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Extract from the Register of European Patents

EP About this file: EP2811015

EP2811015 - CULTURE-MEDIUM COMPOSITION FOR REJUVENATING STEM CELLS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  09.07.2021
Database last updated on 17.05.2024
FormerThe patent has been granted
Status updated on  31.07.2020
FormerGrant of patent is intended
Status updated on  06.04.2020
FormerExamination is in progress
Status updated on  03.01.2017
Most recent event   Tooltip22.07.2022Lapse of the patent in a contracting state
New state(s): BE
published on 24.08.2022  [2022/34]
Applicant(s)For all designated states
R Bio Co., Ltd.
10, Gukhoe-daero 76-gil
Yeongdeungpo-gu
Seoul
150-870 / KR
[2016/24]
Former [2014/50]For all designated states
K-Stemcell Co., Ltd.
10, Gukhoe-daero 76-gil
Yeongdeungpo-gu
Seoul 150-870 / KR
Inventor(s)01 / KANG, Sung Keun
116-504 Gwanakdreamtown Apt.
Sunghyun-dong
Gwanak-gu
Seoul 151-770 / KR
02 / RA, Jeong Chan
626-701 Shungsol maeul SKhanhwa Apt.
918 Jungja-dong
Jangan-gu
Suwon-si Gyeonggi-do 440-300 / KR
03 / PARK, Hyeong Geun
106-601 Chunchunpurugio Apt.
chunchun-dong
Jangan-gu
Suwon-si Gyeonggi-do 440-330 / KR
04 / LEE, Hang Young
526-1803 Beakseolmaeul Jinro Apt.
Jungja-dong
Jangan-gu
Suwon-si Gyeonggi-do 440-300 / KR
 [2014/50]
Representative(s)Ladendorf, Oliver
Kraus & Weisert
Patentanwälte PartGmbB
Thomas-Wimmer-Ring 15
80539 München / DE
[2014/50]
Application number, filing date12852618.303.12.2012
[2020/36]
WO2012KR10380
Priority number, dateKR2011012788501.12.2011         Original published format: KR 20110127885
[2014/50]
Filing languageKO
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2013081436
Date:06.06.2013
Language:KO
[2013/23]
Type: A1 Application with search report 
No.:EP2811015
Date:10.12.2014
Language:EN
[2014/50]
Type: B1 Patent specification 
No.:EP2811015
Date:02.09.2020
Language:EN
[2020/36]
Search report(s)International search report - published on:KR06.06.2013
(Supplementary) European search report - dispatched on:EP18.12.2014
ClassificationIPC:C12N5/02, C12N5/0775, C12N1/38
[2014/50]
CPC:
C12N5/0667 (EP,US); C12N5/00 (KR); C12N1/38 (KR);
C12N5/06 (KR); C12N2500/90 (EP,US); C12N2501/11 (EP,US);
C12N2501/115 (EP,US); C12N2501/33 (EP,US); C12N2501/39 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/50]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:KULTURMEDIENZUSAMMENSETZUNG ZUR VERJÜNGUNG VON STAMMZELLEN[2014/50]
English:CULTURE-MEDIUM COMPOSITION FOR REJUVENATING STEM CELLS[2014/50]
French:COMPOSITION DE MILIEU DE CULTURE POUR RAJEUNIR DES CELLULES SOUCHES[2014/50]
Entry into regional phase27.05.2014Translation filed 
27.05.2014National basic fee paid 
27.05.2014Search fee paid 
27.05.2014Designation fee(s) paid 
27.05.2014Examination fee paid 
Examination procedure27.05.2014Examination requested  [2014/50]
02.07.2015Amendment by applicant (claims and/or description)
24.07.2015Despatch of a communication from the examining division (Time limit: M04)
30.09.2015Reply to a communication from the examining division
20.11.2015Despatch of a communication from the examining division (Time limit: M04)
16.03.2016Reply to a communication from the examining division
29.08.2016Despatch of a communication from the examining division (Time limit: M04)
21.12.2016Reply to a communication from the examining division
11.10.2017Despatch of a communication from the examining division (Time limit: M04)
12.02.2018Reply to a communication from the examining division
18.12.2018Despatch of a communication from the examining division (Time limit: M04)
17.04.2019Reply to a communication from the examining division
07.04.2020Communication of intention to grant the patent
23.07.2020Fee for grant paid
23.07.2020Fee for publishing/printing paid
23.07.2020Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  24.07.2015
Opposition(s)03.06.2021No opposition filed within time limit [2021/32]
Fees paidRenewal fee
28.11.2014Renewal fee patent year 03
28.12.2015Renewal fee patent year 04
30.11.2016Renewal fee patent year 05
29.12.2017Renewal fee patent year 06
29.11.2018Renewal fee patent year 07
20.12.2019Renewal fee patent year 08
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See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU03.12.2012
AL02.09.2020
AT02.09.2020
CY02.09.2020
CZ02.09.2020
DK02.09.2020
EE02.09.2020
FI02.09.2020
HR02.09.2020
IT02.09.2020
LT02.09.2020
LV02.09.2020
MC02.09.2020
MK02.09.2020
MT02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IE03.12.2020
LU03.12.2020
BE31.12.2020
CH31.12.2020
LI31.12.2020
IS02.01.2021
