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Extract from the Register of European Patents

EP About this file: EP2788354

EP2788354 - FUNCTIONALISATION OF CAGE AMINE LIGANDS FOR METALLO-RADIOPHARMACEUTICALS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  06.10.2017
Database last updated on 24.08.2024
Most recent event   Tooltip17.07.2020Lapse of the patent in a contracting state
New state(s): AL		published on 19.08.2020  [2020/34]
Applicant(s)For all designated states
The University of Melbourne
205-211 Grattan Street
Carlton, Victoria 3053 / AU
[2016/48]
Former [2014/42]For all designated states
The University Of Melbourne
205-211 Grattan Street
Carlton, Victoria 3053 / AU
Inventor(s)01 / DONNELLY, Paul
c/- UoM Commercial Ltd The University of Melbourne
Victoria 3010 / AU
02 / PATERSON, Brett
C/- UoM Commercial Ltd The University of Melbourne
Victoria 3010 / AU
 [2014/42]
Representative(s)Regimbeau
20, rue de Chazelles
75847 Paris Cedex 17 / FR
[2014/42]
Application number, filing date12856248.506.12.2012
[2016/48]
WO2012AU01483
Priority number, dateUS201161567255P06.12.2011         Original published format: US 201161567255 P
[2014/42]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2013082655
Date:13.06.2013
Language:EN
[2013/24]
Type: A1 Application with search report 
No.:EP2788354
Date:15.10.2014
Language:EN
The application published by WIPO in one of the EPO official languages on 13.06.2013 takes the place of the publication of the European patent application.
[2014/42]
Type: B1 Patent specification 
No.:EP2788354
Date:30.11.2016
Language:EN
[2016/48]
Search report(s)International search report - published on:AU13.06.2013
(Supplementary) European search report - dispatched on:EP15.05.2015
ClassificationIPC:C07D487/08, A61K51/06, A61K51/08
[2014/42]
CPC:
A61K51/0482 (EP,US); A61K47/547 (EP,US); A61K51/082 (EP,US);
A61K51/088 (EP,US); C07D487/08 (EP,US)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/42]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:FUNKTIONALISIERUNG VON CAGE-AMINLIGANDEN FÜR METALLO-RADIOPHARMAZEUTIKA[2014/42]
English:FUNCTIONALISATION OF CAGE AMINE LIGANDS FOR METALLO-RADIOPHARMACEUTICALS[2014/42]
French:FONCTIONNALISATION DE LIGANDS AMINE À EFFET DE CAGE POUR PRODUITS MÉTALLO-RADIOPHARMACEUTIQUES[2014/42]
Entry into regional phase03.07.2014National basic fee paid 
03.07.2014Search fee paid 
03.07.2014Designation fee(s) paid 
03.07.2014Examination fee paid 
Examination procedure03.07.2014Examination requested  [2014/42]
08.12.2015Amendment by applicant (claims and/or description)
20.06.2016Communication of intention to grant the patent
18.10.2016Fee for grant paid
18.10.2016Fee for publishing/printing paid
18.10.2016Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  20.06.2016
Opposition(s)31.08.2017No opposition filed within time limit [2017/45]
Fees paidRenewal fee
11.12.2014Renewal fee patent year 03
10.12.2015Renewal fee patent year 04
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU06.12.2012
AL30.11.2016
CY30.11.2016
CZ30.11.2016
EE30.11.2016
HR30.11.2016
IS30.11.2016
LT30.11.2016
LV30.11.2016
MC30.11.2016
MK30.11.2016
PL30.11.2016
RO30.11.2016
RS30.11.2016
SI30.11.2016
SK30.11.2016
SM30.11.2016
TR30.11.2016
LU06.12.2016
MT06.12.2016
BG28.02.2017
GR01.03.2017
[2020/34]
Former [2018/45]HU06.12.2012
CY30.11.2016
CZ30.11.2016
EE30.11.2016
HR30.11.2016
IS30.11.2016
LT30.11.2016
LV30.11.2016
MC30.11.2016
MK30.11.2016
PL30.11.2016
RO30.11.2016
RS30.11.2016
SI30.11.2016
SK30.11.2016
SM30.11.2016
TR30.11.2016
LU06.12.2016
MT06.12.2016
BG28.02.2017
GR01.03.2017
Former [2018/43]HU06.12.2012
CY30.11.2016
CZ30.11.2016
EE30.11.2016
HR30.11.2016
IS30.11.2016
LT30.11.2016
LV30.11.2016
MC30.11.2016
MK30.11.2016
PL30.11.2016
RO30.11.2016
RS30.11.2016
SI30.11.2016
SK30.11.2016
SM30.11.2016
LU06.12.2016
MT06.12.2016
BG28.02.2017
GR01.03.2017
Former [2018/30]HU06.12.2012
CY30.11.2016
CZ30.11.2016
EE30.11.2016
HR30.11.2016
IS30.11.2016
LT30.11.2016
LV30.11.2016
MC30.11.2016
MK30.11.2016
PL30.11.2016
RO30.11.2016
RS30.11.2016
SI30.11.2016
SK30.11.2016
SM30.11.2016
LU06.12.2016
BG28.02.2017
GR01.03.2017
Former [2017/49]CZ30.11.2016
EE30.11.2016
HR30.11.2016
LT30.11.2016
LV30.11.2016
MC30.11.2016
PL30.11.2016
RO30.11.2016
RS30.11.2016
SI30.11.2016
SK30.11.2016
SM30.11.2016
LU06.12.2016
BG28.02.2017
GR01.03.2017
Former [2017/42]CZ30.11.2016
EE30.11.2016
HR30.11.2016
LT30.11.2016
LV30.11.2016
MC30.11.2016
PL30.11.2016
RO30.11.2016
RS30.11.2016
SK30.11.2016
SM30.11.2016
BG28.02.2017
GR01.03.2017
Former [2017/37]CZ30.11.2016
EE30.11.2016
HR30.11.2016
LT30.11.2016
LV30.11.2016
PL30.11.2016
RO30.11.2016
RS30.11.2016
SK30.11.2016
SM30.11.2016
GR01.03.2017
Former [2017/26]HR30.11.2016
LT30.11.2016
LV30.11.2016
PL30.11.2016
RS30.11.2016
GR01.03.2017
Former [2017/12]LV30.11.2016
Documents cited:Search[A]WO2010063069  (UNIV MELBOURNE [AU], et al) [A] 1-17 * the whole document *;
 [A]  - NADINE DI BARTOLO ET AL, "New 64Cu PET imaging agents for personalised medicine and drug development using the hexa-aza cage, SarAr", ORGANIC & BIOMOLECULAR CHEMISTRY, (20060101), vol. 4, no. 17, doi:10.1039/b605615f, ISSN 1477-0520, page 3350, XP055187005 [A] 1-17 * the whole document *

