blank Quick help
blank Maintenance news

Scheduled maintenance

Regular maintenance outages:
between 05.00 and 05.15 hrs CET (Monday to Sunday).

Other outages
Availability
Register Forum

2022.02.11

More...
blank News flashes

News flashes

New version of the European Patent Register - SPC information for Unitary Patents.

2024-03-06

More...
blank Related links

Extract from the Register of European Patents

EP About this file: EP2753605

EP2753605 - COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  07.02.2020
Database last updated on 14.06.2024
FormerThe patent has been granted
Status updated on  22.02.2019
FormerGrant of patent is intended
Status updated on  04.10.2018
FormerExamination is in progress
Status updated on  17.11.2017
Most recent event   Tooltip01.07.2022Lapse of the patent in a contracting state
New state(s): MK
published on 03.08.2022  [2022/31]
Applicant(s)For all designated states
Lantheus Medical Imaging, Inc.
331 Treble Cove Road
North Billerica, MA 01862 / US
[2014/29]
Inventor(s)01 / RADEKE, Heike, S.
15 Seaver Farm Lane
South Grafton, MA 01560 / US
02 / CESATI, Richard, R.
63 Nashua Road
Pepperell, MA 01463 / US
03 / PUROHIT, Ajay
33 Country Village Lane
Sudbury, MA 01776-1638 / US
04 / HARRIS, Thomas, D.
56 Zion Hill Road
Salem, NH 03079 / US
05 / ROBINSON, Simon, P.
22 Kettell Plain Road
Stow, MA 01775 / US
06 / YU, Ming
360 Littleton Road
Chelmsford, MA 01824 / US
07 / CASEBIER, David, S.
161 Ember Lane
Carlisle, MA 01741 / US
08 / HU, Carol, Hui
209 Riverwoods Drive
New Hope, PA 18938 / US
09 / BROEKEMA, Matthias
209 Riverwoods Drive
New Hope, PA 18938 / US
10 / ONTHANK, David, C.
21 Kirk Farm Road
Groton, MA 01450 / US
 [2014/29]
Representative(s)Carpmaels & Ransford LLP
One Southampton Row
London WC1B 5HA / GB
[2014/29]
Application number, filing date12829763.707.09.2012
[2019/13]
WO2012US54309
Priority number, dateUS201161533133P09.09.2011         Original published format: US 201161533133 P
US201261656492P06.06.2012         Original published format: US 201261656492 P
US201261656489P06.06.2012         Original published format: US 201261656489 P
[2014/29]
Filing languageEN
Procedural languageEN
PublicationType: A2 Application without search report
No.:WO2013036869
Date:14.03.2013
Language:EN
[2013/11]
Type: A2 Application without search report 
No.:EP2753605
Date:16.07.2014
Language:EN
The application published by WIPO in one of the EPO official languages on 14.03.2013 takes the place of the publication of the European patent application.
[2014/29]
Type: B1 Patent specification 
No.:EP2753605
Date:27.03.2019
Language:EN
[2019/13]
Search report(s)International search report - published on:KR02.05.2013
(Supplementary) European search report - dispatched on:EP22.06.2015
ClassificationIPC:C07D233/44, A61K49/00, A61K49/06, C07C257/14, A61K51/04, C07C279/04, C07C279/06, C07C279/08, C07C279/12, C07C279/14, C07C281/18, C07D233/46, C07C217/70, C07D209/14
[2015/30]
CPC:
A61P9/06 (EP); C07D233/46 (EP,CN,KR,US); C07C257/14 (EP,CN,US);
A61K51/0459 (US); A61K51/04 (US); A61K51/0453 (KR,US);
A61K51/0497 (US); C07B59/001 (KR); C07B59/002 (KR);
C07C217/70 (EP,CN,US); C07C279/04 (EP,CN,US); C07C279/06 (EP,CN,KR,US);
C07C279/08 (EP,CN,US); C07C279/10 (KR); C07C279/12 (EP,CN,US);
C07C279/14 (EP,CN,US); C07C281/18 (EP,CN,US); C07C291/00 (CN);
C07D209/08 (CN); C07D209/14 (EP,CN,KR,US); C07D233/48 (CN);
C07D233/88 (CN); C07D235/30 (CN); C07D239/42 (CN);
C07D249/04 (CN); C07D249/14 (CN); C07D263/56 (CN);
C07D265/30 (CN); C07D277/42 (CN); C07D295/073 (CN);
C07D295/096 (CN); C07D295/215 (CN); A61K51/041 (US);
C07B2200/05 (EP,CN,US); Y02P20/55 (EP) (-)
Former IPC [2014/29]C07D233/44, A61K49/00, A61K49/06
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/29]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:ZUSAMMENSETZUNGEN, VERFAHREN UND SYSTEME ZUR SYNTHESE UND VERWENDUNG VON KONTRASTMITTELN[2014/29]
English:COMPOSITIONS, METHODS, AND SYSTEMS FOR THE SYNTHESIS AND USE OF IMAGING AGENTS[2014/29]
French:COMPOSITIONS, PROCÉDÉS ET SYSTÈMES DE SYNTHÈSE ET D'UTILISATION D'AGENTS D'IMAGERIE[2014/29]
Entry into regional phase08.04.2014National basic fee paid 
08.04.2014Search fee paid 
08.04.2014Designation fee(s) paid 
08.04.2014Examination fee paid 
Examination procedure08.04.2014Examination requested  [2014/29]
19.01.2016Amendment by applicant (claims and/or description)
15.11.2017Despatch of a communication from the examining division (Time limit: M06)
21.05.2018Reply to a communication from the examining division
05.10.2018Communication of intention to grant the patent
15.02.2019Fee for grant paid
15.02.2019Fee for publishing/printing paid
15.02.2019Receipt of the translation of the claim(s)
Divisional application(s)EP19165299.9  / EP3567029
The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  15.11.2017
Opposition(s)03.01.2020No opposition filed within time limit [2020/11]
Fees paidRenewal fee
29.09.2014Renewal fee patent year 03
28.09.2015Renewal fee patent year 04
27.09.2016Renewal fee patent year 05
27.09.2017Renewal fee patent year 06
27.09.2018Renewal fee patent year 07
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court
See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU07.09.2012
AL27.03.2019
AT27.03.2019
CY27.03.2019
CZ27.03.2019
EE27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
MC27.03.2019
MK27.03.2019
