-
EP2744808
European procedure
- EP About this file
- EP Legal status
- EP Federated register
- EP Event history
- EP Citations
- EP Patent family
- EP All documents
Extract from the Register of European Patents
EP About this file: EP2744808
| EP2744808 - TRICYCLIC COMPOUNDS AS ANTICANCER AGENTS [Right-click to bookmark this link] | Status | The application is deemed to be withdrawn Status updated on 25.01.2019 Database last updated on 11.04.2026 | |
| Former | Examination is in progress Status updated on 26.12.2016 | Most recent event Tooltip | 25.01.2019 | Application deemed to be withdrawn | published on 27.02.2019 [2019/09] | Applicant(s) | For all designated states Icahn School of Medicine at Mount Sinai One Gustave L. Levy Place Box 1675 New York, NY 10029-6574 / US | [2018/08] |
| Former [2014/26] | For all designated states Mount Sinai School of Medicine One Gustave L. Levy Place Box 1675 New York, NY 10029-6574 / US | Inventor(s) | 01 /
OHLMEYER, Michael 6 Beechtree Lane Plainsboro, NJ 08536 / US | 02 /
NARLA, Goutham 26800 Amhearst Circle Apt. 111 Beachwood, OH 44122 / US | 03 /
DHAWAN, Neil 50 E. 98th Street Apt. 11L New York, NY 10029 / US | 04 /
KASTRINSKY, David 15-11 Landzettel Way Fair Lawn, NJ 07410 / US | [2014/26] | Representative(s) | Hutchins, Michael Richard, et al Schlich 9 St Catherine's Road Littlehampton, West Sussex BN17 5HS / GB | [2014/26] | Application number, filing date | 12823881.3 | 16.08.2012 | WO2012US51097 | Priority number, date | US201161523897P | 16.08.2011 Original published format: US 201161523897 P | [2014/26] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO2013025882 | Date: | 21.02.2013 | Language: | EN | [2013/08] | Type: | A2 Application without search report | No.: | EP2744808 | Date: | 25.06.2014 | Language: | EN | The application published by WIPO in one of the EPO official languages on 21.02.2013 takes the place of the publication of the European patent application. | [2014/26] | Search report(s) | International search report - published on: | KR | 25.04.2013 | (Supplementary) European search report - dispatched on: | EP | 03.03.2015 | Classification | IPC: | C07D417/06, C07D279/28, A61K31/5415, A61P35/00 | [2014/26] | CPC: |
C07D409/12 (EP,CN,US);
C07D417/06 (EP,CN,US);
A61P1/04 (EP);
A61P17/00 (EP);
A61P21/02 (EP);
A61P25/00 (EP);
A61P25/14 (EP);
A61P25/16 (EP);
A61P25/28 (EP);
A61P3/10 (EP);
A61P35/00 (EP);
A61P35/02 (EP);
A61P37/02 (EP);
A61P37/06 (EP);
A61P9/10 (EP);
C07C247/10 (CN);
C07C311/16 (CN);
C07C311/18 (CN);
C07C311/20 (CN,US);
C07C311/29 (CN);
C07D207/26 (EP,US);
C07D211/76 (EP,US);
C07D223/22 (CN);
C07D223/28 (EP,CN,US);
C07D279/26 (CN);
C07D279/28 (EP,CN,US);
C07D307/94 (EP,US);
C07D311/96 (EP,US);
C07D335/12 (CN);
C07D335/20 (CN);
C07D401/12 (EP,CN,US);
C07D405/06 (CN);
C07D417/12 (CN);
| Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2014/26] | Extension states | BA | 14.03.2014 | ME | 14.03.2014 | Title | German: | TRICYCLISCHE VERBINDUNGEN ALS WIRKSTOFFE GEGEN KREBS | [2014/26] | English: | TRICYCLIC COMPOUNDS AS ANTICANCER AGENTS | [2014/26] | French: | COMPOSÉS TRICYCLIQUES EN TANT QU'AGENTS ANTICANCÉREUX | [2014/26] | Entry into regional phase | 14.03.2014 | National basic fee paid | 14.03.2014 | Search fee paid | 14.03.2014 | Designation fee(s) paid | 14.03.2014 | Examination fee paid | Examination procedure | 14.03.2014 | Examination requested [2014/26] | 