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Extract from the Register of European Patents

EP About this file: EP2794860

EP2794860 - METHOD FOR INDUCING DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS INTO INTERMEDIATE MESODERM CELLS [Right-click to bookmark this link]
StatusNo opposition filed within time limit
Status updated on  09.03.2018
Database last updated on 26.06.2024
FormerThe patent has been granted
Status updated on  31.03.2017
FormerGrant of patent is intended
Status updated on  29.03.2017
FormerExamination is in progress
Status updated on  03.03.2017
FormerGrant of patent is intended
Status updated on  20.11.2016
Most recent event   Tooltip17.07.2020Lapse of the patent in a contracting state
New state(s): AL		published on 19.08.2020  [2020/34]
Applicant(s)For all designated states
Kyoto University
36-1, Yoshida-honmachi Sakyo-ku
Kyoto-shi, Kyoto 606-8501 / JP
[2014/44]
Inventor(s)01 / OSAFUNE, Kenji
c/o Kyoto University
36-1 Yoshida-honmachi
Sakyo-ku
Kyoto-shi Kyoto 606-8501 / JP
02 / ARAOKA, Toshikazu
c/o Kyoto University
36-1 Yoshida-honmachi
Sakyo-ku
Kyoto-shi Kyoto 606-8501 / JP
 [2014/44]
Representative(s)D Young & Co LLP
3 Noble Street
London EC2V 7BQ / GB
[N/P]
Former [2017/18]D Young & Co LLP
120 Holborn
London EC1N 2DY / GB
Former [2014/44]Dempster, Robert Charles
D Young & Co LLP
120 Holborn
London EC1N 2DY / GB
Application number, filing date12860444.419.12.2012
[2017/18]
WO2012JP83762
Priority number, dateUS201161577345P19.12.2011         Original published format: US 201161577345 P
[2014/44]
Filing languageEN
Procedural languageEN
PublicationType: A1 Application with search report
No.:WO2013094771
Date:27.06.2013
Language:EN
[2013/26]
Type: A1 Application with search report 
No.:EP2794860
Date:29.10.2014
Language:EN
The application published by WIPO in one of the EPO official languages on 27.06.2013 takes the place of the publication of the European patent application.
[2014/44]
Type: B1 Patent specification 
No.:EP2794860
Date:03.05.2017
Language:EN
[2017/18]
Search report(s)International search report - published on:JP27.06.2013
(Supplementary) European search report - dispatched on:EP01.06.2015
ClassificationIPC:C12N5/10, C12N5/073, C12N5/0735, C12N5/0775, C12N15/09
[2014/44]
CPC:
C12N5/0686 (EP,US); C12N5/0605 (US); C12N2501/155 (EP,US);
C12N2501/385 (EP,US); C12N2501/415 (EP,US); C12N2501/727 (EP,US);
C12N2501/999 (US); C12N2506/45 (EP,US) (-)
Designated contracting statesAL,   AT,   BE,   BG,   CH,   CY,   CZ,   DE,   DK,   EE,   ES,   FI,   FR,   GB,   GR,   HR,   HU,   IE,   IS,   IT,   LI,   LT,   LU,   LV,   MC,   MK,   MT,   NL,   NO,   PL,   PT,   RO,   RS,   SE,   SI,   SK,   SM,   TR [2014/44]
Extension statesBANot yet paid
MENot yet paid
