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Extract from the Register of European Patents

EP About this file: EP2935256

EP2935256 - 4,6-DIARYLAMINOTHIAZINES AS BACE1 INHIBITORS AND THEIR USE FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  30.11.2018
Database last updated on 15.06.2024
FormerThe patent has been granted
Status updated on  22.12.2017
FormerGrant of patent is intended
Status updated on  27.07.2017
FormerRequest for examination was made
Status updated on  12.07.2017
FormerGrant of patent is intended
Status updated on  22.06.2017
Most recent event   Tooltip03.07.2020Lapse of the patent in a contracting state
New state(s): HU, MK		published on 05.08.2020  [2020/32]
Applicant(s)For all designated states
Bristol-Myers Squibb Company
Route 206 and Province Line Road
Princeton, NJ 08543 / US
[2015/44]
Inventor(s)01 / WU, Yong-Jin
c/o Bristol-Myers Squibb Company
5 Research Parkway
Wallingford, Connecticut 06492 / US
02 / GUERNON, Jason M.
c/o Bristol-Myers Squibb Company
5 Research Parkway
Wallingford, Connecticut 06492 / US
 [2015/44]
Representative(s)Vögeli-Lange, Regina
Swords Laboratories
Swiss Branch, Steinhausen
Hinterbergstrasse 16
6330 Cham / CH
[2015/44]
Application number, filing date12806857.419.12.2012
[2015/44]
WO2012US70546
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2014098831
Date:26.06.2014
Language:EN
[2014/26]
Type: A1 Application with search report 
No.:EP2935256
Date:28.10.2015
Language:EN
The application published by WIPO in one of the EPO official languages on 26.06.2014 takes the place of the publication of the European patent application.
[2015/44]
Type: B1 Patent specification 
No.:EP2935256
Date:24.01.2018
Language:EN
[2018/04]
Search report(s)International search report - published on:EP26.06.2014
ClassificationIPC:C07D417/04, C07D417/10, C07D417/12, C07D417/14, A61P25/28
[2015/44]
CPC:
C07D279/06 (EP,US); A61P25/28 (EP); C07D417/04 (EP,US);
C07D417/10 (EP,US); C07D417/12 (EP,US); C07D417/14 (EP,US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2015/44]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:4,6-DIARYLAMINOTHIAZINE ALS BACE1-INHIBITOREN UND IHRE VERWENDUNG ZUR VERMINDERUNG DER BETA-AMYLOID-PRODUKTION[2015/44]
English:4,6-DIARYLAMINOTHIAZINES AS BACE1 INHIBITORS AND THEIR USE FOR THE REDUCTION OF BETA-AMYLOID PRODUCTION[2015/44]
French:4,6-DIARYLAMINOTHIAZINES À TITRE D'INHIBITEURS DE BACE1 ET LEUR UTILISATION POUR RÉDUIRE LA PRODUCTION DES BÊTA-AMYLOÏDES[2015/44]
Entry into regional phase22.06.2015National basic fee paid 
22.06.2015Designation fee(s) paid 
22.06.2015Examination fee paid 
Examination procedure22.06.2015Examination requested  [2015/44]
21.12.2015Amendment by applicant (claims and/or description)
28.07.2017Communication of intention to grant the patent
09.11.2017Fee for grant paid
09.11.2017Fee for publishing/printing paid
