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Extract from the Register of European Patents

EP About this file: EP2776404

EP2776404 - HETEROCYCLIC ANALOGS OF PROPARGYL-LINKED INHIBITORS OF DIHYDROFOLATE REDUCTASE [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  12.05.2017
Database last updated on 26.07.2024
Most recent event   Tooltip12.10.2018Lapse of the patent in a contracting state
New state(s): AL		published on 14.11.2018  [2018/46]
Applicant(s)For all designated states
University of Connecticut
400 Farmington Avenue
MC6400
Farmington, CT 06032 / US
[2016/46]
Former [2014/38]For all designated states
University of Connecticut
263 Farmington Avenue
Farmington, CT 06030-6207 / US
Inventor(s)01 / ANDERSON, Amy, C.
166 Baxter Road
Storrs, CT 06268 / US
02 / WRIGHT, Dennis, L.
166 Baxter Road
Storrs, CT 06268 / US
03 / FREY, Kathleen, M.
324 Saint John Street
Unit 1
New Haven, CT 06511 / US
04 / PAULSEN, Janet, L.
47 B Esquire Drive
Manchester, CT 06042 / US
05 / SCOCCHERA, Eric, W.
35a Mount Vernon Drive
Vernon, CT 06066 / US
06 / VISWANATHAN, Kishore
526 Storrs Road Apt.4
Storrs, CT / US
 [2014/38]
Representative(s)Calamita, Roberto
Dehns
St Bride's House
10 Salisbury Square
London
EC4Y 8JD / GB
[2014/38]
Application number, filing date12846926.906.11.2012
[2016/27]
WO2012US63729
Priority number, dateUS20111329074107.11.2011         Original published format: US201113290741
[2014/38]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2013070620
Date:16.05.2013
Language:EN
[2013/20]
Type: A1 Application with search report 
No.:EP2776404
Date:17.09.2014
Language:EN
The application published by WIPO in one of the EPO official languages on 16.05.2013 takes the place of the publication of the European patent application.
[2014/38]
Type: B1 Patent specification 
No.:EP2776404
Date:06.07.2016
Language:EN
[2016/27]
Search report(s)International search report - published on:KR16.05.2013
(Supplementary) European search report - dispatched on:EP10.03.2015
ClassificationIPC:C07D239/42, C07D239/48, C07D401/10, C07D403/10, C07D413/10, C07D487/10, C07D491/107, A61K31/505, A61P35/00
[2015/15]
CPC:
C07D239/42 (EP,US); A61P31/04 (EP); A61P31/10 (EP);
A61P33/02 (EP); A61P35/00 (EP); A61P43/00 (EP);
C07D239/48 (EP,US); C07D401/10 (EP,US); C07D403/10 (EP,US);
C07D413/10 (EP,US); C07D487/10 (EP,US); C07D491/107 (EP,US);
Y02A50/30 (US) (-)
Former IPC [2014/38]C07D239/32, C07D401/06, A61K31/505, A61P35/00
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/38]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:HETEROCYCLISCHE ANALOGA VON PROPARGYL-LINKED INHIBITOREN DER DIHYDROFOLATREDUKTASE[2014/38]
English:HETEROCYCLIC ANALOGS OF PROPARGYL-LINKED INHIBITORS OF DIHYDROFOLATE REDUCTASE[2014/38]
French:ANALOGUE HÉTÉROCYCLIQUE D'INHIBITEURS DU DIHYDROFOLATE LIÉS À PROPARGYLE RÉDUCTASE[2014/38]
Entry into regional phase16.05.2014National basic fee paid 
16.05.2014Search fee paid 
16.05.2014Designation fee(s) paid 
16.05.2014Examination fee paid 
Examination procedure16.05.2014Examination requested  [2014/38]
06.10.2015Amendment by applicant (claims and/or description)
04.01.2016Communication of intention to grant the patent
30.03.2016Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
30.03.2016Fee for grant paid
30.03.2016Fee for publishing/printing paid
11.05.2016Communication of intention to grant the patent
25.05.2016Fee for grant paid
25.05.2016Fee for publishing/printing paid
25.05.2016Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  04.01.2016
Opposition(s)07.04.2017No opposition filed within time limit [2017/24]
Fees paidRenewal fee
01.09.2014Renewal fee patent year 03
16.11.2015Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU06.11.2012
AL06.07.2016
AT06.07.2016
BE06.07.2016
CY06.07.2016
CZ06.07.2016
EE06.07.2016
FI06.07.2016
HR06.07.2016
LT06.07.2016
LV06.07.2016
MC06.07.2016
MK06.07.2016
NL06.07.2016
PL06.07.2016
RO06.07.2016
RS06.07.2016
SE06.07.2016
SI06.07.2016
SK06.07.2016
SM06.07.2016
TR06.07.2016
BG06.10.2016
NO06.10.2016
IE06.11.2016
IS06.11.2016
MT06.11.2016
PT07.11.2016
LU30.11.2016
[2018/46]
Former [2018/45]HU06.11.2012
AT06.07.2016
BE06.07.2016