TitleGerman:VERFAHREN ZUR INDUZIERUNG DER DIFFERENZIERUNG MENSCHLICHER PLURIPOTENTER STAMMZELLEN IN INTERMEDIÄRE MESODERMZELLEN[2014/44]
English:METHOD FOR INDUCING DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS INTO INTERMEDIATE MESODERM CELLS[2014/44]
French:PROCÉDÉ D'INDUCTION D'UNE DIFFÉRENTIATION DE CELLULES SOUCHES PLURIPOTENTES HUMAINES EN CELLULES DE MÉSODERME INTERMÉDIAIRE[2014/44]
Entry into regional phase25.03.2014National basic fee paid 
25.03.2014Search fee paid 
25.03.2014Designation fee(s) paid 
25.03.2014Examination fee paid 
Examination procedure25.03.2014Examination requested  [2014/44]
15.01.2015Amendment by applicant (claims and/or description)
28.04.2016Despatch of a communication from the examining division (Time limit: M04)
08.09.2016Reply to a communication from the examining division
21.11.2016Communication of intention to grant the patent
24.02.2017Disapproval of the communication of intention to grant the patent by the applicant or resumption of examination proceedings by the EPO
21.03.2017Fee for grant paid
21.03.2017Fee for publishing/printing paid
29.03.2017Information about intention to grant a patent
29.03.2017Receipt of the translation of the claim(s)
Divisional application(s)The date of the Examining Division's first communication in respect of the earliest application for which a communication has been issued is  28.04.2016
Opposition(s)06.02.2018No opposition filed within time limit [2018/15]
Fees paidRenewal fee
15.12.2014Renewal fee patent year 03
10.12.2015Renewal fee patent year 04
15.12.2016Renewal fee patent year 05
Opt-out from the exclusive  Tooltip
competence of the Unified
Patent Court		 See the Register of the Unified Patent Court for opt-out data
Responsibility for the accuracy, completeness or quality of the data displayed under the link provided lies entirely with the Unified Patent Court.
Lapses during opposition  TooltipHU19.12.2012
AL03.05.2017
AT03.05.2017
CY03.05.2017
CZ03.05.2017
DK03.05.2017
EE03.05.2017
ES03.05.2017
FI03.05.2017
HR03.05.2017
IT03.05.2017
LT03.05.2017
LV03.05.2017
MC03.05.2017
MK03.05.2017
NL03.05.2017
PL03.05.2017
PT03.05.2017
RO03.05.2017
RS03.05.2017
SE03.05.2017
SI03.05.2017
SK03.05.2017
SM03.05.2017
TR03.05.2017
BG03.08.2017
NO03.08.2017
GR04.08.2017
IS03.09.2017
IE19.12.2017
LU19.12.2017
MT19.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
[2020/34]
Former [2020/28]HU19.12.2012
AT03.05.2017
CY03.05.2017
CZ03.05.2017
DK03.05.2017
EE03.05.2017
ES03.05.2017
FI03.05.2017
HR03.05.2017
IT03.05.2017
LT03.05.2017
LV03.05.2017
MC03.05.2017
MK03.05.2017
NL03.05.2017
PL03.05.2017
PT03.05.2017
RO03.05.2017
RS03.05.2017
SE03.05.2017
SI03.05.2017
SK03.05.2017
SM03.05.2017
TR03.05.2017
BG03.08.2017
NO03.08.2017
GR04.08.2017
IS03.09.2017
IE19.12.2017
LU19.12.2017
