08.2017
RO09.08.2017
RS09.08.2017
SE09.08.2017
SK09.08.2017
BG09.11.2017
NO09.11.2017
GR10.11.2017
IS09.12.2017
Former [2018/21]AT09.08.2017
CZ09.08.2017
DK09.08.2017
ES09.08.2017
FI09.08.2017
HR09.08.2017
LT09.08.2017
LV09.08.2017
NL09.08.2017
PL09.08.2017
RS09.08.2017
SE09.08.2017
BG09.11.2017
NO09.11.2017
GR10.11.2017
IS09.12.2017
Former [2018/12]AT09.08.2017
ES09.08.2017
FI09.08.2017
HR09.08.2017
LT09.08.2017
LV09.08.2017
NL09.08.2017
PL09.08.2017
RS09.08.2017
SE09.08.2017
BG09.11.2017
NO09.11.2017
GR10.11.2017
IS09.12.2017
Former [2018/11]AT09.08.2017
ES09.08.2017
FI09.08.2017
HR09.08.2017
LT09.08.2017
NL09.08.2017
PL09.08.2017
RS09.08.2017
SE09.08.2017
BG09.11.2017
NO09.11.2017
GR10.11.2017
IS09.12.2017
Former [2018/10]AT09.08.2017
FI09.08.2017
HR09.08.2017
LT09.08.2017
NL09.08.2017
RS09.08.2017
SE09.08.2017
NO09.11.2017
Former [2018/09]FI09.08.2017
LT09.08.2017
NL09.08.2017
SE09.08.2017
NO09.11.2017
Former [2018/08]FI09.08.2017
LT09.08.2017
NL09.08.2017
NO09.11.2017
Former [2018/07]LT09.08.2017
NO09.11.2017
Documents cited:Search[A]  - MUKASA A ET AL, "DISTINCTION IN GENE EXPRESSION PROFILES OF OLIGODENDROGLIOMAS WITH AND WITHOUT ALLELIC LOSS OF 1P", ONCOGENE, NATURE PUBLISHING GROUP, GB, (20020606), vol. 21, no. 25, doi:10.1038/SJ.ONC.1205495, ISSN 0950-9232, pages 3961 - 3968, XP008062288 [A] 1-15 * table 2 *

DOI:   http://dx.doi.org/10.1038/sj.onc.1205495
 [A]  - M TANORI ET AL, "Opposite modifying effects of HR and NHEJ deficiency on cancer risk in Ptc1 heterozygous mouse cerebellum", ONCOGENE, (20110523), vol. 30, no. 47, doi:10.1038/onc.2011.178, ISSN 0950-9232, pages 4740 - 4749, XP055166530 [A] 1-15 * the whole document * * abstract * * page 4747, column 2 *

DOI:   http://dx.doi.org/10.1038/onc.2011.178
 [A]  - BELLO M J ET AL, "High-Resolution analysis of Chromosome Arm 1p alterations in Meningioma", CANCER GENETICS AND CYTOGENETICS, ELSEVIER SCIENCE PUBLISHING, NEW YORK, NY, US, (20000101), vol. 120, doi:10.1016/S0165-4608(99)00249-6, ISSN 0165-4608, pages 30 - 36, XP003024730 [A] 1-15 * page 35, column 1, paragraph 1 *

DOI:   http://dx.doi.org/10.1016/S0165-4608(99)00249-6
 [A]  - M.J BELLO ET AL, "hRAD54 Gene and 1p High-Resolution Deletion-Mapping Analyses in Oligodendrogliomas", CANCER GENETICS AND CYTOGENETICS, (20000101), vol. 116, no. 2, doi:10.1016/S0165-4608(99)00122-3, ISSN 0165-4608, pages 142 - 147, XP055166534 [A] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1016/S0165-4608(99)00122-3
 [A]  - JUDITH W M JEUKEN ET AL, "Molecular pathogenesis of oligodendroglial tumors", JOURNAL OF NEURO-ONCOLOGY, KLUWER ACADEMIC PUBLISHERS, BO, (20041101), vol. 70, no. 2, ISSN 1573-7373, pages 161 - 181, XP019260539 [A] 1-15 * page 164, column 2, paragraph 2 * * page 171, column 2, paragraph 2 - page 176, column 1, paragraph 1 *
 [A]  - Jeremy D. Henson ET AL, "A Robust Assay for Alternative Lengthening of Telomeres in Tumors Shows the Significance of Alternative Lengthening of Telomeres in Sarcomas and Astrocytomas", Clinical Cancer Research, United States, (20050101), page 217, URL: http://clincancerres.aacrjournals.org/content/11/1/217.abstract, XP055166212 [A] 1-15 * the whole document *
International search[A]US2002110820  (RAMASWAMY SRIDHAR [US], et al);
 [A]WO2008132752  (TEL HASHOMER MEDICAL RES INFRASTRUCTURE & SERVICES LTD [IL], et al);
 [A]WO2008021483  (ORDWAY RES INST [US], et al)
 [XP]  - HEAPHY, C. M. ET AL., "Altered telomeres in tumors with ATRX and DAXX mutations", SCIENCE, (20110722), vol. 333, no. 6041, page 425, XP055140966

DOI:   http://dx.doi.org/10.1126/science.1207313
Examination   - Marco Bisoffi ET AL, "Telomeres: Prognostic markers for solid tumors", International Journal of Cancer, US, (20060720), vol. 119, no. 10, doi:10.1002/ijc.22120, ISSN 0020-7136, pages 2255 - 2260, XP055339163

DOI:   http://dx.doi.org/10.1002/ijc.22120
    - Jeremy D Henson ET AL, "Alternative lengthening of telomeres in mammalian cells", doi:10.1038/sj/onc/, (20020121), URL: http://www.nature.com/onc/journal/v21/n4/pdf/1205058a.pdf, (20170126), XP055339188

DOI:   http://dx.doi.org/10.1038/sj.onc.1205058
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