EP2742155 - BIOMARKER FOR ALZHEIMER'S DISEASE AND/OR MILD COGNITIVELY IMPAIRMENT [Right-click to bookmark this link] | |||
Former [2014/25] | BIOMARKER FOR ALZHEIMER'S DISEASE AND/OR MILD COGNITIVELY IMPAIRMENT, AND USE THEREOF | ||
[2017/36] | Status | No opposition filed within time limit Status updated on 30.11.2018 Database last updated on 28.05.2024 | |
Former | The patent has been granted Status updated on 22.12.2017 | ||
Former | Grant of patent is intended Status updated on 10.10.2017 | ||
Former | Examination is in progress Status updated on 09.11.2016 | Most recent event Tooltip | 26.06.2020 | Lapse of the patent in a contracting state New state(s): MK | published on 29.07.2020 [2020/31] | Applicant(s) | For all designated states Advanced Genomic Technology LLC 5100 U.S. Highway 42 Louisville, KY 40241 / US | [2014/25] | Inventor(s) | 01 /
WANG, Eugenia 5100 U.s. Highway 42 Louisville, KY 40241 / US | [2014/25] | Representative(s) | Gallois, Valérie, et al Cabinet BECKER & ASSOCIES 25, rue Louis Le Grand 75002 Paris / FR | [N/P] |
Former [2014/25] | Gallois, Valérie, et al Cabinet BECKER & ASSOCIES 25, rue Louis Le Grand 75002 Paris / FR | Application number, filing date | 12821977.1 | 08.08.2012 | [2018/04] | WO2012US49971 | Priority number, date | US201161521241P | 08.08.2011 Original published format: US 201161521241 P | US201261586291P | 13.01.2012 Original published format: US 201261586291 P | US201261647214P | 15.05.2012 Original published format: US 201261647214 P | [2014/25] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO2013022953 | Date: | 14.02.2013 | Language: | EN | [2013/07] | Type: | A2 Application without search report | No.: | EP2742155 | Date: | 18.06.2014 | Language: | EN | The application published by WIPO in one of the EPO official languages on 14.02.2013 takes the place of the publication of the European patent application. | [2014/25] | Type: | B1 Patent specification | No.: | EP2742155 | Date: | 24.01.2018 | Language: | EN | [2018/04] | Search report(s) | International search report - published on: | US | 10.05.2013 | (Supplementary) European search report - dispatched on: | EP | 13.05.2015 | Classification | IPC: | C12Q1/68, G01N33/53 | [2014/25] | CPC: |
C12Q1/6883 (EP,US);
G16B20/00 (EP,US);
C12Q2600/112 (US);
C12Q2600/178 (EP,US)
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2014/25] | Extension states | BA | Not yet paid | ME | Not yet paid | Title | German: | BIOMARKER FÜR MORBUS ALZHEIMER UND/ODER LEICHTE KOGNITIVE BEEINTRÄCHTIGUNG | [2017/36] | English: | BIOMARKER FOR ALZHEIMER'S DISEASE AND/OR MILD COGNITIVELY IMPAIRMENT | [2017/36] | French: | BIOMARQUEUR POUR LA MALADIE D'ALZHEIMER ET/OU LE TROUBLE LÉGER COGNITIF | [2017/41] |
Former [2014/25] | BIOMARKER FÜR MORBUS ALZHEIMER UND/ODER LEICHTE KOGNITIVE BEEINTRÄCHTIGUNG UND ANWENDUNG DAVON | ||
Former [2014/25] | BIOMARKER FOR ALZHEIMER'S DISEASE AND/OR MILD COGNITIVELY IMPAIRMENT, AND USE THEREOF | ||