MT19.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
Former [2020/15]HU19.12.2012
AT03.05.2017
CY03.05.2017
CZ03.05.2017
DK03.05.2017
EE03.05.2017
ES03.05.2017
FI03.05.2017
HR03.05.2017
IT03.05.2017
LT03.05.2017
LV03.05.2017
MC03.05.2017
MK03.05.2017
NL03.05.2017
PL03.05.2017
RO03.05.2017
RS03.05.2017
SE03.05.2017
SI03.05.2017
SK03.05.2017
SM03.05.2017
TR03.05.2017
BG03.08.2017
NO03.08.2017
GR04.08.2017
IS03.09.2017
IE19.12.2017
LU19.12.2017
MT19.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
Former [2019/51]HU19.12.2012
AT03.05.2017
CY03.05.2017
CZ03.05.2017
DK03.05.2017
EE03.05.2017
ES03.05.2017
FI03.05.2017
HR03.05.2017
IT03.05.2017
LT03.05.2017
LV03.05.2017
MC03.05.2017
MK03.05.2017
NL03.05.2017
PL03.05.2017
RO03.05.2017
RS03.05.2017
SE03.05.2017
SI03.05.2017
SK03.05.2017
SM03.05.2017
BG03.08.2017
NO03.08.2017
GR04.08.2017
IS03.09.2017
IE19.12.2017
LU19.12.2017
MT19.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
Former [2019/47]HU19.12.2012
AT03.05.2017
CY03.05.2017
CZ03.05.2017
DK03.05.2017
EE03.05.2017
ES03.05.2017
FI03.05.2017
HR03.05.2017
IT03.05.2017
LT03.05.2017
LV03.05.2017
MC03.05.2017
NL03.05.2017
PL03.05.2017
RO03.05.2017
RS03.05.2017
SE03.05.2017
SI03.05.2017
SK03.05.2017
SM03.05.2017
BG03.08.2017
NO03.08.2017
GR04.08.2017
IS03.09.2017
IE19.12.2017
LU19.12.2017
MT19.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
Former [2019/31]HU19.12.2012
AT03.05.2017
CZ03.05.2017
DK03.05.2017
EE03.05.2017
ES03.05.2017
FI03.05.2017
HR03.05.2017
IT03.05.2017
LT03.05.2017
LV03.05.2017
MC03.05.2017
NL03.05.2017
PL03.05.2017
RO03.05.2017
RS03.05.2017
SE03.05.2017
SI03.05.2017
SK03.05.2017
SM03.05.2017
BG03.08.2017
NO03.08.2017
GR04.08.2017
IS03.09.2017
IE19.12.2017
LU19.12.2017
MT19.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
Former [2019/30]AT03.05.2017
CZ03.05.2017
DK03.05.2017
EE03.05.2017
ES03.05.2017
FI03.05.2017
HR03.05.2017
IT03.05.2017
LT03.05.2017
LV03.05.2017
MC03.05.2017
NL03.05.2017
PL03.05.2017
RO03.05.2017
RS03.05.2017
SE03.05.2017
SI03.05.2017
SK03.05.2017
SM03.05.2017
BG03.08.2017
NO03.08.2017
GR04.08.2017
IS03.09.2017
IE19.12.2017
LU19.12.2017
MT19.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
Former [2018/52]AT03.05.2017
CZ03.05.2017
DK03.05.2017
EE03.05.2017
ES03.05.2017
FI03.05.2017
HR03.05.2017
IT03.05.2017
LT03.05.2017
LV03.05.2017
NL03.05.2017
PL03.05.2017
RO03.05.2017
RS03.05.2017
SE03.05.2017
SI03.05.2017
SK03.05.2017
SM03.05.2017
BG03.08.2017
NO03.08.2017
GR04.08.2017
IS03.09.2017
IE19.12.2017
LU19.12.2017
MT19.12.2017
BE31.12.2017
CH31.12.2017
LI31.12.2017
Former [2018/50]AT03.05.2017
CZ03.05.2017
DK03.05.2017
EE03.05.2017
ES03.05.2017
FI03.05.2017
HR03.05.2017
IT03.05.2017
LT03.05.2017
LV03.05.2017
NL03.05.2017
PL03.05.2017
RO03.05.2017
RS03.05.2017