CY06.07.2016
CZ06.07.2016
EE06.07.2016
FI06.07.2016
HR06.07.2016
LT06.07.2016
LV06.07.2016
MC06.07.2016
MK06.07.2016
NL06.07.2016
PL06.07.2016
RO06.07.2016
RS06.07.2016
SE06.07.2016
SI06.07.2016
SK06.07.2016
SM06.07.2016
TR06.07.2016
BG06.10.2016
NO06.10.2016
IE06.11.2016
IS06.11.2016
MT06.11.2016
PT07.11.2016
LU30.11.2016
Former [2018/43]HU06.11.2012
AT06.07.2016
BE06.07.2016
CY06.07.2016
CZ06.07.2016
EE06.07.2016
FI06.07.2016
HR06.07.2016
LT06.07.2016
LV06.07.2016
MC06.07.2016
MK06.07.2016
NL06.07.2016
PL06.07.2016
RO06.07.2016
RS06.07.2016
SE06.07.2016
SI06.07.2016
SK06.07.2016
SM06.07.2016
BG06.10.2016
NO06.10.2016
IE06.11.2016
IS06.11.2016
MT06.11.2016
PT07.11.2016
LU30.11.2016
Former [2018/34]HU06.11.2012
AT06.07.2016
BE06.07.2016
CY06.07.2016
CZ06.07.2016
EE06.07.2016
FI06.07.2016
HR06.07.2016
LT06.07.2016
LV06.07.2016
MC06.07.2016
MK06.07.2016
NL06.07.2016
PL06.07.2016
RO06.07.2016
RS06.07.2016
SE06.07.2016
SI06.07.2016
SK06.07.2016
SM06.07.2016
BG06.10.2016
NO06.10.2016
IE06.11.2016
IS06.11.2016
PT07.11.2016
LU30.11.2016
Former [2018/30]HU06.11.2012
AT06.07.2016
BE06.07.2016
CY06.07.2016
CZ06.07.2016
EE06.07.2016
FI06.07.2016
HR06.07.2016
LT06.07.2016
LV06.07.2016
MC06.07.2016
MK06.07.2016
NL06.07.2016
PL06.07.2016
RO06.07.2016
RS06.07.2016
SE06.07.2016
SI06.07.2016
SK06.07.2016
SM06.07.2016
BG06.10.2016
NO06.10.2016
IE06.11.2016
IS06.11.2016
PT07.11.2016
LU30.11.2016
Former [2017/51]AT06.07.2016
BE06.07.2016
CZ06.07.2016
EE06.07.2016
FI06.07.2016
HR06.07.2016
LT06.07.2016
LV06.07.2016
NL06.07.2016
PL06.07.2016
RO06.07.2016
RS06.07.2016
SE06.07.2016
SI06.07.2016
SK06.07.2016
SM06.07.2016
BG06.10.2016
NO06.10.2016
IE06.11.2016
IS06.11.2016
PT07.11.2016
LU30.11.2016
Former [2017/45]AT06.07.2016
BE06.07.2016
CZ06.07.2016
EE06.07.2016
FI06.07.2016
HR06.07.2016
LT06.07.2016
LV06.07.2016
NL06.07.2016
PL06.07.2016
RO06.07.2016
RS06.07.2016
SE06.07.2016
SI06.07.2016
SK06.07.2016
SM06.07.2016
BG06.10.2016
NO06.10.2016
IS06.11.2016
PT07.11.2016
LU30.11.2016
Former [2017/37]AT06.07.2016
BE06.07.2016
CZ06.07.2016
EE06.07.2016
FI06.07.2016
HR06.07.2016
LT06.07.2016
LV06.07.2016
NL06.07.2016
PL06.07.2016
RO06.07.2016
RS06.07.2016
SE06.07.2016
SI06.07.2016
SK06.07.2016
SM06.07.2016
BG06.10.2016
NO06.10.2016
IS06.11.2016
PT07.11.2016
Former [2017/31]AT06.07.2016
BE06.07.2016
CZ06.07.2016
EE06.07.2016
FI06.07.2016
HR06.07.2016
LT06.07.2016
LV06.07.2016
NL06.07.2016
PL06.07.2016
RO06.07.2016
RS06.07.2016
SE06.07.2016
SK06.07.2016
SM06.07.2016
BG06.10.2016
NO06.10.2016
IS06.11.2016
PT07.11.2016
Former [2017/13]AT06.07.2016
BE06.07.2016
FI06.07.2016
HR06.07.2016
LT06.07.2016
LV06.07.2016
NL06.07.2016
PL06.07.2016
RS06.07.2016
SE06.07.2016
NO06.10.2016
IS06.11.2016
PT07.11.2016
Former [2017/11]AT06.07.2016
BE06.07.2016
FI06.07.2016
HR06.07.2016
LT06.07.2016
NL06.07.2016
PL06.07.2016
RS06.07.2016
SE06.07.2016
NO06.10.2016
IS06.11.2016
PT07.11.2016
Former [2017/10]BE06.07.2016
FI06.07.2016
HR06.07.2016
LT06.07.2016
NL06.07.2016
PL06.07.2016
RS06.07.2016
SE06.07.2016
NO06.10.2016
IS06.11.2016
Former [2017/09]FI06.07.2016
LT06.07.2016
NL06.07.2016
NO06.10.2016
Former [2017/07]LT06.07.2016
Documents cited:Search[XP]  - ZHOU ET AL., "Acetylenic Linkers in Lead Compounds: A Study of the Stability of the Propargyl-Linked Antifolates", DRUG METABOLISM AND DISPOSITION, (20120718), vol. 40, no. 10, doi:10.1124/dmd.112.046870, pages 2002 - 2008, XP055171404 [XP] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1124/dmd.112.046870
 [XP]  - FREY ET AL., "Prospective Screening of Novel Antibacterial Inhibitors of Dihydrofolate Reductase for Mutational Resistance", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, (20120409), vol. 56, no. 7, doi:10.1128/AAC.06263-11, ISSN 0066-4804, pages 3556 - 3562, XP055171407 [XP] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1128/AAC.06263-11
 [XP]  - VISWANATHAN ET AL., "Toward New Therapeutics for Skin and Soft Tissue Infections: Propargyl-Linked Antifolates Are Potent Inhibitors of MRSA and Streptococcus pyogenes", PLOS ONE, (20120207), vol. 7, no. 2, doi:10.1371/journal.pone.0029434, page e29434, XP055171409 [XP] 1-15 * the whole document *

