EP2771349 - BIOINFORMATIC PROCESSES FOR DETERMINATION OF PEPTIDE BINDING [Right-click to bookmark this link] | Status | No opposition filed within time limit Status updated on 01.01.2021 Database last updated on 22.05.2024 | |
Former | The patent has been granted Status updated on 24.01.2020 | ||
Former | Grant of patent is intended Status updated on 31.05.2018 | ||
Former | Examination is in progress Status updated on 15.09.2017 | Most recent event Tooltip | 08.07.2022 | Lapse of the patent in a contracting state New state(s): MK | published on 10.08.2022 [2022/32] | Applicant(s) | For all designated states Iogenetics, LLC. 3591 Anderson Street Suite 218 Madison, Wisconsin 53704 / US | [2014/36] | Inventor(s) | 01 /
BREMEL, Robert D. E3352 Chapel Road Hillpoint, Wisconsin 53937 / US | 02 /
HOMAN, Jane E3352 Chapel Road Hillpoint, Wisconsin 53937 / US | [2014/36] | Representative(s) | Algemeen Octrooi- en Merkenbureau B.V. P.O. Box 645 5600 AP Eindhoven / NL | [2014/36] | Application number, filing date | 12831761.7 | 13.09.2012 | [2020/09] | WO2012US55038 | Priority number, date | US201161535495P | 16.09.2011 Original published format: US 201161535495 P | [2014/36] | Filing language | EN | Procedural language | EN | Publication | Type: | A2 Application without search report | No.: | WO2013040142 | Date: | 21.03.2013 | Language: | EN | [2013/12] | Type: | A2 Application without search report | No.: | EP2771349 | Date: | 03.09.2014 | Language: | EN | The application published by WIPO in one of the EPO official languages on 21.03.2013 takes the place of the publication of the European patent application. | [2014/36] | Type: | B1 Patent specification | No.: | EP2771349 | Date: | 26.02.2020 | Language: | EN | [2020/09] | Search report(s) | International search report - published on: | US | 13.02.2014 | (Supplementary) European search report - dispatched on: | EP | 18.05.2015 | Classification | IPC: | C07K1/00, C07K5/00, C07K14/00, G01N33/53, A61K39/00, A61K39/04, A61K39/08, A61K39/085, A61K39/09, A61K39/145, A61K39/15, A61K39/21, A61K39/285, G06F19/16 | [2015/25] | CPC: |
A61K39/00 (EP);
G16B15/30 (EP,US);
A61K39/0007 (EP);
A61K39/0008 (EP);
A61K39/04 (EP);
A61K39/08 (EP);
A61K39/085 (EP);
A61K39/092 (EP);
A61K39/12 (EP);
A61K39/145 (EP);
A61K39/15 (EP);
A61K39/21 (EP);
A61K39/285 (EP);
A61K2039/55572 (EP);
C12N2710/24034 (EP);
C12N2720/12334 (EP);
C12N2740/14034 (EP);
C12N2760/16134 (EP);
G16B15/00 (EP)
(-)
|
Former IPC [2014/36] | C07K1/00, C07K5/00, C07K14/00, G01N33/53 | Designated contracting states | AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LI, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR [2014/36] | Extension states | BA | Not yet paid | ME | Not yet paid | Title | German: | BIOINFORMATIKVERFAHREN ZUR BESTIMMUNG VON PEPTIDBINDUNGEN | [2014/36] | English: | BIOINFORMATIC PROCESSES FOR DETERMINATION OF PEPTIDE BINDING | [2014/36] | French: | PROCÉDÉS BIO-INFORMATIQUES DE DÉTERMINATION DE LIAISONS PEPTIDIQUES | [2014/36] | Entry into regional phase | 15.04.2014 | National basic fee paid | 15.04.2014 | Search fee paid | 15.04.2014 | Designation fee(s) paid | 15.04.2014 | Examination fee paid | Examination procedure | 15.04.2014 | Examination requested [2014/36] | 10.12.2015 | Amendment by applicant (claims and/or description) | 14.06.2016 | Despatch of a communication from the examining division (Time limit: M02) | 23.08.2016 | Reply to a communication from the examining division | 11.09.2017 | Despatch of a communication from the examining division (Time limit: M06) | 13.03.2018 | Reply to a communication from the examining division | 01.06.2018 | Communication of intention to grant the patent | 21.12.2018 | Despatch of communication that the application is deemed to be withdrawn, reason: fee for grant / fee for printing not paid in time | 21.02.2019 | Fee for grant paid | 21.02.2019 | Fee for publishing/printing paid | 21.02.2019 | Receipt of the translation of the claim(s) | Divisional application(s) | The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is 14.06.2016 | Opposition(s) | 27.11.2020 | No opposition filed within time limit [2021/05] | Request for further processing for: | The application is deemed to be withdrawn due to failure to fulfill actions required for granting the patent | 21.02.2019 | Request for further processing filed | 21.02.2019 | Full payment received (date of receipt of payment) Request granted | 13.03.2019 | Decision despatched | Fees paid | Renewal fee | 29.09.2014 | Renewal fee patent year 03 | 28.09.2015 | Renewal fee patent year 04 | 27.09.2016 | Renewal fee patent year 05 | 27.09.2017 | Renewal fee patent year 06 | 27.09.2018 | Renewal fee patent year 07 | 27.09.2019 | Renewal fee patent year 08 |
Opt-out from the exclusive Tooltip competence of the Unified Patent Court | See the Register of the Unified Patent Court for opt-out data | ||
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court. | Lapses during opposition Tooltip | HU | 13.09.2012 | AL | 26.02.2020 | AT | 26.02.2020 | CY | 26.02.2020 | CZ | 26.02.2020 | DK | 26.02.2020 | EE | 26.02.2020 | ES | 26.02.2020 | FI | 26.02.2020 | HR | 26.02.2020 | IT | 26.02.2020 | LT | 26.02.2020 | LV | 26.02.2020 | MC | 26.02.2020 | MK | 26.02.2020 | MT | 26.02.2020 | NL | 26.02.2020 | PL | 26.02.2020 | RO | 26.02.2020 | RS | 26.02.2020 | SE | 26.02.2020 | SI | 26.02.2020 | SK | 26.02.2020 | SM | 26.02.2020 | TR | 26.02.2020 | BG | 26.05.2020 | NO | 26.05.2020 | GR | 27.05.2020 | IS | 26.06.2020 | PT | 19.07.2020 | IE | 13.09.2020 | LU | 13.09.2020 | BE | 30.09.2020 | CH | 30.09.2020 | LI | 30.09.2020 | [2022/31] |
