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Extract from the Register of European Patents

EP About this file: EP2758565

EP2758565 - CELL SURFACE DISPLAY OF LIGANDS FOR THE INSULIN AND/OR INSULIN GROWTH FACTOR 1 RECEPTOR AND APPLICATIONS THEREOF [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  29.01.2016
Database last updated on 19.10.2024
Most recent event   Tooltip29.01.2016Application deemed to be withdrawnpublished on 02.03.2016  [2016/09]
Applicant(s)For all designated states
Merck Sharp & Dohme Corp.
126 East Lincoln Avenue
Rahway, NJ 07065-0907 / US
[2014/31]
Inventor(s)01 / CHEN, Ming-Tang
21 Lafayette Street
Suite 200
Lebanon New Hampshire 03766 / US
02 / CHOI, Byung-Kwon
21 Lafayette Street
Suite 200
Lebanon New Hampshire 03766 / US
03 / SETHURMAN, Natarajan
21 Lafayette Street
Suite 200
Lebanon New Hampshire 03766 / US
04 / STADHEIM, Terrance
21 Lafayette Street
Suite 200
Lebanon New Hampshire 03766 / US
05 / ZHA, Dongxing
21 Lafayette Street
Suite 200
Lebanon, New Hampshire 03766 / US
06 / SHAHEEN, Hussam Hisham
21 Lafayette Street
Suite 200
Lebanon New Hampshire 03766 / US
07 / LIN, Song
21 Lafayette Street
Suite 200
Lebanon New Hampshire 03766 / US
 [2014/31]
Representative(s)Böhles, Elena
Merck Sharp & Dohme (UK) Limited
120 Moorgate
London EC2M 6UR / GB
[N/P]
Former [2014/31]Böhles, Elena
Merck Sharp & Dohme Limited
Hertford Road
Hoddesdon, Herts EN11 9BU / GB
Application number, filing date12834491.818.09.2012
WO2012US55889
Priority number, dateUS201161538378P23.09.2011         Original published format: US 201161538378 P
[2014/31]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2013043582
Date:28.03.2013
Language:EN
[2013/13]
Type: A1 Application with search report 
No.:EP2758565
Date:30.07.2014
Language:EN
The application published by WIPO in one of the EPO official languages on 28.03.2013 takes the place of the publication of the European patent application.
[2014/31]
Search report(s)International search report - published on:US28.03.2013
(Supplementary) European search report - dispatched on:EP02.02.2015
ClassificationIPC:C40B40/02, G01N33/567, G01N33/569, G01N33/50, G01N33/74, C12N15/10
[2015/10]
CPC:
C12N15/1037 (EP,US); G01N33/74 (US); C40B40/02 (EP,US);
G01N33/5023 (EP,US); G01N2333/62 (US); G01N2333/71 (EP,US);
G01N2333/72 (EP,US) (-)
Former IPC [2014/31]C40B40/02, G01N33/567, G01N33/569
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/31]
TitleGerman:ZELLOBERFLÄCHENANZEIGE VON LIGANDEN FÜR INSULIN UND/ODER DES INSULIN-WACHSTUMSFAKTOR 1-REZEPTORS UND ANWENDUNGEN DAVON[2014/31]
English:CELL SURFACE DISPLAY OF LIGANDS FOR THE INSULIN AND/OR INSULIN GROWTH FACTOR 1 RECEPTOR AND APPLICATIONS THEREOF[2014/31]
French:AFFICHAGE DE SURFACE CELLULAIRE DE LIGANDS POUR L'INSULINE ET/OU LE RÉCEPTEUR DU FACTEUR DE CROISSANCE-1 ANALOGUE À L'INSULINE ET APPLICATIONS CORRESPONDANTES[2014/31]
Entry into regional phase23.04.2014National basic fee paid 
23.04.2014Search fee paid 
23.04.2014Designation fee(s) paid 
23.04.2014Examination fee paid 
Examination procedure10.04.2014Amendment by applicant (claims and/or description)
23.04.2014Examination requested  [2014/31]
02.09.2015Application deemed to be withdrawn, date of legal effect  [2016/09]
09.10.2015Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2016/09]
Fees paidRenewal fee
08.09.2014Renewal fee patent year 03
08.09.2015Renewal fee patent year 04
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Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Documents cited:Search[IY]WO03072014  (MPEX BIOSCIENCE INC [US], et al) [I] 1,2,4-16,18,19,21-25,28-31 * page 4, lines 15-19; claims 13,137 * * page 186, lines 19-23 * * page 189, line 5 * * page 189, line 16 * * page 170, lines 19-23 * * page 171, lines 18-30 * [Y] 3,17,20,26,27;
 [Y]WO2008118476  (CODON DEVICES INC [US], et al) [Y] 1,2,4-16,18,19,21-25,28-31 * claims 1-16 *;
 [Y]WO2009111183  (GLYCOFI INC [US], et al) [Y] 3,17,20,26,27 * claims 6,7,9 *;
 [Y]  - BURTRUM D ET AL, "A fully human monoclonal antibody to the insulin-like growth factor I receptor blocks ligand-dependent signaling and inhibits human tumor growth in vivo", CANCER RESEARCH, AMERICAN ASSOCIATION FOR CANCER RESEARCH, US, (20031215), vol. 63, no. 24, ISSN 0008-5472, pages 8912 - 8921, XP002316542 [Y] 1,2,4-16,18,19,21-25,28-31 * abstract *
 [Y]  - RUBEN J. BOADO ET AL, "Genetic Engineering, Expression, and Activity of a Chimeric Monoclonal Antibody-Avidin Fusion Protein for Receptor-Mediated Delivery of Biotinylated Drugs in Humans", BIOCONJUGATE CHEMISTRY, (20080301), vol. 19, no. 3, doi:10.1021/bc7004076, ISSN 1043-1802, pages 731 - 739, XP055088923 [Y] 1,2,4-16,18,19,21-25,28-31 * abstract *

DOI:   http://dx.doi.org/10.1021/bc7004076
 [A]  - HOFMANN F ET AL, "Blocking the insulin-like growth factor-I receptor as a strategy for targeting cancer", DRUG DISCOVERY TODAY, ELSEVIER, RAHWAY, NJ, US, vol. 10, no. 15, ISSN 1359-6446, (20050801), pages 1041 - 1047, (20050801), XP027684820 [A] 1-31 * abstract *
International search[Y]US2009017496  (MA YANGAO [CN], et al);
 [Y]US2009053807  (PILLUTLA RENUKA [US], et al);
 [Y]US2010331192  (ZHA DONGXING [US], et al);
 [A]  - WENTZ ET AL., "A Novel High-Throughput Screen Reveals Yeast Genes That Increase Secretion of Heterologous Proteins.", APPL ENVIRON MICROBIOL., (2007), vol. 73, no. 4, pages 1189 - 98, XP055148380

DOI:   http://dx.doi.org/10.1128/AEM.02427-06
 [A]  - KJELDSEN ET AL., "Engineering-enhanced protein secretory expression in yeast with application to insulin.", J. BIOL. CHEM., (2002), vol. 277, no. 21, pages 18245 - 18248, XP002284856

DOI:   http://dx.doi.org/10.1074/jbc.C200137200
 [A]  - ARCELLONI ET AL., "Processing and release of human proinsulin-cleavage products into culture media by different engineered non-endocrine cells: a specific assessment by capillary electrophoresis.", J ENDOCRINOL., (2000), vol. 166, no. 2, pages 437 - 45, XP055148381

DOI:   http://dx.doi.org/10.1677/joe.0.1660437
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