MT27.03.2019
PL27.03.2019
RO27.03.2019
RS27.03.2019
SI27.03.2019
SK27.03.2019
SM27.03.2019
TR27.03.2019
BG27.06.2019
GR28.06.2019
IS27.07.2019
PT27.07.2019
IE07.09.2019
LU07.09.2019
BE30.09.2019
CH30.09.2019
LI30.09.2019
[2022/31]
Former [2021/34]HU07.09.2012
AL27.03.2019
AT27.03.2019
CY27.03.2019
CZ27.03.2019
EE27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
MC27.03.2019
MT27.03.2019
PL27.03.2019
RO27.03.2019
RS27.03.2019
SI27.03.2019
SK27.03.2019
SM27.03.2019
TR27.03.2019
BG27.06.2019
GR28.06.2019
IS27.07.2019
PT27.07.2019
IE07.09.2019
LU07.09.2019
BE30.09.2019
CH30.09.2019
LI30.09.2019
Former [2021/33]HU07.09.2012
AL27.03.2019
AT27.03.2019
CY27.03.2019
CZ27.03.2019
EE27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
MC27.03.2019
PL27.03.2019
RO27.03.2019
RS27.03.2019
SI27.03.2019
SK27.03.2019
SM27.03.2019
TR27.03.2019
BG27.06.2019
GR28.06.2019
IS27.07.2019
PT27.07.2019
IE07.09.2019
LU07.09.2019
BE30.09.2019
CH30.09.2019
LI30.09.2019
Former [2021/26]AL27.03.2019
AT27.03.2019
CY27.03.2019
CZ27.03.2019
EE27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
MC27.03.2019
PL27.03.2019
RO27.03.2019
RS27.03.2019
SI27.03.2019
SK27.03.2019
SM27.03.2019
TR27.03.2019
BG27.06.2019
GR28.06.2019
IS27.07.2019
PT27.07.2019
IE07.09.2019
LU07.09.2019
BE30.09.2019
CH30.09.2019
LI30.09.2019
Former [2020/38]AL27.03.2019
AT27.03.2019
CZ27.03.2019
EE27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
MC27.03.2019
PL27.03.2019
RO27.03.2019
RS27.03.2019
SI27.03.2019
SK27.03.2019
SM27.03.2019
TR27.03.2019
BG27.06.2019
GR28.06.2019
IS27.07.2019
PT27.07.2019
IE07.09.2019
LU07.09.2019
BE30.09.2019
CH30.09.2019
LI30.09.2019
Former [2020/36]AL27.03.2019
AT27.03.2019
CZ27.03.2019
EE27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
MC27.03.2019
PL27.03.2019
RO27.03.2019
RS27.03.2019
SI27.03.2019
SK27.03.2019
SM27.03.2019
TR27.03.2019
BG27.06.2019
GR28.06.2019
IS27.07.2019
PT27.07.2019
IE07.09.2019
LU07.09.2019
CH30.09.2019
LI30.09.2019
Former [2020/35]AL27.03.2019
AT27.03.2019
CZ27.03.2019
EE27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
MC27.03.2019
PL27.03.2019
RO27.03.2019
RS27.03.2019
SI27.03.2019
SK27.03.2019
SM27.03.2019
TR27.03.2019
BG27.06.2019
GR28.06.2019
IS27.07.2019
PT27.07.2019
LU07.09.2019
CH30.09.2019
LI30.09.2019
Former [2020/34]AL27.03.2019
AT27.03.2019
CZ27.03.2019
EE27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
MC27.03.2019
PL27.03.2019
RO27.03.2019
RS27.03.2019
SI27.03.2019
SK27.03.2019
SM27.03.2019
TR27.03.2019
BG27.06.2019
GR28.06.2019
IS27.07.2019
PT27.07.2019
CH30.09.2019
LI30.09.2019
Former [2020/25]AL27.03.2019
AT27.03.2019
CZ27.03.2019
EE27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
MC27.03.2019
PL27.03.2019
RO27.03.2019
RS27.03.2019
SI27.03.2019
SK27.03.2019
SM27.03.2019
TR27.03.2019
BG27.06.2019
GR28.06.2019
IS27.07.2019
PT27.07.2019
Former [2020/17]AL27.03.2019
AT27.03.2019
CZ27.03.2019
EE27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
PL27.03.2019
RO27.03.2019
RS27.03.2019
SI27.03.2019
SK27.03.2019
SM27.03.2019
TR27.03.2019
BG27.06.2019
GR28.06.2019
IS27.07.2019
PT27.07.2019
Former [2020/13]AL27.03.2019
AT27.03.2019
CZ27.03.2019
EE27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
PL27.03.2019
RO27.03.2019
RS27.03.2019
SI27.03.2019
SK27.03.2019
SM27.03.2019
BG27.06.2019
GR28.06.2019
IS27.07.2019
PT27.07.2019
Former [2020/04]AL27.03.2019
AT27.03.2019
CZ27.03.2019
EE27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
PL27.03.2019
RO27.03.2019
RS27.03.2019
SK27.03.2019
SM27.03.2019
BG27.06.2019
GR28.06.2019
IS27.07.2019
PT27.07.2019
Former [2020/03]AL27.03.2019
AT27.03.2019
CZ27.03.2019
EE27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
PL27.03.2019
RO27.03.2019
RS27.03.2019
SK27.03.2019
SM27.03.2019
BG27.06.2019
GR28.06.2019
PT27.07.2019
Former [2019/52]AL27.03.2019
CZ27.03.2019
EE27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
PL27.03.2019
RO27.03.2019
RS27.03.2019
SK27.03.2019
SM27.03.2019
BG27.06.2019
GR28.06.2019
PT27.07.2019
Former [2019/49]AL27.03.2019
CZ27.03.2019
EE27.03.2019
HR27.03.2019
LT27.03.2019
LV27.03.2019
RO27.03.2019
RS27.03.2019
SK27.03.2019
BG27.06.2019
GR28.06.2019
PT27.07.2019
Former [2019/48]HR27.03.2019
LT27.03.2019
LV27.03.2019
RS27.03.2019
BG27.06.2019
GR28.06.2019
PT27.07.2019
Former [2019/39]HR27.03.2019
LT27.03.2019
LV27.03.2019
RS27.03.2019
BG27.06.2019
GR28.06.2019
Former [2019/38]LT27.03.2019
BG27.06.2019
GR28.06.2019
Former [2019/37]LT27.03.2019
GR28.06.2019
Former [2019/33]LT27.03.2019
Documents cited:Search[Y]WO2008083056  (BRISTOL MYERS SQUIBB PHARMA CO [US], et al) [Y] 1-14 * page 1, paragraphs 1, 2 * * page 2, paragraph 6 * * page 6, paragraph 15 * * page 10, paragraph 25 * * page 16, paragraph 44 * * page 21, paragraphs 51, 52 ** page 73; claims 20-25 *;
 [Y]WO2011097649  (LANTHEUS MEDICAL IMAGING INC [US], et al) [Y] 1-14 * page 32 - page 38 * * page 71, paragraphs 1st, 3rd *
International search[A]WO0009115  (SMITHKLINE BEECHAM CORP [US], et al);
 [X]US2006127309  (RAFFEL DAVID M [US], et al);
 [X]WO2008083056  (BRISTOL MYERS SQUIBB PHARMA CO [US], et al);
 [XP]WO2011143360  (LANTHEUS MEDICAL IMAGING INC [US], et al);
 [A]  - RAFFEL, D.V. ET AL., "Radiolabeled phenethylguanidines: Novel Imaging Agents for cardiac Sympathetic Neurons and Adrenergic Tumors.", J. MED. CHEM., (2007), vol. 50, no. 9, pages 2078 - 2088, XP002506339