09.11.2017Receipt of the translation of the claim(s)
11.01.2018Request for correction of the decision to grant filed
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  28.07.2017
Opposition(s)25.10.2018No opposition filed within time limit [2019/01]
Fees paidRenewal fee
26.05.2015Renewal fee patent year 03
10.12.2015Renewal fee patent year 04
13.12.2016Renewal fee patent year 05
12.12.2017Renewal fee patent year 06
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU19.12.2012
AL24.01.2018
AT24.01.2018
CY24.01.2018
CZ24.01.2018
DK24.01.2018
EE24.01.2018
ES24.01.2018
FI24.01.2018
HR24.01.2018
IT24.01.2018
LT24.01.2018
LV24.01.2018
MC24.01.2018
MK24.01.2018
NL24.01.2018
PL24.01.2018
PT24.01.2018
RO24.01.2018
RS24.01.2018
SE24.01.2018
SI24.01.2018
SK24.01.2018
SM24.01.2018
TR24.01.2018
BG24.04.2018
NO24.04.2018
GR25.04.2018
IS24.05.2018
[2020/31]
Former [2020/28]AL24.01.2018
AT24.01.2018
CY24.01.2018
CZ24.01.2018
DK24.01.2018
EE24.01.2018
ES24.01.2018
FI24.01.2018
HR24.01.2018
IT24.01.2018
LT24.01.2018
LV24.01.2018
MC24.01.2018
NL24.01.2018
PL24.01.2018
PT24.01.2018
RO24.01.2018
RS24.01.2018
SE24.01.2018
SI24.01.2018
SK24.01.2018
SM24.01.2018
TR24.01.2018
BG24.04.2018
NO24.04.2018
GR25.04.2018
IS24.05.2018
Former [2020/16]AL24.01.2018
AT24.01.2018
CY24.01.2018
CZ24.01.2018
DK24.01.2018
EE24.01.2018
ES24.01.2018
FI24.01.2018
HR24.01.2018
IT24.01.2018
LT24.01.2018
LV24.01.2018
MC24.01.2018
NL24.01.2018
PL24.01.2018
RO24.01.2018
RS24.01.2018
SE24.01.2018
SI24.01.2018
SK24.01.2018
SM24.01.2018
TR24.01.2018
BG24.04.2018
NO24.04.2018
GR25.04.2018
IS24.05.2018
Former [2019/40]AL24.01.2018
AT24.01.2018
CY24.01.2018
CZ24.01.2018
DK24.01.2018
EE24.01.2018
ES24.01.2018
FI24.01.2018
HR24.01.2018
IT24.01.2018
LT24.01.2018
LV24.01.2018
MC24.01.2018
NL24.01.2018
PL24.01.2018
RO24.01.2018
RS24.01.2018
SE24.01.2018
SI24.01.2018
SK24.01.2018
SM24.01.2018
BG24.04.2018
NO24.04.2018
GR25.04.2018
IS24.05.2018
Former [2019/13]AL24.01.2018
AT24.01.2018
CY24.01.2018
CZ24.01.2018
DK24.01.2018
EE24.01.2018
ES24.01.2018
FI24.01.2018
HR24.01.2018
IT24.01.2018
LT24.01.2018
LV24.01.2018
NL24.01.2018
PL24.01.2018
RO24.01.2018
RS24.01.2018
SE24.01.2018
SI24.01.2018
SK24.01.2018
SM24.01.2018
BG24.04.2018
NO24.04.2018
GR25.04.2018
IS24.05.2018
Former [2018/52]AL24.01.2018
AT24.01.2018
CY24.01.2018
CZ24.01.2018
DK24.01.2018
EE24.01.2018
ES24.01.2018
FI24.01.2018
HR24.01.2018
IT24.01.2018
LT24.01.2018
LV24.01.2018
NL24.01.2018
PL24.01.2018
RO24.01.2018
RS24.01.2018
SE24.01.2018
SK24.01.2018
SM24.01.2018
BG24.04.2018
NO24.04.2018
GR25.04.2018
IS24.05.2018
Former [2018/51]AL24.01.2018
AT24.01.2018
CY24.01.2018
CZ24.01.2018
DK24.01.2018
EE24.01.2018
ES24.01.2018
FI24.01.2018
HR24.01.2018
IT24.01.2018
LT24.01.2018
LV24.01.2018
NL24.01.2018
PL24.01.2018
RO24.01.2018
RS24.01.2018
SE24.01.2018
SK24.01.2018
BG24.04.2018
NO24.04.2018
GR25.04.2018