28.09.2015 | Amendment by applicant (claims and/or description) | 26.02.2016 | Despatch of a communication from the examining division (Time limit: M06) | 25.08.2016 | Reply to a communication from the examining division | 15.12.2016 | Despatch of a communication from the examining division (Time limit: M04) | 24.04.2017 | Reply to a communication from the examining division | 08.03.2018 | Despatch of a communication from the examining division (Time limit: M06) | 19.09.2018 | Application deemed to be withdrawn, date of legal effect [2019/09] | 18.10.2018 | Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time [2019/09] | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 26.02.2016 | Fees paid | Renewal fee | 27.08.2014 | Renewal fee patent year 03 | 27.08.2015 | Renewal fee patent year 04 | 29.08.2016 | Renewal fee patent year 05 | 28.08.2017 | Renewal fee patent year 06 | 27.08.2018 | Renewal fee patent year 07 |
| Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
| Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Documents cited: | Search | [A] WO2006116157 (ALANTOS PHARMACEUTICALS INC et al.) [A] 1-16 * the whole document * | [X] VAN DORT M E ET AL: "Synthesis of <11>C-Labeled Desipramine and Its Metabolite 2-Hydroxydesipramine: Potential Radiotracers for PET Studies of the Norepinephrine Transporter", NUCLEAR MEDICINE AND BIOLOGY, ELSEVIER, NY, US, vol. 24, no. 8, 1 November 1997 (1997-11-01), pages 707 - 711, XP004097008, ISSN: 0969-8051, DOI: 10.1016/S0969-8051(97)00109-1 [X] 1 * example 7 * DOI: http://dx.doi.org/10.1016/S0969-8051(97)00109-1 | [X] RUNYON S P ET AL: "Influence of chain length and N-alkylation on the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 11, no. 5, 12 March 2001 (2001-03-12), pages 655 - 658, XP004230083, ISSN: 0960-894X, DOI: 10.1016/S0960-894X(01)00023-3 [X] 1 * RN = 106561-78-8 * DOI: http://dx.doi.org/10.1016/S0960-894X(01)00023-3 | [I] HADRICH D ET AL: "Synthesis and Characterization of Fluorescent ligands for the Norepinephrine Transporter: Potential Neuroblastoma Imaging Agents", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 42, no. 16, 16 July 1999 (1999-07-16), pages 3101 - 3108, XP003003932, ISSN: 0022-2623, DOI: 10.1021/JM9811155 [I] 1-16 * example 2 * DOI: http://dx.doi.org/10.1021/jm9811155 | [I] ILIES, M. ET AL.: "Protease Inhibitors: Synthesis of Bacterial Collagenase and Matrix Metalloproteinase Inhibitors Incorporating Arylsulfonylureido and 5-Dibenzo-suberenyl/suberyl Moieties", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, 2003, pages 2227 - 2239, XP002736173 [I] 1 * the whole document * DOI: http://dx.doi.org/10.1016/S0968-0896(03)00113-5 | International search | DATABASE PUBCHEM [online] 29 May 2009 (2009-05-29), "N-[4-methoxy-3-(3-phenothiazin-10-ylpropylsulfamoyl)phenyl]acetamide", XP003032833, Database accession no. CID_32012574 | [X] CUI-FENG YANG ET AL.: "Catalytic decarboxylative alkylation of beta-keto acids with sulfonamides via the cleavage of carbon-nitrogen and carbon- carbon bonds", CHEMICAL COMMUNICATIONS, vol. 47, no. 29, 2011, pages 8343 - 8345, XP055145050 DOI: http://dx.doi.org/10.1039/c1cc12790j | [X] MAGNUS A. AZUINE ET AL.: "Cancer chemopreventive effect of phenothiazines and related tri-heterocyclic analogues in the 12-0-tetradecanoylphorbol- 13-acetate promoted Epstein-Barr virus early antigen activation and the mouse skin