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Extract from the Register of European Patents

EP About this file: EP2763674

EP2763674 - SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF CANCERS, INCLUDING HEPATOCELLULAR CARCINOMA, AND AS INHIBITORS OF HEPATITIS VIRUS REPLICATION [Right-click to bookmark this link]
StatusThe application is deemed to be withdrawn
Status updated on  13.01.2017
Database last updated on 19.10.2024
Most recent event   Tooltip13.01.2017Application deemed to be withdrawnpublished on 15.02.2017  [2017/07]
Applicant(s)For all designated states
Baruch S. Blumberg Institute
The Pennsylvania Biotechnology Center
3805 Old Easton Road
Doylestown PA 18902 / US
For all designated states
Drexel University
3141 Chestnut Street Philadelphia
Pennsylvania 19104 / US
[2015/23]
Former [2014/33]For all designated states
Institute for Hepatitis and Virus Research
The Pennsylvania Biotechnology Center
3805 Old Easton Road
Doylestown, PA 18902 / US
Inventor(s)01 / CUCONATI, Andrea
204 Weldy Avenue
Oreland, PA 19075 / US
02 / XU, Xiaodong
4564 Summer Hill Drive
Doylestown, PA 18902 / US
03 / BLOCK, Timothy, M.
80 Foxcroft Drive
Doylestown, PA 18901 / US
 [2014/33]
Representative(s)Kelly, Donal Morgan
FRKelly
27 Clyde Road
Dublin D04 F838 / IE
[N/P]
Former [2014/33]Kelly, Donal Morgan
FRKelly
27 Clyde Road
Dublin 4 / IE
Application number, filing date12838333.804.10.2012
WO2012US58674
Priority number, dateUS201161542907P04.10.2011         Original published format: US 201161542907 P
[2014/33]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2013052613
Date:11.04.2013
Language:EN
[2013/15]
Type: A1 Application with search report 
No.:EP2763674
Date:13.08.2014
Language:EN
The application published by WIPO in one of the EPO official languages on 11.04.2013 takes the place of the publication of the European patent application.
[2014/33]
Search report(s)International search report - published on:US11.04.2013
(Supplementary) European search report - dispatched on:EP26.03.2015
ClassificationIPC:A61K31/425, A61K31/426, C07D417/04, C07D417/12, A61K31/427, A61P35/00, A61P31/12, C07D277/42, C07D417/14, C07D487/04, C07D495/04
[2015/17]
CPC:
C07D417/14 (EP,US); A61K31/425 (EP,US); A61K31/426 (EP,US);
A61P1/16 (EP); A61P31/12 (EP); A61P31/14 (EP);
A61P31/20 (EP); A61P35/00 (EP); A61P35/02 (EP);
A61P35/04 (EP); A61P43/00 (EP); C07D277/42 (EP,US);
C07D417/04 (EP,US); C07D417/12 (EP,US); C07D487/04 (EP,US);
C07D495/04 (EP,US); Y02A50/30 (EP,US) (-)
Former IPC [2015/15]A61K31/425, A61K31/426, C07D417/00, C07D417/02, A61K31/427, A61P35/00, A61P31/12
Former IPC [2014/33]A61K31/425, A61K31/426, C07D417/00, C07D417/02
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/33]
TitleGerman:SUBSTITUIERTE AMINOTHIAZOLE ALS HEMMER VON KREBSZELLEN EINSCHLIESSLICH HEPATOZELLULÄRER KARZINOME UND ALS HEPATITIS-VIRUS-REPLIKATIONSHEMMER[2014/33]
English:SUBSTITUTED AMINOTHIAZOLES AS INHIBITORS OF CANCERS, INCLUDING HEPATOCELLULAR CARCINOMA, AND AS INHIBITORS OF HEPATITIS VIRUS REPLICATION[2014/33]