IS24.05.2018
Former [2018/50]AL24.01.2018
AT24.01.2018
CY24.01.2018
CZ24.01.2018
EE24.01.2018
ES24.01.2018
FI24.01.2018
HR24.01.2018
IT24.01.2018
LT24.01.2018
LV24.01.2018
NL24.01.2018
PL24.01.2018
RO24.01.2018
RS24.01.2018
SE24.01.2018
SK24.01.2018
BG24.04.2018
NO24.04.2018
GR25.04.2018
IS24.05.2018
Former [2018/47]AL24.01.2018
AT24.01.2018
CY24.01.2018
ES24.01.2018
FI24.01.2018
HR24.01.2018
IT24.01.2018
LT24.01.2018
LV24.01.2018
NL24.01.2018
PL24.01.2018
RS24.01.2018
SE24.01.2018
BG24.04.2018
NO24.04.2018
GR25.04.2018
IS24.05.2018
Former [2018/46]AL24.01.2018
AT24.01.2018
CY24.01.2018
ES24.01.2018
FI24.01.2018
HR24.01.2018
LT24.01.2018
LV24.01.2018
NL24.01.2018
PL24.01.2018
RS24.01.2018
SE24.01.2018
BG24.04.2018
NO24.04.2018
GR25.04.2018
IS24.05.2018
Former [2018/40]AT24.01.2018
CY24.01.2018
ES24.01.2018
FI24.01.2018
HR24.01.2018
LT24.01.2018
LV24.01.2018
NL24.01.2018
PL24.01.2018
RS24.01.2018
SE24.01.2018
BG24.04.2018
NO24.04.2018
GR25.04.2018
IS24.05.2018
Former [2018/39]AT24.01.2018
CY24.01.2018
ES24.01.2018
FI24.01.2018
HR24.01.2018
LT24.01.2018
LV24.01.2018
NL24.01.2018
PL24.01.2018
RS24.01.2018
SE24.01.2018
NO24.04.2018
GR25.04.2018
IS24.05.2018
Former [2018/37]CY24.01.2018
ES24.01.2018
FI24.01.2018
HR24.01.2018
LT24.01.2018
NL24.01.2018
PL24.01.2018
NO24.04.2018
GR25.04.2018
Former [2018/36]CY24.01.2018
ES24.01.2018
FI24.01.2018
HR24.01.2018
LT24.01.2018
NL24.01.2018
PL24.01.2018
NO24.04.2018
Former [2018/35]CY24.01.2018
FI24.01.2018
HR24.01.2018
LT24.01.2018
NL24.01.2018
NO24.04.2018
Former [2018/34]FI24.01.2018
LT24.01.2018
NL24.01.2018
NO24.04.2018
Cited inInternational search[XI]EP1942105  (SHIONOGI & CO [JP]) [X] 1,2,9,13,16 * compound 835 * * the whole document * [I] 1-18;
 [X]EP2151435  (SHIONOGI & CO [JP]) [X] 1,2,9,13,16 * compound 835 ** the whole document *;
 [X]  - JIE-PING WAN ET AL, "Microwave-Assisted Three-Component Reaction for Rapid Synthesis of Some 5,6-Dihydro-4H-1,3-thiazine Derivatives Under Solvent-Free Conditions", vol. 40, no. 5, doi:10.1080/00397910903013689, ISSN 0039-7911, (20100501), pages 709 - 716, SYNTHETIC COMMUNICATIONS: AN INTERNATIONAL JOURNAL FOR RAPID COMMUNICATION OF SYNTHETIC ORGANIC CHEMISTRY, TAYLOR & FRANCIS INC, PHILADELPHIA, PA; US, URL: www.tandfonline.com/doi/abs/10.1080/00397910903013689, (20100204), XP002679247 [X] 1,2 * compounds 4a-l *

DOI:   http://dx.doi.org/10.1080/00397910903013689
 [X]  - YULIN ZHU ET AL, "Two Novel Diastereoselective Three-Component Reactions of Alkenes or 3,4-Dihydro-(2 H )-pyran with Urea/Thiourea-Aldehyde Mixtures:? [4 + 2] Cycloaddition vs Biginelli-Type Reaction", ORGANIC LETTERS, (20060601), vol. 8, no. 12, doi:10.1021/ol060874b, ISSN 1523-7060, pages 2599 - 2602, XP055031849 [X] 1,2 * compounds 4a-h *

DOI:   http://dx.doi.org/10.1021/ol060874b
by applicantWO2011005738
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