DOI:   http://dx.doi.org/10.1039/b605615f
 [A]  - Voss D.S. ET AL, "Positron emission tomography (PET) imaging of neuroblastoma and melanoma with Cu-SarAr immunoconjugates", Proceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 44, (20070101), URL: http://www.pnas.org/content/104/44/17489.full.pdf, (20150430), XP055187006 [A] 1-17 * the whole document *
 [AP]  - MAGGIE S. COOPER ET AL, "Comparison of 64 Cu-Complexing Bifunctional Chelators for Radioimmunoconjugation: Labeling Efficiency, Specific Activity, and in Vitro / in Vivo Stability", BIOCONJUGATE CHEMISTRY, (20120516), vol. 23, no. 5, doi:10.1021/bc300037w, ISSN 1043-1802, pages 1029 - 1039, XP055187002 [AP] 1-17 * the whole document *

DOI:   http://dx.doi.org/10.1021/bc300037w
 [A]  - MICHELLE T. MA ET AL, "A new bifunctional chelator for copper radiopharmaceuticals: a cage amine ligand with a carboxylate functional group for conjugation to peptides", CHEMICAL COMMUNICATIONS, (20090101), no. 22, doi:10.1039/b903426a, ISSN 1359-7345, page 3237, XP055057963 [A] 1-17 * the whole document *

DOI:   http://dx.doi.org/10.1039/b903426a
International search[X]WO2010063069  (UNIV MELBOURNE [AU], et al);
 [X]  - JARRETT, B. R. ET AL., "Synthesis of 64Cu-Labeled Magnetic Nanoparticles for Multimodal Imaging", BIOCONJUGATE CHEMISTRY, (2008), vol. 19, pages 1496 - 1504, XP002547464

DOI:   http://dx.doi.org/10.1021/BC800108V
 [X]  - MA, M. T. ET AL., "A New Bifunctional Chelator for Copper Radiopharmaceuticals: A Cage Amine Ligand with a Carboxylate Functional Group for Conjugation to Peptides", CHEMICAL COMMUNICATIONS, (2009), vol. 22, pages 3237 - 3239, XP055057963

DOI:   http://dx.doi.org/10.1039/b903426a
 [X]  - HUANG, CHIUN-WEI ET AL., "Biological Stability Evaluation of the alpha2beta1 Receptor Imaging Agents: Diamsar and DOTA Conjugated DGEA Peptide", BIOCONJUGATE CHEMISTRY, (2011), vol. 22, no. 2, pages 256 - 263, XP055071397

DOI:   http://dx.doi.org/10.1021/bc100388g
 [X]  - WEI, LIHUI. ET AL., "64Cu-Labeled CB-TE2A and Diamsar-Conjugated RGD Peptide Analogs for Targeting Angiogenesis: Comparison of their Biological Activity", NUCLEAR MEDICINE AND BIOLOGY, (2009), vol. 36, no. 3, pages 277 - 285, XP026029883

DOI:   http://dx.doi.org/10.1016/j.nucmedbio.2008.12.008
 [X]  - MA, M. T. ET AL., "Macrobicyclic Cage Amine Ligands for Copper Radiopharmaceuticals: A Single Bivalent Cage Amine Containing Two Lys3-bombesin Targeting Peptides", INORGANIC CHEMISTRY, (2011), vol. 50, no. 14, pages 6701 - 6710, XP055071399

DOI:   http://dx.doi.org/10.1021/ic200681s
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