two-stage carcinogenesis models", PHARMACOLOGICAL RESEARCH, vol. 49, no. 2, 2004, pages 161 - 169, XP002403162 | Examination | EP1481673 | WO2006066879 | WO2008121859 | SEIDLOVA VERA ET AL: "Neurotropic and psychotropic substances. XIII.Contributions to the synthesis of amitriptyline, nortriptyline and related substances", PROTEIN ENGINEE, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 32, no. 8, 1 January 1967 (1967-01-01), pages 2826 - 2839, XP009102824, ISSN: 0269-2139 [I] 1 * the whole document * | by applicant | VAN DORT M E ET AL.: "Synthesis of ''C-Labeled Desipramine and Its Metabolite 2-Hydroxydesipramine: Potential Radiotracers for PET Studies of the Norepinephrine Transporter", NUCLEAR MEDICINE AND BIOLOGY, vol. 24, no. 8, 1997, pages 707 - 711 | RUNYON S P ET AL.: "Influence of chain length and N-alkylation on the selective serotonin receptor ligand 9-(aminomethyl)-9,10-dihydroanthracene", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 11, no. 5, 2001, pages 655 - 658 | HADRICH D ET AL.: "Synthesis and Characterization of Fluorescent Ligands for the Norepinephrine Transporter: Potential Neuroblastoma Imaging Agents", JOURNAL OF MEDICINAL CHEMISTRY, vol. 42, no. 16, 1999, pages 3101 - 3108 | HIES M. ET AL.: "Protease Inhibitors: Synthesis of Bacterial Collagenase and Matrix Metalloproteinase Inhibitors Incorporating Arylsulfonylureido and 5-Dibenzo-suberenyl/suberyl Moieties", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 11, 2003, pages 2227 - 2239 | CUI-FENG YANG ET AL.: "Catalytic decarboxylative alkylation of beta-keto acids with sulfonamides via the cleavage of carbon-nitrogen and carbon- carbon bonds", CHEMICAL COMMUNICATIONS, vol. 47, no. 29, 2011, pages 8343 - 8345 | AZUINE ET AL.: "Cancer chemopreventive effect of phenothiazines and related tri-heterocyclic analogues in the 12-0-tetradecanoylphorbol- 13-acetate promoted Epstein-Barr virus early antigen activation and the mouse skin two-stage carcinogenesis models", PHARMACOLOGICAL RESEARCH, vol. 49, no. 2, 2004, pages 161 - 169 | TAYLOR ET AL., BLOOD, vol. 99, 2002, pages 3493 - 3499 | T.W.GREENE; P.G.M.WUTS: "Protective Groups in Organic Synthesis", 1999, JOHN WILEY & SONS | "Protecting Group Chemistry", 2000, OXFORD UNIVERSITY PRESS | "March's Advanced Organic chemistry: Reactions, Mechanisms, and Structure", 2001, WILEY-INTERSCIENCE PUBLICATION | J. HETEROCYCL. CHEM., vol. 32, 1995, pages 1027 - 1032 | TETRAHEDRON, vol. 68, 2012, pages 747 - 753 | J. AM. CHEM. SOC., vol. 96, no. 25, 1974, pages 7765 - 7770 | ORG. LETT., vol. 8, no. 10, 2006, pages 2175 - 2178 | BIOORG. MED. CHEM., vol. 12, no. 23, 2004, pages 6301 - 6315 | TETRAHEDRON: ASYMMETRY, vol. 5, no. 10, 1994, pages 1869 - 1872 | ADV. SYNTH. CATAL., vol. 350, 2008, pages 1419 - 1424 | INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, vol. 14, 2000, pages 203 - 207 | THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, no. 11, 2009, pages 8363 - 8374 | THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 285, no. 11, 2010, pages 8363 - 8374 | J. MED. CHEM., vol. 44, 2001, pages 2152 - 2163 | JACS, vol. 133, 2011, pages 1428 - 1437 | DENIZOT, F.; R. LANG, JOURNAL OF IMMUNOLOGICAL METHODS, vol. 89, no. 22, 1986, pages 271 - 277 | SANGODKAR ET AL., J CLIN INVEST, vol. 122, 2012, pages 2637 - 2651 | POLITI ET AL., GENES DEV., vol. 20, 1 June 2006 (2006-06-01), pages 1496 - 1510 |