SE03.05.2017
SI03.05.2017
SK03.05.2017
SM03.05.2017
BG03.08.2017
NO03.08.2017
GR04.08.2017
IS03.09.2017
IE19.12.2017
LU19.12.2017
MT19.12.2017
BE31.12.2017
Former [2018/45]AT03.05.2017
CZ03.05.2017
DK03.05.2017
EE03.05.2017
ES03.05.2017
FI03.05.2017
HR03.05.2017
IT03.05.2017
LT03.05.2017
LV03.05.2017
NL03.05.2017
PL03.05.2017
RO03.05.2017
RS03.05.2017
SE03.05.2017
SI03.05.2017
SK03.05.2017
SM03.05.2017
BG03.08.2017
NO03.08.2017
GR04.08.2017
IS03.09.2017
IE19.12.2017
LU19.12.2017
MT19.12.2017
Former [2018/43]AT03.05.2017
CZ03.05.2017
DK03.05.2017
EE03.05.2017
ES03.05.2017
FI03.05.2017
HR03.05.2017
IT03.05.2017
LT03.05.2017
LV03.05.2017
NL03.05.2017
PL03.05.2017
RO03.05.2017
RS03.05.2017
SE03.05.2017
SI03.05.2017
SK03.05.2017
SM03.05.2017
BG03.08.2017
NO03.08.2017
GR04.08.2017
IS03.09.2017
LU19.12.2017
MT19.12.2017
Former [2018/25]AT03.05.2017
CZ03.05.2017
DK03.05.2017
EE03.05.2017
ES03.05.2017
FI03.05.2017
HR03.05.2017
IT03.05.2017
LT03.05.2017
LV03.05.2017
NL03.05.2017
PL03.05.2017
RO03.05.2017
RS03.05.2017
SE03.05.2017
SI03.05.2017
SK03.05.2017
SM03.05.2017
BG03.08.2017
NO03.08.2017
GR04.08.2017
IS03.09.2017
Former [2018/11]AT03.05.2017
CZ03.05.2017
DK03.05.2017
EE03.05.2017
ES03.05.2017
FI03.05.2017
HR03.05.2017
IT03.05.2017
LT03.05.2017
LV03.05.2017
NL03.05.2017
PL03.05.2017
RO03.05.2017
RS03.05.2017
SE03.05.2017
SK03.05.2017
SM03.05.2017
BG03.08.2017
NO03.08.2017
GR04.08.2017
IS03.09.2017
Former [2018/10]AT03.05.2017
CZ03.05.2017
DK03.05.2017
EE03.05.2017
ES03.05.2017
FI03.05.2017
HR03.05.2017
LT03.05.2017
LV03.05.2017
NL03.05.2017
PL03.05.2017
RO03.05.2017
RS03.05.2017
SE03.05.2017
SK03.05.2017
BG03.08.2017
NO03.08.2017
GR04.08.2017
IS03.09.2017
Former [2018/09]AT03.05.2017
DK03.05.2017
EE03.05.2017
ES03.05.2017
FI03.05.2017
HR03.05.2017
LT03.05.2017
LV03.05.2017
NL03.05.2017
PL03.05.2017
RS03.05.2017
SE03.05.2017
BG03.08.2017
NO03.08.2017
GR04.08.2017
IS03.09.2017
Former [2017/52]AT03.05.2017
ES03.05.2017
FI03.05.2017
HR03.05.2017
LT03.05.2017
LV03.05.2017
NL03.05.2017
PL03.05.2017
RS03.05.2017
SE03.05.2017
BG03.08.2017
NO03.08.2017
GR04.08.2017
IS03.09.2017
Former [2017/50]AT03.05.2017
ES03.05.2017
FI03.05.2017
HR03.05.2017
LT03.05.2017
LV03.05.2017
PL03.05.2017
RS03.05.2017
SE03.05.2017
BG03.08.2017
NO03.08.2017
GR04.08.2017
IS03.09.2017
Former [2017/49]AT03.05.2017
ES03.05.2017
FI03.05.2017
HR03.05.2017
LT03.05.2017
NO03.08.2017
GR04.08.2017
IS03.09.2017
Documents cited:Search[A]  - SUMI TOMOYUKI ET AL, "Defining early lineage specification of human embryonic stem cells by the orchestrated balance of canonical Wnt/beta-catenin, Activin/Nodal and BMP signaling", DEVELOPMENT, THE COMPANY OF BIOLOGISTS LTD, GB, vol. 135, no. 17, ISSN 0950-1991, (20080901), pages 2969 - 2979, (20080730), XP009165629 [A] 1-15