Former [2022/30] | HU | 13.09.2012 | |
AL | 26.02.2020 | ||
AT | 26.02.2020 | ||
CY | 26.02.2020 | ||
CZ | 26.02.2020 | ||
DK | 26.02.2020 | ||
EE | 26.02.2020 | ||
ES | 26.02.2020 | ||
FI | 26.02.2020 | ||
HR | 26.02.2020 | ||
IT | 26.02.2020 | ||
LT | 26.02.2020 | ||
LV | 26.02.2020 | ||
MC | 26.02.2020 | ||
MT | 26.02.2020 | ||
NL | 26.02.2020 | ||
PL | 26.02.2020 | ||
RO | 26.02.2020 | ||
RS | 26.02.2020 | ||
SE | 26.02.2020 | ||
SI | 26.02.2020 | ||
SK | 26.02.2020 | ||
SM | 26.02.2020 | ||
TR | 26.02.2020 | ||
BG | 26.05.2020 | ||
NO | 26.05.2020 | ||
GR | 27.05.2020 | ||
IS | 26.06.2020 | ||
PT | 19.07.2020 | ||
IE | 13.09.2020 | ||
LU | 13.09.2020 | ||
BE | 30.09.2020 | ||
CH | 30.09.2020 | ||
LI | 30.09.2020 | ||
Former [2022/27] | HU | 13.09.2012 | |
AT | 26.02.2020 | ||
CY | 26.02.2020 | ||
CZ | 26.02.2020 | ||
DK | 26.02.2020 | ||
EE | 26.02.2020 | ||
ES | 26.02.2020 | ||
FI | 26.02.2020 | ||
HR | 26.02.2020 | ||
IT | 26.02.2020 | ||
LT | 26.02.2020 | ||
LV | 26.02.2020 | ||
MC | 26.02.2020 | ||
MT | 26.02.2020 | ||
NL | 26.02.2020 | ||
PL | 26.02.2020 | ||
RO | 26.02.2020 | ||
RS | 26.02.2020 | ||
SE | 26.02.2020 | ||
SI | 26.02.2020 | ||
SK | 26.02.2020 | ||
SM | 26.02.2020 | ||
TR | 26.02.2020 | ||
BG | 26.05.2020 | ||
NO | 26.05.2020 | ||
GR | 27.05.2020 | ||
IS | 26.06.2020 | ||
PT | 19.07.2020 | ||
IE | 13.09.2020 | ||
LU | 13.09.2020 | ||
BE | 30.09.2020 | ||
CH | 30.09.2020 | ||
LI | 30.09.2020 | ||
Former [2022/26] | AT | 26.02.2020 | |
CZ | 26.02.2020 | ||
DK | 26.02.2020 | ||
EE | 26.02.2020 | ||
ES | 26.02.2020 | ||
FI | 26.02.2020 | ||
HR | 26.02.2020 | ||
IT | 26.02.2020 | ||
LT | 26.02.2020 | ||
LV | 26.02.2020 | ||
MC | 26.02.2020 | ||
NL | 26.02.2020 | ||
PL | 26.02.2020 | ||
RO | 26.02.2020 | ||
RS | 26.02.2020 | ||
SE | 26.02.2020 | ||
SI | 26.02.2020 | ||
SK | 26.02.2020 | ||
SM | 26.02.2020 | ||
TR | 26.02.2020 | ||
BG | 26.05.2020 | ||
NO | 26.05.2020 | ||
GR | 27.05.2020 | ||
IS | 26.06.2020 | ||
PT | 19.07.2020 | ||
IE | 13.09.2020 | ||
LU | 13.09.2020 | ||
BE | 30.09.2020 | ||
CH | 30.09.2020 | ||
LI | 30.09.2020 | ||
Former [2021/37] | AT | 26.02.2020 | |
CZ | 26.02.2020 | ||
DK | 26.02.2020 | ||
EE | 26.02.2020 | ||
ES | 26.02.2020 | ||
FI | 26.02.2020 | ||
HR | 26.02.2020 | ||
IT | 26.02.2020 | ||
LT | 26.02.2020 | ||
LV | 26.02.2020 | ||
MC | 26.02.2020 | ||
NL | 26.02.2020 | ||
PL | 26.02.2020 | ||
RO | 26.02.2020 | ||
RS | 26.02.2020 | ||
SE | 26.02.2020 | ||
SI | 26.02.2020 | ||
SK | 26.02.2020 | ||
SM | 26.02.2020 | ||
BG | 26.05.2020 | ||
NO | 26.05.2020 | ||
GR | 27.05.2020 | ||
IS | 26.06.2020 | ||
PT | 19.07.2020 | ||
IE | 13.09.2020 | ||
LU | 13.09.2020 | ||
BE | 30.09.2020 | ||
CH | 30.09.2020 | ||
LI | 30.09.2020 | ||
Former [2021/36] | AT | 26.02.2020 | |
CZ | 26.02.2020 | ||
DK | 26.02.2020 | ||
EE | 26.02.2020 | ||
ES | 26.02.2020 | ||
FI | 26.02.2020 | ||
HR | 26.02.2020 | ||
IT | 26.02.2020 | ||
LT | 26.02.2020 | ||
LV | 26.02.2020 | ||
MC | 26.02.2020 | ||
NL | 26.02.2020 | ||
PL | 26.02.2020 | ||
RO | 26.02.2020 | ||
RS | 26.02.2020 | ||
SE | 26.02.2020 | ||
SI | 26.02.2020 | ||
SK | 26.02.2020 | ||
SM | 26.02.2020 | ||
BG | 26.05.2020 | ||
NO | 26.05.2020 | ||
GR | 27.05.2020 | ||
IS | 26.06.2020 | ||
PT | 19.07.2020 | ||
LU | 13.09.2020 | ||
BE | 30.09.2020 | ||
Former [2021/27] | AT | 26.02.2020 | |
CZ | 26.02.2020 | ||
DK | 26.02.2020 | ||
EE | 26.02.2020 | ||
ES | 26.02.2020 | ||
FI | 26.02.2020 | ||
HR | 26.02.2020 | ||
IT | 26.02.2020 | ||
LT | 26.02.2020 | ||
LV | 26.02.2020 | ||
MC | 26.02.2020 | ||
NL | 26.02.2020 | ||
PL | 26.02.2020 | ||
RO | 26.02.2020 | ||
RS | 26.02.2020 | ||
SE | 26.02.2020 | ||
SI | 26.02.2020 | ||
SK | 26.02.2020 | ||
SM | 26.02.2020 | ||
BG | 26.05.2020 | ||
NO | 26.05.2020 | ||
GR | 27.05.2020 | ||
IS | 26.06.2020 | ||
PT | 19.07.2020 | ||
LU | 13.09.2020 | ||
Former [2021/23] | AT | 26.02.2020 | |
CZ | 26.02.2020 | ||
DK | 26.02.2020 | ||
EE | 26.02.2020 | ||
ES | 26.02.2020 | ||
FI | 26.02.2020 | ||
HR | 26.02.2020 | ||
IT | 26.02.2020 | ||
LT | 26.02.2020 | ||
LV | 26.02.2020 | ||
MC | 26.02.2020 | ||
NL | 26.02.2020 | ||
PL | 26.02.2020 | ||
RO | 26.02.2020 | ||
RS | 26.02.2020 | ||
SE | 26.02.2020 | ||
SI | 26.02.2020 | ||
SK | 26.02.2020 | ||
SM | 26.02.2020 | ||
BG | 26.05.2020 | ||
NO | 26.05.2020 | ||
GR | 27.05.2020 | ||
IS | 26.06.2020 | ||
PT | 19.07.2020 | ||
Former [2021/10] | AT | 26.02.2020 | |
CZ | 26.02.2020 | ||
DK | 26.02.2020 | ||
EE | 26.02.2020 | ||
ES | 26.02.2020 | ||
FI | 26.02.2020 | ||
HR | 26.02.2020 | ||
IT | 26.02.2020 | ||
LT | 26.02.2020 | ||
LV | 26.02.2020 | ||
NL | 26.02.2020 | ||
PL | 26.02.2020 | ||
RO | 26.02.2020 | ||
RS | 26.02.2020 | ||
SE | 26.02.2020 | ||
SI | 26.02.2020 | ||
SK | 26.02.2020 | ||
SM | 26.02.2020 | ||
BG | 26.05.2020 | ||
NO | 26.05.2020 | ||
GR | 27.05.2020 | ||
IS | 26.06.2020 | ||
PT | 19.07.2020 | ||
Former [2020/50] | CZ | 26.02.2020 | |
DK | 26.02.2020 | ||
EE | 26.02.2020 | ||
ES | 26.02.2020 | ||
FI | 26.02.2020 | ||
HR | 26.02.2020 | ||
LT | 26.02.2020 | ||
LV | 26.02.2020 | ||
NL | 26.02.2020 | ||
RO | 26.02.2020 | ||
RS | 26.02.2020 | ||
SE | 26.02.2020 | ||
SK | 26.02.2020 | ||
SM | 26.02.2020 | ||
BG | 26.05.2020 | ||
NO | 26.05.2020 | ||
GR | 27.05.2020 | ||
IS | 26.06.2020 | ||
PT | 19.07.2020 | ||
Former [2020/49] | CZ | 26.02.2020 | |
DK | 26.02.2020 | ||
ES | 26.02.2020 | ||
FI | 26.02.2020 | ||
HR | 26.02.2020 | ||
LT | 26.02.2020 | ||
LV | 26.02.2020 | ||
NL | 26.02.2020 | ||
RO | 26.02.2020 | ||
RS | 26.02.2020 | ||
SE | 26.02.2020 | ||
SK | 26.02.2020 | ||
SM | 26.02.2020 | ||
BG | 26.05.2020 | ||
NO | 26.05.2020 | ||
GR | 27.05.2020 | ||
IS | 26.06.2020 | ||
PT | 19.07.2020 | ||