French:AMINOTHIAZOLES SUBSTITUÉS EN TANT QU'INHIBITEURS DE CANCERS, NOTAMMENT LE CARCINOME HÉPATOCELLULAIRE, ET EN TANT QU'INHIBITEURS DE LA RÉPLICATION DU VIRUS DE L'HÉPATITE[2014/33]
Entry into regional phase06.05.2014National basic fee paid 
06.05.2014Search fee paid 
06.05.2014Designation fee(s) paid 
06.05.2014Examination fee paid 
Examination procedure06.05.2014Examination requested  [2014/33]
12.10.2015Amendment by applicant (claims and/or description)
01.03.2016Despatch of a communication from the examining division (Time limit: M06)
13.09.2016Application deemed to be withdrawn, date of legal effect  [2017/07]
11.10.2016Despatch of communication that the application is deemed to be withdrawn, reason: reply to the communication from the examining division not received in time  [2017/07]
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  01.03.2016
Fees paidRenewal fee
25.09.2014Renewal fee patent year 03
12.10.2015Renewal fee patent year 04
Penalty fee
Additional fee for renewal fee
31.10.201605   M06   Not yet paid
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Documents cited:Search[XY]WO03015773  (JANSSEN PHARMACEUTICA NV [BE], et al) [X] 1-5,9-13 * page 25, lines 24, 34-37 - page 26, lines 1-3; examples 38, 39, 54 * [Y] 1-13;
 [XY]WO2005099673  (ICAGEN INC [US], et al) [X] 1-5,9-13 * page 3, line 14; page 6, line 8; page 27, line 10; claim 20;; compounds 9.2t, 9.2w, 9.2x, 9.2y, 9.2aa, 11.2a * [Y] 1-13;
 [XY]WO2007103550  (ACHILLION PHARMACEUTICALS INC [US], et al) [X] 1-5,9-13 * paragraphs [0153] , [0188]; claim - * [Y] 1-13;
 [XY]WO2008083098  (UNIV JOHNS HOPKINS [US], et al) [X] 1-5,9-13 * paragraphs [0011] , [0017] , [0082] , [0083]; compounds (I), (II) * [Y] 1-13;
 [XY]WO2009114552  (UNIV LELAND STANFORD JUNIOR [US], et al) [X] 1-5,9-13 * paragraphs [0202] - [0205]; table 1; compounds 3,13,73 * [Y] 1-13;
 [XY]WO2010111711  (ZACHARON PHARMACEUTICALS INC [US], et al) [X] 1-5,9-13 * paragraphs [00188] , [00189]; figure 36A * [Y] 1-13;
 [XY]  - HAY, MICHAEL P. ET AL, "4-Pyridylanilinothiazoles That Selectively Target von Hippel-Lindau Deficient Renal Cell Carcinoma Cells by Inducing Autophagic Cell Death", JOURNAL OF MEDICINAL CHEMISTRY, (2010), vol. 53, no. 2, doi:10.1021/JM901457W, pages 787 - 797, XP002736467 [X] 1-5,9-13 * compounds 1, 9, 56, 80 * [Y] 1-13

DOI:   http://dx.doi.org/10.1021/JM901457W 10.1021/JM901457W
 [AP]  - DIGHE, SATISH N. ET AL, "A remarkably high-speed solution-phase combinatorial synthesis of 2-substituted-amino-4-aryl thiazoles in polar solvents in the absence of a catalyst under ambient conditions and study of their antimicrobial activities", ISRN ORGANIC CHEMISTRY 434613, 6 PP. CODEN: IOCSBF; ISSN: 2090-5157 URL: HTTP://DOWNLOADS.HINDAWI.COM/ISRN/OC/2011/434613.PDF, (2011), vol. 2011, no. 434613, doi:10.5402/2011/434613, XP002736468 [AP] 1-13 * compound thiazole 3b (disclaimed);; table 3 *

DOI:   http://dx.doi.org/10.5402/2011/434613 10.5402/2011/434613
International search[X]US2005227989  (WANG XIAODONG [US], et al);
 [A]US2007203147  (COBURN CRAIG A [US], et al);
 [X]US2007213301  (ZHANG SOUMING [US], et al)
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.