Former [2014/25] | BIOMARQUEUR POUR MALADIE D'ALZHEIMER ET/OU TROUBLE LÉGER COGNITIF, ET SON UTILISATION | Entry into regional phase | 21.01.2014 | National basic fee paid | 21.01.2014 | Search fee paid | 21.01.2014 | Designation fee(s) paid | 21.01.2014 | Examination fee paid | Examination procedure | 21.01.2014 | Examination requested [2014/25] | 25.11.2015 | Amendment by applicant (claims and/or description) | 12.02.2016 | Despatch of a communication from the examining division (Time limit: M06) | 27.05.2016 | Reply to a communication from the examining division | 28.10.2016 | Despatch of a communication from the examining division (Time limit: M04) | 01.02.2017 | Reply to a communication from the examining division | 26.07.2017 | Cancellation of oral proceeding that was planned for 22.09.2017 | 22.09.2017 | Date of oral proceedings (cancelled) | 11.10.2017 | Communication of intention to grant the patent | 14.12.2017 | Fee for grant paid | 14.12.2017 | Fee for publishing/printing paid | 14.12.2017 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 12.02.2016 | Opposition(s) | 25.10.2018 | No opposition filed within time limit [2019/01] | Fees paid | Renewal fee | 16.06.2014 | Renewal fee patent year 03 | 09.07.2015 | Renewal fee patent year 04 | 26.08.2016 | Renewal fee patent year 05 | 10.08.2017 | Renewal fee patent year 06 |
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 08.08.2012 | AL | 24.01.2018 | AT | 24.01.2018 | CY | 24.01.2018 | CZ | 24.01.2018 | DK | 24.01.2018 | EE | 24.01.2018 | ES | 24.01.2018 | FI | 24.01.2018 | HR | 24.01.2018 | IT | 24.01.2018 | LT | 24.01.2018 | LV | 24.01.2018 | MC | 24.01.2018 | MK | 24.01.2018 | NL | 24.01.2018 | PL | 24.01.2018 | PT | 24.01.2018 | RO | 24.01.2018 | RS | 24.01.2018 | SE | 24.01.2018 | SI | 24.01.2018 | SK | 24.01.2018 | SM | 24.01.2018 | TR | 24.01.2018 | BG | 24.04.2018 | NO | 24.04.2018 | GR | 25.04.2018 | IS | 24.05.2018 | GB | 08.08.2018 | IE | 08.08.2018 | LU | 08.08.2018 | MT | 08.08.2018 | BE | 31.08.2018 | CH | 31.08.2018 | FR | 31.08.2018 | LI | 31.08.2018 | [2020/31] |
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CH | 31.08.2018 | ||
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IE | 08.08.2018 | ||
LU | 08.08.2018 | ||
BE | 31.08.2018 | ||
CH | 31.08.2018 | ||
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LI | 31.08.2018 | ||
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IE | 08.08.2018 | ||
LU | 08.08.2018 | ||
CH | 31.08.2018 | ||
LI | 31.08.2018 | ||
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SM | 24.01.2018 | ||
BG | 24.04.2018 | ||
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GR | 25.04.2018 | ||
IS | 24.05.2018 | ||
LU | 08.08.2018 | ||
CH | 31.08.2018 | ||
LI | 31.08.2018 | ||
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BG | 24.04.2018 | ||
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NO | 24.04.2018 | Documents cited: | Search | [XI]WO2009025852 (XENOMICS INC [US], et al) [X] 8,11 * abstract * [I] 9,10; | [A]WO2009009457 (UNIV LOUISVILLE RES FOUND [US], et al) [A] 1-16 * abstract * * page 3 - page 4 * * page 15 - page 16 *; | [XI] - HODGES A K ET AL, "Plasma microRNA: A new source of biomarker for Alzheimer's disease", ALZHEIMER'S & DEMENTIA: THE JOURNAL OF THE ALZHEIMER'SASSOCIATION, ELSEVIER, NEW YORK, NY, US, vol. 