Former [2020/48] | DK | 26.02.2020 | |
ES | 26.02.2020 | ||
FI | 26.02.2020 | ||
HR | 26.02.2020 | ||
LT | 26.02.2020 | ||
LV | 26.02.2020 | ||
NL | 26.02.2020 | ||
RO | 26.02.2020 | ||
RS | 26.02.2020 | ||
SE | 26.02.2020 | ||
SM | 26.02.2020 | ||
BG | 26.05.2020 | ||
NO | 26.05.2020 | ||
GR | 27.05.2020 | ||
IS | 26.06.2020 | ||
PT | 19.07.2020 | ||
Former [2020/47] | DK | 26.02.2020 | |
ES | 26.02.2020 | ||
FI | 26.02.2020 | ||
HR | 26.02.2020 | ||
LT | 26.02.2020 | ||
LV | 26.02.2020 | ||
NL | 26.02.2020 | ||
RS | 26.02.2020 | ||
SE | 26.02.2020 | ||
BG | 26.05.2020 | ||
NO | 26.05.2020 | ||
GR | 27.05.2020 | ||
IS | 26.06.2020 | ||
Former [2020/45] | FI | 26.02.2020 | |
HR | 26.02.2020 | ||
LV | 26.02.2020 | ||
NL | 26.02.2020 | ||
RS | 26.02.2020 | ||
SE | 26.02.2020 | ||
BG | 26.05.2020 | ||
NO | 26.05.2020 | ||
GR | 27.05.2020 | ||
IS | 26.06.2020 | ||
Former [2020/40] | FI | 26.02.2020 | |
HR | 26.02.2020 | ||
LV | 26.02.2020 | ||
RS | 26.02.2020 | ||
SE | 26.02.2020 | ||
BG | 26.05.2020 | ||
NO | 26.05.2020 | ||
GR | 27.05.2020 | ||
IS | 26.06.2020 | ||
Former [2020/39] | FI | 26.02.2020 | |
HR | 26.02.2020 | ||
LV | 26.02.2020 | ||
RS | 26.02.2020 | ||
SE | 26.02.2020 | ||
BG | 26.05.2020 | ||
NO | 26.05.2020 | ||
GR | 27.05.2020 | ||
Former [2020/38] | FI | 26.02.2020 | |
HR | 26.02.2020 | ||
LV | 26.02.2020 | ||
RS | 26.02.2020 | ||
SE | 26.02.2020 | ||
NO | 26.05.2020 | ||
GR | 27.05.2020 | ||
Former [2020/37] | FI | 26.02.2020 | |
HR | 26.02.2020 | ||
LV | 26.02.2020 | ||
RS | 26.02.2020 | ||
SE | 26.02.2020 | ||
NO | 26.05.2020 | ||
Former [2020/35] | FI | 26.02.2020 | |
NO | 26.05.2020 | Documents cited: | Search | [IY]US5693325 (KAHN MICHAEL [US]) [I] 1-15 * columns 3, 22 * [Y] 1-15; | [Y] - BREMEL ROBERT D ET AL, "An integrated approach to epitope analysis II: A system for proteomic-scale prediction of immunological characteristics", IMMUNOME RESEARCH, BIOMED CENTRAL, LONDON, GB, (20101102), vol. 6, no. 1, doi:10.1186/1745-7580-6-8, ISSN 1745-7580, page 8, XP021080936 [Y] 1-15 * page 6; table 1 * DOI: http://dx.doi.org/10.1186/1745-7580-6-8 | [A] - BREMEL ROBERT D ET AL, "An integrated approach to epitope analysis I: Dimensional reduction, visualization and prediction of MHC binding using amino acid principal components and regression approaches", IMMUNOME RESEARCH, BIOMED CENTRAL, LONDON, GB, (20101102), vol. 6, no. 1, doi:10.1186/1745-7580-6-7, ISSN 1745-7580, page 7, XP021080935 [A] 1-15 * the whole document * DOI: http://dx.doi.org/10.1186/1745-7580-6-7 | [A] - GUO-PING SHI ET AL, "Molecular Biology Molecular Cloning and Expression of Human Alveolar Macrophage Cathepsin S, an Elastinolytic Cysteine Protease*", THE JOURNAL OF BIOLOGICAL CHEMISTRY, (19920415), vol. 267, no. 11, pages 7258 - 7262, XP055148816 [A] 1-15 * the whole document * | International search | [Y]US5693325 (KAHN MICHAEL [US]); | [Y] - BREMEL ET AL., "An integrated approach to epitope analysis II: A system for proteomic-scale prediction of immunological characteristics.", IMMUNOME RESEARCH, (20101102), vol. 6, no. 8, pages 1 - 21, XP021080936 DOI: http://dx.doi.org/10.1186/1745-7580-6-8 | [Y] - SHI ET AL., "Molecular cloning and expression of human alveolar macrophage cathepsin S, an elastinolytic cysteine protease.", J BIOL CHEM, (19920415), vol. 267, no. 11, pages 7258 - 7262, XP055148816 | Examination | WO2004052930 | - PIZZA M. ET AL., "Identification of vaccine andidates against serogroup B meningococcus by whole-genome sequencing.", SCIENCE, (20000310), vol. 287, no. 5459, pages 1816 - 1820 | by applicant | US507348 | US4168146 | US4246339 | US4277560 | US4366241 | EP0125023 | EP0171496 | EP0173494 | WO8601533 | EP0184187 | US4632901 | US4703017 | US4743560 | EP0296724 | US4812293 | US4816567 | US4855240 | US4861711 | WO9002809 | US4920046 | WO9005305 | US4946778 | WO9100906 | WO9110741 | WO9117271 | WO9201047 | WO9203918 | WO9203917 | US5120643 | WO9209690 | WO9215679 | WO9218619 | WO9220791 | WO9301288 | US5223409 | US5225539 | US5229073 | US5279935 | US5451504 | US5451507 | US5484707 | US5591645 | WO9706439 | WO9836278 | US5798273 | US5958715 | US6001658 | US6197599 | US2001014461 | US6294790 | US2003049857 | US2004146990 | US2004241876 | - SPELLBERG et al., Clin.Infect.Dis., (20040000), vol. 38, pages 1279 - 1286 | - BURNIE et al., Infect.Immun., (20000000), vol. 68, pages 3200 - 3209 | - MUSSER, J. M., Nat.Biotechnol., (20060000), vol. 24, pages 157 - 158 | - SERRUTO, D., L. et al., Vaccine, (20090000), vol. 27, pages 3245 - 3250 | - PIZZA et al., Science, (20000000), vol. 287, pages 1816 - 1820 | - ARIEL, Infect.Immun., (20020000), vol. 70, pages 6817 - 6827 | - BETTS, J. C., IUBMB.Life, (20020000), vol. 53, pages 239 - 242 | - CHAKRAVARTI et al., Vaccine, (20000000), vol. 19, pages 601 - 612 | - MONTIGIANI et al., Infect.Immun., (20020000), vol. 70, pages 368 - 379 | - ROSS et al., Vaccine, (20010000), vol. 19, pages 4135 - 4142 | - WIZEMANN et al., Infect.Immun., (20010000), vol. 69, pages 1593 - 1598 | - RODRIGUEZ-ORTEGA et al., Nat.Biotechnol., (20060000), vol. 24, pages 191 - 197 | - PASQUETTO et al., J Immunol, (20050000), vol. 175, pages 5504 - 5515 | - SAVITZKY; GOLAY, Anal Chem, (19640000), vol. 36, pages 1627 - 1639 | - LARSEN et al., Immunome Research, (20060000), vol. 2, page 2 | - HOPP T et al., PNAS, (19810000), vol. 78, pages 3824 - 3828 | - PARKER J et al., Biochem., (19860000), vol. 25, pages 5425 - 5432 | - MARSH et al., "Nomenclature for Factors of the HLA System", Tissue Antigens, (20100000), vol. 75, pages 291 - 455 | - HARLOW; LANE, Antibodies: A Laboratory Manual, Cold Spring Harbor Laboratory Press | - KOHLER; MILSTEIN, Nature, (19750000), vol. 256, pages 495 - 497 | - KOZBOR et al., Immunol. Today, (19830000), vol. 4, page 72 | - COLE et al., Monoclonal Antibodies and Cancer Therapy, Alan R. Liss, Inc., (19850000), pages 77 - 96 | - HUSE et al., Science, (19890000), vol. 246, pages 1275 - 1281 | - WOLD,S.; SJORSTROM,M.; ERIKSSON,L., Chemometrics and Intelligent Laboratory Systems, (20010000), vol. 58, pages 109 - 130 | - FINEGOLD; MARTIN, Diagnostic Microbiology, CV Mosby, (19820000), pages 13 - 15 | - ZAHRADNIK et al., J.Infect.Dis., (19870000), vol. 155, pages 903 - 908 | - MUZZI et al., Drug Discov.Today, (20070000), vol. 12, pages 429 - 439 | - SUBBARAO et al., Virology, (20030000), vol. 305, pages 192 - 200 | - PIZZA et al., Methods Mol.Med., (20030000), vol. 87, pages 133 - 152 | - BUCCATO et al., J.Infect.Dis., (20060000), vol. 194, pages 331 - 340 | - JENNINGS, G. T.; M. F. BACHMANN, Biol.Chem., (20080000), vol. 389, pages 521 - 536 | - RAPPUOLI, Nat.Biotechnol., (20070000), vol. 25, pages 1361 - 1366 | - DE GROOT, Drug Discov.Today, (20060000), vol. 11, pages 203 - 209 | - KAUFMANN, Nat.Rev.Microbiol., (20070000), vol. 5, pages 491 - 504 | - ZANETTI; FRANCHINI, Trends Immunol., (20060000), vol. 27, pages 511 - 517 | - VAUGHAN et al., Parasite Immunol., (20090000), vol. 31, pages 78 - 97 | - SETTE et al., Immunity, (20080000), vol. 28, pages 847 - 858 | - MCMURRAY et al., Tuberculosis (Edinb., (20050000), vol. 85, pages 95 - 105 | - MOUTAFTSTI et al., Nat.Biotechnol., (20060000), vol. 24, pages 817 - 819 | - SETTE, A. et al., Immunity, (20080000), vol. 28, pages 847 - 858 | - LANZAVECCHIA A, Nature, (19850000), vol. 314, pages 537 - 539 | - MUZZI, Drug Discov.Today, (20070000), vol. 12, pages 429 - 439 | - SERRUTO; RAPPUOLI, FEBS Lett., (20060000), vol. 580, pages 2985 - 2992 | - ZHANG et al., Nucleic Acids Res., (20080000), vol. 36, pages W513 - W518 | - BREMEL RD; HOMAN EJ, Immunome Res, (20101102), vol. 6, page 7 | - BREMEL RD; HOMAN EJ, Immunome Res, (20101102), vol. 6, page 8 | - LAFUENTE,E.M.; RECHE,P.A., Curr.Pharm.Des, (20090000), vol. 15, pages 3209 - 3220 | - GOWTHAMAN,U.; AGREWALA,J.N., J.Proteome.Res., (20080000), vol. 7, pages 154 - 163 | - BOULAND, H.; KAMP,Y., Biological Cybernetics, (19880000), vol. 59, pages 291 - 294 | - WOLD, S.; SJORSTROM,M.; ERIKSSON,L., Chemometrics and Intelligent Laboratory Systems, (20010000), vol. 58, pages 109 - 130 | - TIAN et al., Protein Pept.Lett., (20080000), vol. 15, pages 1033 - 1043 | - TIAN et al., Amino.Acids, (20090000), vol. 36, pages 535 - 554 | - HUANG et al., J.Theor.Biol., (20090000), vol. 256, pages 428 - 435 | - SPECKT, D.F., "A Generalized Regression Neural Network", IEEE Transactions on Neural Networks, (19910000), vol. 2, no. 6, pages 568 - 576 | - NIELSEN,M.; LUND,O., BMC.Bioinformatics, (20090000), vol. 10, page 296 | - "Genbank", Database accession no. NC 002951 | - SAVITZKY,A.; GOLAY,M.J.E., Anal.Chem., (19640000), vol. 36, pages 1627 - 1639 | - KLEVENS et al., Emerg.Infect.Dis., (20060000), vol. 12, pages 1991 - 1993 | - KLEVENS et al., JAMA, (20070000), vol. 298, pages 1763 - 1771 | - KUEHNERT et al., Emerg.Infect.Dis., (20050000), vol. 11, pages 868 - 872 | - ANDERSON; KAYE, Infect.Dis.Clin.North Am., (20090000), vol. 23, pages 53 - 72 | - KELLNER et al., Morbidity and Mortality Weekly Reports, (20070000), vol. 58, pages 52 - 55 | - MILLER; KAPLAN, Infect.Dis.Clin.North Am., (20090000), vol. 23, pages 35 - 52 | - THOMPSON; TORRIANI, Curr.HIV./AIDS Rep., (20060000), vol. 3, pages 107 - 112 | - NICKERSON et al., Lancet Infect.Dis., (20090000), vol. 9, pages 130 - 135 | - KALLEN et al., Ann.Emerg.Med., (20090000), vol. 53, pages 358 - 365 | - WRIGHT et al., Lancet, (20090000), vol. 373, pages 1861 - 1873 | - HUYGEN et al., Med.Microbiol.Immunol., (20090000), vol. 198, pages 69 - 77 | - BHATTACHARYA et al., Science, (20090000), vol. 324, page 885 | - LYNCH; ZHANEL, Semin.Respir.Crit Care Med., (20090000), vol. 30, pages 189 - 209 | - LYNCH; ZHANEL, Semin.Respir.Crit Care Med., (20090000), vol. 30, pages 210 - 238 | - HIDRON et al., Lancet Infect.Dis., (20090000), vol. 9, pages 384 - 392 | - BRUNDAGE; SHANKS, Emerg.Infect.Dis., (20080000), vol. 14, pages 1193 - 1199 | - ROTHBERG et al., Am.J.Med., (20080000), vol. 121, pages 258 - 264 | - MARIOTTI et al., Br.J.Ophthalmol., (20090000), vol. 93, pages 563 - 568 | - SHAPIRO, E. D.; M. A. GERBER, Clin.Infect.Dis., (20000000), vol. 31, pages 533 - 542 | - NCHINDA TL, Emerging Infect. Dis., (19980000), vol. 4, pages 398 - 403 | - MITA T, Parasit Int., (20090000), vol. 58, pages 201 - 209 | - FEVRE et al., PLoS.Negl.Trop.Dis., (20080000), vol. 2, page e333 | - DILLINGHAM et al., Microbes Infect, (20020000), vol. 4, page 1059 | - DUBEY, J. P., J.Eukaryot.Microbiol., (20080000), vol. 55, pages 467 - 475 | - DUBEY, J. P.; J. L. JONES, Int.J.Parasitol., (20080000), vol. 38, pages 1257 - 1278 | - BLAIR et al., Clin.Infect.Dis., (20080000), vol. 47, pages 1513 - 1518 | - LIN; HEI, "The biology of the Cryptococcus neoformans species complex", Annu.Rev.Microbiol., (20060000), vol. 60, pages 69 - 105 | - KAUFFMAN, Infect.Dis.Clin.North Am., (20060000), vol. 20, pages 645 - 62 | - KAUFFMAN, Clin.Microbiol.Rev., (20070000), vol. 20, pages 115 - 132 | - SUNDARAM et al., Biopolymers, (20020000), vol. 66, pages 200 - 216 | - SUNDARAM et al., Biopolymers (Pept Sci, (20020000), vol. 66, pages 200 - 216 | - LOO; MATHER, Curr.Opin.Pharmacol., (20080000), vol. 8, pages 627 - 631 | - REICHERTAND; VALGE-ARCHER, Nat.Rev.Drug Discov., (20070000), vol. 6, pages 349 - 356 | - KING et al., QJM., (20080000), vol. 101, pages 675 - 683 | - JONES, E. Y. et al., Nat.Rev.Immunol., (20060000), vol. 6, pages 271 - 282 | - HILDENBRAND, P. et al., Am.J.Neuroradiol., (20090000), vol. 30, pages 1079 - 1087 | - LEE, J. L. et al., Autoimmun.Rev., (20090000), vol. 10.1016 | - LEIDINGER, P. et al., Respir.Res., (20090000), vol. 10, page 20 | - GIUDICE et al., "Bullous pemphigoid and herpes gestationis autoantibodies recognize a common non-collagenous site on the BP180 ectodomain", J Immunol, (19930000), vol. 151, pages 5742 - 5750 | - GIUDICE et al., "Cloning and primary structural analysis of the bullous pemphigoid autoantigen BP180", J Invest Dermatol, (19920000), vol. 99, pages 243 - 250 | - SALATO et al., "Role of intramolecular epitope spreading in pemphigus vulgaris", Clin Immunol, (20050000), vol. 116, doi:doi:10.1016/j.clim.2005.03.005, pages 54 - 64, XP004909268 DOI: http://dx.doi.org/10.1016/j.clim.2005.03.005 | - BHOL et al., "Correlation of peptide specificity and IgG subclass with pathogenic and nonpathogenic autoantibodies in pemphigus vulgaris: a model for autoimmunity", Proc Natl Acad Sci USA, (19950000), vol. 92, pages 5239 - 5243 | - HACKER-FOEGEN et al., "T cell receptor gene usage of BP 180-specific T lymphocytes from patients with bullous pemphigoid and pemphigoid gestationis", Clin Immunol, (20040000), vol. 113, doi:doi:10.1016/j.clim.2004.08.003, pages 179 - 186, XP004576822 DOI: http://dx.doi.org/10.1016/j.clim.2004.08.003 | - YUKI N, Lancet Infect Dis, (20010000), vol. 1, no. 1, pages 29 - 37 | - YUKI N, Curr Opin Immunol, (20050000), vol. 17, no. 6, pages 577 - 582 | - KIESEIER BC et al., Muscle Nerve, (20040000), vol. 30, no. 2, pages 131 - 156 | - RASHID T et al., Clin Exp Rheumatol, (20070000), vol. 25, no. 2, pages 259 - 267 | - ZHANG et al., N Engl J Med, (20090000), vol. 361, no. 27, pages 2609 - 2618 | - RAMAGOPALAN SV et al., Genome Med, (20090000), vol. 1, no. 11, page 105 | - STEPHENS HA, Curr Top Microbiol Immunol, (20100000), vol. 338, pages 99 - 114 | - TOBON GJ et al., J Autoimmun, (20100000), pages S0896 - 8411 | - RAULF-HEIMSOTH M et al., Allergy, (20040000), vol. 59, no. 7, pages 724 - 733 | - QUIRALTE J et al., JInvestig Allergol Clin Immunol, (20070000), vol. 17, no. 1, pages 24 - 30 | - KIM SH et al., Clin Exp Allergy, (20050000), vol. 35, no. 3, pages 339 - 344 | - MALHERBE L, Ann Allergy Asthma Immunol, (20090000), vol. 103, no. 1, pages 76 - 79 | - RAPPUOLI et al., Science, (20020000), vol. 297, pages 937 - 939 | - KOHLER; MILSTEIN, Nature, (19750000), vol. 256, page 495 | - N. LONBERG et al., Nature, (19940000), vol. 368, pages 856 - 859 | - L.L. GREEN et al., Nature Genet, (19940000), vol. 7, pages 13 - 21 | - S.L. MORRISON et al., Proc. Nat. Acad. Sci. USA, (19940000), vol. 81, pages 6851 - 6855 | - BRUGGEMAN et al., Immunol, (19930000), vol. 7, pages 33 - 40 | - TUAILLON et al., Proc. Nat. Acad. Sci. USA, (19930000), vol. 90, pages 3720 - 3724 | - BRUGGERNAN et al., Eur. J. Immunol., (19910000), vol. 21, pages 1323 - 1326 | - SASTRY et al., Proc. Nat. Acad. Sci. USA, (19890000), vol. 86, page 5728 | - HUSE et al., Science, (19890000), vol. 246, page 1275 | - ORLANDI et al., Proc. Nat. Acad. Sci. USA, (19890000), vol. 86, page 3833 | - FUCHS et al., Biol. Technology, (19910000), vol. 9, pages 1370 - 1372 | - HAY et al., Hum. Antibod. Hybridomas, (19920000), vol. 3, pages 81 - 85 | - HUSE et al., Science, (19890000), vol. 46, pages 1275 - 1281 | - HAWKINS et al., J. Mol. Biol., (19920000), vol. 226, pages 889 - 896 | - CLACKSON et al., Nature, (19910000), vol. 352, pages 624 - 628 | - GRAM et al., Proc. Nat. Acad. Sci. USA, (19920000), vol. 89, pages 3576 - 3580 | - GARRAD et al., Bio/Technolog, (19910000), vol. 2, pages 1373 - 1377 | - HOOGENBOOM et al., Nuc. Acid Res., (19910000), vol. 19, pages 4133 - 4137 | - BARBAS et al., Proc. Nat. Acad. Sci. USA, (19910000), vol. 88, page 7978 | - BETTER et al., Science, (19880000), vol. 240, pages 1041 - 1043 | - LIU et al., Proc. Nat. Acad. Sci. USA, (19870000), vol. 84, pages 3439 - 3443 | - LIU et al., J. Immunol., (19870000), vol. 139, pages 3521 - 3526 | - SUN et al., Proc. Nat. Acad. Sci. USA, (19870000), vol. 84, pages 214 - 218 | - NISHIMURA et al., Cane. Res., (19870000), vol. 47, pages 999 - 1005 | - WOOD et al., Nature, (19850000), vol. 314, pages 446 - 449 | - SHAW et al., J. Natl. Cancer Inst., (19880000), vol. 80, pages 1553 - 1559 | - JONES et al., Nature, (19860000), vol. 321, pages 552 - 525 | - VERHOEYAN et al., Science, (19880000), vol. 239, page 1534 | - BEIDLER et al., J. Immunol., (19880000), vol. 141, page 4053 | - CASADEVALL, Nature Reviews Microbiology, (20040900), vol. 2, pages 695 - 703 | - SHORTLE D, Gene, (19830000), vol. 22, no. 2-3, pages 181 - 189 | - SCHAEFFER EB et al., Proc Natl Acad Sci USA, (19890000), vol. 86, no. 12, pages 4649 - 4653 | - Proc Natl Acad Sci USA, (19890600), vol. 86, no. 12, pages 4649 - 53 | - Cell Immunol., (19960915), vol. 172, no. 2, pages 254 - 61 | - J Immunol., (19930815), vol. 151, no. 4, pages 1852 - 8 | - J Exp Med., (19920201), vol. 175, no. 2, pages 387 - 96 | - FEMS Immunol Med Microbiol., (19970100), vol. 17, no. l, page l-10 | - J Immunol., (19970101), vol. 158, no. 1, pages 247 - 54 | - Can J Microbiol., (20000200), vol. 46, no. 2, pages 171 - 9 | - J Infect Dis., (19961200), vol. 174, no. 6, pages 1261 - 70 | - J Infect Dis., (20010615), vol. 183, no. 12, pages 1739 - 48 | - Vaccine, (20000428), vol. 18, no. 21, pages 2312 - 20 | - J Vet Med Sci., (20010300), vol. 63, no. 3, pages 237 - 41 | - Clin.Vaccine Immunol., (20090000), vol. 16, pages 1095 - 1104 | - Infect Immun., (20000600), vol. 68, no. 6, pages 3200 - 9 | - KITZE B; USUKU K; YAMANO Y; YASHIKI S; NAKAMURA M; FUJIYOSHI T; IZUMO S; OSAME M; SONODA S, "Human CD4+ T lymphocytes recognize a highly conserved epitope of human T lymphotropic virus type 1 (HTLV-1) env gp21 restricted by HLA DRB1 0101", Clin Exp Immunol, (19980000), vol. 111, no. 2, doi:doi:10.1046/j.1365-2249.1998.00497.x, pages 278 - 285, XP002295539 DOI: http://dx.doi.org/10.1046/j.1365-2249.1998.00497.x | - YAMANO Y; KITZE B; YASHIKI S; USUKU K; FUJIYOSHI T; KAMINAGAYOSHI T; UNOKI K; IZUMO S; OSAME M; SONODA S, "Preferential recognition of synthetic peptides from HTLV-I gp21 envelope protein by HLA-DRB1 alleles associated with HAM/TSP (HTLV-I-associated myelopathy/tropical spastic paraparesis", J Neuroimmunol, (19970000), vol. 76, no. 1-2, doi:doi:10.1016/S0165-5728(97)00041-6, pages 50 - 60, XP002295537 DOI: http://dx.doi.org/10.1016/S0165-5728(97)00041-6 | - KITZE B; USUKU K, "HTLV-1-mediated immunopathological CNS disease", Curr Top Microbiol Immunol, (20020000), vol. 265, pages 197 - 211 | - "Genbank", Database accession no. Q03816 | - J Immunol, vol. 143, no. 8, pages 2677 - 2683 | - HAYMAN WA; BRANDT ER; RELF WA; COOPER J; SAUL A; GOOD MF, "Mapping the minimal murine T-cell and B-cell epitopes within a peptide vaccine candidate from the conserved region of the M protein of group A streptococcus", Int Immunol, (19970000), vol. 9, no. 11, doi:doi:10.1093/intimm/9.11.1723, pages 1723 - 1733, XP055439442 DOI: http://dx.doi.org/10.1093/intimm/9.11.1723 | - WALDEMARSSON J et al., PLoS One, (20090000), vol. 4, no. 10 | - LEWINSOHN DA. et al., PLOS Pathogens, (20070000), vol. 3, pages 1240 - 1249 | - WARD KH; ANWAR H; BROWN RW; WALE J; GOWAR J, "Antibody response to outer-membrane antigens of Pseudomonas aeruginosa in human burn wound infection", J Med Microbiol, (19880000), vol. 27, no. 3, pages 179 - 90 | - KAMALA T., J Immunol Methods, (20070000), vol. 328, no. 1-2, pages 204 - 14 | - VAN DEN BROECK W; DERORE A; SIMOENS P, J Immunol Methods, (20060000), vol. 312, no. 1-2, pages 12 - 9 | - KOHLER; MILSTEIN, Nature, (19750807), vol. 256, no. 5517, pages 495 - 7 | - CBS. BUUS et al., "Sensitive quantitative predictions of peptide-MHC binding by a 'Query by Committee' artificial neural network approach", Tissue Antigens, (20030000), vol. 62, pages 378 - 384 | - NIELSEN et al., "Reliable prediction of T-cell epitopes using neural networks with novel sequence representations", Protein Sci, (20030000), vol. 12, doi:doi:10.1110/PS.0239403, pages 1007 - 1017, XP002582947 DOI: http://dx.doi.org/10.1110/PS.0239403 | - LUNDEGAARD et al., "Accurate approximation method for prediction of class I MHC affinities for peptides of length 8, 10 and 11 using prediction tools trained on 9mers", Bioinformatics, (20080000), vol. 24, pages 1397 - 1398 | - NIELSEN et al., "Improved prediction of MHC class I and class II epitopes using a novel Gibbs sampling approach", Bioinformatics, (20040000), vol. 20, doi:doi:10.1093/bioinformatics/bth100, pages 1388 - 1397, XP003022703 DOI: http://dx.doi.org/10.1093/bioinformatics/bth100 | - WANG et al., "A systematic assessment of MHC class II peptide binding predictions and evaluation of a consensus approach", PLoS Comput Biol, (20080000), vol. 4, page e1000048 | - "Genbank", Database accession no. NC_002951 | - BHOL et al., Proc Natl Acad Sci U S A, (19950000), vol. 92, pages 5239 - 5243 | - SALATO et al., Clin Immunol, (20050000), vol. 116, pages 54 - 64 | - GIUDICE et al., J Invest Dermatol, (19920000), vol. 99, pages 243 - 250 | - HACKER-FOEGEN et al., Clin Immunol, (20040000), vol. 113, pages 179 - 186 | - LIN et al., Clin Immunol, (19990000), vol. 92, pages 285 - 292 | - SHORNICK et al., J Clin Invest, (19810000), vol. 68, pages 553 - 555 | - GIUDICE et al., J Immunol, (19930000), vol. 151, pages 5742 - 5750 | - LIN et al., Clin Immunol, (20020000), vol. 102, pages 310 - 319 | - MULLER et al., Clin Immunol, (20100000), vol. 135, pages 99 - 107 | - WILEY et al., "Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation", Nature, (19810000), vol. 289, pages 373 - 378 | - FERGUSON et al., "Ecological and immunological determinants of influenza evolution", Nature, (20030000), vol. 422, pages 428 - 433 | - A VIRUS, Nat Med, (20020000), vol. 8, pages 562 - 563 | - SMITH et al., "Mapping the antigenic and genetic evolution of influenza virus", Science, (20040000), vol. 305, doi:doi:10.1126/SCIENCE.1097211, pages 371 - 376, XP002537402 DOI: http://dx.doi.org/10.1126/SCIENCE.1097211 | - HONEYMAN et al., "Evidence for molecular mimicry between human T cell epitopes in rotavirus and pancreatic islet autoantigens", J Immunol, (20100000), vol. 184, doi:doi:10.4049/jimmunol.0900709, pages 2204 - 2210, XP055250048 DOI: http://dx.doi.org/10.4049/jimmunol.0900709 | - IMMUNITY, vol. S1074-76, no. 08, pages 00235 - 5 | - Infect Dis Obstet Gynecol, (20110000), vol. 2011, page 963513 | - Expert Rev Anti Infect Ther., (20110200), vol. 9, no. 2, pages 237 - 44 | - STEFANELLI P., Emerg Infect Dis., (20110100), vol. 17, no. l, pages 148 - 9 | - LANZAVECCHIA A, "Antigen-specific interaction between T and B cells", Nature, (19850000), vol. 314, no. 6011, pages 537 - 539 | - DAVIDSON HW; WATTS C, "Epitope-directed processing of specific antigen by B lymphocytes", J Cell Biol, (19890000), vol. 109, no. 1, pages 85 - 92 | - BERGTOLD A; DESAI DD; GAVHANE A; CLYNES R, "Cell surface recycling of internalized antigen permits dendritic cell priming of B cells", Immunity, (20050000), vol. 23, no. 5, pages 503 - 514 | - DELAMARRE L; PACK M; CHANG H; MELLMAN I; TROMBETTA ES, "Differential lysosomal proteolysis in antigen-presenting cells