PT04.01.2021
[2022/34]
Former [2022/32]HU03.12.2012
AL02.09.2020
AT02.09.2020
CY02.09.2020
CZ02.09.2020
DK02.09.2020
EE02.09.2020
FI02.09.2020
HR02.09.2020
IT02.09.2020
LT02.09.2020
LV02.09.2020
MC02.09.2020
MK02.09.2020
MT02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IE03.12.2020
LU03.12.2020
CH31.12.2020
LI31.12.2020
IS02.01.2021
PT04.01.2021
Former [2022/27]HU03.12.2012
AL02.09.2020
AT02.09.2020
CY02.09.2020
CZ02.09.2020
DK02.09.2020
EE02.09.2020
FI02.09.2020
HR02.09.2020
IT02.09.2020
LT02.09.2020
LV02.09.2020
MC02.09.2020
MT02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IE03.12.2020
LU03.12.2020
CH31.12.2020
LI31.12.2020
IS02.01.2021
PT04.01.2021
Former [2021/52]AL02.09.2020
AT02.09.2020
CZ02.09.2020
DK02.09.2020
EE02.09.2020
FI02.09.2020
HR02.09.2020
IT02.09.2020
LT02.09.2020
LV02.09.2020
MC02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IE03.12.2020
LU03.12.2020
CH31.12.2020
LI31.12.2020
IS02.01.2021
PT04.01.2021
Former [2021/48]AL02.09.2020
AT02.09.2020
CZ02.09.2020
DK02.09.2020
EE02.09.2020
FI02.09.2020
HR02.09.2020
IT02.09.2020
LT02.09.2020
LV02.09.2020
MC02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IE03.12.2020
LU03.12.2020
IS02.01.2021
PT04.01.2021
Former [2021/47]AL02.09.2020
AT02.09.2020
CZ02.09.2020
DK02.09.2020
EE02.09.2020
FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
MC02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IE03.12.2020
LU03.12.2020
IS02.01.2021
PT04.01.2021
Former [2021/46]AL02.09.2020
AT02.09.2020
CZ02.09.2020
DK02.09.2020
EE02.09.2020
FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
MC02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IE03.12.2020
IS02.01.2021
PT04.01.2021
Former [2021/40]AL02.09.2020
AT02.09.2020
CZ02.09.2020
DK02.09.2020
EE02.09.2020
FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
MC02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
Former [2021/37]AL02.09.2020
AT02.09.2020
CZ02.09.2020
DK02.09.2020
EE02.09.2020
FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
Former [2021/36]AL02.09.2020
AT02.09.2020
CZ02.09.2020
EE02.09.2020
FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SI02.09.2020
SK02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
Former [2021/28]AL02.09.2020
AT02.09.2020
CZ02.09.2020
EE02.09.2020
FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SK02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
Former [2021/25]AL02.09.2020
AT02.09.2020
CZ02.09.2020
EE02.09.2020
FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
IS02.01.2021
PT04.01.2021
Former [2021/24]AT02.09.2020
CZ02.09.2020
EE02.09.2020
FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
PT04.01.2021
Former [2021/23]CZ02.09.2020
EE02.09.2020
FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
SM02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
PT04.01.2021
Former [2021/22]CZ02.09.2020
EE02.09.2020
FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
NL02.09.2020
PL02.09.2020
RO02.09.2020
RS02.09.2020
SE02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
PT04.01.2021
Former [2021/21]FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
NL02.09.2020
PL02.09.2020
RS02.09.2020
SE02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
PT04.01.2021
Former [2021/18]FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
NL02.09.2020
PL02.09.2020
RS02.09.2020
SE02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
Former [2021/10]FI02.09.2020
HR02.09.2020
LT02.09.2020
LV02.09.2020
PL02.09.2020
RS02.09.2020
SE02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
Former [2021/09]FI02.09.2020
LT02.09.2020
SE02.09.2020
BG02.12.2020
NO02.12.2020
GR03.12.2020
Former [2021/08]FI02.09.2020
LT02.09.2020
SE02.09.2020
BG02.12.2020
NO02.12.2020
Former [2021/07]FI02.09.2020
LT02.09.2020
NO02.12.2020
Documents cited:Search[XP]WO2012074265  (RNL BIO CO LTD [KR], et al) [XP] 1-6,8 * the whole document *;
 [A]WO2007145438  (RNL BIO CO LTD [KR], et al) [A] 1-8;
 [AP]  - MADONNA R ET AL, "Mesenchymal stem cells rejuvenation afforded by human telomerase gene transfer restored myogenic responses and suppressed fas-mediated apoptosis via induction of myocardin-A", CARDIOVASCULAR RESEARCH, OXFORD UNIVERSITY PRESS, GB, (20120301), vol. 93, no. Suppl. 1, ISSN 0008-6363, page s40, XP009181629 [AP] 1-8
 [A]  - MADONNA ROSALINDA ET AL, "Enhanced Survival and Myocardin-A Induced Cardiomyogenesis in Aged Mesenchymal Stem Cells Rejuvenated by Human Telomerase Gene Transfer", CIRCULATION RESEARCH, vol. 109, no. 12, doi:10.1161/RES.0B013E31823C90BD, ISSN 0009-7330, (20111112), pages E57 - E58, (20111111), XP009181630 [A] 1-8