DOI:   http://dx.doi.org/10.1021/JM061398Y
by applicantUS4270537
 US4596556
 US4790824
 US4886499
 US4940460
 US4941880
 US5015235
 US5064413
 US5141496
 US5190521
 US5312335
 US5328483
 US5334144
 US5339163
 US5383851
 US5417662
 US5466220
 US5480381
 US5503627
 US5520639
 US5527288
 US5569189
 US5599302
 WO9713537
 US5649912
 WO9737705
 US5704911
 US5893397
 WO9934850
 US5993412
 US6511648
 WO2005079391
 WO2005105159
 WO2008083056
 WO2011005322
 WO2011097649
    - BELETSKAYA et al., Synthesis, (20070000), pages 2534 - 2538
    - HUBBARD et al., J. Org. Chem., (20080000), vol. 73, pages 316 - 319
    - FILIMONOV et al., Org. Lett., (20080000), vol. 10, pages 3961 - 3964
    - KRASNOKUTSKAYA et al., Synthesis, (20070000), pages 81 - 84
    - A. KLAPARS; S. L. BUCHWALD, J. Am. Chem. Soc., (20020000), vol. 124, pages 14844 - 14845
    - THIEBES et al., Syntett, (19980000), pages 141 - 142
    - MURPHY et al., J. Am. Chem. Soc., (20070000), vol. 129, pages 15434 - 15435
    - THOMPSON et al., Synthesis, (20050000), pages 547 - 550
    - G. W. KABALKA; A. R. MEREDDY, Organometallics, (20040000), vol. 23, pages 4519 - 4521
    - KRASZKIEWICZ et al., Synthesis, (20060000), pages 1195 - 1199
    - GANGULY et al., Synthesis, (20100000), pages 1467 - 1472
    - ISKRA et al., Synthesis, (20040000), pages 1869 - 1873
    - CASTANET, Tetrahedron Lett., (20020000), vol. 43, pages 5047 - 5048
    - PRAKASH, J. Am. Chem. Soc., (20040000), vol. 126, pages 15570 - 15776
    - LULINSKI et al., Synthesis, (20040000), pages 441 - 445
    - GANGULY, Synthesis, (20050000), pages 1103 - 1108
    - RAJESH et al., Org. Chem., (20070000), vol. 72, pages 5867 - 5869
    - BENGEL FM; SCHWAIGER M, "Assessment of cardiac sympathetic neuronal function using PET imaging", J Nucl Cardiol, (20040000), vol. 11, no. 5, doi:doi:10.1016/j.nuclcard.2004.06.133, pages 603 - 16, XP004592870