determines antigen fate", Science, (20050000), vol. 307, no. 5715, pages 1630 - 1634 | - ROCK KL; FARFAN-ARRIBAS DJ; SHEN L, "Proteases in MHC class I presentation and cross-presentation", J Immunol, (20100000), vol. 184, no. 1, pages 9 - 15 | - SHEDLOCK DJ; SHEN H, "Requirement for CD4 T cell help in generating functional CD8 T cell memory", Science, (20030000), vol. 300, no. 5617, pages 337 - 339 | - MCHEYZER-WILLIAMS M; OKITSU S; WANG N; MCHEYZER-WILLIAMS L, "Molecular programming of B cell memory", Nature reviews Immunology, (20120000), vol. 12, no. 1, pages 24 - 34 | - BIRO A; HERINCS Z; FELLINGER E; SZILAGYI L; BARAD Z; GERGELY J; GRAF L; SARMAY G, "Characterization of a trypsin-like serine protease of activated B cells mediating the cleavage of surface proteins", Biochim Biophys Acta, (20030000), vol. 1624, no. 1-3, doi:doi:10.1016/j.bbagen.2003.09.010, pages 60 - 69, XP004475872 DOI: http://dx.doi.org/10.1016/j.bbagen.2003.09.010 | - CATRON DM; PAPE KA; FIFE BT; VAN ROOIJEN N; JENKINS MK, "A protease-dependent mechanism for initiating T-dependent B cell responses to large particulate antigens", J Immunol, (20100000), vol. 184, no. 7, doi:doi:10.4049/jimmunol.1000077, pages 3609 - 3617, XP055295908 DOI: http://dx.doi.org/10.4049/jimmunol.1000077 | - MOSS CX; TREE TI; WATTS C, "Reconstruction of a pathway of antigen processing and class II MHC peptide capture", EMBO J, (20070000), vol. 26, no. 8, pages 2137 - 2147 | - WATTS C, "The endosome-lysosome pathway and information generation in the immune system", Biochim Biophys Acta, (20120000), vol. 1824, no. 1, doi:doi:10.1016/j.bbapap.2011.07.006, pages 14 - 21, XP028336040 DOI: http://dx.doi.org/10.1016/j.bbapap.2011.07.006 | - VIJAYAKRISHNAN L; SARKAR S; ROY RP; RAO KV, "B cell responses to a peptide epitope: IV. Subtle sequence changes in flanking residues modulate immunogenicity", J Immunol, (19970000), vol. 159, no. 4, pages 1809 - 1819 | - AIBA Y; KOMETANI K; HAMADATE M; MORIYAMA S; SAKAUE-SAWANO A; TOMURA M; LUCHE H; FEHLING HJ; CASELLAS R; KANAGAWA O et al., "Preferential localization of IgG memory B cells adjacent to contracted germinal centers", Proc Natl Acad Sci U S A, (20100000), vol. 107, no. 27, pages 12192 - 12197 | - SETTE A; MOUTAFTSI M; MOYRON-QUIROZ J; MCCAUSLAND MM; DAVIES DH; JOHNSTON RJ; PETERS B; RAFII-EL-IDRISSI BM; HOFFMANN J; SU HP et, "Selective CD4+ T cell help for antibody responses to a large viral pathogen: deterministic linkage of specificities", Immunity, (20080000), vol. 28, no. 6, pages 847 - 858 | - BARNETT BC; GRAHAM CM; BURT DS; SKEHEL JJ; THOMAS DB, "The immune response of BALB/c mice to influenza hemagglutinin: commonality of the B cell and T cell repertoires and their relevance to antigenic drift", EurJImmunol, (19890000), vol. 19, no. 3, pages 515 - 521 | - TAKESHITA T; TAKAHASHI H; KOZLOWSKI S; AHLERS JD; PENDLETON CD; MOORE RL; NAKAGAWA Y; YOKOMURO K; FOX BS; MARGULIES DH et al., "Molecular analysis of the same HIV peptide functionally binding to both a class I and a class II MHC molecule", J Immunol, (19950000), vol. 154, no. 4, pages 1973 - 1986 | - PAUL S; PIONTKIVSKA H, "Frequent associations between CTL and T-Helper epitopes in HIV-1 genomes and implications for multi-epitope vaccine designs", BMC microbiology, (20100000), vol. 10, doi:doi:10.1186/1471-2180-10-212, page 212, XP021073090 DOI: http://dx.doi.org/10.1186/1471-2180-10-212 | - VAUGHAN K; BLYTHE M; GREENBAUM J; ZHANG Q; PETERS B; DOOLAN DL; SETTE A, "Meta-analysis of immune epitope data for all Plasmodia: overview and applications for malarial immunobiology and vaccine-related issues", Parasite Immunol, (20090000), vol. 31, no. 2, doi:doi:10.1111/j.1365-3024.2008.01077.x, pages 78 - 97, XP055062946 DOI: http://dx.doi.org/10.1111/j.1365-3024.2008.01077.x | - NAKAMURA Y; KAMEOKA M; TOBIUME M; KAYA M; OHKI K; YAMADA T; IKUTA K, "A chain section containing epitopes for cytotoxic T, B and helper T cells within a highly conserved region found in the human immunodeficiency virus type 1 Gag protein", Vaccine, (19970000), vol. 15, no. 5, doi:doi:10.1016/S0264-410X(96)00224-1, pages 489 - 496, XP004059887 DOI: http://dx.doi.org/10.1016/S0264-410X(96)00224-1 | - BREMEL RD; HOMAN EJ, "An integrated approach to epitope analysis II: A system for proteomic-scale prediction of immunological characteristics", Immunome research, (20100000), vol. 6, doi:doi:10.1186/1745-7580-6-8, page 8, XP021080936 DOI: http://dx.doi.org/10.1186/1745-7580-6-8 | - BREMEL RD; HOMAN EJ, "An integrated approach to epitope analysis I: Dimensional reduction, visualization and prediction of MHC binding using amino acid principal components and regression approaches", Immunome research, (20100000), vol. 6, doi:doi:10.1186/1745-7580-6-7, page 7, XP021080935 DOI: http://dx.doi.org/10.1186/1745-7580-6-7 | - HOMAN EJ; BREMEL RD, "Patterns of predicted T-cell epitopes associated with antigenic drift in influenza H3N2 hemagglutinin", PloS one, (20110000), vol. 6, no. 10, page e26711 | - IMPENS F; COLAERT N; HELSENS K; GHESQUIERE B; TIMMERMAN E; DE BOCK PJ; CHAIN BM; VANDEKERCKHOVE J; GEVAERT K, "A quantitative proteomics design for systematic identification of protease cleavage events", MolCell Proteomics, (20100000), vol. 9, no. 10, pages 2327 - 2333 | - BINIOSSEK ML; NAGLER DK; BECKER-PAULY C; SCHILLING O, "Proteomic identification of protease cleavage sites characterizes prime and non-prime specificity of cysteine cathepsins B, L, and S", JProteomeRes, (20110000), vol. 10, no. 12, pages 5363 - 5373 | - BENMOHAMED L; KRISHNAN R; LONGMATE J; AUGE C; LOW L; PRIMUS J; DIAMOND DJ, "Induction of CTL response by a minimal epitope