DOI:   http://dx.doi.org/10.1242/dev.021121
 [A]  - H. K. BONE ET AL, "A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3", JOURNAL OF CELL SCIENCE, (20110615), vol. 124, no. 12, doi:10.1242/jcs.081679, ISSN 0021-9533, pages 1992 - 2000, XP055157158 [A] 1-15

DOI:   http://dx.doi.org/10.1242/jcs.081679
 [A]  - GREGORY R. DRESSLER, "The Cellular Basis of Kidney Development", ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, (20061101), vol. 22, no. 1, doi:10.1146/annurev.cellbio.22.010305.104340, ISSN 1081-0706, pages 509 - 529, XP055184273 [A] 1-15

DOI:   http://dx.doi.org/10.1146/annurev.cellbio.22.010305.104340
 [A]  - KIM DOYEOB ET AL, "Nephrogenic factors promote differentiation of mouse embryonic stem cells into renal epithelia", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, WILLIAMS AND WILKINS, BALTIMORE, MD, US, vol. 16, no. 12, doi:10.1681/ASN.2005050544, ISSN 1046-6673, (20051201), pages 3527 - 3534, (20051102), XP002587898 [A] 1-15

DOI:   http://dx.doi.org/10.1681/ASN.2005050544
 [T]  - TOSHIKAZU ARAOKA ET AL, "Efficient and Rapid Induction of Human iPSCs/ESCs into Nephrogenic Intermediate Mesoderm Using Small Molecule-Based Differentiation Methods", PLOS ONE, (20140115), vol. 9, no. 1, doi:10.1371/journal.pone.0084881, page e84881, XP055184928

DOI:   http://dx.doi.org/10.1371/journal.pone.0084881
International search[AP]WO2012011610  (UNIV KYOTO [JP], et al);
 [A]  - MAE,S. ET AL., "Differentiation Induction of Intermediate Mesoderm from Mouse ES Cell Using Low-Molecular Compounds.", THE 420D ANNUAL MEETING OF THE JAPANESE SOCIETY FOR CLINICAL MOLECULAR MORPHOLOGY, (2010), page 44, XP008173127
 [A]  - AO,A. ET AL., "Regenerative Chemical Biology: Current Challenges and Future Potential.", CHEM.BIOL., (201104), vol. 18, pages 413 - 424, XP055146549

DOI:   http://dx.doi.org/10.1016/j.chembiol.2011.03.011
 [A]  - XU,Y. ET AL., "A chemical approach to stem-cell biology and regenerative medicine.", NATURE, (2008), vol. 453, pages 338 - 344, XP055013324

DOI:   http://dx.doi.org/10.1038/nature07042
 [A]  - MAE,S. ET AL., "Combination of small molecules enhances differentiation of mouse embryonic stem cells into intermediate mesoderm through BMP7-positive cells.", BIOCHEM.BIOPHYS.RES.COMMUN., (2010), vol. 393, pages 877 - 882, XP026970773

DOI:   http://dx.doi.org/10.1016/j.bbrc.2010.02.111
 [A]  - OSAFUNE K. ET AL., "In vitro regeneration of kidney from pluripotent stem cells.", EXP.CELL RES., (2010), vol. 316, pages 2571 - 2577, XP027264821
 [AP]  - OSAFUNE K., "Kidney regeneration and its clinical application using iPS cell technology.", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, (20111231), vol. 239, no. 14, pages 1379 - 1384, XP008172812
by applicantWO2012011610
    - TADA, M. ET AL., CURR. BIOL., (2001), vol. 11, pages 1553 - 1558
    - COWAN, C. A. ET AL., SCIENCE, (20050826), vol. 309, no. 5739, pages 1369 - 1373
 WO2011JP67181
The EPO accepts no responsibility for the accuracy of data originating from other authorities; in particular, it does not guarantee that it is complete, up to date or fit for specific purposes.