DOI:   http://dx.doi.org/10.1016/j.nuclcard.2004.06.133
    - HENNEMAN MM; BENGEL FM; VAN DER WALL EE; KNUUTI J; BAX JJ, "Cardiac neuronal imaging: application in the evaluation of cardiac disease", J Nucl Cardiol., (20080000), vol. 15, no. 3, doi:doi:10.1016/j.nuclcard.2008.02.023, pages 442 - 55, XP022676108

DOI:   http://dx.doi.org/10.1016/j.nuclcard.2008.02.023
    - TRAVIN MI, "Cardiac neuronal imaging at the edge of clinical application", Cardiol Clin., (20090000), vol. 27, no. 2, pages 311 - 27
    - CARRIO I., "Cardiac neurotransmission imaging", JNucl Med., (20010000), vol. 42, no. 7, pages 1062 - 76, XP002597251
    - "Periodic Table of the Elements, CAS version", Handbook of Chemistry and Physics, 75th ed, .
    - BERGE et al., "describe pharmaceutically acceptable salts in detail", J. Pharmaceutical Sciences, (19770000), vol. 66, pages 1 - 19
    - Wilen S.H. et al, Tetrahedron, vol. 33, page 2725
    - WILEN, S.H., Tables of Resolving Agents and Optical Resolutions, Univ. of Notre Dame Press, (19720000), page 268
 WO2011US24109
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.