6, no. 4, doi:10.1016/J.JALZ.2010.05.1701, ISSN 1552-5260, (20100701), page S510, (20100701), XP027440172 [X] 8,11 * the whole document * [I] 1-10,12-16 DOI: http://dx.doi.org/10.1016/j.jalz.2010.05.1701 | [A] - HYMAN SCHIPPER ET AL, "MicroRNA expression in Alzheimer blood mononuclear cells.", GENE REGULATION AND SYSTEMS BIOLOGY, (20070101), vol. 1, ISSN 1177-6250, pages 263 - 274, XP055047309 [A] 1-16 * abstract * | [A] - OLIVIER C MAES ET AL, "MicroRNA: Implications for Alzheimer Disease and other Human CNS Disorders", CURRENT GENOMICS, BENTHAM SCIENCE PUBLISHERS LTD, NL, (20090501), vol. 10, no. 3, doi:10.2174/138920209788185252, ISSN 1389-2029, pages 154 - 168, XP002617830 [A] 1-16 * abstract * DOI: http://dx.doi.org/10.2174/138920209788185252 | [A] - WANG X ET AL, "miR-34a, a microRNA up-regulated in a double transgenic mouse model of Alzheimer's disease, inhibits bcl2 translation", BRAIN RESEARCH BULLETIN, ELSEVIER SCIENCE LTD, OXFORD, GB, vol. 80, no. 4-5, doi:10.1016/J.BRAINRESBULL.2009.08.006, ISSN 0361-9230, (20091028), pages 268 - 273, (20090814), XP026662852 [A] 1-16 * abstract * DOI: http://dx.doi.org/10.1016/j.brainresbull.2009.08.006 | [A] - JUAN NUNEZ-IGLESIAS ET AL, "Joint Genome-Wide Profiling of miRNA and mRNA Expression in Alzheimer's Disease Cortex Reveals Altered miRNA Regulation", PLOS ONE, (20100201), vol. 5, no. 2, doi:10.1371/journal.pone.0008898, page e8898, XP055187191 [A] 1-16 * abstract * DOI: http://dx.doi.org/10.1371/journal.pone.0008898 | [T] - ATHANASIOS ZOVOILIS ET AL, "microRNA-34c is a novel target to treat dementias", THE EMBO JOURNAL, (20110923), vol. 30, no. 20, doi:10.1038/emboj.2011.327, ISSN 0261-4189, pages 4299 - 4308, XP055047170 [T] 12 * the whole document * DOI: http://dx.doi.org/10.1038/emboj.2011.327 | [T] - BHATNAGAR SHEPHALI ET AL, "Increased nnicroRNA-34c abundance in Alzheimer's disease circulating blood plasma", FRONTIERS IN MOLECULAR NEUROSCIENCE, (201402), vol. 7, XP055187385 [T] 1-16 DOI: http://dx.doi.org/10.3389/fnmol.2014.00002 | International search | [X]WO2009009457 (UNIV LOUISVILLE RES FOUND [US], et al); | [Y]US2010292281 (LOVELL MARK [US], et al); | [A]WO2011015829 (CAMBRIDGE ENTPR LTD [GB], et al); | [Y] - WANG, W.-X. ET AL., "The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1", J NEUROSCI., (20080130), vol. 28, no. 5, pages 1213 - 1223, XP002617832 DOI: http://dx.doi.org/10.1523/JNEUROSCI.5065-07.2008 | [A] - HEBERT, S.S. ET AL., "Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE 1 /beta-secretase expression", PROC NAT ACAD SCI., (20080429), vol. 105, no. 17, pages 6415 - 6420, XP055127732 | by applicant | - YAO ET AL., PLOS ONE, (20101216), vol. 5, no. 12, page E15546 | - SMITH ET AL., J NEUROCHEM, (201101), vol. 1 16, no. 2, pages 240 - 7 | - LI ET AL., NEUROSCI LETT., (20110103), vol. 487, no. 1, pages 94 - 8 | - WANG ET AL., BRAIN RES, (20101021), vol. 1357, pages 166 - 74 | - HEBERT ET AL., HUM MOL GENET., (20101015), vol. 19, no. 20, pages 3959 - 69 | - SCHONROCK ET AL., PLOS ONE, (20100601), vol. 5, no. 6, page E1 1070 | - WANG ET AL., BRAIN RES BULL., (20091028), vol. 80, no. 4-5, pages 268 - 73 |