DOI:   http://dx.doi.org/10.1161/RES.0b013e31823c90bd
 [A]  - TROY C. LUND ET AL, "Mesenchymal stromal cells from donors varying widely in age are of equal cellular fitness after in vitro expansion under hypoxic conditions", CYTOTHERAPY, (20101201), vol. 12, no. 8, doi:10.3109/14653249.2010.509394, ISSN 1465-3249, pages 971 - 981, XP055157798 [A] 1-8

DOI:   http://dx.doi.org/10.3109/14653249.2010.509394
 [A]  - Y. SUN ET AL, "Rescuing replication and osteogenesis of aged mesenchymal stem cells by exposure to a young extracellular matrix", THE FASEB JOURNAL, (20110119), vol. 25, no. 5, doi:10.1096/fj.10-161497, ISSN 0892-6638, pages 1474 - 1485, XP055095553 [A] 1-8

DOI:   http://dx.doi.org/10.1096/fj.10-161497
 [A]  - WEI ZHENG ET AL, "Loss of Proliferation and Differentiation Capacity of Aged Human Periodontal Ligament Stem Cells and Rejuvenation by Exposure to the Young Extrinsic Environment", TISSUE ENGINEERING PART A, (20090901), vol. 15, no. 9, doi:10.1089/ten.tea.2008.0562, ISSN 1937-3341, pages 2363 - 2371, XP055157933 [A] 1-8

DOI:   http://dx.doi.org/10.1089/ten.tea.2008.0562
 [A]  - MIKHAIL V. BLAGOSKLONNY, "Aging, Stem Cells, and Mammalian Target of Rapamycin: A Prospect of Pharmacologic Rejuvenation of Aging Stem Cells", REJUVENATION RESEARCH, (20080801), vol. 11, no. 4, doi:10.1089/rej.2008.0722, ISSN 1549-1684, pages 801 - 808, XP055157940 [A] 1-8

DOI:   http://dx.doi.org/10.1089/rej.2008.0722
 [A]  - IRINA M. CONBOY ET AL, "Rejuvenation of aged progenitor cells by exposure to a young systemic environment", NATURE, (20050217), vol. 433, no. 7027, doi:10.1038/nature03260, ISSN 0028-0836, pages 760 - 764, XP055018002 [A] 1-8

DOI:   http://dx.doi.org/10.1038/nature03260
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DOI:   http://dx.doi.org/10.1089/ten.tea.2007.0207
International search[A]KR101041914B  (APPLICANT PUSAN NATIONAL UNIVERSITY INDUSTRY- UNIVERSITY COOPERATION F);
 [A]KR100679642B  (RNL BIO CO LTD [KR]);
 [A]WO0111011  (FURCHT LEO T [US], et al);
 [A]KR100883565B  (PROSTEMICS ET AL.);
 [A]US6900051  (KERR-CONTE JULIE [FR], et al)
ExaminationEP2840133
 EP2865749
by applicantKR20090108141
    - SHIBATA, K.R. ET AL., STEM CELLS, (2007), vol. 25, pages 2371 - 2382
    - ZHANG, X. ET AL., BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, (2006), vol. 351, pages 853 - 859
    - ITO, T. ET AL., BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, (2007), vol. 359, pages 108 - 114
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.