vaccine in HLA A*0201/DR1 transgenic mice: dependence on HLA class II restricted T(H) response", Human immunology, (20000000), vol. 61, no. 8, doi:doi:10.1016/S0198-8859(00)00139-7, pages 764 - 779, XP002314834 DOI: http://dx.doi.org/10.1016/S0198-8859(00)00139-7 | - ANDERSEN-BECKH B; BINZ T; KURAZONO H; MAYER T; EISEL U; NIEMANN H, "Expression of tetanus toxin subfragments in vitro and characterization of epitopes", Infect Immun, (19890000), vol. 57, no. 11, pages 3498 - 3505 | - DIETHELM-OKITA BM; RAJU R; OKITA DK; CONTI-FINE BM, "Epitope repertoire of human CD4+ T cells on tetanus toxin: identification of immunodominant sequence segments", J Infect Dis, (19970000), vol. 175, no. 2, pages 382 - 391 | - SCHECHTER I; BERGER A, "On the size of the active site in proteases. I. Papain", BiochemBiophysResCommun, (19670000), vol. 27, no. 2, doi:doi:10.1016/S0006-291X(67)80055-X, pages 157 - 162, XP000987004 DOI: http://dx.doi.org/10.1016/S0006-291X(67)80055-X | - TURK D; GUNCAR G, "Lysosomal cysteine proteases (cathepsins): promising drug targets", Acta crystallographica Section D, Biological crystallography, (20030000), vol. 59, doi:doi:10.1107/S0907444902021479, pages 203 - 213, XP009144668 DOI: http://dx.doi.org/10.1107/S0907444902021479 | - BECK H; SCHWARZ G; SCHROTER CJ; DEEG M; BAIER D; STEVANOVIC S; WEBER E; DRIESSEN C; KALBACHER H, "Cathepsin S and an asparagine-specific endoprotease dominate the proteolytic processing of human myelin basic protein in vitro", EurJImmunol, (20010000), vol. 31, no. 12, pages 3726 - 3736 | - TURK V; STOKA V; VASILJEVA O; RENKO M; SUN T; TURK B; TURK D, "Cysteine cathepsins: from structure, function and regulation to new frontiers", BiochimBiophysActa, (20120000), vol. 1824, no. 1, doi:doi:10.1016/j.bbapap.2011.10.002, pages 68 - 88, XP028336046 DOI: http://dx.doi.org/10.1016/j.bbapap.2011.10.002 | - NIELSEN M; LUNDEGAARD C; LUND O; KESMIR C, "The role of the proteasome in generating cytotoxic T-cell epitopes: insights obtained from improved predictions of proteasomal cleavage", Immunogenetics, (20050000), vol. 57, no. 1-2, doi:doi:10.1007/s00251-005-0781-7, pages 33 - 41, XP019331607 DOI: http://dx.doi.org/10.1007/s00251-005-0781-7 | - BREMEL RD; HOMAN EJ, "An integrated approach to epitope analysis I: Dimensional reduction, visualization and prediction of MHC binding using amino acid principal components and regression approaches", ImmunomeRes, (20100000), vol. 6, no. 1, doi:doi:10.1186/1745-7580-6-7, page 7, XP021080935 DOI: http://dx.doi.org/10.1186/1745-7580-6-7 | - LARSEN JE; LUND O; NIELSEN M, "Improved method for predicting linear B-cell epitopes", ImmunomeRes, (20060000), vol. 2, doi:doi:10.1186/1745-7580-2-2, page 2, XP021019965 DOI: http://dx.doi.org/10.1186/1745-7580-2-2 | - PARKER JM; GUO D; HODGES RS, "New hydrophilicity scale derived from high-performance liquid chromatography peptide retention data: correlation of predicted surface residues with antigenicity and X-ray-derived accessible sites", Biochemistry, (19860000), vol. 25, no. 19, doi:doi:10.1021/bi00367a013, pages 5425 - 5432, XP001062495 DOI: http://dx.doi.org/10.1021/bi00367a013 | - SIMITSEK PD; CAMPBELL DG; LANZAVECCHIA A; FAIRWEATHER N; WATTS C, "Modulation of antigen processing by bound antibodies can boost or suppress class II major histocompatibility complex presentation of different T cell determinants", J Exp Med, (19950000), vol. 181, no. 6, doi:doi:10.1084/jem.181.6.1957, pages 1957 - 1963, XP009135878 DOI: http://dx.doi.org/10.1084/jem.181.6.1957 | - BATISTA FD; IBER D; NEUBERGER MS, "B cells acquire antigen from target cells after synapse formation", Nature, (20010000), vol. 411, no. 6836, pages 489 - 494 | - SLANSKY JE; JORDAN KR, "The Goldilocks model for TCR-too much attraction might not be best for vaccine design", PLoS biology, (20100000), vol. 8, no. 9 | - LANDRY SJ, "Local protein instability predictive of helper T-cell epitopes", Immunol Today, (19970000), vol. 18, no. 11, doi:doi:10.1016/S0167-5699(97)01152-3, pages 527 - 532, XP004093518 DOI: http://dx.doi.org/10.1016/S0167-5699(97)01152-3 | - MELTON SJ; LANDRY SJ, "Three dimensional structure directs T-cell epitope dominance associated with allergy", Clinical and molecular allergy : CMA, (20080000), vol. 6, doi:doi:10.1186/1476-7961-6-9, page 9, XP021043810 DOI: http://dx.doi.org/10.1186/1476-7961-6-9 | - VAN REGENMORTEL MH, "What is a B-cell epitope?", Methods MolBiol, (20090000), vol. 524, pages 3 - 20 | - HOMAN EJ; BREMEL RD, "Patterns of Predicted T-Cell Epitopes Associated with Antigenic Drift in Influenza H3N2 Hemagglutinin", PLoSOne, (20110000), vol. 6, no. 10, page e26711 | - ROCK KL; YORK IA; SARIC T; GOLDBERG AL, "Protein degradation and the generation of MHC class I-presented peptides", Advances in immunology, (20020000), vol. 80, pages 1 - 70 | - BRYANT PW; LENNON-DUMENIL AM; FIEBIGER E; LAGAUDRIERE-GESBERT C; PLOEGH HL, "Proteolysis and antigen presentation by MHC class II molecules", Advances in immunology, (20020000), vol. 80, pages 71 - 114 | - STORM VAN'S GRAVESANDE K; LAYNE MD; YE Q; LE L; BARON RM; PERRELLA MA; SANTAMBROGIO L; SILVERMAN ES; RIESE RJ, "IFN regulatory factor-1 regulates IFN-gamma-dependent cathepsin S expression", J Immunol, (20020000), vol. 168, no. 9, pages 4488 - 4494 | - JOHNSON NL, "Systems of frequency curves generated by methods of translation", Biometrika, (19490000), vol. 36, no. 1-2, pages 149 - 176 | - WARD JH, "Hierarchical Grouping to Optimize an Objective Function", JAmStatAssoc, (19630000), vol. 48, pages 236 - 244, XP009036875 | WO1986US02269 | US20070844837 | US20080254500 | US20090536291 | US20090545601 |