DOI:   http://dx.doi.org/10.1371/journal.pone.0029434
International search[A]WO2009025919  (UNIV CONNECTICUT [US], et al);
 [A]US2009105287  (ANDERSON AMY C [US], et al);
 [A]  - JENNIFER M. BEIERLEIN ET AL., "Targeted Mutations of Bacillus anthracis Dihy drofolate Reductase Condense Complex Structure-Activity Relationships.", JOURN AL OF MEDICINAL CHEMISTRY., (20101028), vol. 53, no. 20, pages 7327 - 7336, XP055150034

DOI:   http://dx.doi.org/10.1021/jm100727t
 [A]  - JIEYING LIU ET AL., "Towards New Antifolates Targeting Eukaryotic Opportunis tic Infections.", EUKARYOTIC CELL., (200904), vol. 8, no. 4, pages 483 - 486, XP055150036

DOI:   http://dx.doi.org/10.1128/EC.00298-08
 [A]  - DAVID B. BOLSTAD ET AL., "Structure-Based Approach to the Development of Pot ent and Selective Inhibitors of Dihydrofolate Reductase from Cryptosporidium .", JOURNAL OF MEDICINAL CHEMISTRY, (20081113), vol. 51, no. 21, pages 6839 - 6852, XP055150039

DOI:   http://dx.doi.org/10.1021/jm8009124
Examination   - ANONYMOUS, "Sulfonamides", DRUGS.COM, pages 1 - 2, Drugs.com, URL: www.drugs.com/drug-class/sulfonamides.html
    - The Penguin Dictionary of Chemistry: entry sulpha drugs, London, Penguin Group, (2003), pages 378 - 379, ISBN 9780140514452
by applicantWO2009025919
 US2009105287
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.